117,425 results match your criteria replacement therapy


Concomitant valve-sparing aortic root replacement with tetralogy of Fallot repair in a 30-year-old patient: A case report.

Int J Surg Case Rep 2021 Apr 29;82:105930. Epub 2021 Apr 29.

Adult Cardiac Surgical Intensive Care Unit, Hanoi Heart Hospital, Hanoi, Viet Nam.

Introduction And Importance: Aortic regurgitation and aortic root dilatation are common features in adults with both repaired and unrepaired tetralogy of Fallot (TOF). Valve-sparing aortic root replacement (VSARR) is an effective repair for aortic regurgitation due to progressive aortic root dilatation with TOF after repair. However, the effectiveness of this technique for unrepaired patients has rarely been reported. Read More

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Differentiation of human dental pulp stem cells into functional motor neuron: In vitro and ex vivo study.

Tissue Cell 2021 Apr 18;72:101542. Epub 2021 Apr 18.

ENT and Head & Neck Research Center and Department, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

There are several therapeutic options for spinal cord injury (SCI), among these strategies stem cell therapy is a potential treatment. The stem cells based therapies have been investigating in acute phase of clinical trials for promoting spinal repair in humans through replacement of functional neuronal and glial cells. The aim of this study was to evaluate the differentiation of Human Dental Pulp Stem Cells (hDPSCs) into functional motor neuron like cells (MNLCs) and promote neuroregeneration by stimulating local neurogenesis in the adult spinal cord slice culture. Read More

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Identification of distinct clinical subphenotypes in critically ill patients with COVID-19.

Chest 2021 May 5. Epub 2021 May 5.

Center for Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Pulmonary, Allergy and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Background: Subphenotypes have been identified in patients with sepsis and acute respiratory distress syndrome (ARDS), and are associated with different outcomes and response to therapies.

Research Question: Can unique subphenotypes be identified among critically ill patients with coronavirus disease 2019 (COVID-19)?

Study Design: & Methods: Using data from a multicenter cohort study that enrolled critically ill patients with COVID-19 from 67 hospitals across the United States, we randomly divided centers into Discovery and Replication cohorts. We utilized latent class analysis independently in each cohort to identify subphenotypes based on clinical and laboratory variables. Read More

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Further characterisation of psychosis-like behaviours induced by L-DOPA in the MPTP-lesioned marmoset.

Naunyn Schmiedebergs Arch Pharmacol 2021 May 8. Epub 2021 May 8.

Neurodegenerative Disease Group, Montreal Neurological Institute-Hospital (The Neuro), 3801 University St, Montreal, QC, H3A 2B4, Canada.

Parkinson's disease (PD) psychosis afflicts over half of patients and poses a significant burden on quality of life. The aetiology of PD psychosis is multifactorial and likely arises from the complex interaction between dopamine replacement therapy and disease state. The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned common marmoset is a validated model to predict the efficacy of therapeutic compounds for treatment-related complications, including PD psychosis. Read More

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Post-Liver Transplant Acute Kidney Injury.

Liver Transpl 2021 May 8. Epub 2021 May 8.

Division of Gastroenterology (Liver Unit), University of Alberta, Edmonton, Canada.

Acute kidney injury (AKI) is a common condition following liver transplantation (LT). It negatively impacts patient outcomes by increasing the chances of developing chronic kidney disease (CKD) and reducing graft and patient survival. Multiple definitions of AKI have been proposed and utilized throughout the years with the International Club of Ascites (ICA) definition being the most widely used now for cirrhosis patients. Read More

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Fluid and Electrolyte therapy in Childhood Diabetic Ketoacidosis management - A rationale for new national guideline.

Diabet Med 2021 May 8:e14595. Epub 2021 May 8.

Paediatric Department, Southport and Ormskirk NHS Trust, Ormskirk, UK.

