Diagn Mol Pathol 2007 Mar;16(1):50-3
Molecular Pathology Laboratory, Department of Pathology, Montefiore Medical Center, Albert Einstien College of Medicine, Bronx, NY 10467, USA.
UDP glucuronosyltransferase (UGT) 1A1 gene promoter polymorphism can affect the expression level of the UGT 1A1 enzyme. The polymorphism consists of an insertion of a TA nucleotide sequence into a (TA)6TAA sequence in the gene promoter resulting in (TA)7TAA (UGT1A1*28). This results in a reduced UGT 1A1 expression with 70% less glucuronidation capacity for bilirubin and other UGT1A1 substrates. Read More