2,188 results match your criteria representative muscles

Associations between pain, self-efficacy, sleep duration, and symptoms of depression in adolescents: a cross-sectional survey.

BMC Public Health 2021 09 5;21(1):1617. Epub 2021 Sep 5.

Department of Child and Adolescence Mental Health, Sørlandet Hospital, Kristiansand, Norway.

Background: Although pain has been identified as an important public health problem among adolescents, few studies have investigated possible protective and risk factors for pain. The main aim of the present study was to investigate associations between prevalence of daily pain, self-efficacy, sleep duration, and symptoms of depression in a representative sample of Norwegian adolescents.

Methods: A comprehensive cross-sectional survey was completed by 12,867 junior high school students and high school students (response rate: 90%) aged 14-19 years. Read More

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September 2021

Hyperspectral imaging and artificial intelligence to detect oral malignancy - part 1 - automated tissue classification of oral muscle, fat and mucosa using a light-weight 6-layer deep neural network.

Head Face Med 2021 Sep 3;17(1):38. Epub 2021 Sep 3.

Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, University Medical Centre Mainz, Augustusplatz 2, 55131, Mainz, Germany.

Background: Hyperspectral imaging (HSI) is a promising non-contact approach to tissue diagnostics, generating large amounts of raw data for whose processing computer vision (i.e. deep learning) is particularly suitable. Read More

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September 2021

[Cardiovascular safety pharmacology: in vitro strategies and improvements in technology and evaluation].

Nihon Yakurigaku Zasshi 2021 ;156(5):297-302

Eisai Co., Ltd.

Safety pharmacology studies have been clearly defined through discussions at the International Council for Harmonization of Pharmaceutical Regulations (ICH), and are conducted as non-clinical studies according to the ICH S7A and S7B to ensure the safety of subjects participating in clinical studies. The representative of in vitro studies of cardiovascular system is hERG assay, but CiPA recommendations by FDA/HESI (multi-ion channel assays, simulation with in silico model using the multi-ion channel data, human iPS cell-derived cardiomyocyte assay), a new clinical risk prediction strategy that makes effective use of non-clinical data is being established. In addition, regarding the risk of heart failure that induced by anticancer drugs, which are attracting attention as a social problem, technology development has been made centering on human iPS cell-derived cardiomyocytes. Read More

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September 2021

Ergonomic considerations when slotting piece-pick operations in distribution centers.

Appl Ergon 2021 Nov 13;97:103554. Epub 2021 Aug 13.

Integrated Systems Engineering, The Ohio State University, Columbus, OH, USA.

Many warehouse slotting algorithms have overlooked worker ergonomics. This research aimed to develop ergonomics slotting guidelines based upon the back and shoulder postures and electromyographic (EMG) responses of the deltoid and erector spinae muscles when individual items are picked from, or full cases replenished to, different shelf heights In the first study of two studies, participants lifted small items representative of piece-pick tasks from seven shelf heights. In the second study, participants performed a simulated full case replenishment task in which they lifted boxes weighing between 2. Read More

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November 2021

Pregnant women's experiences with a pelvic floor muscle training program in Nepal.

Glob Health Action 2021 Jan;14(1):1940762

Division of Orthopaedic Surgery, Oslo University Hospital, Oslo, Norway.

Background: In Nepal, pelvic floor disorders affect about 24% of the women in reproductive age whereof 10% suffer from pelvic organ prolapse (POP). Still, many do not seek health care. Strengthening exercises for the pelvic floor muscles for prevention and treatment of POP has shown strong evidence internationally, but for women in Nepal surgery is primarily offered. Read More

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January 2021

Magnetization Transfer Ratio of Peripheral Nerve and Skeletal Muscle : Correlation with Demographic Variables in Healthy Volunteers.

Clin Neuroradiol 2021 Aug 10. Epub 2021 Aug 10.

Department of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Purpose: To assess the correlation of peripheral nerve and skeletal muscle magnetization transfer ratio (MTR) with demographic variables.

Methods: In this study 59 healthy adults evenly distributed across 6 decades (mean age 50.5 years ±17. Read More

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Shoulder electromyography-based indicators to assess manifestation of muscle fatigue during laboratory-simulated manual handling task.

