631 results match your criteria reports abortive

Evidence of Arctic Fox Survival following Exposure to Rabies Virus.

J Wildl Dis 2021 Nov 23. Epub 2021 Nov 23.

US Department of Agriculture, National Wildlife Research Center, 4101 Laporte Avenue, Fort Collins, Colorado 80521, USA.

The arctic fox variant of the rabies virus (RABV) is enzootic in the circumpolar north. Reports of abortive RABV exposures motivated a retrospective analysis of sera from 41 arctic foxes captured at Karrak Lake in Nunavut, Canada, during 2011-2015. Estimated RABV antibody prevalence among foxes was 14% (95% confidence interval, 7-28%). Read More

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November 2021

Chronic migraine reversal and prevention with the LIFE diet: a nutrient dense whole food plant-based diet (WFPBD).

BMJ Case Rep 2021 Nov 18;14(12). Epub 2021 Nov 18.

Private Practice, East Setauket, New York, USA.

We report a case of a 60-year-old man who struggled with frequent migraines for 12.5 years, which were refractory to all conventional therapies. Six months before initial consultation, these migraines become chronic. Read More

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November 2021

Rapid preparation of 6S RNA-free B. subtilis σ-RNA polymerase and σ.

J Microbiol Methods 2021 11 8;190:106324. Epub 2021 Sep 8.

Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 6, 35037 Marburg, Germany. Electronic address:

The regulatory 6S-1 and 6S-2 RNAs of B. subtilis bind to the housekeeping RNA polymerase holoenzyme (σ-RNAP) with submicromolar affinity. We observed copurification of endogenous 6S RNAs from a published B. Read More

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November 2021

Ureteral diverticulum complicated by urinary lihiasis: About a case report.

Urol Case Rep 2021 Nov 17;39:101810. Epub 2021 Aug 17.

Departement of Urology, La Rabta Hospital, Tunisia.

Ureteral diverticulum is a rare urinary malformation and can frequently lead to urinary complications. It can be congenital, acquired or an abortive ureteral duplication. Most are treated conservatively. Read More

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November 2021

Post-abortive vesicovaginal fistula associated with bladder lithiasis: About an observation.

Urol Case Rep 2021 Nov 9;39:101748. Epub 2021 Jun 9.

Urology-Andrology Department, Aristide Le Dantec Hospital, Dakar, Senegal.

Illegally induced abortions remain a significant public health issue in developing countries. We report a case that was complicated by a vesicovaginal fistula with intravesical calcification of the piece of wood used to perform the illegal abortion. A -vesical approach allowed extraction of the calcified foreign body and closure of the vesicovaginal fistula. Read More

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November 2021

Peripheral Neuromodulation for the Management of Headache.

Anesth Pain Med 2020 Dec 30;10(6):e110515. Epub 2020 Nov 30.

Department of Anesthesiology, LSU Health Shreveport, Shreveport, LA, USA.

Context: Neuromodulation is an expanding field of study for headache treatment to reduce pain by targeting structures within the nervous system that are commonly involved in headache pathophysiology, such as the vagus nerve (VNS), occipital nerves, or sphenopalatine ganglion (SPG) for stimulation. Pharmaceutical medical therapies for abortive and prophylactic treatment, such as triptans, NSAIDs, beta-blockers, TCAs, and antiepileptics, are effective for some individuals, but the role that technology plays in investigating other therapeutic modalities is essential. Peripheral neuromodulation has gained popularity and FDA approval for use in treating certain headaches and migraine headache conditions, particularly in those who are refractory to treatment. Read More

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December 2020

Headache attributed to idiopathic intracranial hypertension and persistent post-idiopathic intracranial hypertension headache: A narrative review.

Headache 2021 06 9;61(6):808-816. Epub 2021 Jun 9.

Birmingham Neuro-Ophthalmology, Queen Elizabeth Hospital, Birmingham, UK.

Objective: Headache is a near-universal sequela of idiopathic intracranial hypertension (IIH). The aim of this paper is to report current knowledge of headache in IIH and to identify therapeutic options.

Background: Disability in IIH is predominantly driven by headache; thus, headache management is an urgent and unmet clinical need. Read More

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Retinal Migraine: Evaluation and Management.

Curr Neurol Neurosci Rep 2021 05 11;21(7):35. Epub 2021 May 11.

Division of Neurology, University of Toronto, Toronto, Canada.

Purpose Of Review: This review aims to summarize the last 15 years of literature and case reports detailing retinal migraine-an uncommon and somewhat poorly understood migraine variant.

