8,928 results match your criteria reported integral

Electronic Health Records As a Platform for Audiological Research: Data Validity, Patient Characteristics, and Hearing-Aid Use Persistence Among 731,213 U.S. Veterans.

Ear Hear 2020 Dec 16. Epub 2020 Dec 16.

1Manchester Centre for Audiology and Deafness, School of Health Sciences, University of Manchester, Manchester, United Kingdom; 2VA Rehabilitation R&D, National Center for Rehabilitative Auditory Research, Portland, Oregon, USA; 3Department of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, Wisconsin, USA 4Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom.

Objectives: This article presents a summary of audiological, general health, and hearing aid (HA) outcome data in a large sample of U.S. Veterans receiving HAs. Read More

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December 2020

Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice.

Nat Commun 2021 May 10;12(1):2595. Epub 2021 May 10.

Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Tissue regeneration is a process that recapitulates and restores organ structure and function. Although previous studies have demonstrated wound-induced hair neogenesis (WIHN) in laboratory mice (Mus), the regeneration is limited to the center of the wound unlike those observed in African spiny (Acomys) mice. Tissue mechanics have been implicated as an integral part of tissue morphogenesis. Read More

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The experiences, attitudes and understanding of research amongst medical students at an Australian medical school.

BMC Med Educ 2021 May 10;21(1):267. Epub 2021 May 10.

School of Clinical Sciences, Monash University, Melbourne, Australia.

Background: Research engagement plays an integral role in developing clinicians that practice effective, evidence-based medicine. Research participation by clinicians, however, is declining. Given the link between research during medical school and future research output, promotion of medical student research is one avenue by which this shortage can be addressed. Read More

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Developing an Intervention to Improve Occupational Participation for Justice-Involved People with a Personality Disorder: Defining and Describing Intervention Components.

Int J Offender Ther Comp Criminol 2021 May 10:306624X211013520. Epub 2021 May 10.

University of Warwick, Coventry, UK.

Occupational participation is undertaking personally meaningful and socially valued activities and roles. It is an important outcome for health and justice interventions, as it is integral to health and desistance. We report the third of a four-stage research project to develop an intervention to improve occupational participation for justice-involved people with a personality disorder in the community. Read More

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Numerical and experimental study on turbulence statistics in a large fan-stirred combustion vessel.

M E Morsy J Yang

Exp Fluids 2021 3;62(5):116. Epub 2021 May 3.

School of Mechanical Engineering, University of Leeds, Leeds, LS2 9JT United Kingdom.

Abstract: Particle image velocimetry (PIV) has become a popular non-intrusive tool for measuring various types of flows. However, when measuring three-dimensional flows with two-dimensional (2D) PIV, there are some uncertainties in the measured velocity field due to out-of-plane motion, which might alter turbulence statistics and distort the overall flow characteristics. In the present study, three different turbulence models are employed and compared. Read More

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Nuclear Translocation of OsMFT1 That is Impeded by OsFTIP1 Promotes Drought Tolerance in Rice.

Mol Plant 2021 May 4. Epub 2021 May 4.

State Key Laboratory of Rice Biology, Zhejiang Provincial Key Laboratory of Crop Genetic Resources, Institute of Crop Science, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China. Electronic address:

Drought has been the leading environmental threat affecting the productivity of crops, and plants have evolved a series of mechanisms to adapt to drought stress. The FT-INTERACTING PROTEINs (FTIPs) and phosphatidylethanolamine-binding proteins (PEBPs) play key roles in developmental processes, whereas their roles in the regulation of stress response are still largely unknown. Here, we report that OsFTIP1 negatively affects drought response. Read More

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Translational evidence for the Inflammatory Response System (IRS)/Compensatory Immune Response System (CIRS) and neuroprogression theory of major depression.

Prog Neuropsychopharmacol Biol Psychiatry 2021 May 4:110343. Epub 2021 May 4.

Deakin University, School of Medicine, IMPACT Strategic Research Centre, Barwon Health, Geelong, Victoria, Australia; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria.

Major depressive disorder (MDD) is a common, severe and disabling neuropsychiatric disorder with a heterogenous aetiology. Among the most widely recognized etiological models, immunopathogenesis is a predominant one. Numerous studies have demonstrated aberrant levels of inflammatory markers in the peripheral blood, cerebrospinal fluid (CSF) and brain of patients with MDD. Read More

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Investigations of plastic contamination of seawater, marine and coastal sediments in the Russian seas: a review.

