1,050,268 results match your criteria required

Development and validation of a patient face-mounted, negative-pressure antechamber for reducing exposure of healthcare workers to aerosolized particles during endonasal surgery.

J Neurosurg 2021 May 14:1-8. Epub 2021 May 14.

5Department of Neurosurgery, Weill Cornell Medicine, New York, New York.

Objective: The authors developed a negative-pressure, patient face-mounted antechamber and tested its efficacy as a tool for sequestering aerated particles and improving the safety of endonasal surgical procedures.

Methods: Antechamber prototyping was performed with 3D printing and silicone-elastomer molding. The lowest vacuum settings needed to meet specifications for class I biosafety cabinets (flow rate ≥ 0. Read More

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Influence of interface structure in redox and optical properties of thio and seleno-Ureidopeptide functionalized bimetallic gold nanocluster: DFT study.

J Mol Graph Model 2021 May 6;106:107929. Epub 2021 May 6.

Department of Chemistry, Bangalore University, Bangalore, 560056, India. Electronic address:

A simple cluster-ligand interaction model is introduced to describe the surface passivation of bimetallic gold clusters by SUP (Thioureidopeptide) and SeUP (Selenoureidopeptide) ligands. The conformational search based on neutral peptide binding modes and their computed interaction energies show the existence of various structural isomers within 10 kcal mol. Further, the negatively charged deprotonated peptide was found to strongly interact with metal cluster through the carboxylate unit. Read More

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Spider web biomonitoring: A cost-effective source apportionment approach for urban particulate matter.

Environ Pollut 2021 May 8;286:117328. Epub 2021 May 8.

Institute of Geosciences, Friedrich Schiller University Jena, Burgweg 11, 07749, Jena, Germany. Electronic address:

Elevated levels of particulate matter (PM) in urban atmospheres are one of the major environmental challenges of the Anthropocene. To effectively lower those levels, identification and quantification of sources of PM is required. Biomonitoring methods are helpful tools to tackle this problem but have not been fully established yet. Read More

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Low-cost devices with fluorescence spots brightness and size dual-mode readout for the rapid detection of Cr(VI) based on smartphones.

J Hazard Mater 2021 May 5;417:125986. Epub 2021 May 5.

State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province, Department of Chemistry, Lanzhou University, Lanzhou 730000, China. Electronic address:

Sensitive, convenient and rapid detection devices for toxic Cr(VI) suitable for filed use are required. Smartphone can be used as the detector, but the quality of images taken with a smartphone may depend on the ambient light and the operator. In this work, two types of low-cost and portable smartphone-based devices used for fluorescence spots brightness and size dual-mode detection of Cr(VI) were constructed with the aid of the 3D printing, which avoids the effect of ambient light and maintains a fixed position of the phone camera relative to the samples. Read More

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Ten-year assessment of a cancer fast-track programme to connect primary care with oncology: reducing time from initial symptoms to diagnosis and treatment initiation.

ESMO Open 2021 May 11;6(3):100148. Epub 2021 May 11.

Department of Medical Oncology, Biomedical Research Institute INCLIVA, University of Valencia, Valencia, Spain. Electronic address:

Background: Cancer is the second leading cause of mortality worldwide. Integrating different levels of care by implementing screening programmes, extending diagnostic tools and applying therapeutic advances may increase survival. We implemented a cancer fast-track programme (CFP) to shorten the time between suspected cancer symptoms, diagnosis and therapy initiation. Read More

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Incidence and clinical profile of venous thromboembolism in hospitalized COVID-19 patients from Madrid region.

Thromb Res 2021 May 8;203:93-100. Epub 2021 May 8.

Hematology Department, University Hospital Puerta de Hierro Majadahonda, Madrid, Spain.

Background: COVID-19 related in-hospital venous thromboembolism (VTE) incidence is high but data reported vary significantly. Some studies show that up to half of the events are diagnosed early after admission.

Objectives: To study symptomatic VTE incidence in acute COVID-19 hospitalized patients and to describe timing of VTE diagnosis. Read More

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Clinical, epidemiological, and laboratory features of Rickettsia parkeri rickettsiosis: A systematic review.

Ticks Tick Borne Dis 2021 May 1;12(4):101734. Epub 2021 May 1.

Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA; Committee of Tropical Medicine, Zoonoses and Travel Medicine, Asociación Colombiana de Infectología, Bogotá, Colombia. Electronic address:

Rickettsia parkeri rickettsiosis is recognized as the second most prevalent tick-borne disease caused by spotted fever group rickettsiae in the Americas, where two pathogenic strains (R. parkeri sensu stricto and R. parkeri strain Atlantic rainforest) have been related to human infections and transmitted by Amblyomma spp. Read More

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Disseminated peritoneal leiomyomatosis and malignant transformation: A case series in a single referral center.

Eur J Obstet Gynecol Reprod Biol 2021 May 5;262:21-27. Epub 2021 May 5.

Division of Gynecologic Oncology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, Italy.

Objective: The aim of this study was to describe one of the largest series of disseminated peritoneal leiomyomatosis (DPL) and its malignant counterpart, evaluating possible risk factors for both the benign and malignant condition, and highlighting any differences between them in terms of surgical and clinical management.

Study Design: Clinical, surgical and histopathological characteristics of patients diagnosed with DPL (group 1) and malignant-DPL (group 2), between July 2010 and July 2020, were retrospectively retrieved.

Results: A total of 14 benign and 5 malignant cases were selected. Read More

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Passive smoking induces nasal biofilms in children.

Int J Pediatr Otorhinolaryngol 2021 May 7;146:110755. Epub 2021 May 7.

Clinical Sciences Department, University of Sharjah, United Arab Emirates.

Objectives: Passive exposure of children to cigarette smoke has been implicated in several recalcitrant respiratory childhood disorders. However, to our knowledge, no information is available regarding the connection between passive exposure to tobacco smoke and the formation of nasal biofilms in children. The present study was therefore geared at investigating the hypothesis that exposure of children to household passive smoking may induce the formation of nasal biofilms. Read More

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Extended dwell and standard ultrasound guided peripheral intravenous catheters: Comparison of durability and reliability.

Am J Emerg Med 2021 May 6;47:267-273. Epub 2021 May 6.

Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA.

Background Vascular access is a critical component of emergency department (ED) care. Ultrasound guided placement of peripheral intravenous (USIV) catheters is increasingly common. However, USIV are thought to suffer from reduced durability and higher complication rates. Read More

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Integrating multi-omics data through deep learning for accurate cancer prognosis prediction.

Comput Biol Med 2021 May 9;134:104481. Epub 2021 May 9.

School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, 510000, China; Key Laboratory of Machine Intelligence and Advanced Computing (MOE), Sun Yat-sen University, Guangzhou, 510000, China. Electronic address:

Background: Genomic information is nowadays widely used for precise cancer treatments. Since the individual type of omics data only represents a single view that suffers from data noise and bias, multiple types of omics data are required for accurate cancer prognosis prediction. However, it is challenging to effectively integrate multi-omics data due to the large number of redundant variables but relatively small sample size. Read More

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Difference in the malignancy between RAS and GLI1-transformed astrocytes is associated with frequency of p27-positive cells in xenograft tissues.

Pathol Res Pract 2021 May 5;223:153465. Epub 2021 May 5.

Department of Cancer Pathology, Faculty of Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo, 060-8638, Japan; WPI Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, N21 W10, Kita-ku, Sapporo, 001-0021, Japan.

We demonstrate that the introduction of GLI1 is sufficient for immortalized human astrocytes to be transformed whereas FOXM1 fails to induce malignant transformation, suggesting differences between GLI1 and FOXM1 in terms of transforming ability despite both transcription factors being overexpressed in malignant gliomas. Moreover, in investigations of mechanisms underlying relatively less-malignant features of GLI1-transformed astrocytes, we found that p27-positive cells were frequently observed in xenografts derived from GLI1-transformed astrocytes compared to those from RAS-transformed cells. As shRNA-mediated knockdown of p27 accelerates tumor progression of GLI1-transformed astrocytes, downregulation of p27 contributes to malignant features of transformed astrocytes. Read More

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Efficacy and Safety of Oritavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections: A Systematic Review and Meta-analysis.

J Glob Antimicrob Resist 2021 May 11. Epub 2021 May 11.