Recent Findings: In the last 15 years, only 12 cases of retinal migraine have been outlined. Similar to other migraine statistics, retinal migraine appears to affect women more so than men and presents with unilateral headache which tends to be ipsilateral to the side of vision loss. Read More

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Entry-competent-replication-abortive African horse sickness virus strains elicit robust immunity in ponies against all serotypes.

Vaccine 2021 05 3;39(23):3161-3168. Epub 2021 May 3.

Department of Infection Biology, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, United Kingdom. Electronic address:

African horse sickness virus (AHSV) is an Orbivirus within the Reoviridae family, spread by Culicoides species of midges, which infects equids with high mortality, particularly in horses and has a considerable impact on the equine industry. In order to control the disease, we previously described Entry Competent Replication Abortive (ECRA) virus strains for each of the nine distinct AHSV serotypes and demonstrated their potential as vaccines, first in type I interferon receptor (IFNAR-/-) knockout mice, and then in ponies. In this report we have investigated whether or not a combination ECRA vaccine comprising nine vaccine strains as two different cocktails is as efficient in ponies and the duration of the immunity triggered by ECRA vaccines. Read More

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Case Report: QT Prolongation and Abortive Sudden Death Observed in an 85-Year-Old Female Patient With Advanced Lung Cancer Treated With Tyrosine Kinase Inhibitor Osimertinib.

Front Cardiovasc Med 2021 19;8:655808. Epub 2021 Mar 19.

Division of Cardiology, Department of Internal Medicine, Kyushu Central Hospital, Fukuoka, Japan.

Cardiac arrest occurred in an 85-year-old female administered osimertinib for advanced lung cancer expressing epidermal growth factor receptor (EGFR) mutations. Electrocardiogram (ECG) recorded at recurrence of spontaneous circulation showed sinus rhythm associated with mild QT prolongation (QTc = 455 ms) to which silent myocardial ischemia and coadministration of itraconazole and herbal drug causing hypokalemia (2.1 mEq/L) may have contributed. Read More

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Risperidone for successful treatment of postictal psychosis refractory to olanzapine.

Proc (Bayl Univ Med Cent) 2021 Jan 20;34(2):318-320. Epub 2021 Jan 20.

Harvard Medical School, Boston, Massachusetts.

Postictal psychosis (PIP) in patients with epilepsy is often mistaken for other primary psychiatric disorders. Depending on its severity, PIP often prompts empiric treatment with atypical antipsychotics, which are balanced against the risk of lowered seizure thresholds. Here we present a case of olanzapine-resistant PIP, where risperidone was used as a safe and effective abortive treatment. Read More

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January 2021

Improvement of Cyclic Vomiting Syndrome with Outpatient Ketamine Infusions.

Case Rep Gastroenterol 2021 Jan-Apr;15(1):9-16. Epub 2021 Jan 18.

Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Cyclic vomiting syndrome (CVS) is a disorder characterized by recurrent flares of nausea and vomiting, often with significant abdominal pain, of several days duration. Although traditional prophylactic and abortive treatments for CVS are often successful, a subset of CVS patients with chronic abdominal pain may not respond as well to standard therapies. This report is the first, to our knowledge, to describe the use of outpatient ketamine infusions as therapy for refractory CVS. Read More

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January 2021

DNA ligase I fidelity mediates the mutagenic ligation of pol β oxidized and mismatch nucleotide insertion products in base excision repair.

J Biol Chem 2021 Jan-Jun;296:100427. Epub 2021 Feb 16.

Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA. Electronic address:

DNA ligase I (LIG1) completes the base excision repair (BER) pathway at the last nick-sealing step after DNA polymerase (pol) β gap-filling DNA synthesis. However, the mechanism by which LIG1 fidelity mediates the faithful substrate-product channeling and ligation of repair intermediates at the final steps of the BER pathway remains unclear. We previously reported that pol β 8-oxo-2'-deoxyribonucleoside 5'-triphosphate insertion confounds LIG1, leading to the formation of ligation failure products with a 5'-adenylate block. Read More

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Renal angiomyoadenomatous tumor (RAT): a rare distinct entity with diagnostic challenges-a case report.

J Egypt Natl Canc Inst 2021 Jan 7;33(1). Epub 2021 Jan 7.

Department of Radiology, Goa Medical College, Bambolim, Goa, India.

