36,935 results match your criteria replacing phosphate

New Advances in Transplants and Bioengineering Aid in Replacing the Womb.

IEEE Pulse 2021 Mar-Apr;12(2):12-16

When Kayla Edwards turned 13, she began to wonder if she was different. It started as a seed of suspicion when her friends began their menstrual cycles, and hers never arrived. Her grandmother was late, she learned, but for Edwards, it still seemed odd. Read More

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Mediator-Enabled Electrocatalysis with Ligandless Copper for Anaerobic Chan-Lam Coupling Reactions.

J Am Chem Soc 2021 Apr 16. Epub 2021 Apr 16.

Department of Chemistry and Biochemistry, The Ohio State University, 151 W. Woodruff Avenue, Columbus, Ohio 43210, United States.

Simple copper salts serve as catalysts to effect C-X bond-forming reactions in some of the most utilized transformations in synthesis, including the oxidative coupling of aryl boronic acids and amines. However, these Chan-Lam coupling reactions have historically relied on chemical oxidants that limit their applicability beyond small-scale synthesis. Despite the success of replacing strong chemical oxidants with electrochemistry for a variety of metal-catalyzed processes, electrooxidative reactions with ligandless copper catalysts are plagued by slow electron-transfer kinetics, irreversible copper plating, and competitive substrate oxidation. Read More

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Dual Substitution Strategy in Co-Free Layered Cathode Materials for Superior Lithium Ion Batteries.

ACS Appl Mater Interfaces 2021 Apr 16. Epub 2021 Apr 16.

College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Chemical Power Sources, and Hunan Provincial Key Laboratory of Efficient and Clean Utilization of Manganese Resources, Central South University, Changsha, Hunan 410083, P. R. China.

A dual substitution strategy is introduced to Co-free layered material LiNiMnO by partially replacing Li and Ni with Na and Al, respectively, to achieve a superior cathode material for lithium ion batteries. Na ion functions as a "pillar" and a " cationic barrier" in the lithium layer while Al ion plays an auxiliary role in stabilizing structure and lattice oxygen to improve the electrochemical performance and safety. The stability of lattice oxygen comes from the binding energy between the Ni and O, which is larger due to higher valences of Ni ions, along with a stronger Al-O bond in the crystal structure and the "cationic barrier" effect of Na ion at the high-charge. Read More

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Effect of formulation and heat treatment on 5-hydroxymethylfurfural formation and quality parameters in dulce de leche.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2021 Apr 16:1-8. Epub 2021 Apr 16.

Programa Institucional De Fomento a La Investigación, Desarrollo E Innovación, Universidad Tecnológica Metropolitana, Santiago, Chile.

This work assessed the effect of formulation and heat treatment on the formation of HMF, non-enzymatic browning and rheology of dulce de leche (DL). Laboratory scale trials were developed with different DL formulas: whole powdered milk, skimmed milk, and lactose-free skimmed milk, and added sucrose, subjected to different processing temperatures (110°C, 120°C, and 130°C). Additionally, an alternative formulation was designed in which half the sucrose was replaced by 50% tagatose. Read More

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Chiral-at-Iron Catalyst for Highly Enantioselective and Diastereoselective Hetero-Diels-Alder Reaction.

Chemistry 2021 Apr 15. Epub 2021 Apr 15.

Philipps-University Marburg, Department of Chemistry, Hans-Meerwein-Strasse, 35043, Marburg, GERMANY.

This study demonstrates that chiral-at-iron complexes, in which all coordinated ligands are achiral and the overall chirality the consequence of a stereogenic iron center, are capable of catalyzing asymmetric transformations with very high enantioselectivities. The catalyst is based on a previously reported design ( J. Am. Read More

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Combinations of by-products from biodiesel production included in the supplement for finishing heifers on deferred pastures.

Trop Anim Health Prod 2021 Apr 15;53(2):262. Epub 2021 Apr 15.

College of Veterinary Medicine and Animal Science, Federal University of Mato Grosso do Sul, Av. Senador Filinto Muller, 2443, Vila Ipirang, Campo Grande, Mato Grosso do Sul, 79074-460, Brazil.

