340,202 results match your criteria replacement therapyconclusion


Vibrational and conformational analysis of structural phase transition in Estradiol 17β valerate with temperature.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 24;263:120219. Epub 2021 Jul 24.

Instituto de Fìsica de São Carlos, Universidade de São Paulo,C.P 369, 13560-970,São Carlos, S P, Brazil.

Estradiol 17β valerate (E2V) is a hormonal medicine widely used in hormone replacement therapy. E2V undergoes a reversible isosymmetric structural phase transition at low temperature (̴ 250 K) which results from the reorientation of the valerate chain. The reversible isosymmetric structural phase transition follows Ehrenfest's classification when described as first-order and Buerger's classification when classified as order-disorder. Read More

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Bilingual phonological development across generations: Segmental accuracy and error patterns in second- and third-generation British Bengali children.

J Commun Disord 2021 Jul 4;93:106140. Epub 2021 Jul 4.

Department of Child and Family Studies, Rongxiang Xu College of Health and Human Services, California State University, Los Angeles, 5151 State University Drive, Los Angeles, CA 90032, United States of America. Electronic address:

Introduction: While developmental norms for speech sound development have been widely reported for monolingual children, and increasingly for bilingual children, little is known about speech sound development across different generations of children growing up in heritage language settings. The purpose of the present study was to gain a better understanding of inter-generational differences in the phonological development of British Bengali children.

Methods: Typically-developing second-generation and third-generation Bengali heritage children living in Wales (n=19), aged between 4 and 5 years, participated in a picture-naming task in Sylheti and English. Read More

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Harnessing the power of microphysiological systems for COVID-19 research.

Drug Discov Today 2021 Jul 28. Epub 2021 Jul 28.

National Centre for the Replacement, Refinement and Reduction of Animals in Research, London, UK. Electronic address:

The pharmaceutical industry is constantly striving for innovative ways to bridge the translational gap between preclinical and clinical drug development to reduce attrition. Substantial effort has focused on the preclinical application of human-based microphysiological systems (MPSs) to better identify compounds not likely to be safe or efficacious in the clinic. The Coronavirus 2019 (COVID-19) pandemic provides a clear opportunity for assessing the utility of MPS models of the lungs and other organ systems affected by the disease in understanding the pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in the development of effective therapeutics. Read More

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Inkk Trial - Intraoperative ketamine for perioperative pain management following total knee endoprosthetic replacement in oncology: a double-blinded randomized trial.

Braz J Anesthesiol 2021 Jul 28. Epub 2021 Jul 28.

Tata Memorial Hospital and Homi Bhabha National Institute, Department of Physiotherapy, Mumbai, India.

Background: There has been a growing interest in the use of ketamine following orthopedic surgeries. We hypothesized that low dose intravenous ketamine during surgery would help in mobilization following total knee replacement (TKR) in oncology patients as assessed by the timed to up and go (TUG) test at 72 hours post-surgery. Our secondary objectives were to compare the opioid requirement at end of 72 hours, pain scores, satisfaction with pain management, adverse effects, range of joint movement achieved in the post-operative period and the functional recovery at the end of 1 month. Read More

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New Insights into Pathogenesis of L-DOPA-Induced Dyskinesia.

Neurotoxicology 2021 Jul 28. Epub 2021 Jul 28.

Laboratory Animal Center and Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China. Electronic address:

Parkinson's disease (PD) is a progressive and self-propelling neurodegenerative disorder, which is characterized by motor symptoms, such as rigidity, tremor, slowness of movement and problems with gait. These symptoms become worse over time. To date, Dopamine (DA) replacement therapy with 3, 4-dihydroxy-L-phenylalanine (L-DOPA) is still the most effective pharmacotherapy for motor symptoms of PD. Read More

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Final 3-year clinical outcomes following transcatheter aortic valve implantation with a supra-annular self-expanding repositionable valve in a real-world setting: Results from the multicenter FORWARD study.

Catheter Cardiovasc Interv 2021 Jul 31. Epub 2021 Jul 31.

Department of Medicine, University of Bonn, Bonn, Germany.

Objectives: The Evolut R FORWARD study confirmed safety and effectivenesss of the Evolut R THV in routine clinical practice out to 1 year. Herein, we report the final 3-year clinical follow up of the FORWARD study.

