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Qualitative Components of Dyspnea during Incremental Exercise across the COPD Continuum.

Med Sci Sports Exerc 2021 Jul 7. Epub 2021 Jul 7.

Respiratory Investigation Unit, Department of Medicine, Queen's University and Kingston Health Sciences Centre Kingston General Hospital Campus, Kingston, Ontario, Canada Department of Chest Diseases, Faculty of Medicine, Alexandria University, Alexandria, Egypt Centre for Heart Lung Innovation, Providence Health Care Research Institute, University of British Columbia, St. Paul's Hospital, Vancouver, British Columbia, Canada Kingston General Health Research Institute, Kingston, Ontario, Canada.

Introduction: Evaluation of the intensity and quality of activity-related dyspnea is potentially useful in people with chronic obstructive pulmonary disease (COPD). The present study sought to examine associations between qualitative dyspnea descriptors, dyspnea intensity ratings, dynamic respiratory mechanics, and exercise capacity during cardiopulmonary exercise testing (CPET) in COPD and healthy controls.

Methods: In this cross-sectional study, 261 patients with mild-to-very severe COPD (forced expiratory volume in 1 second [FEV1] 62 ± 25 %pred) and 94 age-matched controls (FEV1 114 ± 14 %pred) completed an incremental cycle CPET to determine peak oxygen uptake (V[Combining Dot Above]O2peak). Read More

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Age and sex differences in associations between self-reported health, physical function, mental function and mortality.

Arch Gerontol Geriatr 2021 Sep 29;98:104537. Epub 2021 Sep 29.

Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan; Aging and Health Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan; Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan. Electronic address:

Objectives: To explore how age and sex affect the impacts of self-rated health, self-reported physical activities, physical function, and depressive symptoms on long-term mortality among community-dwelling middle-aged and older adults using a nationally representative population-based cohort study.

Methods: Data from 1550 study participants from the Social Environment and Biomarkers of Aging Study (SEBAS) were retrieved for analysis, and all participants were divided into four groups based on their age and gender. Middle aged participants were aged 53 to 64 years, and elderly subjects were ≥ 65 years old. Read More

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September 2021

Comparing the performance of the palliative prognostic (PaP) score with clinical predictions of survival: A systematic review.

Eur J Cancer 2021 Oct 11;158:27-35. Epub 2021 Oct 11.

Marie Curie Palliative Care Research Department, Division of Psychiatry, UCL, London, UK; Primary Care and Population Health, Institute of Epidemiology and Health Care, University College London (UCL), London, UK.

Background: In patients with advanced cancer, prognosis is usually determined using clinicians' predictions of survival (CPS). The palliative prognostic (PaP) score is a prognostic algorithm that was developed to predict survival in patients with advanced cancer. The score categorises patients into three risk groups in accordance with their probability of surviving for 30 days. Read More

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October 2021

Intracranial tuberculomas: A case report of clinical, radiological, and pathological characteristics.

Int J Surg Case Rep 2021 Oct 8;88:106477. Epub 2021 Oct 8.

Division of Neurosurgery, Department of Surgery, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Alfaisal University, Riyadh, Saudi Arabia.

Background: Intracranial tuberculomas are uncommon yet devastating forms of extrapulmonary tuberculosis with a high mortality rate and morbidity risk. A high level of suspicion is required for a prompt diagnosis and treatment.

Case Description: A 67-year-old male, medically free, presented at the Emergency Department with a 1-day history of nausea and vomiting, and a 15-day history of imbalance and dizziness. Read More

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October 2021

Changes in social support of pregnant and postnatal mothers during the COVID-19 pandemic.

Midwifery 2021 Oct 1;103:103162. Epub 2021 Oct 1.

Division of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry, University of Southern California, 1540 Alcazar St, CHP 155, Los Angeles, CA, 90033, United States; Department of Pediatrics, Keck School of Medicine, University of Southern California, 1975 Zonal Ave Los Angeles, California, 90033, United States; Division of Research on Children, Youth, and Families, Children's Hospital Los Angeles, 4650 Sunset Blvd Los Angeles, CA, 90027, United States; Developmental Neuroscience and Neurogenetics Program, The Saban Research Institute, Children's Hospital Los Angeles, 4650 Sunset Blvd Los Angeles, California, 90027, United States.