Centre of Medicine Clinical Research, Department of Pharmacy, PLA General Hospital, Beijing 100853, China. Electronic address:

Objectives: In the present work, we aimed to evaluate the efficacy and safety of oritavancin (ORI) versus its comparators for the treatment of acute bacterial skin and skin structure infections (ABSSSIs) based on available clinical studies.

Methods: PubMed, Cochrane Library, and Embase were searched from database inception to July 28, 2020 to identify clinical studies assessing the efficacy and safety of ORI and its comparators for the treatment of ABSSSIs. Primary efficacy outcome, investigator-assessed clinical cure, lesion size reduction ≥20%, additional post-treatment antibiotics, 30-day emergency room (ER) visits and readmission were assessed as efficacy outcomes, while adverse events (AEs) and mortality were assessed as safety outcomes. Read More

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Fate and transport of unruptured tri-structural isotropic (TRISO) fuel particles in the event of environmental release for advanced and micro reactor applications.

J Environ Radioact 2021 May 11;234:106630. Epub 2021 May 11.

Pacific Northwest National Laboratory, USA.

Advanced nuclear reactor designs and advanced fuel types offer safety features that may reduce environmental consequences in an accident scenario when compared to conventional reactors and fuels. One advanced reactor fuel is tri-structural isotropic (TRISO) fuel particles which are approximately 0.9 mm in diameter. Read More

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Effector-independent brain network for auditory-motor integration: fMRI evidence from singing and cello playing.

Neuroimage 2021 May 11:118128. Epub 2021 May 11.

BRAMS International Laboratory for Brain, Music, and Sound Research, Montreal, QC, Canada; Centre for Interdisciplinary Research in Music Media and Technology, Montreal, QC, Canada; Department of Psychology, Concordia University, Montreal, QC, Canada. Electronic address:

Many everyday tasks share high-level sensory goals but differ in the movements used to accomplish them. One example of this is musical pitch regulation, where the same notes can be produced using the vocal system or a musical instrument controlled by the hands. Cello playing has previously been shown to rely on brain structures within the singing network for performance of single notes, except in areas related to primary motor control, suggesting that the brain networks for auditory feedback processing and sensorimotor integration may be shared (Segado et al. Read More

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Right Ventricular Pressure-Volume Analysis during LVAD Speed Optimization Studies: Insights into Interventricular Interactions and Right Ventricular Failure.

J Card Fail 2021 May 11. Epub 2021 May 11.

Division of Cardiology, Columbia University Medical Center-NewYork Presbyterian Hospital in New York, NY; Cardiovascular Research Foundation in New York, NY.

Background: Interventricular interaction, which refers to the impact of left ventricular (LV) function on right ventricular (RV) function and vice versa, has been implicated in the pathogenesis of RV failure in LVAD recipients. We sought to understand more about interventricular interaction by quantifying changes in right ventricular (RV) systolic and diastolic function with varying LVAD speeds.

Methods And Results: Four patients (ages 22-69, 75% male, and 25% with ischemic cardiomyopathy) underwent a protocolized hemodynamic ramp test within 12 months of LVAD implantation where RV pressure-volume loops were recorded with a conductance catheter. Read More

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Effectiveness of photobiomodulation therapy in radiation dermatitis: a systematic review and meta-analysis.

Crit Rev Oncol Hematol 2021 May 11:103349. Epub 2021 May 11.

Nursing Department, School of Health Sciences, University of Brasília, Brasília, DF, Brazil. Electronic address:

Purpose: To evaluate the effectiveness of photobiomodulation therapy (PBMT) in the prevention and treatment of radiation dermatitis (RD).

Methods: A systematic review was conducted using six databases and the gray literature. We performed a meta-analysis to summarize the effect sizes of response rates (RRs). Read More

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Niclosamide Inhalation Powder Made by Thin-Film Freezing: Multi-dose tolerability and exposure in Rats and Pharmacokinetics in Hamsters.

Int J Pharm 2021 May 11:120701. Epub 2021 May 11.

Molecular Pharmaceutics and Drug Delivery Division, College of Pharmacy, The University of Texas at Austin, 2409 University Avenue, Austin, TX, 78712, USA.