We hypothesized that by-products from biodiesel production like crambe meal (Crambe abyssinica) totally replace soybean meal (Glycine max) and crude glycerin could partially replace corn (Zea mays). Our aim was to evaluate different supplements with combinations of crambe meal and crude glycerin replacing soybean meal or corn on performance and carcass traits of finishing heifers. Sixty Nellore heifers 18 months old were used, and 298. Read More

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Nosocomial Infection Outbreak due to SARS-COV-2 in a Hospital Unit of Particularly Vulnerable Patients.

Int J Med Sci 2021 19;18(10):2146-2154. Epub 2021 Mar 19.

Research group in Nursing and Health Care, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña, A Coruña, Spain.

To report a COVID-19 outbreak among workers and inpatients at a medical ward for especially vulnerable patients. Descriptive study of a nosocomial COVID-19 outbreak registered in March-April 2020 at medical ward of onco-hematological patients in an Spanish hospital. Confirmed cases were hospitalized patients, healthcare and non-healthcare workers who tested positive by PCR on a nasopharyngeal swab. Read More

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An Ultrasensitive Label-Free Fluorescent Aptasensor Platform for Detection of Sulfamethazine.

Int J Nanomedicine 2021 9;16:2751-2759. Epub 2021 Apr 9.

College of Life Science, Chongqing Normal University, Chongqing, 401331, People's Republic of China.

Purpose: Sulfamethazine (SMZ) exposed in the environment can enter the human body through the food chain and pose a serious threat to human health. Therefore, it is important to develop a rapid and sensitive method for detecting SMZ in environmental samples. In order to fastly and quantitatively detect SMZ in environmental samples, we developed a label-free fluorescent aptasensor based on specific aptamer (SMZ1S) and fluorescence resonance energy transfer (FRET) between gold nanoparticles (AuNPs) and rhodamine B (RhoB). Read More

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Can nursing educators learn to trust the world's most trusted profession?

Nurs Inq 2021 Apr 15:e12412. Epub 2021 Apr 15.

School of Nursing and Midwifery, Queen's University Belfast, Belfast, UK.

Nursing and nursing education face a paradox whereby the world's most trusted profession seems not to trust its own students and practitioners. Much of nursing education has adopted what has been memorably described as the 'cop shit' approach. This is the panoply of surveillance, anti-plagiarism and proctoring technologies that appear to be used more for policing and punishment of an inherently dishonest student body than to develop ethical and scholarly writing among future peers and colleagues. Read More

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A "push-pull-restrain" strategy to improve citronellol production in Saccharomyces cerevisiae.

Metab Eng 2021 Apr 12. Epub 2021 Apr 12.

Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin, 300072, China.

Microbial production of monoterpenes has attracted increasing attention in recent years. Up to date, there are only few reports on the biosynthesis of the monoterpene alcohol citronellol that is widely used as fragrant and pharmaceutical intermediates. Here, we engineered Saccharomyces cerevisiae by employing a "push-pull-restrain" strategy to improve citronellol production based on the reduction of geraniol. Read More

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Cation Modulation of Cobalt Sulfide Supported by Mesopore-Rich Hydrangea-Like Carbon Nanoflower for Oxygen Electrocatalysis.

ACS Appl Mater Interfaces 2021 Apr 15. Epub 2021 Apr 15.

Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, Department of Chemistry and Chemical Engineering, Huazhong University of Science & Technology, Wuhan 430074, P. R. China.

Transition-metal sulfide is pursued for replacing scare platinum-group metals for oxygen electrocatalysis and is of great importance in developing low-cost, high-performance rechargeable metal-air batteries. We report herein a facile cationic-doping strategy for preparing nickel-doped cobalt sulfide embedded into a mesopore-rich hydrangea-like carbon nanoflower. Nickel cations are introduced to induce the formation of Co-active species and more oxygen vacancies due to higher electronegativity and smaller ionic radius, thereby strengthening the intrinsic activity for oxygen electrocatalysis. Read More

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The effects of partially replacing amine collectors by a commercial frother in a reverse cationic hematite flotation.

Heliyon 2021 Mar 25;7(3):e06559. Epub 2021 Mar 25.

Department of Chemical Engineering, Texas Tech University, Lubbock, TX, 79409, USA.