Objective: Our objectives were to assess in perinatal women: the most effective methods used to meet social support needs during COVID-19, the impact of COVID-19 on self-reported social support levels, and how perceived change in social support related to distress, depression, and mental health.

Design: One-time survey administered from April to August 2020 SETTING: Online PARTICIPANTS: Pregnant and postpartum women with infants less than 6 months of age MEASUREMENT AND FINDINGS: Participants indicated the methods they used to meet social support needs during COVID-19. They self-rated their social support level pre- and during pandemic and their distress, depressive symptoms, and mental health changes on a Likert scale. Read More

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October 2021

Use of 3D printing and pre-contouring plate in the surgical planning of acetabular fractures: A systematic review.

Orthop Traumatol Surg Res 2021 Oct 11:103111. Epub 2021 Oct 11.

Department of General Surgery and Medical Surgical Specialties, Section of Orthopaedics and Traumatology, A.O.U. Policlinico "Rodolico-San Marco", University of Catania, Catania, Italy. Electronic address:

Background: Acetabular fractures are caused by high energy injuries. The treatment aims to reconstruct the articular surface, restoring the anatomical structure. The surgical management of these fractures is difficult because it requires familiarity with the 3D anatomy of the pelvis. Read More

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October 2021

Health Plans Struggle to Report on Depression Quality Measures that Require Clinical Data.

Acad Pediatr 2021 Oct 11. Epub 2021 Oct 11.

National Committee for Quality Assurance (E Morden, S Byron, L Roth, SS Olin and H Scholle), Wash.

Objective: Depression quality measures aligned with evidence-based practices require that health care organizations use standardized tools for tracking and monitoring patient-reported symptoms and functioning over time. This study describes challenges and opportunities for reporting five HEDIS measures which use electronic clinical data to assess adolescent and perinatal depression care quality.

Methods: Two learning collaboratives were convened with 10 health plans from five states to support reporting of the depression measures. Read More

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October 2021

The effects of medicinal herbs and marine natural products on wound healing of cutaneous leishmaniasis: A systematic review.

Microb Pathog 2021 Oct 11:105235. Epub 2021 Oct 11.

Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran; Shahrekord Branch, Islamic Azad University, Shahrekord, Iran. Electronic address:

This study aimed to investigate the effects of medicinal herbs and marine natural products on wound healing of cutaneous leishmaniasis. To carry out this literature review, the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) instructions were used. Articles on the potential of medicinal plants and natural substances of marine origin against wound healing of cutaneous leishmaniasis were explored. Read More

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October 2021

Clinical outcome of different total knee arthroplasty designs in one-stage revision for periprosthetic infection.

J Arthroplasty 2021 Oct 11. Epub 2021 Oct 11.

Department of Orthopedic Surgery, ENDO-Klinik Hamburg, Holstenstrasse 2, 22767, Hamburg, Germany; Department of Trauma and Orthopaedic Surgery, University Medical Center Hamburg- Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

Background: Despite the growing number of studies reporting on the best surgical treatment in the management of periprosthetic joint infection, there are no robust data regarding the type of infected prosthesis prior to any kind of exchange arthroplasty. To overcome these shortcomings, we asked the following questions: (1) What is the survivorship of non-hinged and hinged knee implants following one-stage exchange arthroplasty and (2) What is the functional outcome after one-stage exchange procedure focusing on knee prostheses and the type of prior infected knee implant. In a secondary radiographic analysis, we also investigated if (3) the type of femoral bone morphology measured by the inner femoral diameter influences the rate of aseptic failures also in PJI patients. Read More

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October 2021

Degree of Myopia and Glaucoma Risk: A Dose-Response Meta-Analysis.

Am J Ophthalmol 2021 Oct 11. Epub 2021 Oct 11.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea; Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea. Electronic address:

Purpose: To verify the dose-response relation between degree of myopia and open-angle glaucoma (OAG) risk DESIGN: Dose-response meta-analysis METHODS: We searched the PubMed, EMBASE, and Cochrane databases for population-based studies published until 30 November 2020 and reporting on both myopia and OAG. Random-effect models generated pooled odds ratios (OR) and 95% confidence intervals (CIs). Results robustness was confirmed by influence and subgroup analyses. Read More

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October 2021

Non-obese non-alcoholic fatty liver disease (NAFLD) in Asia: an international registry study.