Ergonomics 2021 Aug 14:1-16. Epub 2021 Aug 14.

Laboratoire de Simulation et Modélisation du Mouvement, École de Kinésiologie et des sciences de l'activité physique, Université de Montréal, Laval, Canada.

Muscle fatigue is a risk factor for developing shoulder musculoskeletal disorders. The aim of this study was to identify shoulder electromyographic indicators that are most indicative of muscle fatigue during a laboratory simulated manual handling task. Thirty-two participants were equipped with electromyographic electrodes on 10 shoulder muscles and moved boxes for 45-minutes. Read More

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Diabetes Mellitus Promotes Smooth Muscle Cell Proliferation in Mouse Ureteral Tissue through the P-ERK/P-JNK/VEGF/PKC Signaling Pathway.

Medicina (Kaunas) 2021 Jun 1;57(6). Epub 2021 Jun 1.

Department of Urology, College of Medicine, Kyung Hee University, Seoul 02447, Korea.

The aim of our study was to evaluate the role of diabetes mellitus (DM) as a significant factor affecting spontaneous stone expulsion, as suggested by previous research. We investigated the influence of DM on the ureter using a murine model. The mouse-model arm of this study used 20 15 -week-old mice, including 10 normal (control) mice and 10 DM mice. Read More

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miRNAs generated from Meg3-Mirg locus are downregulated during aging.

Aging (Albany NY) 2021 06 22;13(12):15875-15897. Epub 2021 Jun 22.

Laboratory of Stem Cell Biology, Institute of Cellular Biology and Pathology "Nicolae Simionescu", Bucharest 050568, Romania.

Aging determines a multilevel functional decline and increases the risk for cardiovascular pathologies. MicroRNAs are recognized as fine tuners of all cellular functions, being involved in various cardiac diseases. The heart is one of the most affected organs in aged individuals, however little is known about the extent and robustness to which miRNA profiles are modulated in cardiac cells during aging. Read More

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Neuropeptide ACP facilitates lipid oxidation and utilization during long-term flight in locusts.

Elife 2021 Jun 21;10. Epub 2021 Jun 21.

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

Long-term flight depends heavily on intensive energy metabolism in animals; however, the neuroendocrine mechanisms underlying efficient substrate utilization remain elusive. Here, we report that the adipokinetic hormone/corazonin-related peptide (ACP) can facilitate muscle lipid utilization in a famous long-term migratory flighting species, . By peptidomic analysis and RNAi screening, we identified brain-derived ACP as a key flight-related neuropeptide. Read More

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Identifying the parameters of viscoelastic model for a gel-type material as representative of cardiac muscle in dynamic tests.

Proc Inst Mech Eng H 2021 Oct 17;235(10):1205-1216. Epub 2021 Jun 17.

Faculty of Mechanical Engineering, University of Tabriz, Tabriz, Iran.

In this paper, mechanical parameters of a calf heart muscle are identified and a gel-type material as the representative of the cardiac muscle in dynamic tests is introduced. The motivation of this study is to introduce a replacement material of the heart muscle to use in experimental studies of the leadless pacemaker. A particular test setup is developed to capture the experimental data based on the stress relaxation test method where its outputs are time histories of the force and displacement. Read More

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October 2021

The origins, relationships, evolution and conservation of the weirdest marine bivalves: The watering pot shells. A review.

Adv Mar Biol 2021 21;88:137-220. Epub 2021 May 21.

Department of Animal Biology, Universidade Estadual de Campinas, Campinas, Brazil. Electronic address:

The fossil record shows that the two clavagelloid or watering pot families evolved at different times, the Clavagellidae first in the late Mesozoic (100-66mya), the Penicillidae later in the Cenozoic (33-23mya)-the former originally with, thus, a near-global Tethyan distribution, the latter restricted to the Indo-West Pacific. Representatives of the two clavagelloid families, moreover, have wholly different adventitious tube/crypt structures and, thus, methods of formation suggesting that evolutionary experiments have been undertaken to achieve such radical architectural novelties. This has resulted in one of the most surprising examples of convergent evolution in the Bivalvia. Read More

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Once-Weekly Whole-Body Electromyostimulation Increases Strength, Stability and Body Composition in Amateur Golfers. A Randomized Controlled Study.