Iron ore froth flotation has recently been used to obtain pure minerals due to the depletion of high-grade deposits. Amine collectors have often been used in cationic reverse iron ore flotation to achieve the separation with quartz impurities. The main problem associated with these collectors is related to the control of frothing properties and the high cost of amine reagents. Read More

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Molecular assessment of proteins encoded by the mitochondrial genome of and .

Biochem Biophys Rep 2021 Jul 25;26:100985. Epub 2021 Mar 25.

Department of Zoology, Patna University, Patna, Bihar, 800005, India.

The population of catfish, has substantially diminished in various countries and studies show that another related species is replacing it. The better adaptability and survivability of over could be attributed to the metabolic differences between these two species, which is primarily regulated by mitochondrial activities. To understand the reasons behind this phenomenon, we performed analyses to decipher the differences between the proteins encoded by the mitochondrial genome of these two related species. Read More

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Cooking oil/fat consumption and deaths from cardiometabolic diseases and other causes: prospective analysis of 521,120 individuals.

BMC Med 2021 Apr 15;19(1):92. Epub 2021 Apr 15.

Department of Nutrition, School of Public Health, and Department of Nutrition of Affiliated Second Hospital, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, 310058, Zhejiang, China.

Background: Increasing evidence highlights healthy dietary patterns and links daily cooking oil intake with chronic diseases including cardiovascular disease (CVD) and diabetes. However, food-based evidence supporting the consumption of cooking oils in relation to total and cardiometabolic mortality remains largely absent. We aim to prospectively evaluate the relations of cooking oils with death from cardiometabolic (CVD and diabetes) and other causes. Read More

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Mycelial dynamics during interactions between Stropharia caerulea and other cord-forming, saprotrophic basidiomycetes.

New Phytol 2001 Sep;151(3):691-704

Cardiff School of Biosciences, University of Wales, Cardiff CF10 3TL, Wales, UK.

•  Macroscopic mycelial interactions between Stropharia caerulea and four other cord-forming wood decomposer basidiomycetes (Phanerochaete velutina, Phallus impudicus, Hypholoma fasciculare and Agrocybe gibberosa) on nonsterile soil were quantified using nondestructive image analysis. •  Interaction development and outcome was species dependent. Once S. Read More

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September 2001

Azobispyrazole family as photoswitches combining (near-) quantitative bidirectional isomerization and widely tunable thermal half-lives from hours to years.

Angew Chem Int Ed Engl 2021 Apr 14. Epub 2021 Apr 14.

School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, organic solids, 800 Dongchuan RD. Minhang District, 200240, Shanghai, CHINA.

Azobenzenes are classical molecular photoswitches that have received widespread application. In recent endeavors of molecular design, replacing one or both phenyl rings by heteroaromatic ones is emerging as a strategy to expand the molecular diversity and access improved photoswitch properties. Many mono-heteroaryl azo molecules with unique structure/properties have been developed, but the potential of bis-heteroaryl architecture is  far from exploited . Read More

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Thermal Conductivity of Aluminum Scandium Nitride for 5G Mobile Applications and Beyond.

ACS Appl Mater Interfaces 2021 Apr 14. Epub 2021 Apr 14.

Department of Mechanical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.

Radio frequency (RF) microelectromechanical systems (MEMS) based on AlScN are replacing AlN-based devices because of their higher achievable bandwidths, suitable for the fifth-generation (5G) mobile network. However, overheating of AlScN film bulk acoustic resonators (FBARs) used in RF MEMS filters limits power handling and thus the phone's ability to operate in an increasingly congested RF environment while maintaining its maximum data transmission rate. In this work, the ramifications of tailoring of the piezoelectric response and microstructure of AlScN films on the thermal transport have been studied. Read More

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Voice Feature Selection to Improve Performance of Machine Learning Models for Voice Production Inversion.

Zhaoyan Zhang

J Voice 2021 Apr 10. Epub 2021 Apr 10.