Environ Sci Pollut Res Int 2021 May 7. Epub 2021 May 7.

Marine Hydrophysical Institute, Russian Academy of Sciences, Sevastopol, 299011, Russia.

Twelve seas with an integral coastline length of about 38,000 km wash upon the Russian coasts. They belong to the basins of the Atlantic, the Arctic, and the Pacific Oceans and stretch over temperate, subpolar, and polar climate zones. This review of 32 studies published between 2015 and August 2020 analyses the available peer-reviewed scientific publications related to the topic of plastic contamination. Read More

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Architecture of the membrane-bound cytochrome c heme lyase CcmF.

Nat Chem Biol 2021 May 6. Epub 2021 May 6.

Institut für Biochemie, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany.

The covalent attachment of one or multiple heme cofactors to cytochrome c protein chains enables cytochrome c proteins to be used in electron transfer and redox catalysis in extracytoplasmic environments. A dedicated heme maturation machinery, whose core component is a heme lyase, scans nascent peptides after Sec-dependent translocation for CXCH-binding motifs. Here we report the three-dimensional (3D) structure of the heme lyase CcmF, a 643-amino acid integral membrane protein, from Thermus thermophilus. Read More

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Perceived Barriers to Primary Care Services Utilization and its Associations with Overall Satisfaction of Patients in Saudi Arabia: A Cross-Sectional Questionnaire-Based Study.

J Prim Care Community Health 2021 Jan-Dec;12:21501327211014065

Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Introduction: Primary care plays an integral role in modern healthcare systems. More so in a country that is currently undergoing a reform of its health system. Their remains barriers that hinder patients from seeking medical assistance from primary physicians. Read More

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Reference Ranges for the Pulsed wave Doppler of the Fetal Cardiac Inflow and Outflow Tracts from 13 to 36 Weeks Gestation: Short title: Zidere, Fetal inflow and outflow tract, Pulsed wave Doppler, z scores.

J Am Soc Echocardiogr 2021 May 3. Epub 2021 May 3.

Medway Fetal and Maternal Medicine Centre, Medway Maritime Hospital, Gillingham, Kent, United Kingdom; Institute of Medical Sciences, Canterbury Christ Church University, Rowan William's Court, Chatham, Kent ME4 4UF.

Objective: Doppler assessment ventricular filling and outflow tract velocities are an integral part of the fetal echocardiogram, to assess diastolic function, systolic function and outflow tract obstruction. There is a paucity of prospective data from a large sample of normal fetuses in the published literature. We report reference ranges for pulsed wave Doppler flow of the mitral valve, tricuspid valve, aortic valve and pulmonary valve as well as heart rate, in a large number of fetuses prospectively examined at a single tertiary fetal cardiology centre. Read More

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Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity.

Nucleic Acids Res 2021 May 6. Epub 2021 May 6.

West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, Sichuan 610041, China.

The emergence of SARS-CoV-2 infection has posed unprecedented threat to global public health. The virus-encoded non-structural protein 14 (nsp14) is a bi-functional enzyme consisting of an exoribonuclease (ExoN) domain and a methyltransferase (MTase) domain and plays a pivotal role in viral replication. Here, we report the structure of SARS-CoV-2 nsp14-ExoN domain bound to its co-factor nsp10 and show that, compared to the SARS-CoV nsp10/nsp14-full-length complex, SARS-CoV-2 nsp14-ExoN retains an integral exoribonuclease fold and preserves an active configuration in the catalytic center. Read More

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Harvesting social media sentiment analysis to enhance stock market prediction using deep learning.

PeerJ Comput Sci 2021 13;7:e476. Epub 2021 Apr 13.

Symbiosis Centre for Applied Artificial Intelligence, Symbiosis International University, Pune, Maharastra, India.

Information gathering has become an integral part of assessing people's behaviors and actions. The Internet is used as an online learning site for sharing and exchanging ideas. People can actively give their reviews and recommendations for variety of products and services using popular social sites and personal blogs. Read More

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Breastfeeding in Primary Healthcare Setting: Evaluation of Nurses and Midwives Competencies, Training, Barriers and Satisfaction of Breastfeeding Educational Experiences in Northern Ghana.