Fluid and electrolyte therapy in childhood diabetic ketoacidosis (DKA) management has been controversial. Previous National Institute for Health and Care Excellence (NICE) 2015 guidance advocated a restricted fluid regimen while more recent guidelines have advocated a more liberal approach to fluid replacement in DKA. At the core of the debate is the need to avoid developing cerebral oedema as a complication. Read More

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Recent Advances in the Development of Stem-Cell-Derived Dopaminergic Neuronal Transplant Therapies for Parkinson's Disease.

Mov Disord 2021 May 8. Epub 2021 May 8.

Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan.

The last decade has seen exciting advances in the development of potential stem cell-based therapies for Parkinson's disease (PD), which have used different types of stem cells as starting material. These cells have been developed primarily to replace dopamine-producing neurons in the substantia nigra that are progressively lost in the disease process. The aim is to largely restore lost motor functions, whilst not ever being curative. Read More

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Effect of enzyme replacement therapy on Fabry cardiomyopathy: evaluation of cardiac function is more useful than structural evaluation.

Eur Heart J Cardiovasc Imaging 2021 May 8. Epub 2021 May 8.

Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.

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Rhabdomyolysis Following Recovery from Severe COVID-19: A Case Report.

Am J Case Rep 2021 May 8;22:e931616. Epub 2021 May 8.

Oregon Health & Science University, Portland, OR, USA.

BACKGROUND Rhabdomyolysis occurs when muscle injury leads to the release of muscle cell constituents into circulation, often leading to significant systemic complications. There are many causes of rhabdomyolysis, and the etiology is often multifactorial or unclear. Current data suggest that acute COVID-19 may cause muscle injury that can lead to rhabdomyolysis, particularly in cases of severe illness requiring prolonged hospitalization; however, data on the long-term effects of COVID-19 on the musculoskeletal system are lacking. Read More

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Long-term structural and symptomatic effects of intra-articular sprifermin in patients with knee osteoarthritis: 5-year results from the FORWARD study.

Ann Rheum Dis 2021 May 7. Epub 2021 May 7.

Rheumatology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

Objective: The FORWARD (FGF-18 Osteoarthritis Randomized Trial with Administration of Repeated Doses) trial assessed efficacy and safety of the potential disease-modifying osteoarthritis drug (DMOAD) sprifermin in patients with knee osteoarthritis. Here, we report 5-year efficacy and safety results.

Methods: Patients were randomised to intra-articular sprifermin 100 µg or 30 µg every 6 months (q6mo) or 12 months, or placebo, for 18 months. Read More

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Chronic giardiasis: a rare cause of exocrine pancreatic insufficiency.

BMJ Case Rep 2021 May 7;14(5). Epub 2021 May 7.

Medicine, Jack D Weiler Hospital of the Albert Einstein College of Medicine, Bronx, New York, USA.

Exocrine pancreatic insufficiency (EPI) is a major cause of maldigestion/malabsorption syndromes. It is routinely diagnosed in clinical practice with the use of faecal elastase 1 levels, and pancreatic enzyme replacement therapy continues to be the mainstay of treatment. Numerous primary pancreatic and extrapancreatic causes for EPI have been established. Read More

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Letter to the Editor on "COVID-19 Infection in Men on Testosterone Replacement Therapy".

J Sex Med 2021 Mar 19. Epub 2021 Mar 19.

Alpert Medical School of Brown University, Providence, RI, USA. Electronic address:

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A 45-year-old female patient with Sheehan's syndrome presenting with imminent adrenal crisis: a case report.

J Med Case Rep 2021 May 8;15(1):229. Epub 2021 May 8.

Department of Epidemiology and Biostatistics, School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.

Background: Sheehan's syndrome is hypopituitarism due to pituitary gland necrosis resulting from hemorrhagic shock during pregnancy. It is a rare complication with varied manifestations and a considerable delay in diagnosis.