Department of Head and Neck Surgery, University of California, Los Angeles, 31-24 Rehabilitation Center, Los Angeles, California. Electronic address:

Objective: Estimation of physiological control parameters of the vocal system from the produced voice outcome has important applications in clinical management of voice disorders . Previously we developed a simulation-based neural network for estimation of vocal fold geometry, mechanical properties, and subglottal pressure from voice outcome features that characterize the acoustics of the produced voice. The goals of this study are to (1) explore the possibility of improving the estimation accuracy of physiological control parameters by including voice outcome features characterizing vocal fold vibration; and (2) identify voice feature sets that optimize both estimation accuracy and robustness to measurement noise. Read More

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Environmental DNA and environmental RNA: Current and prospective applications for biological monitoring.

Sci Total Environ 2021 Apr 5;782:146891. Epub 2021 Apr 5.

Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada; Faculty of Science and Technology and Athabasca River Basin Research Institute, Athabasca University, Athabasca, Alberta, Canada.

Traditional environmental biomonitoring approaches have limitations in terms of species detectability and their capacity to account for spatial and temporal variation. Furthermore, as invasive techniques they can be harmful to individual organisms, populations and habitats. The application of non-invasive sampling methods that extract, isolate and identify nucleic acid sequences (i. Read More

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"Aptamer-locker" DNA coupling with CRISPR/Cas12a-guided biosensing for high-efficiency melamine analysis.

Biosens Bioelectron 2021 Apr 7;183:113233. Epub 2021 Apr 7.

State Key Laboratory of Biocatalysts and Enzyme Engineering, Hubei University, China; Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, China. Electronic address:

Herein, we report a method that combined "aptamer-locker" DNA with CRISPR/Cas12a-based biosensing for sensitive and rapid melamine analysis. Three strategies were harnessed for designing the DNA sensors that were well characterized by circular dichroism (CD) spectroscopy and isothermal titration calorimetry (ITC) in the absence and presence of melamine. The detection parameters were optimized to achieve good analytic performance. Read More

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Development and maintenance of vision's first synapse.

Dev Biol 2021 Apr 10. Epub 2021 Apr 10.

Huffington Center on Aging, Department of Neuroscience, Baylor College of Medicine, Houston, TX, 77030, USA. Electronic address:

Synapses in the outer retina are the first information relay points in vision. Here, photoreceptors form synapses onto two types of interneurons, bipolar cells and horizontal cells. Because outer retina synapses are particularly large and highly ordered, they have been a useful system for the discovery of mechanisms underlying synapse specificity and maintenance. Read More

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Coiling directions in the planktonic foraminifer Pulleniatina: A complex eco-evolutionary dynamic spanning millions of years.

PLoS One 2021 13;16(4):e0249113. Epub 2021 Apr 13.

School of Earth and Ocean Sciences, Cardiff University, Cardiff, United Kingdom.

Planktonic foraminifera are heterotrophic sexually reproducing marine protists with an exceptionally complete fossil record that provides unique insights into long-term patterns and processes of evolution. Populations often exhibit strong biases towards either right (dextral) or left (sinistral) shells. Deep-sea sediment cores spanning millions of years reveal that some species show large and often rapid fluctuations in their dominant coiling direction through time. Read More

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The Association of Energy and Macronutrient Intake at Dinner Versus Breakfast With The Incidence of Type 2 Diabetes Mellitus in Cohort Study: The China Health and Nutrition Survey, 1997-2011.

J Diabetes 2021 Apr 13. Epub 2021 Apr 13.

National Key Discipline, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, P. R. China.

Background: This study aims to investigate the association of energy and macronutrient intake at dinner versus breakfast with the incidence of type 2 diabetes mellitus (T2DM).

Methods: 11,153 adults, including 811 with T2DM, completed a questionnaire about energy and macronutrient intake in the China Health and Nutrition Survey (1997-2011). The differences (Δ) in energy and macronutrient intake between dinner and breakfast (Δ = dinner - breakfast) were categorized into quintiles. Read More

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Two people, one graph: the effect of rotated viewpoints on accessibility of data visualizations.

Cogn Res Princ Implic 2021 Apr 13;6(1):31. Epub 2021 Apr 13.

Leibniz-Institut Für Wissensmedien, Schleichstr. 6, 72076, Tübingen, Germany.

