21,222 results match your criteria required confirm

Runx1 shapes the chromatin landscape via a cascade of direct and indirect targets.

PLoS Genet 2021 Jun 10;17(6):e1009574. Epub 2021 Jun 10.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.

Runt-related transcription factor 1 (Runx1) can act as both an activator and a repressor. Here we show that CRISPR-mediated deletion of Runx1 in mouse metanephric mesenchyme-derived mK4 cells results in large-scale genome-wide changes to chromatin accessibility and gene expression. Open chromatin regions near down-regulated loci enriched for Runx sites in mK4 cells lose chromatin accessibility in Runx1 knockout cells, despite remaining Runx2-bound. Read More

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Sinonasal surgery alters brain structure and function: Neuroanatomical correlates of olfactory dysfunction.

J Neurosci Res 2021 Jun 10. Epub 2021 Jun 10.

Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.

Olfactory dysfunction (OD) is more common than hearing loss, partial blindness, or blindness and can have a significant impact on the quality of life. Moreover, unexplained OD is an early biomarker in neurodegenerative diseases and increases 5-year mortality risk. Structural alterations in olfactory eloquent brain regions may represent the neuroanatomical correlates of OD. Read More

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Mechano-regulation of Vascular Network Formation without Branches in 3D Bioprinted Cell-laden Hydrogel Constructs.

Biotechnol Bioeng 2021 Jun 10. Epub 2021 Jun 10.

Ruihua Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215104, China.

Restoration of a wound is a common surgical procedure in clinic. Currently, the skin required for clinical use is taken from the patient's own body. However, it can be difficult to obtain enough skin sources for large-sized wounds and thus surgeons have started using commercial skin substitutes. Read More

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Immunological modulation of the Th1/Th2 shift by ionizing radiation in tumors (Review).

Int J Oncol 2021 Jul 10;59(1). Epub 2021 Jun 10.

Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China.

Extensive evidence has documented that the balance between cytokines from T helper type 1 (Th1) and type 2 (Th2) cells is disrupted in the tumorigenic microenvironment compared with immunocompetent individuals. Ionizing radiation (IR) has been reported to markedly modulate the Th1/Th2 polarization in a concentration‑dependent manner. In the present review article, the immune modulation of Th1/Th2 and the IR‑induced crosstalk of the Th1/Th2 shift with immunocytes and tumor cells are summarized. Read More

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Does ventral mesh rectopexy at the time of sacrocolpopexy prevent subsequent posterior wall prolapse?

J Turk Ger Gynecol Assoc 2021 Jun 10. Epub 2021 Jun 10.

Department of Female Pelvic Medicine and Reconstructive Surgery, Ascension St John Hospital, Detroit, MI, United States of America.

Objective: To determine whether ventral mesh rectopexy at the time of sacrocolpopexy reduces the rate of future posterior wall prolapse.

Material And Methods: This is a retrospective cohort study of 150 women with pelvic organ prolapse (POP) who underwent sacrocolpopexy with (n=41) and without concomitant rectopexy (n= 109) at a single community hospital from December 1, 2015 to June 30, 2019. Preoperative Pelvic Organ Prolapse Quantification (POP-Q) and urodynamic testing was used in evaluation of pelvic organ prolapse. Read More

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QRS dispersion detected in ARVC patients and healthy gene carriers using 252-leads Body Surface Mapping - an explorative study of a potential diagnostic tool for Arrhythmogenic Right Ventricular Cardiomyopathy.

Pacing Clin Electrophysiol 2021 Jun 10. Epub 2021 Jun 10.

Department of Cardiology and Medical Science, Uppsala University, Uppsala, SE-75185, Sweden.

Background: The diagnosis of ARVC remains complex requiring both imaging and electrocardiographic (ECG) techniques. The purpose was therefore to investigate whether QRS dispersion assessed by body surface mapping (BSM) could be used to detect early signs of ARVC, particularly in gene carriers.