Clin Med Insights Pediatr 2021 19;15:11795565211010704. Epub 2021 Apr 19.

Department of Health Information, Hohoe Municipal Hospital, Hohoe, Ghana.

Background: Breastfeeding education is critical in improving healthcare professionals' competencies in providing breastfeeding care to mothers. We evaluated breastfeeding competencies, training, barriers and satisfaction of breastfeeding educational experiences among nurses and midwives in the Sagnarigu Municipality, Ghana.

Methods: This cross-sectional study included nurses and midwives providing maternal and child health services at various primary healthcare facilities in Sagnarigu Municipality. Read More

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Medication Adherence Interventions for Cardiovascular Disease in Low- and Middle-Income Countries: A Systematic Review.

Patient Prefer Adherence 2021 29;15:885-897. Epub 2021 Apr 29.

Johns Hopkins University School of Nursing, Baltimore, MD, USA.

Purpose: The burden of cardiovascular diseases (CVD) is high in low- and middle-income countries (LMICs). Medications are integral to the management and control of CVD; however, suboptimal adherence impacts health outcomes. This systematic review aims to critically examine interventions targeted at improving medication adherence among persons with CVD in LMICs. Read More

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Lessons From Learners: Adapting Medical Student Education During and Post-COVID-19.

Acad Med 2021 May 4. Epub 2021 May 4.

M.R.H. Castro is a third-year medical student, University of California San Francisco School of Medicine, San Francisco, California; ORCID: https://orcid.org/0000-0002-2085-4893. L.M. Calthorpe is a third-year medical student, University of California San Francisco School of Medicine, San Francisco, California; ORCID: https://orcid.org/0000-0002-0496-9471. S.E. Fogh is associate professor, Department of Radiation Oncology, University of California San Francisco School of Medicine, San Francisco, California. S. McAllister is a third-year medical student, University of California San Francisco School of Medicine, San Francisco, California. C.L Johnson is a third-year medical student, University of California San Francisco School of Medicine, San Francisco, California. E.D. Isaacs is professor of emergency medicine, Department of Emergency Medicine, University of California San Francisco, San Francisco, California. A. Ishizaki is manager, Clinical Microsystems Clerkship, University of California San Francisco School of Medicine, San Francisco, California. A. Kozas is curriculum coordinator, Clinical Microsystems Clerkship, University of California San Francisco School of Medicine, San Francisco, California. D. Lo is assistant professor of medicine, Division of Geriatrics, Department of Medicine, University of California San Francisco School of Medicine; and Department of Geriatrics and Extended Care, San Francisco Veterans Affairs Health Care System, San Francisco, California. S. Rennke is professor of medicine, Division of Hospital Medicine, Department of Medicine, University of California San Francisco School of Medicine, San Francisco, California. J. Davis is professor of medicine and associate dean for curriculum, University of California San Francisco School of Medicine, San Francisco, California. A. Chang is professor of medicine, Division of Geriatrics, Department of Medicine, University of California San Francisco, San Francisco, California.

In response to the COVID-19 pandemic, many medical schools suspended clinical clerkships and implemented newly adapted curricula to facilitate continued educational progress. While the implementation of these new curricula has been described, an understanding of the impact on student learning outcomes is lacking. In 2020, the authors followed Kern's 6-step approach to curricular development to create and evaluate a novel COVID-19 curriculum for medical students at the University of California San Francisco School of Medicine and evaluate its learning outcomes. Read More

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Prevalence of atrial fibrillation and outcomes in older long-term care residents: a systematic review.

Age Ageing 2021 May;50(3):744-757

Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.

Background: anticoagulation is integral to stroke prevention for atrial fibrillation (AF), but there is evidence of under-treatment in older people in long-term care (LTC).

Objective: to synthesise evidence on the prevalence and outcomes (stroke, mortality or bleeding) of AF in LTC and the factors associated with the prescription of anticoagulation.

Methods: studies were identified from Medline, CINAHL, PsycINFO, Scopus and Web of Science from inception to 31 October 2019. Read More

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A colorimetric optical thermometry of host-sensitized Pr-doped niobate phosphors based on electronic-rich-site strategy.

Dalton Trans 2021 May 4. Epub 2021 May 4.

Department of Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China.

