1,055,479 results match your criteria required dapk1-mediated

Pediatric Ocular Injury Due to Hand Sanitizer Exposure An Emerging Hazard.

Pediatr Emerg Care 2021 Jun 11. Epub 2021 Jun 11.

From the Department of Ophthalmology, Shaare Zedek Medical Center, Jerusalem Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel Hashomer Pediatric Emergency Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.

Objectives: The objective of this study was to describe the incidence and severity of ocular exposure to alcohol-based hand rub (ABHR) in children presenting to a tertiary medical center during the severe acute respiratory syndrome coronavirus 2 pandemic.

Methods: A retrospective single-center observational study conducted from February 21, 2020, to October 11, 2020. Subjects 10 years or younger who presented with ABHR-induced ocular injury were included. Read More

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Identification and quantification of microplastic particles in drinking water treatment sludge as an integrative approach to determine microplastic abundance in a freshwater river.

Environ Pollut 2021 Jun 4;286:117524. Epub 2021 Jun 4.

Leibniz-Institut für Ostseeforschung Warnemünde (IOW), D-18119, Rostock, Germany. Electronic address:

Microplastic (MP) has been detected ubiquitously in freshwater systems. Until now MP sampling, however, is predominantly based on short-term net or pumping and filtration systems which can only provide snapshots of MP abundance; especially in flowing water bodies. To improve representativeness in the determination of MP occurrences in these aquatic compartments, an integrative approach that covers larger water volumes for a longer period of time is required. Read More

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Predicting feed intake using modelling based on feeding behaviour in finishing beef steers.

Animal 2021 Jun 8;15(7):100231. Epub 2021 Jun 8.

Scotland's Rural College, Beef and Sheep Research Centre, SRUC, West Mains Road, Edinburgh EH9 3JG, UK.

Current techniques for measuring feed intake in housed cattle are both expensive and time-consuming making them unsuitable for use on commercial farms. Estimates of individual animal intake are required for assessing production efficiency. The aim of this study was to predict individual animal intake using parameters that can be easily obtained on commercial farms including feeding behaviour, liveweight and age. Read More

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Spatial and temporal changes in bomb radiocarbon in the northern Indian Ocean.

J Environ Radioact 2021 Jun 8;237:106680. Epub 2021 Jun 8.

Physical Research Laboratory, Ahmedabad, India.

For improved understanding of ocean circulation in the northern Indian Ocean region, long term continuous record of radiocarbon measurement is required. Limited radiocarbon records from the region demands investigations of natural archives. Coral core records along with some literature data were analysed to study the temporal changes in C values over the northern Indian Ocean. Read More

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A comparative study of navigation interfaces in virtual reality environments: A mixed-method approach.

Appl Ergon 2021 Jun 8;96:103482. Epub 2021 Jun 8.

Division of Future Convergence (HCI Science Major), Dongduk Women's University, Seoul, South Korea. Electronic address:

Recently, motion-based navigation interfaces have been widely utilized in virtual reality (VR) environments. However, improper navigation interfaces can negatively impact the VR experience, and because different interfaces have different characteristics, the navigation experience may vary. Although comparative studies have been conducted with various interfaces, information obtained by focusing on qualitative evaluation was limited. Read More

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The spectrum of acute leukoencephalopathy with restricted diffusion (ALERD): A case series and review of literature.

Eur J Paediatr Neurol 2021 Jun 6;33:86-93. Epub 2021 Jun 6.

Department of Pediatric Neurology, Rainbow Children's Hospital, Hyderabad, Telangana, India. Electronic address:

Introduction: The clinico-etiological spectrum of Acute leukoencephalopathy with restricted diffusion (ALERD) is not well known in Indian population. This is likely to vary between populations and ethnicities.

Methods: We retrospectively reviewed the clinicoetiological spectrum of ALERD at a tertiary care pediatric center, and described the clinical, imaging, etiological spectrum and short-term outcomes. Read More

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Medial olivary complex reflex in term newborns with hyperbilirubinemia.

Int J Pediatr Otorhinolaryngol 2021 May 21;147:110777. Epub 2021 May 21.

Dept. of Otolaryngology, Faculty of Medicine, Baskent University, Ankara, Turkey.