Methods: ARVC patients, gene carriers without a history of arrhythmias or structural cardiac changes and healthy controls underwent 12 lead resting ECG, signal-averaged ECG, echocardiographic examination, 24-hours Holter monitoring and BSM with electrocardiographic imaging. Read More

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Multiplexed Ion Beam Imaging Readout of Single-Cell Immunoblotting.

Anal Chem 2021 Jun 9. Epub 2021 Jun 9.

Chan Zuckerberg Biohub, San Francisco, California 94158, United States.

Improvements in single-cell protein analysis are required to study the cell-to-cell variation inherent to diseases, including cancer. Single-cell immunoblotting (scIB) offers proteoform detection specificity, but often relies on fluorescence-based readout and is therefore limited in multiplexing capability. Among rising multiplexed imaging methods is multiplexed ion beam imaging by time-of-flight (MIBI-TOF), a mass spectrometry imaging technology. Read More

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Use of β-D-glucan in diagnosis of suspected pneumonia in adults with HIV infection.

Int J STD AIDS 2021 Jun 9:9564624211022247. Epub 2021 Jun 9.

4965Royal Free London NHS Foundation Trust, London, UK.

Objectives: An elevated serum (1-3)-β-D-glucan (BDG) concentration has high sensitivity for a diagnosis of pneumonia (PCP) in people with HIV (PWH). At the current manufacturer-recommended positive threshold of 80 pg/mL (Fungitell), specificity for PCP is variable and other diagnostic tests are required. We evaluated the utility of serum BDG for diagnosis of suspected PCP in PWH at three inner-London hospitals to determine BDG concentrations for diagnosis and exclusion of PCP. Read More

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Evaluating the Clinical Realism of Synthetic Chest X-Rays Generated Using Progressively Growing GANs.

SN Comput Sci 2021 4;2(4):321. Epub 2021 Jun 4.

School of Electrical and Information Engineering, University of the Witwatersrand, Johannesburg, 1 Jan Smuts Avenue, Braamfontein South Africa.

Chest X-rays are a vital diagnostic tool in the workup of many patients. Similar to most medical imaging modalities, they are profoundly multi-modal and are capable of visualising a variety of combinations of conditions. There is an ever pressing need for greater quantities of labelled images to drive forward the development of diagnostic tools; however, this is in direct opposition to concerns regarding patient confidentiality which constrains access through permission requests and ethics approvals. Read More

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Mortality incidence among critically ill burn patients infected with multidrug-resistant organisms: A retrospective cohort study.

Scars Burn Heal 2021 Jan-Dec;7:20595131211015133. Epub 2021 May 25.

Critical Care Departement, Al-Wakra Hospital, Hamad Medical Corporation, Doha, Qatar.

Introduction: Many risk factors have been reported to increase mortality among burn patients. Previously, a higher mortality incidence was reported in acute burn patients infected with multidrug-resistant organisms (MDROs) when compared to patients infected with non-MDROs. However, considering this as an independent risk factor for mortality in acute burn patients is not yet confirmed. Read More

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Effects of renal transplantation on erectile dysfunction: a systematic review and meta-analysis.

Int J Impot Res 2021 Jun 8. Epub 2021 Jun 8.

Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Erectile dysfunction (ED) is a major global health burden commonly observed in patients with end-stage renal disease (ESRD). Although renal transplantation improves the problem in some patients, it persists in ≈20-50% of recipients. Studies regarding the effects of kidney transplantation on ED present contradictory findings. Read More

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Adherence to low-carbohydrate diet in relation to gastric cancer: findings from a case-control study in Iran.

Eur J Cancer Prev 2021 Jul;30(4):297-303

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences.