Case Presentation: We describe the case of a 45-year-old Ethiopian woman who presented with generalized fatigue for 18 years which progressed to anorexia, nausea, vomiting, diarrhea, and abdominal pain of 6 years' duration, for which she was treated symptomatically throughout these years. Read More

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Exercise-based cardiac rehabilitation for adults after heart valve surgery.

Cochrane Database Syst Rev 2021 May 7;5:CD010876. Epub 2021 May 7.

REHPA, The Danish Knowledge Centre for Rehabilitation and Palliative Care, Odense University Hospital, Nyborg, Denmark.

Background: The impact of exercise-based cardiac rehabilitation (CR) following heart valve surgery is uncertain. We conducted an update of this systematic review and a meta-analysis to assess randomised controlled trial evidence for the use of exercise-based CR following heart valve surgery.

Objectives: To assess the benefits and harms of exercise-based CR compared with no exercise training in adults following heart valve surgery or repair, including both percutaneous and surgical procedures. Read More

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Identification of a modified coagulation factor X with enhanced activation properties as potential hemostatic agent.

Blood Cells Mol Dis 2021 Apr 23;89:102570. Epub 2021 Apr 23.

Research and Development, CSL Behring Innovation GmbH, Marburg, Germany.

Hemophilia A and hemophilia B are X-linked inherited bleeding disorders caused by a deficiency of coagulation factor VIII and IX, respectively. Standard of care is prophylactic factor replacement therapy; however, the development of neutralizing antibodies against these factors represents serious complications underlining the need for alternative treatment approaches. Human coagulation factor X has a central role within the blood coagulation system making it an attractive target for the development of alternative treatment strategies for patients with hemophilia. Read More

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High-dose CytoSorb hemoadsorption is associated with improved survival in patients with septic shock: A retrospective cohort study.

J Crit Care 2021 Apr 20;64:184-192. Epub 2021 Apr 20.

Department of Anesthesiology, Surgical Intensive Care, Emergency and Pain Medicine, Ruhr-University Bochum, Klinikum Herford, Herford, Germany.

Background And Purpose: Hemoadsorption with CytoSorb® offers a possible therapeutic approach in septic shock, but modes of application and dosing are still undetermined.

Materials And Methods: Data from surgical patients with septic shock, treated with hemoadsorption adjunctive to renal replacement therapy were analyzed retrospectively. The 28-day mortality was compared to predicted mortality. Read More

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Barriers to pre-emptive kidney transplantation in New Zealand children.

J Paediatr Child Health 2021 May 7. Epub 2021 May 7.

Paediatric Nephrology Department, Starship Children's Hospital, Auckland, New Zealand.

Aim: Pre-emptive kidney transplantation (PKT) is generally considered the optimal treatment for kidney failure as it minimises dialysis-associated morbidity and mortality and is associated with improved allograft survival. This study aimed to determine rates of paediatric PKT in New Zealand, identify barriers to PKT and consider potential interventions to influence future rates of pre-emptive transplantation.

Methods: Children commencing kidney replacement therapy between 2005 and 2017 in New Zealand were included. Read More

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Restrictive fluid management versus usual care in acute kidney injury (REVERSE-AKI): a pilot randomized controlled feasibility trial.

Intensive Care Med 2021 May 7. Epub 2021 May 7.

Department of Intensive Care, Austin Hospital, Melbourne, Australia.

Purpose: We compared a restrictive fluid management strategy to usual care among critically ill patients with acute kidney injury (AKI) who had received initial fluid resuscitation.

Methods: This multicenter feasibility trial randomized 100 AKI patients 1:1 in seven ICUs in Europe and Australia. Restrictive fluid management included targeting negative or neutral daily fluid balance by minimizing fluid input and/or enhancing urine output with diuretics administered at the discretion of the clinician. Read More

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Evaluation of sleep-disordered breathing and its relationship with respiratory parameters in children with mucopolysaccharidosis Type IVA and VI.

Am J Med Genet A 2021 May 7. Epub 2021 May 7.