Int J Environ Res Public Health 2021 05 25;18(11). Epub 2021 May 25.

Institute of Medical Physics, Friedrich-Alexander University of Erlangen-Nürnberg, 91052 Erlangen, Germany.

Whole-body electromyostimulation (WB-EMS), an innovative training technology, is considered as a joint-friendly, highly customizable and particularly time-effective option for improving muscle strength and stability, body composition and pain relief. The aim of the present study was to determine the effect of 16 weeks of once-weekly WB-EMS on maximum isometric trunk (MITS), leg extensor strength (MILES), lean body mass (LBM) and body-fat content. A cohort of 54 male amateur golfers, 18 to 70 years old and largely representative for healthy adults, were randomly assigned to a WB-EMS ( = 27) or a control group (CG: = 27). Read More

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Metagenomics Analysis Reveals an Extraordinary Inner Bacterial Diversity in Anisakids (Nematoda: Anisakidae) L3 Larvae.

Microorganisms 2021 May 19;9(5). Epub 2021 May 19.

Museo Nacional de Ciencias Naturales, Dpto Biodiversidad y Biología Evolutiva, CSIC, 28006 Madrid, Spain.

L3 larvae of anisakid nematodes are an important problem for the fisheries industry and pose a potential risk for human health by acting as infectious agents causing allergies and as potential vectors of pathogens and microrganisms. In spite of the close bacteria-nematode relationship very little is known of the anisakids microbiota. Fresh fish could be contaminated by bacteria vectored in the cuticle or in the intestine of anisakids when the L3 larvae migrate through the muscles. Read More

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Anthropometric scaling of musculoskeletal models of the hand captures age-dependent differences in lateral pinch force.

J Biomech 2021 06 14;123:110498. Epub 2021 May 14.

J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. Electronic address:

Musculoskeletal models and computer simulations enable non-invasive study of muscle function and contact forces. Hand models are useful for understanding the complexities of hand strength, precision movement, and the dexterity required during daily activities. Yet, generic models fail to accurately represent the entire scope of the population, while subject-specific models are labor-intensive to create. Read More

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Modified Blue Native Gel Approach for Analysis of Respiratory Supercomplexes.

Methods Mol Biol 2021 ;2276:227-234

Department of Anesthesiology, University of Rochester Medical Center, Rochester, NY, USA.

In mitochondrial oxidative phosphorylation (Ox-Phos), individual electron transport chain complexes are thought to assemble into supramolecular entities termed supercomplexes (SCs). The technique of blue native (BN) gel electrophoresis has emerged as the method of choice for analyzing SCs. However, the process of sample extraction for BN gel analysis is somewhat tedious and introduces the possibility for experimental artifacts. Read More

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Possible involvement of the autonomic nervous system in cervical muscles of patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS).

BMC Musculoskelet Disord 2021 May 5;22(1):419. Epub 2021 May 5.

Orthopaedics and Spine Department, Tokyo Neurological Center, Toranomon 4-1-17, Minato-ku, Tokyo, 105-0001, Japan.

Background: Patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) sometimes present with stiffness of the cervical muscles. To investigate the pathophysiology of ME/CFS, this observational study compared patients with versus without recovery from ME/CFS through local modulation of the cervical muscles.

Methods: Over a period of 11 years, a total of 1226 inpatients with ME/CFS who did not respond to outpatient care were enrolled in this study. Read More

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Metabolic scaling: individual versus intraspecific scaling of Nile tilapia (Oreochromis niloticus).

J Comp Physiol B 2021 Jul 2;191(4):721-729. Epub 2021 May 2.

Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation, Ocean College, Beibu Gulf University, Qinzhou, China.