This study examined the association between adherence to low carbohydrate diet (LCD) and risk of gastric cancer (GC). This hospital-based case-control study was conducted in Iran Cancer Institute, Tehran, Iran between 2010 and 2012. Totally, 178 patients with GC and 276 apparently healthy controls participated in this study. Read More

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Personalizing First-Line Systemic Therapy in Metastatic Colorectal Cancer: Is There a Role for Initial Low-Intensity Therapy in 2021 and Beyond? A Perspective From Members of the Australasian Gastrointestinal Trials Group.

Clin Colorectal Cancer 2021 May 11. Epub 2021 May 11.

Department of Medical Oncology, Royal Brisbane Hospital, Herston, Queensland, Australia.

Palliative chemotherapy is the cornerstone of treatment for the majority of patients with metastatic colorectal cancer, with the aim of increasing length and quality of life. Although guidelines outline the available treatment options in the first line, they provide limited guidance on choice and intensity of the chemotherapy backbone. Data from the TRIBE and TRIBE2 studies confirm a survival benefit with triplet FOLFOXIRI and bevacizumab, and this is a preferred option for younger patients with good performance status able to tolerate it. Read More

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Idiopathic pulmonary fibrosis and diabetes mellitus: a meta-analysis and systematic review.

Respir Res 2021 Jun 8;22(1):175. Epub 2021 Jun 8.

Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China.

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse interstitial lung disease, of which the etiology has been poorly understood. Several studies have focused on the relationship between IPF and diabetes mellitus (DM) in the past years but have failed to reach a consensus. This meta-analysis aimed to examine the association between diabetes to IPF. Read More

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Stroke Recurrence in First-Ever Symptomatic Carotid Web: A Cohort Study.

J Stroke 2021 May 31;23(2):253-262. Epub 2021 May 31.

Neurology Department, Martinique University Hospital, Martinique.

Background And Purpose: Carotid web (CaW) is an intimal variant of fibromuscular dysplasia responsible for ipsilateral cerebral ischemic events (CIE). Symptomatic CaW likely has a high risk of recurrent CIE, but no salient prospective data are available. We aimed to assess recurrence rate and its predictors after a first-ever CIE. Read More

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Assessing the ecological risk of pesticides should not ignore the impact of their transformation byproducts - The case of chlorantraniliprole.

J Hazard Mater 2021 May 31;418:126270. Epub 2021 May 31.

State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, PR China. Electronic address:

Risk assessments for pesticides typically focus on the compound itself ignoring the impact of its transformation byproducts. Challenges in isolating such byproducts (i.e. Read More

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More data are required before we embrace EUS-guided coil plus glue injection.

Hepatology 2021 Jun 8. Epub 2021 Jun 8.

Department of Gastroenterology and Hepatology, Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

We appreciate the interest of Dr. Bazarbashi and colleagues in our recently published article(1). They propose EUS-guided coil placement plus glue injection as a more capable alternative to traditional endoscopically glue injection in patients with cirrhosis and gastric varices (GVs). Read More

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Cerebroplacental ratio and aortic isthmus Doppler in early fetal growth restriction.

J Clin Ultrasound 2021 Jun 8. Epub 2021 Jun 8.

DGO, DNB Obstetrics and Gynecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Purpose: To assess the utility of cerebroplacental ratio (CPR) and fetal aortic isthmus (AoI) Doppler in the prediction of perinatal outcome in early fetal growth restriction (FGR).

Methods: A prospective observational cohort study of 70 early FGR cases was conducted through serial Doppler examinations and findings of the last examination were correlated with perinatal outcome. Doppler blood flow measurements of AoI included end diastolic velocity (EDV), peak systolic velocity (PSV), pulsatility index (PI), resistance index (RI), and isthmic flow index (IFI). Read More

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Ulnar-Sided Wrist Pain in the Athlete: Sport-Specific Demands, Clinical Presentation, and Management Options.

Curr Sports Med Rep 2021 Jun;20(6):312-318

Department of Physical Medicine, Rehabilitation and Sports Medicine, University of Puerto Rico, San Juan, PUERTO RICO.