Department of Pediatric Pulmonology, School of Medicine, Hacettepe University, Ihsan Dogramaci Children's Hospital, Ankara, Turkey.

The aims of the study were to evaluate the prevalence of sleep-disordered breathing (SDB) by using polysomnography (PSG) in children with MPS IVA and MPS VI who underwent enzyme replacement therapy (ERT) and to analyze the effect on SDB of having upper airway surgery, pulmonary functions, and exercise capacity. A retrospective cross-sectional study was conducted on patients with MPS IVA (n:17) and MPS VI (n:11) aged under 19 years who underwent polysomnography. Descriptive and nonparametric analyses were performed for demographic, PSG, pulmonary function and exercise capacity variables. Read More

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Principles responsible for trace element concentrations in chronic kidney disease.

Clin Nephrol 2021 May 7. Epub 2021 May 7.

Derangements of trace elements often occur in patients with renal failure and play a crucial role in chronic kidney disease. The natural history of trace element deposition with worsening chronic kidney disease has been poorly described. Some essential trace elements may get wasted (e. Read More

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Time is muscle: A recommendation for early treatment for preterm infants with spinal muscular atrophy.

Muscle Nerve 2021 May 7. Epub 2021 May 7.

Department of Neurology - Neuromuscular Division, University of Rochester, Rochester, NY, USA.

Implementation of newborn screening for spinal muscular atrophy (SMA) in 33 US states and increased genetic carrier screening have led to an increase in early, pre-symptomatic diagnosis of SMA. Early treatment is critically important and is recommended for pre-symptomatic infants with 2 to 4 copies of SMN2. Currently no specific treatment recommendations exist for preterm infants with SMA. Read More

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No Impact of Fluconazole to Echinocandins Replacement as First-Line Therapy on the Epidemiology of Yeast Fungemia (Hospital-Driven Active Surveillance, 2004-2017, Paris, France).

Front Med (Lausanne) 2021 20;8:641965. Epub 2021 Apr 20.

Institut Pasteur, CNRS, Unité de Mycologie Moléculaire, Centre National de Référence Mycoses Invasives et Antifongiques, Paris, France.

Replacement of fluconazole by echinocandins as the first-line therapy for yeast-related fungemia could have an impact on both the mortality rate and the epidemiology of yeast species responsible for candidemia. We analyzed the individual clinical and microbiological data collected through the active surveillance program on yeast fungemia (YEASTS program, 2004-2016, Paris area, France) within 14 University Hospitals. The cohort included 3,092 patients [male:female ratio: 1. Read More

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Fluid Balance in the Critically Ill Child Section: "How Bad Is Fluid in Neonates?"

Front Pediatr 2021 20;9:651458. Epub 2021 Apr 20.

Stead Family Department of Pediatrics (Nephrology), University of Iowa Health Care, Iowa City, IA, United States.

Fluid overload (FO) in neonates is understudied, and its management requires nuanced care and an understanding of the complexity of neonatal fluid dynamics. Recent studies suggest neonates are susceptible to developing FO, and neonatal fluid balance is impacted by multiple factors including functional renal immaturity in the newborn period, physiologic postnatal diuresis and weight loss, and pathologies that require fluid administration. FO also has a deleterious impact on other organ systems, particularly the lung, and appears to impact survival. Read More

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Muscle-Specific Promoters for Gene Therapy.

Acta Naturae 2021 Jan-Mar;13(1):47-58

Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia.

Many genetic diseases that are responsible for muscular disorders have been described to date. Gene replacement therapy is a state-of-the-art strategy used to treat such diseases. In this approach, the functional copy of a gene is delivered to the affected tissues using viral vectors. Read More

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Recent use of formaldehyde-'free' hair straightening product and severe acute kidney injury.

Clin Kidney J 2021 May 11;14(5):1469-1471. Epub 2021 Jan 11.

Edith Wolfson Medical Center Ringgold Standard Institution, Holon, Israel.

