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Reprocessing of Covalent Adaptable Polyamide Networks through Internal Catalysis and Ring-Size Effects.

J Am Chem Soc 2021 Sep 15. Epub 2021 Sep 15.

Polymer Chemistry Research Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Faculty of Sciences, Ghent University, Krijgslaan 281-S4, Ghent 9000, Belgium.

Here, we report the introduction of internally catalyzed amide bonds to obtain covalent adaptable polyamide networks that rely on the dissociation equilibrium between dicarboxamides and imides. While amide bonds are usually considered to be robust and thermally stable, the present study shows that their dynamic character can be activated by a smart choice of available building blocks without the addition of any external catalyst or other additives. Hence, a range of polyamide-based dynamic networks with variable mechanical and viscoelastic properties have been obtained in a systematic study, using a straightforward curing process of dibasic ester and amine compounds. Read More

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September 2021

Genomic insights into the ecological role and evolution of a novel Thermoplasmata order, " Sysuiplasmatales".

Appl Environ Microbiol 2021 Sep 15:AEM0106521. Epub 2021 Sep 15.

School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China.

Recent omics studies have provided invaluable insights into the metabolic potential, adaptation and evolution of novel archaeal lineages from a variety of extreme environments. We have utilized a genome-resolved metagenomic approach to recover eight medium- to high-quality metagenome-assembled genomes (MAGs) that likely represent a new order (" Sysuiplasmatales") within Thermoplasmata from mine tailings and acid mine drainage (AMD) sediments sampled from two copper mines in South China. 16S rRNA gene based analyses revealed a narrow habitat range for these uncultured archaea limiting to AMD and hot spring-related environments. Read More

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September 2021

Probing Microbiome Genotoxicity: A Stable Colibactin Provides Insight into Structure-Activity Relationships and Facilitates Mechanism of Action Studies.

J Am Chem Soc 2021 Sep 15. Epub 2021 Sep 15.

Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States.

Colibactin is a genotoxic metabolite produced by commensal-pathogenic members of the human microbiome that possess the (aka ) biosynthetic gene cluster. bacteria induce tumorigenesis in models of intestinal inflammation and have been causally linked to oncogenesis in humans. While colibactin is believed underlie these effects, it has not been possible to study the molecule directly due to its instability. Read More

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September 2021

Enantioselective Gel Phase Synthesis of Metal-Organic Materials.

Angew Chem Int Ed Engl 2021 Sep 15. Epub 2021 Sep 15.

Haskoli Islands, Department of Chemistry, Science Institute, Dunhagi 3, 107, Reykjavik, ICELAND.

We report the asymmetric synthesis of homochiral metal-organic materials (MOMs) in chiral gels from achiral components. The enantioselectivity of MOMs depends on the chirality of the gel, whereas the synthesis performed in solution phase and achiral gels resulted in conglomerate. Read More

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September 2021

Insight on the Order of Regioselective Ultrafast Formation of Disulfide Bonds in (Antimicrobial) Peptides and Miniproteins.

Angew Chem Int Ed Engl 2021 Sep 15. Epub 2021 Sep 15.

Ben-Gurion University of the Negev, chemistry, ISRAEL.

Disulfide-rich peptides and proteins are among the most fascinating bioactive molecules. The difficulties associated with the preparation of these targets prompted the development of various chemical strategies. Read More

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September 2021

Fluorescent glutamine and asparagine as promising probes for chemical biology.

Org Biomol Chem 2021 Sep 15;19(35):7695-7700. Epub 2021 Sep 15.

Department of Chemistry, Birla Institute of Technology and Science, Pilani 333031, Rajasthan, India.

Fluorescent probes have become valuable tools in chemical biology, providing interesting inferences for unfolding the complexities of natural biochemical processes. In this study, we report the synthesis and characterization of fluorescent labelled glutamine (Gln) and asparagine (Asn) derivatives traceless Staudinger ligation, which exhibited high fluorescence quantum yields, excellent photostabilities and emission of blue fluorescence in the visible region. The successful permeation of these fluorescent amino acids into cellular components proved their potential as fluorescent probes for chemical biology. Read More

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September 2021

A nascent polypeptide sequence modulates DnaA translation elongation in response to nutrient availability.

Elife 2021 Sep 15;10. Epub 2021 Sep 15.