Abstract: Ulnar-sided wrist injuries are common in sports that require repeated pronosupination, wrist radial/ulnar deviation, axial loading, and gripping equipment. Common anatomic structures affected include the triangular fibrocartilage complex, extensor carpi ulnaris tendon, distal radioulnar and ulnocarpal joints, and hamate bone. Presenting symptoms include pain with activity, swelling, possible snapping or clicking, and reproduction of symptoms with provocative maneuvers. Read More

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Injury risk profile of amateur Irish women soccer players and players' opinions on risk factors and prevention strategies.

Phys Ther Sport 2021 Jun 1;50:184-194. Epub 2021 Jun 1.

School of Allied Health, Health Research Institute, University of Limerick (UL), Limerick, Ireland; Ageing Research Centre, Health Research Institute, University of Limerick, Limerick, Ireland. Electronic address:

Objective: To explore injury profile, opinions on risk factors and injury prevention, among Irish amateur women soccer players.

Design: A cross-sectional online survey.

Setting: Irish amateur winter league. Read More

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First report of Grapevine yellow speckle viroid 1 infecting grapevine (Vitis vinifera L.) in Canada.

Plant Dis 2021 Jun 7. Epub 2021 Jun 7.

Agriculture and AgriFood Canada , Research and development center , 430 Gouin, Saint-Jean-sur-Richelieu, Quebec, Canada, J3B3E6;

Quebec is the third largest wine grape producer in Canada in acreage, tonnage, and wine grape sales (Carisse et al. 2017; Ben Moussa et al. 2019). Read More

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Non-inferiority Trial Investigating the Efficacy of Non-steroidal Anti-inflammatory Drugs and Antimicrobial Treatment of Mild to Moderate Clinical Mastitis in Dairy Cows With Long-lasting Udder Diseases.

Front Vet Sci 2021 20;8:660804. Epub 2021 May 20.

Department of Bioprocess Engineering and Microbiology, Faculty II, Hannover University of Applied Sciences and Arts, Hannover, Germany.

To reduce ineffective antimicrobial usage in the treatment of non-severe clinical mastitis (CM) in cows with long-lasting udder diseases, non-antibiotic therapy with a non-steroidal anti-inflammatory drug (NSAID) was conducted and evaluated in a non-blinded, positively controlled, non-inferiority trial. Therefore, three-time systemic ketoprofen treatment at intervals of 24 h was evaluated in comparison with the reference treatment of solely antibiotic therapy in a field study on nine free-stall dairy farms located in Northern Germany. Cows with previous CM cases in current lactation and/or with long-lasting high somatic cell counts in preceding dairy herd improvement test days were randomly allocated to one of the two treatment groups in cases of mild to moderate CM. Read More

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Spontaneous Rupture of Empyema Necessitans in the Emergency Department.

Cureus 2021 May 3;13(5):e14822. Epub 2021 May 3.

Emergency Medicine, California University of Science and Medicine, Colton, USA.

An empyema necessitans is a rare complication of a collection of purulent material in the pleural space that spreads outside of the pleural cavity and involves the soft tissues of the chest wall. Due to compression forces created by the size of the collection of empyema in the chest cavity, patients are usually symptomatic and present with severe dyspnea. Chest X-ray or ultrasound of the chest cavity are the ideal screening tools to visualize the empyema and followed by computerized tomography scan of the chest to confirm the presence and extent of the pathology. Read More

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Adverse events following injection laryngoplasty: An analysis of the MAUDE database.

Am J Otolaryngol 2021 May 27;42(6):103092. Epub 2021 May 27.

Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ, United States of America.

Objective: Injection laryngoplasty (IL) is considered safe in both the operating room and clinical setting. However, safety data is limited to single-institution studies with reduced sample sizes. The objective of this study is to examine a national database for adverse events related to IL in an effort to further confirm the safety of this procedure and better characterize potential complications. Read More

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Intratumoral Steroid Profiling of Adrenal Cortisol-Producing Adenomas by Liquid Chromatography- Mass Spectrometry.