Objective: This study aimed to compare the integrity of the efferent auditory pathways of newborns that had high hyperbilirubinemia levels and required treatment due to these and healthy newborns.

Methods: Term-born (37 weeks or later) infants that were brought to the Newborn Polyclinic of the Başkent University Hospital were included in the study. The study included a total of 84 infants including healthy newborns (n = 42) and those that had jaundice and were receiving phototherapy (n = 42). Read More

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Evaluation of fully automated a priori MCO treatment planning in VMAT for head-and-neck cancer.

Phys Med 2021 Jun 8;87:31-38. Epub 2021 Jun 8.

Centre Léon Bérard, 28 rue Laennec 69373, LYON Cedex 08, France.

Purpose: Automated planning techniques aim to reduce manual planning time and inter-operator variability without compromising the plan quality which is particularly challenging for head-and-neck (HN) cancer radiotherapy. The objective of this study was to evaluate the performance of an a priori-multicriteria plan optimization algorithm on a cohort of HN patients.

Methods: A total of 14 nasopharyngeal carcinoma (upper-HN) and 14 "middle-lower indications" (lower-HN) previously treated in our institution were enrolled in this study. Read More

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An analysis of the reading habits of autistic adults compared to neurotypical adults and implications for future interventions.

Res Dev Disabil 2021 Jun 8;115:104003. Epub 2021 Jun 8.

Department of Primary Care and Mental Health, University of Liverpool, Liverpool, UK.

Background: While research has consistently highlighted the usefulness of narrative texts for social development, this has not been fully explored with autistic adults. It has long been assumed that autistic individuals lack the social understanding to contemplate fiction, preferring non-fiction. This study aimed to explore the self-reported reading habits of autistic adults compared to neurotypical adults, accounting for higher education demands. Read More

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An updated RT-qPCR assay for the simultaneous detection and quantification of chikungunya, dengue and zika viruses.

Infect Genet Evol 2021 Jun 8:104967. Epub 2021 Jun 8.

Grupo de Morfología Celular, Dirección de Investigación en Salud Pública, Instituto Nacional de Salud, Bogotá D.C. 111321, Colombia.

The real-time reverse transcription-polymerase chain reaction (real-time RT-qPCR) has become a leading technique for the detection and quantification of arboviruses, including chikungunya, dengue, and zika viruses. In this study, an updated real-time RT-qPCR assay was designed and evaluated together with a synthetic positive-control chimeric RNA for the simultaneous detection and quantification of chikungunya, dengue, and Zika viruses. Amplification assays were performed to verify the construct integrity and optimal reaction/thermal cycling conditions. Read More

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Partial Arthroscopic Trapeziectomy and Stabilisation by Ligamentoplasty: Outcomes in Patients Younger than 60 Years.

Orthop Traumatol Surg Res 2021 Jun 8:102983. Epub 2021 Jun 8.

Service de chirurgie orthopédique et traumatologique, centre hospitalier de Versailles, 78150 Le Chesnay, France.

Background: Thumb carpo-metacarpal joint (TCMJ) osteoarthritis is the fourth leading cause of referral to elective hand surgery. None of the available techniques has proved superior over the others. Some techniques carry unacceptable risks for younger patients, such as loss of strength and shortening of the thumb column after total trapeziectomy, or wear and loosening after total arthroplasty. Read More

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Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-β-hydroxybutyrate dehydrogenase hepatocyte-deficient mice.

Mol Metab 2021 Jun 8:101269. Epub 2021 Jun 8.

Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, USA. Electronic address:

Objective: Throughout the last decade, interest has intensified in intermittent fasting, ketogenic diets, and exogenous ketone therapies as prospective health-promoting, therapeutic, and performance-enhancing agents. However, the regulatory roles of ketogenesis and ketone metabolism on liver homeostasis remain unclear. Therefore, we sought to develop a better understanding of the metabolic consequences of hepatic ketone body metabolism by focusing on the redox-dependent interconversion of acetoacetate (AcAc) and D-β-hydroxybutyrate (D-βOHB). Read More

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DNA demethylases remodel DNA methylation in rice gametes and zygote and are required for reproduction.

Mol Plant 2021 Jun 8. Epub 2021 Jun 8.