We examined intraspecific scaling of the resting metabolic rate (RMR) of Nile tilapia (Oreochromis niloticus) under different culture conditions and further explored the allometric relationships between organ mass (heart, liver, brain, gills, viscera, and red muscles) and blood parameters (erythrocyte size and red blood cell counts) and body mass. Oreochromis niloticus were bred in individual and group cultures. The scaling exponent of the RMR in the individual cultures was b = 0. Read More

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Hemodynamic Forces Regulate Cardiac Regeneration-Responsive Enhancer Activity during Ventricle Regeneration.

Int J Mol Sci 2021 Apr 11;22(8). Epub 2021 Apr 11.

School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.

Cardiac regenerative capacity varies widely among vertebrates. Zebrafish can robustly regenerate injured hearts and are excellent models to study the mechanisms of heart regeneration. Recent studies have shown that enhancers are able to respond to injury and regulate the regeneration process. Read More

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Only the Fastest Corticospinal Fibers Contribute to β Corticomuscular Coherence.

J Neurosci 2021 Jun 23;41(22):4867-4879. Epub 2021 Apr 23.

Department of Bioengineering, Imperial College London, London SW7 2AZ, United Kingdom.

Human corticospinal transmission is commonly studied using brain stimulation. However, this approach is biased to activity in the fastest conducting axons. It is unclear whether conclusions obtained in this context are representative of volitional activity in mild-to-moderate contractions. Read More

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Determinants of neoadjuvant chemotherapy for urothelial muscle-invasive bladder cancer: Does location matter?

Int J Clin Pract 2021 Aug 1;75(8):e14262. Epub 2021 May 1.

Department of Urology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.

Introduction: Bladder cancer care has been increasingly concentrated in high-volume metropolitan medical centres (ie, "regionalisation" of care). We aimed to assess the potential role of geographic factors, including facility region and distance to treatment centre, as determinants of neoadjuvant chemotherapy (NAC) delivery in patients with non-metastatic urothelial muscle-invasive bladder cancer (MIBC) using nationally representative data from the United States.

Methods: We queried the National Cancer Database to identify patients with cT2-cT4a, N0M0 urothelial MIBC who underwent radical cystectomy (RC) from 2006 to 2015. Read More

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Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders.

J Vis Exp 2021 04 3(170). Epub 2021 Apr 3.

Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital; Department of Pediatrics, The Ohio State University;

Investigations into both the pathophysiology and therapeutic targets in muscular dystrophies have been hampered by the limited proliferative capacity of human myoblasts. Several mouse models have been created but they either do not truly represent the human physiopathology of the disease or are not representative of the broad spectrum of mutations found in humans. The immortalization of human primary myoblasts is an alternative to this limitation; however, it is still dependent on muscle biopsies, which are invasive and not easily available. Read More

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Technical Considerations and Clinical Applications of the Free Anterior Branch Split Latissimus Dorsi Flap.

Ann Plast Surg 2021 06;86(6S Suppl 5):S473-S477

From the Division of Plastic and Reconstructive Surgery, University of Florida College of Medicine, Gainesville, FL.

Background: The free anterior branch split latissimus dorsi flap has a reliable anatomy and advantages over the traditional latissimus dorsi flap. By preserving the posterior branch of the thoracodorsal nerve, morbidity at the donor site is reduced, preserving shoulder strength.

Methodology: The purpose of this article is to review our experience with the split latissimus flap, describe our surgical technique, and finally review representative cases of reconstruction in different anatomical regions. Read More

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Cardio-Vascular Heat Shock Protein (cvHsp, HspB7), an Unusual Representative of Small Heat Shock Protein Family.

Biochemistry (Mosc) 2021 Jan;86(Suppl 1):S1-S11

Faculty of Biology, Lomonosov Moscow State University, Moscow, 119991, Russia.

HspB7 is one of ten human small heat shock proteins. This protein is expressed only in insulin-dependent tissues (heart, skeletal muscle, and fat tissue), and expression of HspB7 is regulated by many different factors. Single nucleotide polymorphism is characteristic for the HspB7 gene and this polymorphism correlates with cardio-vascular diseases and obesity. Read More

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January 2021

Robotic transcranial magnetic stimulation motor maps and hand function in adolescents.

Physiol Rep 2021 04;9(7):e14801

Calgary Pediatric Stroke Program, Alberta Children's Hospital, Calgary, Alberta, Canada.