Background: Transcatheter aortic valve replacement (TAVR) is a proven alternative to surgery in elderly patients with symptomatic severe aortic stenosis. Read More

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Single-stage tracheal transplantation-From bench to bedside.

Am J Transplant 2021 Jul 31. Epub 2021 Jul 31.

Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

We read with great interest and admiration the manuscript by Genden and colleagues titled "Single-stage long-segment tracheal transplantation" (1). In adult patients, the general limits of safe tracheal resection and direct end to end re-anastomosis has always been considered to be a maximum of 5-6 cm. Long-segment tracheal resection and replacement is a challenge and has led to a century-long search for a means of tracheal replacement. Read More

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Hemadsorption as rescue therapy for patients with multisystem organ failure in pediatric intensive care -two case reports and review of the literature.

Artif Organs 2021 Jul 31. Epub 2021 Jul 31.

Division of Neonatology, Pediatric Intensive Care & Neuropediatrics, Department of Pediatric and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

Background: Hemadsorption via the cytokine-adsorber CytoSorb has successfully been used as an adjunctive method in adults, mainly for the purpose of immunomodulation under acute inflammatory conditions such as sepsis and cardiac surgery. In recent years, there has been growing interest in its use in pediatric intensive care to improve outcomes in patients with multiple organ failure following inflammatory illness. Literature on the application of CytoSorb in neonatal and pediatric patients is scarce, though the implication is that it could be an effective last-resort treatment option in critically ill pediatric patients. Read More

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An integrated knowledge synthesis of regional ambient monitoring in Canada's oil sands.

Integr Environ Assess Manag 2021 Jul 31. Epub 2021 Jul 31.

Cumulative Effects Environmental Inc.

Desire to document and understand the cumulative implications of oil sands development in the ambient environment of northeastern Alberta has motivated increased investment and release of information in the last decade. Here, we summarise the knowledge presented in the theme-based review papers within this special issue, including air, surface water, terrestrial biology, and Indigenous community-based monitoring in order to (1) consolidate knowledge gained to date; (2) highlight key commonalities and gaps; and (3) leverage this knowledge to assess the state of integration within environmental monitoring efforts in the oil sands region and suggest next steps. Among air, water, and land studies, the individual reviews identified a clear focus on describing stressors, including primarily (1) contaminant emission, transport, transformation, deposition, and exposure, and (2) landscape disturbance. Read More

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Ventral calcification in the common femoral artery: A risk factor for major transcatheter aortic valve intervention access site complications.

Catheter Cardiovasc Interv 2021 Jul 31. Epub 2021 Jul 31.

Department of Cardiology and Angiology I, University Hospital Freiburg and Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Objectives: We aimed to identify risk factors for major transcatheter aortic valve intervention (TAVI) access site complications based on detailed analysis of the preprocedural computed tomography angiogram (CTA).

Background: Transfemoral TAVI has become the treatment of choice for severe aortic stenosis in elderly patients, especially with increased perioperative risk. Frailty, however, favors complications at the vascular access site due to the large bore vascular sheath devices necessary for valve deployment. Read More

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A Cross-Sectional Study of Retired Great British Olympians (Berlin 1936-Sochi 2014): Olympic Career Injuries, Joint Health in Later Life, and Reasons for Retirement from Olympic Sport.

Sports Med Open 2021 Jul 31;7(1):54. Epub 2021 Jul 31.

Institute for Sport, PE and Health Sciences Moray House School of Education and Sport, University of Edinburgh, Edinburgh, UK.

Background: The relationship between Olympic career sport injury and the long-term musculoskeletal health of the elite athlete remains unclear. This study describes the lifetime prevalence of medical attention injuries that occurred during training and/or competition as part of the athlete's Olympic career, reasons for retirement from Olympic sport, and the point prevalence of pain and osteoarthritis (OA) among retired Great Britain's (GB) Olympians.

Methods: This cross-sectional study involved distributing a questionnaire to retired GB Olympians who had competed at 36 Olympic Games between Berlin 1936 and Sochi 2014. Read More

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Capture of carbon dioxide and hydrogen by engineered Escherichia coli: hydrogen-dependent CO reduction to formate.