National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, 430070 Wuhan China; Institute of Plant Science Paris-Saclay (IPS2), CNRS, INRAE, University Paris-Saclay, 91405 Orsay, France. Electronic address:

Fertilization constitutes a critical step in the plant life cycle during which the gamete genomes undergo chromatin dynamics in preparation for embryogenesis. In mammals, parental chromatin is extensively reprogrammed through the global erasure of DNA methylation. However, in flowering plants it remains unclear whether and how DNA methylation is remodeled in gametes and after fertilization in zygote. Read More

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Tuberculosis of the spine in children - Does drug resistance affect surgical outcomes?

Spine J 2021 Jun 8. Epub 2021 Jun 8.

Paediatric TB Clinic, Bai Jerbai Wadia Hospital for Children, Mumbai, India. Electronic address:

Background Context: The emergence of drug resistance has complicated the management of spinal tuberculosis (TB). While it is well known that the medical management of drug-resistant spinal TB is more difficult, the surgical outcomes of the same have not been studied sufficiently, particularly in children.

Purpose: To analyze the surgical outcomes in a cohort of children treated for spinal TB, and to thus assess whether drug resistant (DR) disease is associated with poorer surgical outcomes. Read More

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Consensus Statement on the Treatment of Massive Irreparable Rotator Cuff Tears - A Delphi Approach by the Neer Circle of the American Shoulder and Elbow Surgeons.

J Shoulder Elbow Surg 2021 Jun 8. Epub 2021 Jun 8.

Department of Orthopedic Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA.

Background: Management of massive irreparable rotator cuff tears (MIRCTs) remains controversial due to variability in patient features and outcomes contributing to a lack of unanimity in treatment recommendations. The purpose of this study was to implement the Delphi process using experts from the Neer Circle of the American Shoulder and Elbow Surgeons (ASES) to determine areas of consensus regarding treatment options for a variety of MIRCTs.

Methods: A panel of 120 shoulder surgeons were sent a survey regarding MIRCT treatments including: arthroscopic débridement and partial cuff repair, graft augmentation, reverse shoulder arthroplasty (RSA), superior capsular reconstruction (SCR), and tendon transfers. Read More

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Efficacy and safety of ciprofol for the sedation/anesthesia in patients undergoing colonoscopy: Phase IIa and IIb multi-center clinical trials.

Eur J Pharm Sci 2021 Jun 8:105904. Epub 2021 Jun 8.

Department of Anesthesiology, West China Hospital, Sichuan University & The Research Units of West China (2018RU012), Chinese Academy of Medical Sciences Chengdu, China. Electronic address:

Objective: Ciprofol is a new intravenous anesthetic agent similar to propofol that has the pharmacodynamic characteristics of a rapid rate of onset and recovery in pre-clinical experiments. The aims of the present clinical trials were to compare the efficacy and safety of ciprofol emulsion for sedation or general anesthesia during colonoscopy and to define optimal doses for a subsequent phase III clinical trial.

Methods: A phase IIa multi-center, open-label, non-randomized, positive control, dose-escalating study was performed to determine a recommended phase IIb dose (RP2D) of ciprofol to induce sedation or anesthesia in patients undergoing colonoscopy. Read More

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Multi-modal imaging of a single mouse brain over five orders of magnitude of resolution.

Neuroimage 2021 Jun 8:118250. Epub 2021 Jun 8.

Department of Neurobiology, University of Chicago, Chicago, IL, United States.

Mammalian neurons operate at length scales spanning six orders of magnitude; they project millimeters to centimeters across brain regions, are composed of micrometer-scale-diameter myelinated axons, and ultimately form nanometer scale synapses. Capturing these anatomical features across that breadth of scale has required imaging samples with multiple independent imaging modalities. Translating between the different modalities, however, requires imaging the same brain with each. Read More

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T2 heterogeneity as an in vivo marker of microstructural integrity in medial temporal lobe subfields in ageing and mild cognitive impairment.

Neuroimage 2021 Jun 8:118214. Epub 2021 Jun 8.

Bristol Medical School, University of Bristol, Bristol, UK; Clinical Neurosciences, North Bristol NHS Trust, Bristol, UK.