In this work, we have developed and tested a dry powder form of niclosamide made by thin-film freezing (TFF) and administered it by inhalation to rats and hamsters to gather data about its toxicology and pharmacokinetics. Niclosamide, a poorly water-soluble drug, is an interesting drug candidate because it was approved over 60 years ago for use as an anthelmintic medication, but recent studies demonstrated its potential as a broad-spectrum antiviral with pharmacological effect against SARS-CoV-2 infection. TFF was used to develop a niclosamide inhalation powder composition that exhibited acceptable aerosol performance with a fine particle fraction (FPF) of 86. Read More

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Fast cycle H2O2 nebulisationagainst frequent healthcare-associated microorganisms: efficacy assessment.

J Hosp Infect 2021 May 11. Epub 2021 May 11.

Division of Microbiology, Department of Pathology, Faculty of Medicine, University of Porto, Portugal; CINTESIS, Center for Health Technology and Services Research, Portugal; Burn Unit and Department of Plastic and Reconstructive Surgery, University Hospital Center of São João, Porto, Portugal.

Background: Aiming to control microbial contamination in hospital settings, hydrogen peroxide based technology is currently in use. However, the required long cycles result in prolonged room turnover time, thus precluding a wider implementation of the technology.

Aim: This study aims to assess the efficacy of a shorter cycle of nebulised H2O2 against healthcare-associated microorganisms, further comparing among multidrug-resistant and multidrug-susceptible strains. Read More

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Systematic review of Ethiopian medicinal plants used for their anti-inflammatory and wound healing activities.

J Ethnopharmacol 2021 May 11:114179. Epub 2021 May 11.

Centre for Global Health Research, Brighton and Sussex Medical School, University of Sussex, Brighton, BN1 9PX, United Kingdom; School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia.

Ethnopharmacological Relevance: Plant materials are used worldwide as complementary and alternative therapeutics for the treatment of various illnesses. In Ethiopia, folk medicines are utilized across a wide range of cultures and settings. Ethiopia has numerous plant species of which around 12% are endemic, making it a rich source of medicinal plants that are potentially important for human wellbeing. Read More

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Kidney Function and Outcomes in Patients Hospitalized with Heart Failure.

J Am Coll Cardiol 2021 May 4. Epub 2021 May 4.

Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Background: Few contemporary data exist evaluating care patterns and outcomes in HF across the spectrum of kidney function.

Objectives: To characterize differences in quality of care and outcomes in patients hospitalized for HF by degree of kidney dysfunction.

Methods: We evaluated quality metrics among patients hospitalized with HF at 418 sites in the GWTG-HF registry from 2014-2019 by discharge CKD-EPI-derived eGFR. Read More

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An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers.

Adv Drug Deliv Rev 2021 May 11. Epub 2021 May 11.

University of Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, Avenue Mounier 73 B1.73.12, 1200 Brussels, Belgium. Electronic address:

Oral administration is the most commonly used route for drug delivery owing to its cost-effectiveness, ease of administration, and high patient compliance. However, the absorption of orally delivered compounds is a complex process that greatly depends on the interplay between the characteristics of the drug/formulation and the gastrointestinal tract. In this contribution, we review the different preclinical models (in vitro, ex vivo and in vivo) from their development to application for studying the transport of drugs across intestinal barriers. Read More

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Meningiomas in patients with long-term exposition to progestins: Characteristics and outcome.

Neurochirurgie 2021 May 11. Epub 2021 May 11.

Aix Marseille Univ, APHM, INSERM, MMG, Department of Neursurgery, CHU Timone, Marseille, France.

Objective: The aim of this study was to describe progestin-associated meningiomas' characteristics, outcome and management.

Material And Methods: We included 53 patients operated on and/or followed in the department for meningioma with progestin intake longer than one year and with recent drug discontinuation.

Results: Cyproterone acetate (CPA), nomegestrol acetate (NomA), and chlormadinone acetate (ChlA) were involved in most cases. Read More

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Structural basis of KdpD histidine kinase binding to the second messenger c-di-AMP.

J Biol Chem 2021 May 11:100771. Epub 2021 May 11.