Most praseodymium-doped red-emitting phosphors need high-temperature synthesis conditions with a reducing atmosphere. The niobate matrix selected in this work provides a sufficient electron-rich-site environment for praseodymium through charge migration, and praseodymium can be self-reduced in air atmosphere, which is safe and environmentally friendly. By building the [NbO6] group → Pr3+ energy transfer and finely modifying the doping concentration of Pr3+ ions, we constructed a dual-luminescence-system of the [NbO6] group and Pr3+. Read More

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High-resolution view of HIV-1 reverse transcriptase initiation complexes and inhibition by NNRTI drugs.

Nat Commun 2021 05 4;12(1):2500. Epub 2021 May 4.

Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.

Reverse transcription of the HIV-1 viral RNA genome (vRNA) is an integral step in virus replication. Upon viral entry, HIV-1 reverse transcriptase (RT) initiates from a host tRNA primer bound to the vRNA genome and is the target of key antivirals, such as non-nucleoside reverse transcriptase inhibitors (NNRTIs). Initiation proceeds slowly with discrete pausing events along the vRNA template. Read More

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Phase I Trial of Cemiplimab, Radiotherapy, Cyclophosphamide, and GM-CSF in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma.

Oncologist 2021 May 4. Epub 2021 May 4.

Regeneron Pharmaceuticals, Inc., Basking Ridge, New Jersey, USA.

Lessons Learned: Cemiplimab in combination with radiation therapy, cyclophosphamide, and granulocyte macrophage colony-stimulating factor (GM-CSF) did not demonstrate efficacy above what can be achieved with other PD-1 inhibitor monotherapies in patients with Refractory and metastatic head and neck squamous cell carcinoma. The safety profile of cemiplimab combination therapy was consistent with previously reported safety profiles of cemiplimab monotherapy. No new safety signal was observed. Read More

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What Survivorship Means to Liver Transplant Recipients-Qualitative Groundwork for A Survivorship Conceptual Model.

Liver Transpl 2021 May 3. Epub 2021 May 3.

Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina (UNC) School of Medicine, Chapel Hill, NC, United States.

Background & Aims: Survivorship is a well-established concept in the cancer care continuum with a focus on disease recurrence, quality of life, and minimizing competing risks for mortality; however, this has not been well studied in liver transplantation (LT). We aimed to investigate what survivorship means to LT patients and identify motivations and coping strategies for overcoming challenges after LT.

Approach & Results: Twenty in-depth home interviews were conducted among adults 3 to 6 months after LT. Read More

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Anorectal Mucosal Melanoma in the Era of Immune Checkpoint Inhibition: Should We Change Our Surgical Management Paradigm?

Dis Colon Rectum 2021 May;64(5):555-562

1 Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 2 New York Medical College at Metropolitan Hospital, New York, New York 3 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: The advent of immune checkpoint inhibition therapy has dramatically improved survival in patients with skin melanoma. Survival outcomes after resection of anorectal melanoma treated with immune checkpoint inhibition have not been reported.

Objective: This study aimed to compare survival outcomes following surgical resection of anorectal melanoma between patients who received immune checkpoint inhibition and patients who did not. Read More

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Tunable Negative Poisson's Ratio in Van der Waals Superlattice.

Research (Wash D C) 2021 10;2021:1904839. Epub 2021 Apr 10.

Department of Physics, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.

Negative Poisson's ratio (NPR) materials are functional and mechanical metamaterials that shrink (expand) longitudinally after being compressed (stretched) laterally. By using first-principles calculations, we found that Poisson's ratio can be tuned from near zero to negative by different stacking modes in van der Waals (vdW) graphene/hexagonal boron nitride (G/-BN) superlattice. We attribute the NPR effect to the interaction of orbitals between the interfacial layers. Read More

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Erythrocyte Binding Like Protein Interacts With Basigin, an Erythrocyte Surface Protein.

Front Cell Infect Microbiol 2021 14;11:656620. Epub 2021 Apr 14.

Division of Medical Zoology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University, Yonago, Japan.

Erythrocyte recognition and invasion is critical for the intra-erythrocytic development of spp. parasites. The multistep invasion process involves specific interactions between parasite ligands and erythrocyte receptors. Read More

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Deep Neural Network to Differentiate Brain Activity Between Patients With First-Episode Schizophrenia and Healthy Individuals: A Multi-Channel Near Infrared Spectroscopy Study.