Introduction: Transcranial magnetic stimulation (TMS) motor mapping can characterize the neurophysiology of the motor system. Limitations including human error and the challenges of pediatric populations may be overcome by emerging robotic systems. We aimed to show that neuronavigated robotic motor mapping in adolescents could efficiently produce discrete maps of individual upper extremity muscles, the characteristics of which would correlate with motor behavior. Read More

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The Impact of Spaceflight and Microgravity on the Human Islet-1+ Cardiovascular Progenitor Cell Transcriptome.

Int J Mol Sci 2021 Mar 30;22(7). Epub 2021 Mar 30.

Department of Pathology and Human Anatomy, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.

Understanding the transcriptomic impact of microgravity and the spaceflight environment is relevant for future missions in space and microgravity-based applications designed to benefit life on Earth. Here, we investigated the transcriptome of adult and neonatal cardiovascular progenitors following culture aboard the International Space Station for 30 days and compared it to the transcriptome of clonally identical cells cultured on Earth. Cardiovascular progenitors acquire a gene expression profile representative of an early-stage, dedifferentiated, stem-like state, regardless of age. Read More

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Synchrotron X-ray phase contrast micro tomography to explore the morphology of abdominal organs in Pterostichus melas italicus Dejean, 1828 (Coleoptera, Carabidae).

Arthropod Struct Dev 2021 May 17;62:101044. Epub 2021 Mar 17.

Department of Biology, Ecology and Earth Science, University of Calabria, Via Bucci, 87036 Arcavacata di Rende, Cosenza, Italy.

Micro-computer tomography imaging is a fast and non-destructive data acquisition technique which can replace or complement the traditional investigation methodologies used in entomology to study morphology. In this paper, Synchrotron Radiation X-ray Phase-Contrast micro tomography (SR-PhC micro-CT) was combined with histology and scanning electron microscopy (SEM) observations to describe the abdominal organs of Pterostichus melas italicus Dejean, 1828 (Coleoptera, Carabidae). This species was used as a representative model because of its ecological role as a generalist predator in agroecosystems. Read More

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Calf circumference: cutoff values from the NHANES 1999-2006.

Am J Clin Nutr 2021 06;113(6):1679-1687

Pennington Biomedical Research Center, LSU System, Baton Rouge, LA, USA.

Background: Calf circumference (CC) is used in geriatric studies as a simple and practical skeletal muscle (SM) marker for diagnosing low SM and sarcopenia. Currently applied CC cutoff points were developed in samples including older participants; values representative of the full adult lifespan are lacking.

Objectives: We aimed to develop CC cutoff points and to identify relevant confounding factors from the large and diverse NHANES 1999-2006 population sample. Read More

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The Vagus Nerve Somatosensory-evoked Potential in Neural Disorders: Systematic Review and Illustrative Vignettes.

Clin EEG Neurosci 2021 Mar 12:15500594211001221. Epub 2021 Mar 12.

Miami Neuroscience Institute, Baptist Hospital South Florida, Miami, FL, USA.

To review the scientific publications reporting vagal nerve somatosensory-evoked potential (VSEP) findings from individuals with brain disorders, and present novel physiological explanations on the VSEP origin. We did a systematic review on the papers reporting VSEP findings from individuals with brain disorders and their controls. We evaluated papers published from 2003 to date indexed in PubMed, Web of Science, and Scielo databases. Read More

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Female kinematics and muscle responses in lane change and lane change with braking maneuvers.

Traffic Inj Prev 2021 10;22(3):236-241. Epub 2021 Mar 10.

Department of Mechanics and Maritime Sciences, Chalmers University of Technology, Gothenburg, Sweden.

Objective: The primary aim of this article is to extensively study female occupant kinematics and muscle activations in vehicle maneuvers potentially occurring in precrash situations and with different seat belt configurations. The secondary aim is to provide validation data for active human body models (AHBMs) of female occupants in representative precrash loading situations.

Methods: Front seat female passengers wearing a 3-point seat belt, with either standard or pre-pretensioning functionality, were subjected to multiple autonomously carried-out lane change and lane change with braking maneuvers while traveling at 73 km/h. Read More

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