Background: Renal angiomyoadenomatous tumor (RAT) is a recently described rare renal neoplasm with variations in the presentation, gross, and microscopic findings, and having a benign course and good prognosis. It is characterized microscopically by the admixture of three components-epithelial cells arranged in tubules and nests, angiomyomatous stroma, and capillary-sized interconnecting vascular channels in close association with the epithelial cell clusters. Microscopically, these tumors can be confused with clear cell carcinoma, papillary carcinoma, mixed epithelial and stromal tumors, and angiomyolipoma. Read More

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January 2021

Heteropagus Twins: A Tale of Two.

Neurol India 2020 Nov-Dec;68(6):1453-1455

Department of Pediatric Surgery, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Parasitic twin is a rare occurrence, with rachispagus being the rarest. The surgical approach and timing are not standardized. We describe the management of two cases of rachispagus and review the sparse literature on this entity. Read More

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Positive HCMV DNAemia in stem cell recipients undergoing letermovir prophylaxis is expression of abortive infection.

Am J Transplant 2021 04 8;21(4):1622-1628. Epub 2021 Feb 8.

Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Letermovir (LMV) inhibits HCMV replication by binding to components of the HCMV-terminase complex showing a potential role in prevention of HCMV-related complications in allogenic hematopoietic stem cell transplant recipients (allo-HSCTRs). However, little is known about breakthrough HCMV infection and the relevance of HCMV DNAemia during prophylaxis. We reported the results of a multicenter prospective study involving five Italian centers in the management of HCMV DNAemia in 75 adult HCMV-seropositive allo-HSCTRs undergoing LMV prophylaxis. Read More

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Early impact of the COVID-19 pandemic on outpatient migraine care in Hawaii: Results of a quality improvement survey.

Headache 2021 01 14;61(1):149-156. Epub 2020 Dec 14.

Clinical Research Center, Brain Research, Innovation & Translation Labs, Hawaii Pacific Neuroscience, Honolulu, HI, USA.

Objective: A survey was implemented for early assessment of pandemic-related practice processes and quality improvement (QI).

Background: In response to the public health measures in Hawaii to curtail the coronavirus 2019 pandemic, Hawaii Pacific Neuroscience (HPN) adapted their patient care to ensure continuity of neurological treatment.

Methods: The telephone survey was conducted on patients seen at HPN during the period of April 22, 2020-May 18, 2020 to address four areas related to patients' outpatient experience: delivery of care, general well-being, experience with telemedicine, and disease-specific questions. Read More

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January 2021

Cryo-EM Structures Reveal Transcription Initiation Steps by Yeast Mitochondrial RNA Polymerase.

Mol Cell 2021 01 4;81(2):268-280.e5. Epub 2020 Dec 4.

Rega Institute for Medical Research, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium. Electronic address:

Mitochondrial RNA polymerase (mtRNAP) is crucial in cellular energy production, yet understanding of mitochondrial DNA transcription initiation lags that of bacterial and nuclear DNA transcription. We report structures of two transcription initiation intermediate states of yeast mtRNAP that explain promoter melting, template alignment, DNA scrunching, abortive synthesis, and transition into elongation. In the partially melted initiation complex (PmIC), transcription factor MTF1 makes base-specific interactions with flipped non-template (NT) nucleotides "AAGT" at -4 to -1 positions of the DNA promoter. Read More

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January 2021

Migraine Prophylaxis Using Novel Monoclonal Antibody Injections in a Commercial Pilot.

Aerosp Med Hum Perform 2020 Oct;91(10):824-825

Frequent migraine headaches are disabling and aeromedically disqualifying. Four new monoclonal antibody medications, targeting calcitonin gene-related peptide (CGRP), have been approved by the U.S. Read More

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October 2020

Bacterial Retrons Function In Anti-Phage Defense.

Cell 2020 12 5;183(6):1551-1561.e12. Epub 2020 Nov 5.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address:

Retrons are bacterial genetic elements comprised of a reverse transcriptase (RT) and a non-coding RNA (ncRNA). The RT uses the ncRNA as template, generating a chimeric RNA/DNA molecule in which the RNA and DNA components are covalently linked. Although retrons were discovered three decades ago, their function remained unknown. Read More

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December 2020

A Rare Case of Ureteral Diverticulum Incidentally Detected During Angiography.

Curr Med Imaging 2021 ;17(4):549-551

Department of Radiology, Eskişehir Osmangazi University, Faculty of Medicine, Eskisehir, Turkey.

Background: A ureteral diverticulum (UD) is a rare urological malformation characterized by the saccular enlargement of the ureteral wall. It can be of different sizes and in various localizations. In the literature, three types of UD have been defined as abortive bifid ureter, congenital, and acquired. Read More

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October 2021

Functional genomics reveals the toxin-antitoxin repertoire and AbiE activity in .