Science for Life Laboratory and Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.

The ability to regulate DNA replication initiation in response to changing nutrient conditions is an important feature of most cell types. In bacteria, DNA replication is triggered by the initiator protein DnaA, which has long been suggested to respond to nutritional changes; nevertheless, the underlying mechanisms remain poorly understood. Here, we report a novel mechanism that adjusts DnaA synthesis in response to nutrient availability in . Read More

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September 2021

The psychological effects of stillbirth on parents: A qualitative evidence synthesis of psychoanalytic literature.

Z Psychosom Med Psychother 2021 Sep;67(3):329-350

Department of Clinical and Experimental Sciences University of Brescia Viale Europa 11 I-25123 Brescia Italy.

To review and synthesize existing psychoanalytic literature on the psychological impact of stillbirth on mothers and fathers. This qualitative systematic review followed, as far as possible, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The Psychoanalytic Electronic Publishing Archive, the Single Case Archive, and PsycINFO (1999-2019) were searched to identify relevant articles published between 1999-2019 that report clinical material or theoretical considerations concerning the psychological effects of stillbirth on parents, as emerging during classical analytic or psychoanalytic therapy session/journey. Read More

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September 2021

Catalyst-Controlled Diastereoselectivity Switch in the Asymmetric [3 + 2] Annulation of Isatin-Derived MBH Carbonates and 5-Alkenylthiazol-4(5)-ones.

Org Lett 2021 Sep 15. Epub 2021 Sep 15.

Shanghai Frontiers Science Center for Traditional Chinese Medicine Chemical Biology, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.

Exploration of the diastereodivergent synthesis of spirocyclic oxindoles has been challenging. Herein we report asymmetric [3 + 2] annulations of isatin-derived Morita-Baylis-Hillman (MBH) carbonates and 5-alkenylthiazol-4(5)-ones. Interestingly, two different chiral catalysts, amide-phosphine and 4-dimethylaminopyridine (DMAP)-thiourea, could lead to two kinds of diastereomeric dispiro oxindoles with three contiguous stereogenic centers. Read More

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September 2021

Electrochemical Oxidative C(sp)-H/N-H Coupling of Diarylmethanes with Sulfoximines or Benzophenone Imine.

J Org Chem 2021 Sep 15. Epub 2021 Sep 15.

Research Center of Resources and Environment, School of Chemical Engineering and Materials, Changzhou Institute of Technology, Changzhou 213032, China.

Herein, we report an efficient electrochemical method for the synthesis of -alkylated sulfoximines by electrochemical oxidative C(sp)-H/N-H coupling of sulfoximines and diarylmethanes. In addition, we used the same conditions for electrochemical dehydrogenative amination of diarylmethanes with benzophenone imine as an aminating agent. The reactions showed good functional group tolerance and afforded the corresponding products in moderate to good yields without the use of a stoichiometric oxidant, a metal catalyst, or an activating agent. Read More

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September 2021

Corroles: The Hitherto Elusive Parent Macrocycle and its Metal Complexes.

Angew Chem Int Ed Engl 2021 Sep 15. Epub 2021 Sep 15.

Technion Israel Institute of Technology, Chemistry, ISRAEL.

The science and technology of corroles, macrocycles that owe their name to the cobalt-chelating prosthetic group of Vitamin B12 and share numerous features with the iron-chelating porphyrin present in heme proteins/enzymes, constantly crosses new boundaries ever since stable derivatives became easily accessible. Particularly important is the increasing utilization of corroles and the corresponding metal complexes for the benefit of mankind, in terms of new drug candidates for treating various diseases and as catalysts for sustainable energy relevant processes. One still unmet challenge is to gain access to the plain macrocycle, as to allow for a full elucidation of the most fundamental properties of corroles. Read More

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September 2021

Genetic and phenotypic heterogeneity in KIAA0753-related ciliopathies.

Am J Med Genet A 2021 Sep 15. Epub 2021 Sep 15.

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Primary ciliopathies are heterogenous disorders resulting from perturbations in primary cilia form and/or function. Primary cilia are cellular organelles which mediate key signaling pathways during development, such as the sonic hedgehog (SHH) pathway which is required for neuroepithelium and central nervous system development. Joubert syndrome is a primary ciliopathy characterized by cerebellar/brain stem malformation, hypotonia, and developmental delays. Read More

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September 2021

Sustainable food systems and nutrition in the 21st century: A report from the 22nd annual harvard nutrition obesity symposium.