Appl Microbiol Biotechnol 2021 Jul 31. Epub 2021 Jul 31.

Molecular Microbiology & Bioenergetics, Institute of Molecular Biosciences, Johann Wolfgang Goethe University, Max-von-Laue-Str. 9, 60439, Frankfurt am Main, Germany.

In times of global climate change and the fear of dwindling resources, we are facing different considerable challenges such as the replacement of fossil fuel-based energy carriers with the coincident maintenance of the increasing energy supply of our growing world population. Therefore, CO capturing and H storing solutions are urgently needed. In this study, we demonstrate the production of a functional and biotechnological interesting enzyme complex from acetogenic bacteria, the hydrogen-dependent CO reductase (HDCR), in the well-known model organism Escherichia coli. Read More

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Modifiable Risk Factors for Chronic Kidney Disease in Adulthood seen among School Children in Asaba.

West Afr J Med 2021 Jul;38(7):674-678

Department of Paediatrics, College of Medicine, University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria.

Background: The burden of chronic kidney disease (CKD) is huge especially in developing countries like Nigeria. In Nigeria, treatment modalities for ESRD (renal replacement therapy) are not readily available and, where available, they are not affordable. Consequently, preventive nephrology aimed at early detection and prompt treatment of children with CKD risk factors has become the viable alternative in curbing this rising problem. Read More

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Bone and body composition analyses by DXA in adults with GH deficiency: effects of long-term replacement therapy.

Endocrine 2021 Jul 30. Epub 2021 Jul 30.

Bone Metabolic Unit, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.

Purpose: The effects of growth hormone (GH) replacement on bone mass and body composition in adult with GH deficiency (AGHD) are still debated with regard to their persistence in the long term. Moreover, the impact of the gender on the response to GH is controversial. Aim of this study was to evaluate the long-term effects of rhGH replacement on bone mass and body composition in a monocentric cohort of patients with AGHD. Read More

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Emergency surgical retrieval of a migrated LAmbre device through the mitral valve.

Eur J Cardiothorac Surg 2021 Jul 31. Epub 2021 Jul 31.

Cardiac Surgery Department, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.

Left atrial appendage occlusion has become an alternative for long-term anticoagulation for patients with non-valvular atrial fibrillation. Although the procedure is safe, life-threatening complications such as embolization of the device or cardiac tamponade might occur. We present a case of a LAmbre device that migrated 4 days after being implanted and remained trapped in the mitral valve. Read More

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Food sources of dietary fibre and risk of total knee replacement related to severe osteoarthritis, the Singapore Chinese Health Study.

RMD Open 2021 Jul;7(2)

Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Objectives: We aimed to evaluate the association between fibre intake and its food sources, and the risk of total knee replacement (TKR) due to severe knee osteoarthritis (KOA).

Methods: We used data from the Singapore Chinese Health Study, a prospective cohort study that recruited 63 257 participants aged 45-74 years from 1993 to 1998. At baseline, we assessed diet using a validated 165-item semiquantitative food frequency questionnaire, together with body mass index (BMI) and lifestyle factors. Read More

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Reply to the article: Does the delay in the start of replacement therapy influence recovery from postoperative hypocalcemia?

Cir Esp (Engl Ed) 2021 Jul 27. Epub 2021 Jul 27.

Servicio de Cirugía General, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain. Electronic address:

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Survival of Tricuspid Valve Replacement in Patients With Previous Tricuspid Valve Surgery.

Heart Lung Circ 2021 Jul 27. Epub 2021 Jul 27.

Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Vessel Disease, Beijing, China. Electronic address:

Objectives: This study was performed to investigate the short-term and long-term survival of patients who underwent reoperative tricuspid valve replacement (TVR).

Methods: A retrospective analysis was performed of 273 patients who underwent TVRs while hospitalised in Beijing Anzhen Hospital from November 1993 to August 2018. Fifty-six (56) of them underwent reoperative TVR: 36 had previous tricuspid valve repair and 20 had previous TVR. Read More

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The status quo of early burn wound excision: Insights from the German burn registry.

Burns 2021 Jul 10. Epub 2021 Jul 10.

Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Plastic- and Hand Surgery, University of Heidelberg, Germany. Electronic address:

Background: There is a common, well-known and established recommendation to excise burn wounds within 24-72 h in order to mitigate the systemic inflammatory and immunomodulatory response, shorten length of hospitalization through early grafting and optimize patient survival. Despite this apparent consensus, surprisingly few systematic studies have evaluated the actual adherence to this practice and its implications on patient outcomes. In this registry study, we sought to objectify the current status of early burn wound excision, its influencing factors and impact on patient outcomes for all German burn centers. Read More

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Long-Term Outcome After Venoarterial Extracorporeal Membrane Oxygenation as Bridge to Left Ventricular Assist Device Preceding Heart Transplantation.

J Cardiothorac Vasc Anesth 2021 Jul 3. Epub 2021 Jul 3.

Department of Cardiac Surgery, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.

Objectives: To determine if venoarterial extracorporeal membrane oxygenation (VA ECMO) as a bridge to left ventricular assist device (LVAD) in heart transplant (HT) candidates (ie, double bridge to HT) was associated with increased morbidity and mortality when compared to LVAD bridging to HT (ie, single bridge to HT).

Design: A retrospective analysis of patients undergoing LVAD support from 2011 to 2020. A Kaplan-Meier survival curve and Cox-Mantel hazard ratios (HR) were calculated during LVAD support and after HT. Read More

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Safety and efficacy of tetrastarches in surgery and trauma: a systematic review and meta-analysis of randomised controlled trials.

Br J Anaesth 2021 Jul 28. Epub 2021 Jul 28.

Department of Anaesthesia and Perioperative Medicine, University of Cape Town, Cape Town, South Africa.

Background: Hydroxyethyl starch (HES) 130 is a frequently used fluid to replace intravascular losses during surgery or trauma. In the past years, several trials performed in critically ill patients have raised questions regarding the safety of this product. Our aim in this meta-analysis was to evaluate the safety and efficacy of 6% HES during surgery and in trauma. Read More

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Ethical Challenges in Dialysis and Transplantation: Perspectives From the Developing World.

Semin Nephrol 2021 May;41(3):211-219

Department of Pediatric Nephrology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan. Electronic address:

Renal replacement therapies including dialysis and transplantation for patients with end-stage kidney failure are treatment options beyond the reach of a large segment of the population, particularly in resource-constrained settings. Health care professionals practicing within developing countries face unique ethical issues in the provision of these treatment options despite the existence of free treatment at different centers. Apart from issues of accessibility of dialysis services, initiation of treatment can have disastrous consequences for the entire family unit, which is magnified in collectivist societies. Read More

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Surgical outcomes of DeBakey type I and type II acute aortic dissection: a propensity score-matched analysis in 599 patients.

J Cardiothorac Surg 2021 Jul 30;16(1):208. Epub 2021 Jul 30.

Department of Medicine, College of Medicine, Chang Gung University, Taoyuan City, Taiwan.

Background: The DeBakey classification divides Stanford acute type A aortic dissection (ATAAD) into DeBakey type I (D1) and type II (D2) according to the extent of acute aortic dissection (AAD). This retrospective study aimed to compare the early and late outcomes of D1-AAD and D2-AAD through a propensity score-matched analysis.

Methods: Between January 2009 and April 2020, 599 consecutive patients underwent ATAAD repair at our institution, and were dichotomized into D1 (n = 543; 90. Read More

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Early warning of citric acid overdose and timely adjustment of regional citrate anticoagulation based on machine learning methods.

BMC Med Inform Decis Mak 2021 Jul 30;21(Suppl 2):126. Epub 2021 Jul 30.

Department of Primary Care and Family Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.

Background: Regional citrate anticoagulation (RCA) is an important local anticoagulation method during bedside continuous renal replacement therapy. To improve patient safety and achieve computer assisted dose monitoring and control, we took intensive care units patients into cohort and aiming at developing a data-driven machine learning model to give early warning of citric acid overdose and provide adjustment suggestions on citrate pumping rate and 10% calcium gluconate input rate for RCA treatment.

Methods: Patient age, gender, pumped citric acid dose value, 5% NaHCO solvent, replacement fluid solvent, body temperature value, and replacement fluid PH value as clinical features, models attempted to classify patients who received regional citrate anticoagulation into correct outcome category. Read More

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Outcomes of Surface Replacement Arthroplasty in Metacarpophalangeal Joints Affected by Noninflammatory Arthritis.