A better understanding of early brain changes that precede loss of independence in diseases like Alzheimer's disease (AD) is critical for development of disease-modifying therapies. Quantitative MRI, such as T2 relaxometry, can identify microstructural changes relevant to early stages of pathology. Recent evidence suggests heterogeneity of T2 may be a more informative MRI measure of early pathology than absolute T2. Read More

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NMR structural and biophysical analysis of the disease-linked inner mitochondrial membrane protein MPV17.

J Mol Biol 2021 Jun 8:167098. Epub 2021 Jun 8.

Structural Membrane Biochemistry, Bavarian NMR Center (BNMRZ) at the Department of Chemistry, Technical University of Munich, Ernst-Otto-Fischer-Str. 2, 85748 Garching, Germany; Institute of Structural Biology, Helmholtz Center Munich, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany. Electronic address:

MPV17 is an integral inner mitochondrial membrane protein, whose loss-of-function is linked to the hepatocerebral form of the mitochondrial-DNA-depletion syndrome (MDDS), leading to a tissue-specific reduction of mitochondrial DNA and organ failure in infants. Several disease-causing mutations in MPV17 have been identified and earlier studies with reconstituted protein suggest that MPV17 forms a high conductivity channel in the membrane. However, the molecular and structural basis of the MPV17 functionality remain only poorly understood. Read More

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The PHY domain dimer interface of bacteriophytochromes mediates cross-talk between photosensory modules and output domains.

J Mol Biol 2021 Jun 8:167092. Epub 2021 Jun 8.

Institute of Biochemistry, Graz University of Technology, 8010 Graz, Austria; BioTechMed-Graz, 8010 Graz, Austria. Electronic address:

Protein dynamics play a major role for the catalytic function of enzymes, the interaction of protein complexes or signal integration in regulatory proteins. In the context of multi-domain proteins involved in light-regulation of enzymatic effectors, the central role of conformational dynamics is well established. Light activation of sensory modules is followed by long-range signal transduction to different effectors; rather than domino-style structural rearrangements, a complex interplay of functional elements is required to maintain functionality. Read More

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Treatments and outcomes of generalized pustular psoriasis: a cohort of 1516 patients in a nationwide inpatient database in Japan.

J Am Acad Dermatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.

Background: Because generalized pustular psoriasis (GPP) is uncommon, there are few studies reporting treatments and outcomes for large numbers of patients.

Objective: To report treatments and outcomes in a large cohort of hospitalized patients with GPP.

Methods: Using a Japanese national inpatient database, we identified 1516 patients with GPP who required hospitalization from July 2010 to March 2019. Read More

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Is Melanoma Overdiagnosed? A Review of the Evidence.

J Am Acad Dermatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Dermatology, University of Connecticut School of Medicine, Farmington, CT; University of Florida Dermatology Department, Gainesville, FL. Electronic address:

Background: Melanoma is one of the most commonly diagnosed malignancies in the United States (US) and is responsible for the majority of deaths from skin cancer.

Objective: Since the 1970s, the incidence of melanoma has risen appreciably while melanoma-specific mortality has remained stable. This has raised a debate about potential overdiagnosis of melanoma. Read More

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An interdomain hydrogen bond in the Rag GTPases maintains stable mTORC1 signaling in sensing amino acids.

J Biol Chem 2021 Jun 8:100861. Epub 2021 Jun 8.

Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St, Worcester, MA 01605, USA. Electronic address:

Cellular growth and proliferation are primarily dictated by the mechanistic target of rapamycin complex 1 (mTORC1), which balances nutrient availability against the cell's anabolic needs. Central to the activity of mTORC1 is the RagA-RagC GTPase heterodimer, which under favorable conditions recruits the complex to the lysosomal surface to promote its activity. The RagA-RagC heterodimer has a unique architecture in that both subunits are active GTPases. Read More

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Impact of Individual Differences in Eating Rate on Oral Processing, Bolus Properties and Post-Meal Glucose Responses.

Physiol Behav 2021 Jun 8:113495. Epub 2021 Jun 8.

Clinical Nutrition Research Centre, A*STAR Singapore Institute for Food & Biotechnology Innovation; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore. Electronic address:

Purpose: Modifying food texture has been shown to influence oral processing behaviour. We explored the impact of food texture on oral processing, bolus formation and post-prandial glucose responses (PPG) among fast and slow eaters.