Am J Clin Nutr 2021 Sep 15. Epub 2021 Sep 15.

Department of Epidemiology, Harvard T.H. Chan School of Public Health.

Food systems are at the center of a brewing storm consisting of a rapidly changing climate, rising hunger and malnutrition and significant social inequities. At the same time, there are vast opportunities to ensure that food systems produce healthy and safe food in equitable ways that promote environmental sustainability, especially if the world can come together at the UN Food Systems Summit in late 2021 and make strong and binding commitments towards food system transformation. The NIH-funded Nutrition Obesity Research Center at Harvard and the Harvard Medical School Division of Nutrition held their 22nd Annual Harvard Nutrition Obesity Symposium entitled "Global Food Systems and Sustainable Nutrition in the 21st Century" in June 2021. Read More

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September 2021

NocU is a cytochrome P450 oxygenase catalyzing -hydroxylation of the indolic moiety during the maturation of the thiopeptide antibiotics nocathiacins.

Org Biomol Chem 2021 Sep 15. Epub 2021 Sep 15.

State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence on Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.

The ribosomally synthesized and post-translationally modified peptide (RiPP) natural products include the family of thiopeptide antibiotics, where nocathiacins (NOCs) and nosiheptide (NOS) are structurally related bicyclic members featuring an indolic moiety within the side ring system. Compared with NOS, NOCs bear additional functionalities that lead to the improvement of water solubility and bioavailability, a problem inherent to most of the thiopeptide antibiotics, and thus hold potential for clinical use in anti-infective agent development. The process through which post-translational modifications (PTMs) occur to afford these functionalities remains unclear. Read More

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September 2021

Structure and Optical Properties of Hybrid-Layered-Double Perovskites (CHN)AgMBr (M = In, Sb, and Bi).

Inorg Chem 2021 Sep 15. Epub 2021 Sep 15.

Department of Chemistry, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.

The Pb-free hybrid-layered-double perovskites (HLDPs) have been proposed as green and stable semiconducting materials for optoelectronic devices, but the synthesized members are still limited. Here, we report the synthesis of three new HLDPs, (CHN)AgMBr (M = In, Sb, and Bi), by a solution method using 1,4-bis(ammoniomethyl)cyclohexane (CHN) as the organic spacing cation. All three of these HLDPs show ⟨100⟩-oriented layered structures with Ag and In/Sb/Bi order arranged in corner-sharing octahedral layers. Read More

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September 2021

Graves' disease with spontaneous resolution following ocrelizumab in primary progressive multiple sclerosis.

Endocr Regul 2021 Sep 13;55(3):169-173. Epub 2021 Sep 13.

Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar e Universitario do Porto, Oporto, Portugal.

Immune reconstitution therapies (IRT), which include antibody-based cell-depleting therapies targeting CD52+ (alemtuzumab) or CD20+ (rituximab, ocrelizumab) leukocytes, are approved for the treatment of multiple sclerosis. Thyroid autoimmunity is a common adverse effect of alemtuzumab treatment, Graves' disease (GD) being the most prevalent manifestation. To date, thyroid autoimmunity events have not been reported with CD20-targeting monoclonal antibodies. Read More

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September 2021

Direct synthesis of -methyl benzaldehyde from acetaldehyde via an organic amine-catalyzed dehydrogenation mechanism.

iScience 2021 Sep 23;24(9):103028. Epub 2021 Aug 23.

State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

-Methyl benzaldehyde (-MBA) is a class of key chemical intermediates of pharmaceuticals. Conventional industrial processes for -MBA production involve the consecutive photochlorination, amination, and acid hydrolysis of petroleum-derived -xylene, while producing vast pollutants and waste water. Herein, we report a direct, green route for selective synthesis of -MBA from acetaldehyde using a diphenyl prolinol trimethylsilyl ether catalyst. Read More

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September 2021

A Case of Severe Hypocalcemia Caused by Malabsorption Due to Partial Gastrectomy and Small Bowel Resection.

AACE Clin Case Rep 2021 Sep-Oct;7(5):323-326. Epub 2021 Apr 16.