In co-located, multi-user settings such as multi-touch tables, user interfaces need to be accessible from multiple viewpoints. In this project, we investigated how this goal can be achieved for depictions of data in bar graphs. We designed a laboratory task in which participants answered simple questions based on information depicted in bar graphs presented from differently rotated points of view. Read More

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A Home-Based Mobile Health Intervention to Replace Sedentary Time With Light Physical Activity in Older Cancer Survivors: Randomized Controlled Pilot Trial.

JMIR Cancer 2021 Apr 13;7(2):e18819. Epub 2021 Apr 13.

School of Public Health, Rutgers University, Piscataway, NJ, United States.

Background: Older cancer survivors are at risk of the development or worsening of both age- and treatment-related morbidity. Sedentary behavior increases the risk of or exacerbates these chronic conditions. Light-intensity physical activity (LPA) is more common in older adults and is associated with better health and well-being. Read More

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Dietary Macronutrient Composition in Relation to Circulating HDL and Non-HDL Cholesterol: A Federated Individual-Level Analysis of Cross-Sectional Data from Adolescents and Adults in 8 European Studies.

J Nutr 2021 Apr 13. Epub 2021 Apr 13.

Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.

Background: Associations between increased dietary fat and decreased carbohydrate intake with circulating HDL and non-HDL cholesterol have not been conclusively determined.

Objective: We assessed these relations in 8 European observational human studies participating in the European Nutritional Phenotype Assessment and Data Sharing Initiative (ENPADASI) using harmonized data.

Methods: Dietary macronutrient intake was recorded using study-specific dietary assessment tools. Read More

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A conceptual framework for treating jaw deformities in patients with abnormal condyles: preservation versus replacement of the glenoid fossa-disc-condyle-ramus.

Int J Oral Maxillofac Surg 2021 Apr 10. Epub 2021 Apr 10.

Department of Oral and Maxillofacial Surgery, Harvard School of Dental Medicine, Massachusetts General Hospital, Boston, MA, USA. Electronic address:

This article outlines a conceptual approach to the reconstruction of jaw deformities associated with abnormalities in the mandibular condyle. The authors describe a hierarchy of reconstruction, emphasizing use of the least invasive and progressing to the most complex and invasive techniques, depending on the nature and severity of the underlying deformity, prior operations, patient age, and stage of growth. Consider joint preservation orthognathic surgical correction, followed by biological techniques for replacement of the condyle, and avoid replacing a functional temporomandibular joint based only on radiographic remodeling and concerns about potential future flare-ups of disease based on anecdotal data. Read More

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Sacral chordoma with incidental rectal adenocarcinoma: a case report.

J Med Case Rep 2021 Apr 12;15(1):195. Epub 2021 Apr 12.

King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Background: We report a unique case of synchronous sacrococcygeal chordoma in association with rectal invasive adenocarcinoma. Retrorectal tumors are a rare disease caused by a variety of pathologies. To our knowledge, no prior cases of such a coincidental finding of both cancers have been reported in the literature. Read More

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A Review on Natural Sources Derived Protein Nanoparticles as Anticancer Agents.

Curr Top Med Chem 2021 Apr 12. Epub 2021 Apr 12.

Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451. Saudi Arabia.

Cancer notably carcinoma represents a prominent health challenge worldwide. A variety of chemotherapeutic agents are being used to deal with a variety of carcinomas. However, these delivering agents not only enter the targeted site but also affect normal tissues yielding poor therapeutic outcomes. Read More

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Further lead optimization on Bax activators: Design, synthesis and pharmacological evaluation of 2-fluoro-fluorene derivatives for the treatment of breast cancer.

Eur J Med Chem 2021 Apr 3;219:113427. Epub 2021 Apr 3.

Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch (UTMB), Galveston, TX, 77555, United States; Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch (UTMB), Galveston, TX, 77555, United States. Electronic address:

To further pursue potent Bax activators with better safety profiles for the treatment of breast cancer, structural optimization was conducted based on lead compound CYD-4-61 through several strategies, including scaffold hopping on the 2-nitro-fluorene ring, replacement of the nitro group with bioisosteres to avoid potential toxicity, and further optimization on the upper pyridine by exploring diverse alkylamine linkers as a tail or replacing the pyridine with bioisosteric heterocycles. F-containing compound 22d (GL0388) exhibited a good balance between the activity and toxicity, displaying submicromolar activities against a variety of cancer cell lines with 5.8-10. Read More

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