Metabolism 2021 Oct 11:154911. Epub 2021 Oct 11.

Division of Gastroenterology and Hepatology, National University Health System, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

Background: A significant proportion of the non-alcoholic fatty liver disease (NAFLD) population is non-obese. Prior studies reporting the severity of NAFLD amongst non-obese patients were heterogenous. Our study, using data from the largest biopsy-proven NAFLD international registry within Asia, aims to characterize the demographic, metabolic and histological differences between non-obese and obese NAFLD patients. Read More

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October 2021

Prevalence, Risk Factors, and Impact of Delirium on Hospitalized Older Adults With Dementia: A Systematic Review and Meta-Analysis.

J Am Med Dir Assoc 2021 Oct 11. Epub 2021 Oct 11.

Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

Objectives: High prevalence of delirium superimposed on dementia (DSD) was previously reported, with associated negative impact on hospitalized older adults. However, data were conflicting, and no meta-analysis has been conducted. Although dementia is the leading risk factor for delirium, risk factors for DSD have not been adequately studied. Read More

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October 2021

Preferences for transitional HIV care among people living with HIV recently released from prison in Zambia: a discrete choice experiment.

J Int AIDS Soc 2021 Oct;24(10):e25805

Implementation Science Unit, Centre for Infectious Disease Research in Zambia (CIDRZ), Lusaka, Zambia.

Introduction: No studies from sub-Saharan Africa have attempted to assess HIV service delivery preferences among incarcerated people living with HIV as they transition from prisons to the community ("releasees"). We conducted a discrete choice experiment (DCE) to characterize releasee preferences for transitional HIV care services in Zambia to inform the development of a differentiated service delivery model to promote HIV care continuity for releasees.

Methods: Between January and October 2019, we enrolled a consecutive sample of 101 releasees from a larger cohort prospectively following 296 releasees from five prisons in Zambia. Read More

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October 2021

A European, prospective, observational study of enzalutamide in patients with metastatic castration-resistant prostate cancer: PREMISE.

Int J Cancer 2021 Oct 14. Epub 2021 Oct 14.

Department of Urology, Charité University Hospital, Berlin, Germany, and Medical University of Vienna, Vienna, Austria.

In randomized clinical trials, the androgen receptor inhibitor enzalutamide has demonstrated efficacy and safety in metastatic castration-resistant prostate cancer (mCRPC). This study captured efficacy, safety, and patient-reported outcomes (PROs) of enzalutamide in mCRPC patients in a real-world European setting. PREMISE (NCT0249574) was a European, long-term, prospective, observational study in mCRPC patients prescribed enzalutamide as part of standard clinical practice. Read More

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October 2021

Communicating social responsibilities through CSR reports: Comparative study of top European and Asia-Pacific airlines.

Authors:
Xing Zhang

PLoS One 2021 14;16(10):e0258687. Epub 2021 Oct 14.

School of Management, Guizhou University of Commerce, Guiyang, China.

Recently the outbreak of major social incidents has put the airline industry in the forefront of the debate. However, studies related to the social dimension of the Global Reporting Initiative (GRI) Standards in aviation are limited. To fill the gap, this study explored the social themes of corporate social responsibility (CSR) practices between European and Asia-Pacific based airlines. Read More

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October 2021

General practice pharmacists in Australia: A systematic review.

PLoS One 2021 14;16(10):e0258674. Epub 2021 Oct 14.

Faculty of Health, Discipline of Pharmacy, University of Canberra, Bruce, Australian Capital Territory, Australia.

Background: The inclusion of pharmacists into general practices in Australia has expanded in recent years. This systematic review aimed to synthesise the literature of qualitative and quantitative studies, and identify the knowledge gaps, related to pharmacists working in general practice in Australia.

Methods: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Read More

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October 2021

The impact of the COVID-19 response on the provision of other public health services in the U.S.: A cross sectional study.

PLoS One 2021 14;16(10):e0255844. Epub 2021 Oct 14.

Epidemiology Program, University of Delaware, Newark, Delaware, United States of America.

