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Can the mean linear energy transfer of organs be directly related to patient toxicities for current head and neck cancer intensity-modulated proton therapy practice?

Radiother Oncol 2021 Sep 14. Epub 2021 Sep 14.

Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Background And Purpose: The relative biological effectiveness (RBE) of proton therapy is predicted to vary with the dose-weighted average linear energy transfer (LET). However, RBE values may substantially vary for different clinical endpoints. Therefore, the aim of this study was to assess the feasibility of relating mean D⋅LET parameters to patient toxicity for HNC patients treated with proton therapy. Read More

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September 2021

Surgical Treatment of Type III Laryngotracheoesophageal Clefts: Techniques and Outcomes.

Laryngoscope 2021 Sep 17. Epub 2021 Sep 17.

Division of Pediatric Otolaryngology Head and Neck Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A.

Objectives/hypothesis: Determine surgical and swallowing outcomes after surgery for type III laryngotracheoesophageal cleft (LTEC).

Study Design: Case series with chart review.

Methods: Chart review was performed on patients with type III LTEC between 2000 and 2019. Read More

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September 2021

Urofaecal glucocorticoid metabolite concentrations in African penguin () chick populations experiencing different levels of human disturbance.

Conserv Physiol 2021 14;9(1):coab078. Epub 2021 Sep 14.

Department of Biodiversity and Conservation Biology, University of the Western Cape, Bellville, 7535, South Africa.

Despite the importance of ecotourism in species conservation, little is known about the industry's effects on wildlife. In South Africa, some African penguin () colonies have become tourist attractions. The species is globally endangered, with population sizes decreasing over the past 40 years. Read More

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September 2021

Occurrence and antimicrobial resistance of isolated from retail meats in Anhui, China.

Food Sci Nutr 2021 Sep 16;9(9):4701-4710. Epub 2021 Jul 16.

Engineering Research Center of Bio-process Ministry of Education Hefei University of Technology Hefei China.

is considered one of the major foodborne pathogens associated with severe infections. Little attempt has been focused on the distribution of in retail meats and the analysis of its phenotypic characteristics in Anhui Province. The aim of this study was to characterize the prevalence of serovars, antimicrobial susceptibility, antimicrobial resistance genes, and virulence genes in recovered from retail meats in Anhui, China. Read More

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September 2021

Comparison of the Performance of Decision Tree (DT) Algorithms and ELM model in the Prediction of Water Quality of the Upper Green River watershed.

Water Environ Res 2021 Sep 15. Epub 2021 Sep 15.

Department of Civil Engineering, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra (Mandal), Medchal District, Hyderabad, Telangana, India.

Stream waters play a crucial role in catering to the world's needs with the required quality of water. Due to the discharges of wastewater from the various point and nonpoint sources, most of the watersheds are contaminated easily. The Upper Green River watershed in Kentucky, USA, is one such watershed which is contaminated over the years due to the runoff from rural areas and agricultural lands and combined sewer overflows (CSOs) from urban areas. Read More

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September 2021

The Minimum Effective Training Dose Required for 1RM Strength in Powerlifters.

Front Sports Act Living 2021 30;3:713655. Epub 2021 Aug 30.

Faculty of Sport, Health, and Social Sciences, Solent University, Southampton, United Kingdom.

The aim of this multi-experiment paper was to explore the concept of the minimum effective training dose (METD) required to increase 1-repetition-maximum (1RM) strength in powerlifting (PL) athletes. The METD refers to the least amount of training required to elicit meaningful increases in 1RM strength. A series of five studies utilising mixed methods, were conducted using PL athletes & coaches of all levels in an attempt to better understand the METD for 1RM strength. Read More

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Efficacy and safety of a new disposable percutaneous positioning device invented to facilitate the precision of percutaneous core needle lung biopsies: a prospective, open and randomized controlled study.

J Thorac Dis 2021 Aug;13(8):4965-4976

Shanghai Chest Medical Technological Co., Shanghai, China.

Background: A new disposable percutaneous positioning device was developed which permits adjustment of the fixing puncture angle while performing a percutaneous core needle lung biopsy (CNLB). The aim of the study was to explore the positioning accuracy and clinical safety of the new device during CT-guided percutaneous CNLB.

Methods: A prospective, open and randomized controlled study with two parallel groups was conducted on 150 patients with pulmonary nodules between July 1, 2018 and June 30, 2019 including 101 males and 49 females who were divided (allocation ratio: 1:1) into a standard CNLB group without the percutaneous positioning device (control, n=75) and a new percutaneous positioning device group combined with CNLB (experimental, n=75). Read More

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The Feasibility of Ultrasound-Guided Knee Arthrocentesis Training Using Formalin-Embalmed.

JB JS Open Access 2021 Jul-Sep;6(3). Epub 2021 Sep 9.