Methods: Male participants (N=39) were split into fast or slow eaters based on natural differences in eating rate when consuming two carbohydrate-equivalent test-meals differing in texture (white rice and rice cake). Read More

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Biplane mode for more precise intrauterine procedures.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

Department of Obstetrics and Fetal Medicine, Necker Enfants-Malades Hospital, Paris Descartes University, Paris, France; Université de Paris, Paris, France.

The evolution of ultrasound and the introduction of three and four-dimensional ultrasound techniques led to a shift in the perception and usage of ultrasound in fetal medicine. The biplane mode might help in multiple fetal procedures, including but not limited to, basic intrauterine thoracocentesis, thoraco-amniotic shunting, amnioreduction, amnioinfusion, cordocentesis, intraumbilical infusion and ِumbilical cord coagulation, with a possible reduction in the complication rate. Despite its theoretical usefulness, more studies are required to assess the clinical importance of this technique. Read More

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Circular RNA circHIPK3 promotes homeostasis of the intestinal epithelium by reducing miR-29b function.

Gastroenterology 2021 Jun 8. Epub 2021 Jun 8.

Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland; Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland; Baltimore Veterans Affairs Medical Center, Baltimore, Maryland. Electronic address:

Background And Aim: S: Circular RNAs (circRNAs) are a class of endogenous noncoding RNAs that form covalently closed circles. Although circRNAs influence many biological processes, little is known about their role in intestinal epithelium homeostasis. We surveyed circRNAs required to maintain intestinal epithelial integrity and identified circHIPK3 as a major regulator of intestinal epithelial repair after acute injury. Read More

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DMA-tudor interaction modules control the specificity of in vivo condensates.

Cell 2021 Jun 4. Epub 2021 Jun 4.

Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA; Cell Biology, Yale University, New Haven, CT 06520, USA. Electronic address:

Biomolecular condensation is a widespread mechanism of cellular compartmentalization. Because the "survival of motor neuron protein" (SMN) is implicated in the formation of three different membraneless organelles (MLOs), we hypothesized that SMN promotes condensation. Unexpectedly, we found that SMN's globular tudor domain was sufficient for dimerization-induced condensation in vivo, whereas its two intrinsically disordered regions (IDRs) were not. Read More

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Multidrug-resistant species: underestimated fungal pathogens posing imminent threats in clinical settings.

Crit Rev Microbiol 2021 Jun 11:1-20. Epub 2021 Jun 11.

Department of Medicine, Division of Infectious Diseases, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.

Species of and related genera are widely used in biotechnology and, hence, many species have their genome sequenced. Importantly, yeasts of the genus have been increasingly identified as a cause of life-threatening invasive trichosporonosis (IT) in humans and are associated with an exceptionally high mortality rate. spp. Read More

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Oxylipin profiles and levels vary by skeletal muscle type, dietary fat and sex in young rats.

Appl Physiol Nutr Metab 2021 Jun 11. Epub 2021 Jun 11.

University of Manitoba Faculty of Agricultural and Food Sciences, 98691, Human Nutritional Sciences, Winnipeg, Manitoba, Canada.

PUFA-derived bioactive lipid mediators called oxylipins have been shown to influence muscle growth, inflammation and repair in select muscles. Since individual oxylipins have varying effects and potencies, broad profiling in differing muscle types is required to further understand their overall effects. In addition, diet and sex are key determinants of oxylipin levels. Read More

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Ubiquitin Signaling in the Control of Centriole Duplication.

FEBS J 2021 Jun 11. Epub 2021 Jun 11.

School of Biology, Indian Institute of Science Education and Research, Thiruvananthapuram, Vithura, Thiruvananthapuram, 695551, Kerala, India.

Centrosome plays essential roles in maintaining genetic stability, ciliogenesis and cell polarization. The core of centrosome is made of two centrioles that duplicate precisely once during every cell cycle to generate two centrosomes that are required for bipolar spindle assembly and chromosome segregation. Abundance of centriole proteins at optimal levels and their recruitment to the centrosome are tightly regulated in time and space in order to restrict aberrant duplication of centrioles, a phenomenon that is observed in many cancers. Read More

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