Front Psychiatry 2021 15;12:655292. Epub 2021 Apr 15.

Department of Forensic and Addiction Psychiatry, Jianan Psychiatric Center, Ministry of Health and Welfare, Tainan, Taiwan.

Reduced brain cortical activity over the frontotemporal regions measured by near infrared spectroscopy (NIRS) has been reported in patients with first-episode schizophrenia (FES). This study aimed to differentiate between patients with FES and healthy controls (HCs) on basis of the frontotemporal activity measured by NIRS with a support vector machine (SVM) and deep neural network (DNN) classifier. In addition, we compared the accuracy of performance of SVM and DNN. Read More

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Problematic Smartphone and Social Media Use Among Bangladeshi College and University Students Amid COVID-19: The Role of Psychological Well-Being and Pandemic Related Factors.

Front Psychiatry 2021 16;12:647386. Epub 2021 Apr 16.

Department of Organizational Psychology, Birkbeck, University of London, London, United Kingdom.

Smartphone and social media use are an integral part of our daily life. Currently, the impact of excessive smartphone and social media use during the COVID-19 pandemic is poorly understood. The present study aimed to investigate problematic smartphone use (PSPU) and problematic social media use (PSMU) among Bangladeshi college and university students during the COVID-19 pandemic. Read More

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When detection of dairy food fraud fails: An alternate approach through proton nuclear magnetic resonance spectroscopy.

J Dairy Sci 2021 Apr 29. Epub 2021 Apr 29.

Faculty of Applied Chemistry and Materials Science, "C. Nenitescu" Organic Chemistry Department, University "Politehnica" of Bucharest, 1-7 Polizu Str., 011061 Bucharest, Romania. Electronic address:

This paper investigated the limits of the current approach for the determination of the fatty acids profile of milk fats from proton nuclear magnetic resonance data based on the hypothesis that the signal at 0.96 ppm, currently assigned in the literature as a marker for the "short chain fatty acids," is generated only by the butyric moiety (not by all of the short-chain fatty acids, which also include C6:0-caproic acid). The hypothesis was tested and experimentally confirmed. Read More

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Assessment of Preparedness of Government of Nepal in COVID Designated Hospitals and Clinics for Pandemic Response.

J Nepal Health Res Counc 2021 Apr 23;19(1):48-54. Epub 2021 Apr 23.

Nepal Health Research Council, Government of Nepal, Kathmandu, Nepal.

Background: Preparedness, readiness, and response status of any country is integral in identifying, managing, and preventing COVID-19 pandemic. The objective of this study is to assess the status of the Government of Nepal designated COVID hospitals and COVID clinics to respond against COVID-19.

Methods: A cross sectional study was conducted with the focal persons of COVID hospitals and COVID clinics using a semi-structured questionnaire from April 26, 2020 to May 27, 2020 via face to face interview with onsite observation and telephonic interview in few unreachable health facilities. Read More

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Data-Driven multi-Contrast spectral microstructure imaging with InSpect: INtegrated SPECTral component estimation and mapping.

Med Image Anal 2021 Apr 20;71:102045. Epub 2021 Apr 20.

Centre for Medical Image Computing, Department of Computer Science, University College London, UK.

We introduce and demonstrate an unsupervised machine learning technique for spectroscopic analysis of quantitative MRI experiments. Our algorithm supports estimation of one-dimensional spectra from single-contrast data, and multidimensional correlation spectra from simultaneous multi-contrast data. These spectrum-based approaches allow model-free investigation of tissue properties, but require regularised inversion of a Laplace transform or Fredholm integral, which is an ill-posed calculation. Read More

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Coordinated bi-directional trafficking of synaptic vesicle and active zone proteins in peripheral nerves.

Biochem Biophys Res Commun 2021 Apr 29;559:92-98. Epub 2021 Apr 29.

Wallenberg Neuroscience Center, Lund University Biomedical Center, Lund, Sweden. Electronic address:

Synaptic transmission is mediated by neurotransmitters that are stored in synaptic vesicles (SV) and released at the synaptic active zone (AZ). While in recent years major progress has been made in unraveling the molecular machinery responsible for SV docking, fusion and exocytosis, the mechanisms governing AZ protein and SV trafficking through axons still remain unclear. Here, we performed stop-flow nerve ligation to examine axonal trafficking of endogenous AZ and SV proteins. Read More

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