Department of Medical and Molecular Sciences, 15 Innovation Way, University of Delaware, Newark, DE 19711. Electronic address:

The KdpDE two-component system (TCS) regulates potassium homeostasis and virulence in various bacterial species. The KdpD histidine kinases of this system contain a universal stress protein (USP) domain which binds to the second messenger cyclic-di-adenosine monophosphate (c-di-AMP) for regulating transcriptional output from this TCS in Firmicutes such as Staphylococcus aureus. However, the structural basis of c-di-AMP specificity within the KdpD-USP domain is not well understood. Read More

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Pembrolizumab plus cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma: an open-label, multi-arm, non-randomised, multicentre, phase 2 trial.

Lancet Oncol 2021 May 11. Epub 2021 May 11.

Moores Comprehensive Cancer Center, University of California, San Diego, La Jolla, CA, USA.

Background: Pembrolizumab (PD-1 inhibitor) and cetuximab (EGFR inhibitor) are active as single agents and in combination with cytotoxic chemotherapy for recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). Given each drug's single agent activity and unique mechanism of action, we aimed to evaluate the anti-tumour activity of PD-1 blockade with EGFR inhibition in recurrent or metastatic HNSCC.

Methods: This study is an open-label, non-randomised, multi-arm, phase 2 trial done at four academic centres in the USA. Read More

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Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway.

Curr Biol 2021 May 8. Epub 2021 May 8.

Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA. Electronic address:

The primary cilium is an essential organizing center for signal transduction, and ciliary defects cause congenital disorders known collectively as ciliopathies. Primary cilia form by two pathways that are employed in a cell-type- and tissue-specific manner: an extracellular pathway in which the cilium grows out from the cell surface and an intracellular pathway in which the nascent cilium first forms inside the cell. After exposure to the external environment, cilia formed via the intracellular pathway may have distinct functional properties, as they often remain recessed within a ciliary pocket. Read More

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Rab34 is necessary for early stages of intracellular ciliogenesis.

Curr Biol 2021 May 7. Epub 2021 May 7.

Program in Molecular Medicine, University of Massachusetts Medical School, Biotech II, Suite 213, 373 Plantation Street, Worcester, MA 01605, USA. Electronic address:

Primary cilia are sensory organelles present on most vertebrate cells and are critical for development and health. Ciliary dysfunction is associated with a large class of human pathologies collectively known as ciliopathies. These include cystic kidneys, blindness, obesity, skeletal malformations, and other organ anomalies. Read More

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RNA degradation is required for the germ-cell to maternal transition in Drosophila.

Curr Biol 2021 May 5. Epub 2021 May 5.

University at Albany, Department of Biological Sciences, RNA Institute; 1400 Washington Avenue, LSRB 2033D, Albany, NY 12222. Electronic address:

In sexually reproducing animals, the oocyte contributes a large supply of RNAs that are essential to launch development upon fertilization. The mechanisms that regulate the composition of the maternal RNA contribution during oogenesis are unclear. Here, we show that a subset of RNAs expressed during the early stages of oogenesis is subjected to regulated degradation during oocyte specification. Read More

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Bipartite binding of the N terminus of Skp2 to cyclin A.

Structure 2021 May 11. Epub 2021 May 11.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, ON M5S 1A8, Canada; Department of Biochemistry, University of Toronto, ON M5S 1A8, Canada. Electronic address:

Skp2 and cyclin A are cell-cycle regulators that control the activity of CDK2. Cyclin A acts as an activator and substrate recruitment factor of CDK2, while Skp2 mediates the ubiquitination and subsequent destruction of the CDK inhibitor protein p27. The N terminus of Skp2 can interact directly with cyclin A but is not required for p27 ubiquitination. Read More

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Examining unsafe injection practices associated with auto-disable (AD) syringes: a systematic review.

Hum Vaccin Immunother 2021 May 14:1-12. Epub 2021 May 14.

IRD Global, Singapore, Singapore.

Auto-disable (AD) syringes are specifically designed to prevent syringe reuse. However, the notion that specific AD syringe designs may be unsafe due to reuse concerns related to the syringe's activation point has surfaced. We conducted a systematic review for evidence on the association between AD syringe design and syringe reuse, adverse events following immunization (AEFI), or blood borne virus (BBV) transmission. Read More

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