Microb Genom 2020 11;6(11)

Genetics Otago, University of Otago, Dunedin 9054, New Zealand.

Bacteriophage defences are divided into innate and adaptive systems. sp. ATCC 39006 has three CRISPR-Cas adaptive immune systems, but its innate immune repertoire is unknown. Read More

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November 2020

First report of stem smut caused by Tranzscheliella hypodytes (Schltdl.) Vanky & McKenzie on Leymus secalinus (Georgi) Tzvelev in India.

Plant Dis 2020 Sep 16. Epub 2020 Sep 16.

ICAR - Indian Institute of Wheat and Barley Research, 54642, Karnal, Haryana, India;

Leymus secalinus (Blue wild rye) is a perennial grass species distributed in Leh-Ladakh region of India. Culms are usually solitary, 20-100 cm tall, 2-5-noded, smooth and glabrous. It is found on mountain slopes, rocky, stony and pebbled soils, grassy places, river banks, sandy and alkaline soils. Read More

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September 2020

Membranous aplasia cutis congenita in trisomy 18.

Ital J Pediatr 2020 Aug 27;46(1):120. Epub 2020 Aug 27.

Unit of Dentistry, Bambino Gesù Children Hospital and Research Institute, Rome, Italy.

Background: Aplasia cutis congenita (ACC) is a rare congenital condition characterized by the absence of skin layers and sometimes other underlying structures, in a localized or widespread area. The exact etiopathogenesis is not yet completely understood. Membranous ACC (MACC) also described as bullous or cystic ACC is a clinical subtype of ACC, covered with a membranous or glistening surface, and appears as a flat scar. Read More

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Sperm DNA Fragmentation: A New Guideline for Clinicians.

World J Mens Health 2020 Oct 6;38(4):412-471. Epub 2020 Aug 6.

Department of Urology, Lilavati Hospital and Research Centre, Mumbai, India.

Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases of spermatogenesis, which imparts compaction and protects the genetic content. Testicular (defective maturation and abortive apoptosis) and post-testicular (oxidative stress) mechanisms are implicated in the etiology of sperm DNA fragmentation (SDF), which affects both natural and assisted reproduction. Read More

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October 2020

Rare Entity of Proximal Ureteral Diverticulum Managed by Robotic Resection and Ureteroureteral Anastomosis.

J Endourol Case Rep 2020 11;6(1):39-41. Epub 2020 Mar 11.

Department of Urology, JIPMER, Pondicherry, India.

Ureteral diverticulum (UD) is a rare condition. It can be congenital, acquired, or an abortive ureteral duplication. Majority can be managed conservatively. Read More

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Chronic Cluster Headache with a Pediatric Onset: The First Japanese Case Report.

Intern Med 2020 Nov 28;59(22):2937-2940. Epub 2020 Jul 28.

Department of Neurology, Headache Center, Tominaga Hospital, Japan.

A 9-year-old female reported left-sided, excruciatingly severe, stabbing orbital pain with cranial autonomic symptoms. The attacks continued for 1 year with a remission period of 2 months. Each attack duration was approximately 120 minutes with a frequency of two to three times a day. Read More

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November 2020

Characterization of a novel loss-of-function variant in TDP2 in two adult patients with spinocerebellar ataxia autosomal recessive 23 (SCAR23).

J Hum Genet 2020 Dec 10;65(12):1135-1141. Epub 2020 Jul 10.

Medical Genetics Unit, Department of Molecular Medicine, University of Pavia, Pavia, Italy.

TDP2 encodes a 5'-tyrosyl DNA phosphodiesterase required for the efficient repair of double-strand breaks (DSBs) induced by the abortive activity of DNA topoisomerase II (TOP2). To date, only three homozygous variants in TDP2 have been reported in six patients from four unrelated pedigrees with spinocerebellar ataxia 23 (SCAR23). By whole-exome sequencing, we identified a novel TDP2 splice-site variant (c. Read More

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December 2020

Abortive vampire bat rabies infections in Peruvian peridomestic livestock.

PLoS Negl Trop Dis 2020 06 29;14(6):e0008194. Epub 2020 Jun 29.

Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.

Rabies virus infections normally cause universally lethal encephalitis across mammals. However, 'abortive infections' which are resolved prior to the onset of lethal disease have been described in bats and a variety of non-reservoir species. Here, we surveyed rabies virus neutralizing antibody titers in 332 unvaccinated livestock of 5 species from a vampire bat rabies endemic region of southern Peru where livestock are the main food source for bats. Read More

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