Introduction: Funding and staff formerly dedicated to routine public health tasks (e.g., responding to communicable and non-communicable diseases, investigating foodborne outbreaks, conducting routine surveillance) and services (e. Read More

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October 2021

Do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis.

PLoS One 2021 14;16(10):e0249501. Epub 2021 Oct 14.

Cambridge Centre for Sport & Exercise Sciences, Anglia Ruskin University, Cambridge, United Kingdom.

The aim of this systematic review and meta-analysis was to identify a list of common, candidate genes associated with the three components of fitness, specifically cardiovascular fitness, muscular strength, and anaerobic power, and how these genes are associated with exercise response phenotype variability, in previously untrained participants. A total of 3,969 potentially relevant papers were identified and processed for inclusion. After eligibility and study selection assessment, 24 studies were selected for meta-analysis, comprising a total of 3,012 participants (male n = 1,512; females n = 1,239; not stated n = 261; age 28 ± 9 years). Read More

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October 2021

Inconsistencies in the Methodological Framework Throughout Published Studies in High-Impact Orthopaedic Journals: A Systematic Review.

J Bone Joint Surg Am 2021 Oct 14. Epub 2021 Oct 14.

Faculty of Health and Rehabilitation Sciences, Western University, London, Ontario, Canada.

Background: Both the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) and Consolidated Standards of Reporting Trials (CONSORT) guidelines recommend that clinical trials follow a study framework that aligns with their objective to test the relative efficacy or safety (equality) or effectiveness (superiority, noninferiority, or equivalence) between interventions. We conducted a systematic review to assess the proportion of studies that demonstrated inconsistency between the framing of their research question, sample size calculation, and conclusion and those that should have framed their research question differently based on the compared interventions.

Methods: We included studies from 5 high-impact-factor orthopaedic journals published in 2017 and 2019 that compared at least 2 interventions using patient-reported outcome measures. Read More

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October 2021

Exploring a new paradigm for the fetal anomaly ultrasound scan: artificial intelligence in real time.

Prenat Diagn 2021 Oct 14. Epub 2021 Oct 14.

School of Biomedical Engineering and Imaging Sciences, King's College London.

Objective: Advances in artificial intelligence (AI) have demonstrated potential to improve medical diagnosis. We piloted the end-to-end automation of the mid-trimester screening ultrasound scan using AI-enabled tools.

Methods: A prospective method comparison study was conducted. Read More

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October 2021

[Localized prostate cancer].

Pathologe 2021 Oct 14. Epub 2021 Oct 14.

Dr. Senckenbergisches Institut für Pathologie, Universitätsklinikum Frankfurt, Frankfurt, Deutschland.

Prostate cancer is the most prevalent noncutaneous cancer in men. The Gleason grading is considered to be the strongest prognostic parameter regarding progression-free survival and overall survival. The original grading system has been modified during the last decade resulting in a more precise prognostic tool. Read More

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October 2021

Epidemiology and reporting of osteoporotic vertebral fractures in patients with long-term hospital records based on routine clinical CT imaging.

Osteoporos Int 2021 Oct 14. Epub 2021 Oct 14.

Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum Rechts Der Isar, Technical University of Munich, Munich, Germany.

Osteoporotic vertebral fractures signify an increased risk of future fractures and mortality and can manifest the diagnosis of osteoporosis. We investigated the prevalence of vertebral fractures in routine CT of patients with long-term hospital records. Three out of ten patients showed osteoporotic vertebral fractures (VFs) corresponding to the highest rates reported in European population-based studies. Read More

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October 2021

Building Capacity of Community Health Centers to Overcome Data Challenges with the Development of an Agile COVID-19 Public Health Registry: A Multi-State Quality Improvement Effort.

J Am Med Inform Assoc 2021 Oct 14. Epub 2021 Oct 14.

National Association of Community Health Centers, Bethesda, MD USA.

Objective: During the COVID-19 pandemic, federally qualified health centers rapidly mobilized to provide SARS-CoV-2 testing, COVID-19 care, and vaccination to populations at increased risk for COVID-19 morbidity and mortality. We describe the development of a reusable public health data analytics system for reuse of clinical data to evaluate the health burden, disparities, and impact of COVID-19 on populations served by health centers.