Formaldehyde is present in hair straightening products even when labeled as formaldehyde-free. Inhaled absorption of formaldehyde causes renal tubular cytotoxicity. We report a teenager who developed severe acute kidney injury requiring renal replacement therapy shortly after exposure to a formaldehyde-'free' hair straightening product. Read More

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Association of right ventricular dysfunction and pulmonary hypertension with adverse 30-day outcomes in COVID-19 patients.

Pulm Circ 2021 Apr-Jun;11(2):20458940211007040. Epub 2021 Apr 19.

Department of Cardiology, Heart and Vascular Institute, Maimonides Medical Center, Brooklyn, NY, USA.

Background: Cardiac manifestations in COVID-19 are multifactorial and are associated with increased mortality. The clinical utility and prognostic value of echocardiography in COVID-19 inpatients is not clearly defined. We aim to identify echocardiographic parameters that are associated with 30-day clinical outcomes secondary to COVID-19 hospitalization. Read More

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Blood Purification Techniques, Inflammatory Mediators and Mortality in COVID-19 Patients.

Tanaffos 2020 Dec;19(4):291-299

Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Inflammatory mediators are an important component in the pathophysiology of the coronavirus disease 2019 (COVID-19). This study aimed to assess the effects of reducing inflammatory mediators using hemoperfusion (HP) and continuous renal replacement therapy (CRRT) on the mortality of patients with COVID-19.

Materials And Methods: Twelve patients with confirmed diagnosis of COVID-19 were included. Read More

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December 2020

Influence of Vibroacoustic Therapy on Local Status and Rehabilitation of Post-TKR and Post-THR patients.

Ortop Traumatol Rehabil 2021 Apr;23(2):101-113

Klinika Ortopedii i Ortopedii Dziecięcej Centralnego Szpitala Klinicznego w Łodzi, Polska / Department of Orthopaedics and Pediatric Orthopaedics, Central Teaching Hospital of Medical University in Lodz, Poland.

Background: Rehabilitation following major joint replacement surgery is an extremely important part of complementary treatment after the surgical procedure. To obtain the best final treatment outcome possible, apart from improvements in surgical technique, new methods of rehabilitation are still being sought and implemented to increase its effectiveness, safety and patient comfort. One such technique is vibroacoustic therapy, a method of treatment based on the direct transmission of audible sound vibrations through a sound transmitter to the patient's body. Read More

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Outcomes of Prosthesis-Patient Mismatch Following Supra-Annular Transcatheter Aortic Valve Replacement: From the STS/ACC TVT Registry.

JACC Cardiovasc Interv 2021 May;14(9):964-976

Department of Cardiothoracic Surgery, Houston Methodist DeBakey Heart and Vascular Institute, Houston, Texas, USA.

Objectives: The aim of this study was to assess the outcomes of severe prosthesis-patient mismatch (PPM) in the TVT (Transcatheter Valve Therapy) Registry in patients undergoing supra-annular transcatheter aortic valve replacement (TAVR) for de novo stenosis or failed surgical bioprostheses (transcatheter aortic valve [TAV]-in-surgical aortic valve [SAV]).

Background: Severe PPM has been associated with adverse outcomes following TAVR, yet the clinical outcome of severe PPM after supra-annular TAVR is largely unknown.

Methods: Supra-annular TAVR was performed in patients enrolled in the TVT Registry with de novo stenosis (n = 42,174) or TAV-in-SAV (n = 5,446). Read More

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Mechanical Hemolysis Complicating Transcatheter Interventions for Valvular Heart Disease: JACC State-of-the-Art Review.

J Am Coll Cardiol 2021 May;77(18):2323-2334

Department of Cardiac Surgery, Niguarda Hospital, Milan, Italy.

Mechanical intravascular hemolysis is frequently observed following procedures on heart valves and uncommonly observed in native valvular disease. In most cases, its severity is mild. Nevertheless, it can be clinically significant and even life threatening, requiring multiple blood transfusions and renal replacement therapy. Read More

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