Division of Endocrinology, Metabolism, and Lipids, Department of Internal Medicine, Emory University School of Medicine, Atlanta, Georgia.

Objective: Calcium is an essential mineral involved in the functioning of nearly every human cell. Calcium levels are regulated by dietary absorption, vitamin D status, and parathyroid hormone (PTH). This report describes a patient in whom childhood bowel resection and partial gastrectomy resulted in malabsorptive hypocalcemia in adulthood. Read More

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Mycophenolate Mofetil and Plasmapheresis: A Treatment Option for Severe Insulin Resistance caused by Insulin Antibodies.

AACE Clin Case Rep 2021 Sep-Oct;7(5):307-309. Epub 2021 Mar 13.

Division of Endocrinology, Diabetes and Metabolism, Icahn School of Medicine at Mount Sinai, New York, New York.

Objective: Insulin antibody (IA)-mediated insulin resistance (IR) is a rare condition for which immunosuppressive regimens have been described. However, these raise the risk of infection, and the drugs may not be effectively metabolized in patients with liver disease. A 61-year old male with type 2 diabetes mellitus and antibody-mediated IR who required >800 units of daily insulin presented with acute decompensation of his preexisting cirrhosis from recurrent diabetic ketoacidosis. Read More

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Occurrence of Klinefelter Syndrome Mosaic 45,X/46,XY/47,XXY/48,XXYY/48,XXXY and Primary Hyperparathyroidism.

AACE Clin Case Rep 2021 Sep-Oct;7(5):293-298. Epub 2021 Mar 13.

Department of Genetics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, México.

Objective: The presence of primary hyperparathyroidism (PHPT) and Klinefelter syndrome (KS) is rare, and its association with KS mosaicism is even rarer. We report an unusual combination of these entities with a mild phenotype of KS.

Methods: The patient was a 44-year-old male with a history of PHPT who had recurrent urolithiasis despite being treated with a successful parathyroidectomy. Read More

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Leigh syndrome-like MRI changes in a patient with biallelic variants treated with ketogenic diet.

Mol Genet Metab Rep 2021 Dec 4;29:100800. Epub 2021 Sep 4.

Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.

Biallelic 4-hydroxyphenylpyruvate dioxygenase-like protein () variants were recently reported as a cause of progressive and incurable neurodegenerative diseases ranging from neonatal-onset leukoencephalopathy with severe neurodevelopmental delay to spastic paraplegia. Although the physiological function of HPDL remains unknown, its subcellular localization in the mitochondria has been reported. Here, we report a case of -related neurological disease that was clinically and neuroimaging compatible with Leigh syndrome, previously unreported, and was treated with a ketogenic diet. Read More

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December 2021

Attitudes of Physicians in Jordan Towards Non-Disclosure of Health Information.

Sultan Qaboos Univ Med J 2021 Aug 29;21(3):423-427. Epub 2021 Aug 29.

The University of Jordan School of Medicine, Amman, Jordan.

Objectives: This report aims to investigate the attitudes of physicians in Jordan towards non-disclosure of health information among physicians, with a focus on those who are 'always truthful' and those who are not.

Methods: The report is based on the second subset of data from a cross-sectional study-conducted between January and August 2016-of the truth disclosure practices among and attitudes of physicians in Jordan. The sample consisted of 240 physicians selected from four major hospitals by stratified random sampling and invited to complete a self-administered questionnaire regarding truth disclosure attitudes. Read More

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Longitudinal observation of insulin secretory ability before and after the onset of immune checkpoint inhibitor-induced diabetes mellitus: A report of two cases.

Clin Case Rep 2021 Sep 7;9(9):e04574. Epub 2021 Sep 7.

Department of Nephrology, Rheumatology, Endocrinology and Metabolism Dentistry and Pharmaceutical Sciences Okayama University Graduate School of Medicine Okayama Japan.

Immune checkpoint inhibitor-induced diabetes mellitus is a rare immune-related adverse event. This report illustrates clinical data and insulin secretory ability before and after the onset of immune checkpoint inhibitor-induced diabetes. Read More

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September 2021

Large and small herbivores have strong effects on tundra vegetation in Scandinavia and Alaska.

Ecol Evol 2021 Sep 2;11(17):12141-12152. Epub 2021 Aug 2.