Materials And Methods: The Multi-State Data Strategy engaged project partners to assess public health readiness and COVID-19 data challenges. Read More

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October 2021

The Challenges of Nurses Who Care for COVID-19 Patients: A Qualitative Study.

Holist Nurs Pract 2021 Nov-Dec 01;35(6):315-320

Semra ve Vefa Küçük Sağlık Bilimleri Fakültesi, Nevşehir Hacı Bektaş Veli Üniversitesi, Nevşehir, Turkey (Dr Çakıcı); Hemşirelik Fakültesi, Atatürk Üniversitesi, Erzurum, Turkey (Dr Avşar); and Sağlık Bilimleri Fakültesi, Gazi Üniversitesi, Ankara, Turkey (Dr Çalışkan).

This study, which had a qualitative research design, was conducted to identify the challenges experienced by nurses who care for patients diagnosed with COVID-19. The nurses providing one-to-one care to patients diagnosed with COVID-19 in various hospitals in Turkey constituted the population of this study. The maximum variation sampling method was used to determine the sample in the research. Read More

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October 2021

[Effectiveness and challenges in cancer palliative home-care services: a retrospective cohort study.]

Recenti Prog Med 2021 Oct;112(10):647-652

UOC Cure Palliative, Azienda ULSS 8 Berica, Vicenza.

Introduction: Management by the palliative care network (RLCP) has been identified as one of the major determinants of clinical appropriateness and reduction of hospital admissions in cancer patient's end of life. The patient's transition process from hospital cancer care to palliative home care is particularly frail from both a clinical and organizational point of view, requiring a multidimensional assessment (VMD) and the draft of an individual care plan (PAI). The aim of this study was to assess the impact of appropriate home-based palliative care in reducing hospitalizations, and also to identify critical issues in the patient's transition to home palliative care. Read More

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October 2021

Reporting of Research Ethics in Studies Focusing on Foot Health in Patients with Rheumatoid Arthritis - A Systematic Review.

J Empir Res Hum Res Ethics 2021 Oct 14:15562646211047654. Epub 2021 Oct 14.

8058University of Turku, Turku (Finland).

Research ethics is a fundamental part of the entire research. Patients with rheumatoid arthritis are sensitive group of research participants because their long-term health problems cause significant changes in their foot health. In foot health research, data are usually collected through a clinical assessment of the foot or questionnaires. Read More

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October 2021

Ascertaining minimal clinically meaningful changes in symptoms of depression rated by the 15-item Centre for Epidemiologic Studies Depression Scale.

J Eval Clin Pract 2021 Oct 13. Epub 2021 Oct 13.

Department of Psychosomatics and Psychotherapy, Parkland Clinic, Bad Wildungen, Germany.

Rationale, Aims And Objectives: In clinical practise and in clinical studies on depression it is important to estimate whether changes in symptomatology measured by self-rating instruments are, in fact, clinically relevant. Therefore, the aim of the study was to estimate the clinical relevance of changes on the 15-item version of the Centre for Epidemiologic Studies Depression Scale (CES-D-15) based on the concept of the minimal clinically important difference (MCID).

Methods: Data was acquired from 4781 patients with depression symptoms from a German psychosomatic hospital who have been assessed using the CES-D-15 before and after treatment. Read More

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October 2021

Added value of magnetic resonance spectroscopy for diagnosing childhood cerebellar tumours.

NMR Biomed 2021 Oct 13:e4630. Epub 2021 Oct 13.

Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.

H-magnetic resonance spectroscopy (MRS) provides noninvasive metabolite profiles with the potential to aid the diagnosis of brain tumours. Prospective studies of diagnostic accuracy and comparisons with conventional MRI are lacking. The aim of the current study was to evaluate, prospectively, the diagnostic accuracy of a previously established classifier for diagnosing the three major childhood cerebellar tumours, and to determine added value compared with standard reporting of conventional imaging. Read More

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October 2021

A Systematic Review of Parent Report Measures Assessing the Psychosocial Impact of Food Allergy on Patients and Families.

Allergy 2021 Oct 13. Epub 2021 Oct 13.

Children's Healthcare of Atlanta, Atlanta, GA, USA.

Reducing the psychosocial impact of food allergy (FA) represents a top patient-centered research priority. This priority recognizes that psychosocial impact is an important outcome of current FA therapies (e.g. Read More

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October 2021