J Steroid Biochem Mol Biol 2021 Jun 2:105924. Epub 2021 Jun 2.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA. Electronic address:

Endogenous Cushing syndrome (CS) is an endocrine disorder marked by excess cortisol production rendering patients susceptible to visceral obesity, dyslipidemia, hypertension, osteoporosis and diabetes mellitus. Adrenal CS is characterized by autonomous production of cortisol from cortisol-producing adenomas (CPA) via adrenocorticotropic hormone-independent mechanisms. A limited number of studies have quantified the steroid profiles in sera from patients with CS. Read More

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[How do Advanced Practice Nurses participate in building health policy projects?]

Prof Inferm 2021 Jan-Mar;74(1):3-12

Professor of Nursing Science, PhD, Prof. Dr., Responsible Clinical Area, Master nursing science University of applied Sciences and Arts of Southern Switzerland, Department of Business Economics, Health and Social Care, Switzerland Corresponing Author:

Introduction: Patients' needs and the change of health professionals' roles have led researchers to reflect about the involvement of nurses in care processes development, as well as health policies. Studies confirm how advanced nursing training promotes quality of care and reduces the costs of healthcare. The introduction of the Advanced Practice Nurses (APNs) could potentially be an added value also in the Swiss healthcare context, where this figure is positioning. Read More

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Effects of transcranial direct current stimulation on cognitive dysfunction in multiple sclerosis.

Neurophysiol Clin 2021 Jun 1. Epub 2021 Jun 1.

Department of Neurology, School of Medical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Background: Around 40%-70% of patients with multiple sclerosis (MS) may experience cognitive impairments during the course of their disease with detrimental effects on social and occupational activities. Transcranial direct current stimulation (tDCS has been investigated in pain, fatigue, and mood disorders related to MS, but to date, few studies have examined effects of tDCS on cognitive performance in MS.

Objective: The current study aimed to investigate the effects of a multi-session tDCS protocol on cognitive performance and resting-state brain electrical activities in patients with MS. Read More

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Tracheostomy is Safe in Patients With Prolonged Intubation After Coronavirus Disease 2019 Infection.

J Surg Res 2021 Apr 27;266:361-365. Epub 2021 Apr 27.

Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey. Electronic address:

Background: Tracheostomy improves outcomes for critically ill patients requiring prolonged mechanical ventilation. Data are limited on the use and benefit of tracheostomies for intubated, critically ill coronavirus disease 2019 (COVID-19) patients. During the surge in COVID 19 infections in metropolitan New York/New Jersey, our hospital cared for many COVID-19 patients who required prolonged intubation. Read More

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Enhanced Sampling Protocol to Elucidate Fusion Peptide Opening of SARS-CoV-2 Spike Protein.

Biophys J 2021 Jun 1. Epub 2021 Jun 1.

Large-scale conformational transitions in the spike protein S2 domain are required during host cell infection of the SARS-CoV-2 virus. Although conventional molecular dynamics simulations have been extensively used to study therapeutic targets of SARS-CoV-2, it is still challenging to gain molecular insight into the key conformational changes due to the size of the spike protein and the long timescale required to capture these transitions. In this work, we have developed an efficient simulation protocol that leverages many short simulations, a novel selection algorithm, and Markov state models to interrogate the dynamics of the S2 domain. Read More

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Novel Approach to Ultrasound-Guided Thoracostomy.

J Ultrasound Med 2021 Jun 4. Epub 2021 Jun 4.

Department of Emergency Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.

Objectives: Thoracostomy is often a required treatment in patients with thoracic trauma; however, performing a thoracostomy using traditional techniques can have complications. Ultrasound can be a beneficial tool for identifying the correct thoracostomy insertion site. We designed a randomized prospective study to assess if ultrasound guidance can improve thoracostomy site identification over traditional techniques. Read More

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