Int J Gynecol Pathol 2021 Dec 3. Epub 2021 Dec 3.
Departments of Pathology (P.B., İ.K., N.K.) Gynecology and Obstetrics (Ç.T., D.V.), School of Medicine, Koc University Department of Pathology, School of Medicine, Acibadem University (E.H.Z.), Istanbul Departments of Pathology (N.H., Ö.Ö.) Gynecology and Obstetrics (A.A.), School of Medicine, Baskent University Department of Pathology, School of Medicine, Gazi University (Ö.E.), Ankara, Turkey.
Endocervical adenocarcinomas (ECAs) have been recently reclassified according to their morphologic features linked to etiology by the International Endocervical Adenocarcinoma Criteria and Classification (IECC) and this system is adopted by WHO 2020. This classification separates the ECAs as human papillomavirus (HPV)-associated (HPVA) and HPV-independent (HPVI) subtypes. According to WHO 2020, high risk (HR)-HPV association can be histologically recognized by the presence of luminal mitoses and apoptosis. Read More