Rocky Vista University College of Osteopathic Medicine-Southern Utah Campus, Ivins, Utah.

Background: The use of ultrasound guidance during knee arthrocentesis has proven to increase operator confidence and accuracy, particularly in novice healthcare providers. Realistic and practical means of teaching this procedure to medical trainees are needed. This study is intended to assess the feasibility and efficacy of using formalin-embalmed human cadavers in the instruction of ultrasound-guided knee arthrocentesis to medical trainees. Read More

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September 2021

Selection of mesophotic habitats by Oculina patagonica in the Eastern Mediterranean Sea following global warming.

Sci Rep 2021 Sep 13;11(1):18134. Epub 2021 Sep 13.

Department of Marine Biology, Leon H. Charney School of Marine Sciences, University of Haifa, Haifa, Israel.

Globally, species are migrating in an attempt to track optimal isotherms as climate change increasingly warms existing habitats. Stony corals are severely threatened by anthropogenic warming, which has resulted in repeated mass bleaching and mortality events. Since corals are sessile as adults and with a relatively old age of sexual maturity, they are slow to latitudinally migrate, but corals may also migrate vertically to deeper, cooler reefs. Read More

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September 2021

Evaluation of the correlation between preoperative airway assessment tests, anthropometric measurements, and endotracheal intubation difficulty in obesity class III patients undergoing bariatric surgery.

Medicine (Baltimore) 2021 Sep;100(36):e27188

Department of Anesthesiology, University of Health Sciences, Bagcilar Training and Research Hospital, Istanbul, Turkey.

Abstract: In this study, we investigated the correlation between airway assessment tests, anthropometric measurements, and the Modified Cormack- Lehane Classification (MCLC) assessed by videolaryngoscopy in patients undergoing bariatric surgery.This study included 121 morbidly obese patients undergoing bariatric surgery. The body mass index, Modified Mallampati Score (MMS), thyromental distance, sternomental distance, interincisor distance, and neck, waist, and chest circumferences were recorded. Read More

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September 2021

'Working in a comfort formerly unknown': medical holism and the radical ambitions behind interwar Bermondsey's foot clinic.

Med Humanit 2021 Sep 11. Epub 2021 Sep 11.

GKT School of Medical Education, King's College London, London, UK

In 1930, the Bermondsey Public Health Department made the rather unusual decision to establish the first municipal foot clinic in Britain. This pioneering and popular clinic was founded at a time when the aims of public health were being renegotiated. Historical discussion of the reconceptualisation of public health in the interwar period typically depicts a paradigm shift in which public health was no longer focused solely on sanitising the physical environment, but was characterised by an additional, separate aim: the development of hygienic behaviour within patients. Read More

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September 2021

Technological applications of phenolic-rich extracts for the development of non-dairy foods and beverages.

Adv Food Nutr Res 2021 17;98:101-123. Epub 2021 Jun 17.

Department of Biological Sciences, Faculty of Science and Engineering, University of Limerick, Limerick, Ireland. Electronic address:

Fruits and other vegetables are sources of bioactive compounds, especially carotenoids, terpenoids, and phenolic compounds. With the focus on sustainability, these compounds' recovery has become a research trend in the last 20 years. However, the correct use of solvents and the steps required to assess the extracts' suitability to be added in food models have been poorly described. Read More

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Placebo comparator group selection and use in surgical trials: the ASPIRE project including expert workshop.

Health Technol Assess 2021 Sep;25(53):1-52

Editorial Department, The Lancet, London, UK.

Background: The use of placebo comparisons for randomised trials assessing the efficacy of surgical interventions is increasingly being considered. However, a placebo control is a complex type of comparison group in the surgical setting and, although powerful, presents many challenges.

Objectives: To provide a summary of knowledge on placebo controls in surgical trials and to summarise any recommendations for designers, evaluators and funders of placebo-controlled surgical trials. Read More

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September 2021

Immunotherapy in hematological malignancies: recent advances and open questions.

Immunotherapy 2021 Oct 9;13(14):1215-1229. Epub 2021 Sep 9.

Center of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science & Technology (KACST), PO Box 6086, Riyadh, 11442, Saudi Arabia.

Over recent years, tremendous advances in immunotherapy approaches have been observed, generating significant clinical progress. Cancer immunotherapy has been shown, in different types of blood cancers, to improve the overall survival of patients. Immunotherapy treatment of hematopoietic malignancies is a newly growing field that has been accelerating over the past years. Read More

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October 2021

Highly stable surface-enhanced Raman spectroscopy assay on abnormal thrombin levels in the blood plasma of cancer patients.

Anal Methods 2021 Sep 3. Epub 2021 Sep 3.

School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.