Hand (N Y) 2021 Jul 30:15589447211028917. Epub 2021 Jul 30.

Mayo Clinic, Rochester, MN, USA.

Background: The purpose of this study was to investigate the outcomes of surface replacement arthroplasty (SRA) for noninflammatory arthritis of the metacarpophalangeal (MCP) joint.

Methods: Records from 20 SRAs performed between 1995 and 2017 in 17 patients with noninflammatory arthritis affecting the MCP joint were retrospectively reviewed. The mean follow up was 6. Read More

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Metal artifact reduction in 2D CT images with self-supervised cross-domain learning.

Phys Med Biol 2021 Jul 30. Epub 2021 Jul 30.

Department of Radiation Oncology, Stanford University Medical Center, 875 Blake Wilbur Drive, Stanford, California, CA94305-5847, Stanford, California, 94305-5847, UNITED STATES.

The presence of metallic implants often introduces severe metal artifacts in the X-ray CT images, which could adversely influence clinical diagnosis or dose calculation in radiation therapy. In this work, we present a novel deep-learning-based approach for metal artifact reduction (MAR). In order to alleviate the need for anatomically identical CT image pairs (\ie, metal artifact-corrupted CT image and metal artifact-free CT image) for network learning, we propose a self-supervised cross-domain learning framework. Read More

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Bad neighbors? Niche overlap and asymmetric competition between native and Lessepsian limpets in the Eastern Mediterranean rocky intertidal.

Mar Pollut Bull 2021 Jul 27;171:112703. Epub 2021 Jul 27.

Department of Palaeontology, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria; Department of Animal Conservation and Public Engagement, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.

The Eastern Mediterranean Sea hosts more non-indigenous species than any other marine region, yet their impacts on the native biota remain poorly understood. Focusing on mollusks from the Israeli rocky intertidal, we explored the hypothesis that this abiotically harsh habitat supports a limited trait diversity, and thus may promote niche overlap and competition between native and non-indigenous species. Indeed, native and non-indigenous assemblage components often had a highly similar trait composition, caused by functionally similar native (Patella caerulea) and non-indigenous (Cellana rota) limpets. Read More

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Is the skin microbiota a modifiable risk factor for breast disease?: A systematic review.

Breast 2021 Jul 21;59:279-285. Epub 2021 Jul 21.

Department of Plastic and Reconstructive Surgery, Royal Free Hospital, London, UK.

Purpose: High prevalence, unreliable risk discrimination and poor clinical outcomes are observed in malignant and benign breast diseases (BD). The involvement of microbial communities in the development of BD has become topical, and distal influences of microbial dysregulation in the breast have been well established. Despite advances, the role of the breast skin microbiota in BD remains unclear. Read More

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Replaceability of Schiff base proton donors in light-driven proton pump rhodopsins.

J Biol Chem 2021 Jul 27:101013. Epub 2021 Jul 27.

Faculty of Advanced Life Science, Hokkaido University, Sapporo 060-0810, Japan. Electronic address:

Many H-pump rhodopsins conserve "H donor" residues in cytoplasmic (CP) half channels to quickly transport H from the CP medium to Schiff bases at the center of these proteins. For conventional H pumps, the donors are conserved as Asp or Glu but are replaced by Lys in the minority, such as Exiguobacterium sibiricum rhodopsin (ESR). In dark states, carboxyl donors are protonated, whereas the Lys donor is deprotonated. Read More

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Total aortic arch replacement using the J-graft open stent graft for distal aortic arch aneurysm: report from two centres in Japan.

Interact Cardiovasc Thorac Surg 2021 Jul 30. Epub 2021 Jul 30.

Department of Cardiovascular Surgery, Saiseikai Utsunomiya Hospital, Tochigi, Japan.

Objectives: The open-style stent graft technique has been changing the strategy for true distal arch aneurysms extending to the descending aorta. Our mid-term results of surgical repair using a J-graft open stent graft are presented.

Methods: Between May 2015 and June 2020, 69 patients with a distal arch aneurysm (53 males, median age 74 years) underwent total arch replacement combined with J-graft open stent deployment. Read More

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