Department of Ecology and Environmental Science Umeå University Umeå Sweden.

Large and small mammalian herbivores are present in most vegetated areas in the Arctic and often have large impacts on plant community composition and ecosystem functioning. The relative importance of different herbivores and especially how their specific impact on the vegetation varies across the Arctic is however poorly understood.Here, we investigate how large and small herbivores influence vegetation density and plant community composition in four arctic vegetation types in Scandinavia and Alaska. Read More

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September 2021

A general, versatile and divergent synthesis of selectively deuterated amines.

Chem Sci 2021 Aug 13;12(33):11157-11165. Epub 2021 Jul 13.

Laboratoire de Chimie Organique, Service de Chimie et PhysicoChimie Organiques, Université libre de Bruxelles (ULB) Avenue F. D. Roosevelt 50, CP160/06 1050 Brussels Belgium

Deuterated organic molecules are of utmost importance in many areas of science and have been recently intensively investigated in medicinal chemistry due to their enhanced metabolic stability. The development of efficient and broadly applicable methods for the selective incorporation of deuterium atoms into organic molecules from readily available starting materials and reagents is therefore of extreme importance. Such methods however often lack generality and selectivity, notably in the nitrogen series. Read More

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Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons.

J Inflamm Res 2021 7;14:4503-4507. Epub 2021 Sep 7.

Faculty of Medicine and Life Sciences, Biomedical Research Institute BIOMED, Hasselt University, Hasselt, Belgium.

Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). Read More

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September 2021

Risk Preferences, Rationality of Choices, and Willingness to Pay for Preventive Medicine in Patients with Graves' Thyrotoxicosis.

Patient Prefer Adherence 2021 7;15:1971-1979. Epub 2021 Sep 7.

Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Purpose: Patients with thyrotoxicosis show neuropsychological changes, and these may damage the quality of informed consent in clinical practice. Therefore, we examined patients' real-life preferences to assess whether change in risk preferences was dependent on thyroid function state.

Patients And Methods: The participants were 86 patients who were newly diagnosed with Graves' thyrotoxicosis between 1 January and 31 December 2018 (group A), and an additional 33 euthyroid patients diagnosed before 2018 (group B). Read More

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September 2021

Why does continuity of care with family doctors matter? Review and qualitative synthesis of patient and physician perspectives.

Can Fam Physician 2021 09;67(9):679-688

Family physician and Professor in the Department of Family and Community Medicine and the Dalla Lana School of Public Health at the University of Toronto, Head of the Division of Clinical Public Health at the Dalla Lana School of Public Health, and Scientific Director of the Bridgepoint Collaboratory for Research and Innovation.

Objective: To summarize and synthesize qualitative studies that report patient and physician perspectives on continuity of care in family practice.

Data Sources: MEDLINE (Ovid), EMBASE (Ovid), and PsycInfo (Ovid) were searched for qualitative primary research reporting perspectives of patients, physicians, or both, on continuity of care in family practice.

Study Selection: English-language qualitative studies were selected (eg, interviews, focus groups, mixed methods) that were conducted in Canada, the United States, the United Kingdom, the European Union, New Zealand, or Australia. Read More

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September 2021

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J Pharmacol Exp Ther 2021 Sep 14. Epub 2021 Sep 14.

University of Toledo, United States.

Ketone bodies are essential energy substrates in the absence of exogenous nutrients, and more recently, they have been suggested to prevent disease and improve longevity. β-hydroxybutyrate (βHB) is the most abundant ketone body. The secondary alcohol, 1,3-butanediol (1,3-BD), is commonly administered to raise βHB bioavailability and in the absence of nutrient deprivation. Read More

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September 2021

Public health education by emergency nurses: A scoping review and narrative synthesis.

Patient Educ Couns 2021 Sep 2. Epub 2021 Sep 2.

School of Health/Nursing, Federation University Australia, PO Box 3191 Gippsland Mail Centre 3841, Victoria, Australia. Electronic address:

Objective: To identify the extent, range, and nature of the evidence on public health education provided by emergency nurses.

Methods: A scoping review, using the methodological guidance of Joanna Briggs Institute, was conducted to scope and map the literature and research activity. Using predetermined criteria, databases, grey literature, and reference lists were searched for eligible sources. Read More

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September 2021