The accurate discrimination of specific protein levels in the blood of cancer patients is of great importance in clinical diagnostics and prognosis. Here, we report a double-aptamer sandwich strategy on plasmonic magnetic beads (MBs) for a dual-reporter surface-enhanced Raman spectroscopy (SERS) assay for assessing abnormal thrombin (TB) levels in the blood plasma of cancer patients. This SERS assay demonstrated a linear analysis range of 20-400 pM in serum with a limit of detection as low as 20 pM, and to the best of our knowledge, this represents the first attempt to highly stably discriminate an abnormal TB level in the plasma of clinical cancer patients. Read More

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September 2021

Mesoporous silica nanoparticles for pulmonary drug delivery.

Adv Drug Deliv Rev 2021 Aug 30;177:113953. Epub 2021 Aug 30.

Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Spain, Camino de Vera s/n, 46022 València, Spain; Unidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina, Valencia, Universitat Politècnica de València, Centro de Investigación Príncipe Felipe, 46012 València, Spain; Unidad Mixta de Investigación en Nanomedicina y Sensores. Universitat Politècnica de València, Instituto de Investigación Sanitaria La Fe, Valencia, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain. Electronic address:

Over the last years, respiratory diseases represent a clinical concern, being included among the leading causes of death in the world due to the lack of effective lung therapies, mainly ascribed to the pulmonary barriers affecting the delivery of drugs to the lungs. In this way, nanomedicine has arisen as a promising approach to overcome the limitations of current therapies for pulmonary diseases. The use of nanoparticles allows enhancing drug bioavailability at the target site while minimizing undesired side effects. Read More

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Migration of a mesh into the colon after inguinal hernia repair - a case report.

Rozhl Chir 2021 ;100(7):348-352

Introduction: Mesh migration is one of the least common complications that arise after inguinal hernia repair with a mesh. Only small case series have been reported, and an understanding of this issue is limited due to a lack of data. Most of the cases were treated surgically. Read More

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September 2021

Development of mushroom polysaccharide and probiotics based solid self-nanoemulsifying drug delivery system loaded with curcumin and quercetin to improve their dissolution rate and permeability: State of the art.

Int J Biol Macromol 2021 Aug 28;189:744-757. Epub 2021 Aug 28.

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.

The role of mushroom polysaccharides and probiotics as pharmaceutical excipients for development of nanocarriers has never been explored. In the present study an attempt has been made to explore Ganoderma lucidum extract powder (GLEP) containing polysaccharides and probiotics to convert liquid self nanoemulsifying drug delivery system (SNEDDS) into solid free flowing powder. Two lipophilic drugs, curcumin and quercetin were used in this study due to their dissolution rate limited oral bioavailability and poor permeability. Read More

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Virtual reality environment using a dome screen for procedural pain in young children during intravenous placement: A pilot randomized controlled trial.

PLoS One 2021 31;16(8):e0256489. Epub 2021 Aug 31.

Department of Emergency Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

We assessed the feasibility and potential efficacy of a virtual reality (VR) environment using a dome screen as a distraction method in young children during intravenous (IV) placement in the pediatric emergency department. This randomized controlled pilot study enrolled children aged 2 to 6 years who underwent IV placement into either the intervention group or the control group. Children in the intervention group experienced VR using a dome screen during IV placement. Read More

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Surgical Treatment Strategies for Pyogenic Spondylodiscitis of the Thoracolumbar Spine.

Z Orthop Unfall 2021 Aug 30. Epub 2021 Aug 30.

Clinic and Polyclinic for Orthopaedics, Trauma Surgery and Plastic Surgery, University of Leipzig Medical Faculty, Germany.

Background: Despite advances, the morbidity and mortality rates of patients with spondylodiscitis remains high, with an increasing incidence worldwide. Although conservative therapy has progressed, several cases require surgical intervention. However, the indication and opportunities for surgical treatment are still disputable. Read More

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ADAPT First-Line Strategy for MCA Mainstem Occlusion; Analysis for Optimal Salvage Therapy and its Related Factor.

J Stroke Cerebrovasc Dis 2021 Aug 27;30(11):106070. Epub 2021 Aug 27.

Department of Neurosurgery, Asahikawa Red Cross Hospital, Hokkaido, Japan. Electronic address:

Objectives: A direct first-pass aspiration technique (ADAPT) is an attractive interventional technique for mechanical thrombectomy (MT), which could achieve recanalization quickly and safely at a small amount of material resources. To clarify its usefulness, our ADAPT first-line strategy for middle cerebral artery (MCA)-mainstem occlusion was retrospectively analyzed.

Materials And Methods: We reviewed 54 consecutive patients who underwent MT for MCA-mainstem occlusion using ADAPT first-line strategy. Read More

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Delayed primary fascia closure of Björck grade 4 open abdomen with enteroatmospheric fistulas after repeated surgery for adhesive small bowel obstruction: a case report.

BMC Surg 2021 Aug 26;21(1):333. Epub 2021 Aug 26.

Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, 305-8575, Tsukuba, Ibaraki, Japan.

Background: An open abdomen with frozen adherent bowels is classified as grade 4 in Björck's open abdomen classification, and skin grafting after wound granulation is a typical closure option. We achieved delayed primary fascia closure for a patient who developed open abdomen with enteroatmospheric fistulas due to severe adherent small bowel obstruction. We present here the details of his management. Read More

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V-Gel Guided Endotracheal Intubation in Rabbits.

Front Vet Sci 2021 10;8:684624. Epub 2021 Aug 10.

Department of Clinical Studies New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, United States.

General anesthesia in rabbits is associated with higher morbidity and mortality relative to other mammalian species commonly anesthetized. Unique challenges related to endotracheal intubation (ETI) in rabbits contribute to this risk. To improve the safety of ETI in rabbits, we developed two new ETI methods using a supraglottic airway device (v-gel) to facilitate ETI and compared them to traditional "blind" technique. Read More

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Muscular abnormalities in liver cirrhosis.

Andrej Hari

World J Gastroenterol 2021 Aug;27(29):4862-4878

Department of Gastroenterology and Hepatology, General Hospital Celje, Celje 3000, Savinjska, Slovenia.

Sarcopenia is becoming a well-established player in evaluating patients with chronic liver disease. Data regarding its clinical significance and consequences in the course of liver disease have been growing; many of the data support the idea that it impacts decompensation event frequency, prolonged hospitalization, and mortality, as well as providing the possibility to better prioritize patients on lists awaiting liver transplantation. When assessing the whole clinical scope of the field, which includes malnutrition and frailty, as well as the complete spectrum of muscle mass, strength, and function, it becomes clear that a well-founded approach in everyday clinical practice is essential. Read More

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Tick-Borne Pathogens and Diseases in Greece.

Microorganisms 2021 Aug 14;9(8). Epub 2021 Aug 14.

Medical Faculty and University Hospital, The University of Cologne, 50923 Cologne, Germany.

Tick-borne diseases (TBDs) are recognized as a serious and growing public health epidemic in Europe, and are a cause of major losses in livestock production worldwide. This review is an attempt to present a summary of results from studies conducted over the last century until the end of the year 2020 regarding ticks, tick-borne pathogens, and tick-borne diseases in Greece. We provide an overview of the tick species found in Greece, as well as the most important tick-borne pathogens (viruses, bacteria, protozoa) and corresponding diseases in circulation. Read More

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Combination Therapy for Neuropathic Pain: A Review of Recent Evidence.

J Clin Med 2021 Aug 11;10(16). Epub 2021 Aug 11.

Pharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, IDIBELL, University of Barcelona, 08907 L'Hospitalet de Llobregat, Spain.

Pharmacological treatment is not very effective for neuropathic pain (NP). A progressive decrease in the estimated effect of NP drugs has been reported, giving rise to an increase in the use of the multimodal analgesic approach. We performed a new independent review to assess whether more and better-quality evidence has become available since the last systematic review. Read More

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Addressing psychosocial health in the treatment and care of adolescents with obesity.

Obesity (Silver Spring) 2021 Sep;29(9):1413-1422

Department of Internal Medicine (Endocrinology & Metabolism), Yale University School of Medicine, New Haven, Connecticut, USA.

Obesity affects 158 million youth worldwide and is associated with psychosocial comorbidity. This review describes weight management options utilized by adolescents, including both self-directed weight loss and medically supervised obesity treatment interventions, and associated psychosocial impacts. A majority of adolescents with obesity attempt to manage weight on their own, primarily through attempting weight loss, sometimes with supplement use. Read More

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September 2021

Development and Validation of a Low-Cost Endoscopic Spine Surgery Simulator.

Cureus 2021 Jul 21;13(7):e16541. Epub 2021 Jul 21.

Neurosurgery, University of Wisconsin, Madison, USA.

Background Minimally invasive endoscopic techniques in spine surgery continue to gain in popularity. Unfortunately, there is a long learning period for novice endoscope users to acquire basic skills, and complex training simulators are frequently cost-prohibitive. This paper describes the development and validation of a low-cost endoscopic spine training simulator. Read More

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Prevalence and predictors of direct discharge home following hospitalization of patients with serious adverse events managed by the rapid response system in Japan: a multicenter, retrospective, observational study.

Acute Med Surg 2021 Jan-Dec;8(1):e690. Epub 2021 Aug 16.

Department of Emergency and Critical Care Medicine St. Marianna University School of Medicine Kanagawa Japan.

Aim: The rapid response system (RRS) is an in-hospital medical safety system. To date, not much is known about patient disposition after RRS activation, especially discharge home. This study aimed to investigate the prevalence, characteristics, and outcomes of patients with adverse events who required RRS activation. Read More

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