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Macular choroidal thickness: evaluation of variability among measurements and assessment of predictive value of glaucomatous visual field damage.

Ophthalmic Res 2021 Nov 22. Epub 2021 Nov 22.

Introduction: To investigate the relationship between the choroidal circulation and glaucoma, assessing macular choroidal thickness (MCT) as a predictive value of glaucomatous visual field damage.

Methods: Twenty primary open-angle glaucoma patients were recruited. Patients underwent two SS-OCTs scans: one with DRI OCT (Topcon) and the other with PLEX Elite 9000 (Zeiss). Read More

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November 2021

Quantitative evaluation of fetal ventricular function by speckle tracking echocardiography.

Echocardiography 2021 Nov 9;38(11):1924-1931. Epub 2021 Nov 9.

Department of Ultrasonic Medicine, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, China.

Methods: The study included 59 patients with normal fetal heart structure, blood flow, and heart rhythm (fetal abnormality-negative group) and 50 patients with abnormal fetal heart structure, blood flow, and/or heart rhythm (fetal abnormality-positive group). Automated Cardiac Motion Quantification (aCMQ) was performed in both groups to obtain left and right ventricular endocardial global longitudinal strain (GLSendo), mid-myocardial global longitudinal strain (GLSmid), and epicardial global longitudinal strain (GLSepi). Parameters between the two groups were compared and correlation analyses performed. Read More

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November 2021

Application of BOLDMRIbased radiomics in differentiating malignant from benign renal tumors.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Sept 28;46(9):1010-1017

Department of Radiology, Third Affiliated Hospital of Soochow University, Changzhou Jiangsu 213003.

Objectives: Blood oxygen level dependent magnetic resonance imaging (BOLD-MRI) is a kind of non-invasive MRI technology which reflects the tissue blood oxyen levels. This stuy aims to explore the value of radiomics based on BOLD-MRI in differentiating malignant from benign renal tumors.

Methods: A total of 141 patients with renal tumors confirmed by pathology were retrospectively analyzed. Read More

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October 2021

Reliability of the freehand region-of-interest method in quantitative cerebral diffusion tensor imaging.

BMC Med Imaging 2021 10 4;21(1):144. Epub 2021 Oct 4.

Department of Radiology, Medical Imaging Center of Pirkanmaa Hospital District, Tampere, Finland.

Background: Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique used for evaluating changes in the white matter in brain parenchyma. The reliability of quantitative DTI analysis is influenced by several factors, such as the imaging protocol, pre-processing and post-processing methods, and selected diffusion parameters. The region-of-interest (ROI) method is most widely used of the post-processing methods because it is found in commercial software. Read More

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October 2021

Repeatability and reproducibility of deep-learning-based liver volume and Couinaud segment volume measurement tool.

Abdom Radiol (NY) 2021 Oct 4. Epub 2021 Oct 4.

Perspectum Ltd., Gemini One, 5520 John Smith Drive, Oxford, OX4 2LL, UK.

Purpose: Volumetric and health assessment of the liver is crucial to avoid poor post-operative outcomes following liver resection surgery. No current methods allow for concurrent and accurate measurement of both Couinaud segmental volumes for future liver remnant estimation and liver health using non-invasive imaging. In this study, we demonstrate the accuracy and precision of segmental volume measurements using new medical software, Hepatica™. Read More

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October 2021

Precision of MRI radiomics features in the liver and hepatocellular carcinoma.

Eur Radiol 2021 Sep 26. Epub 2021 Sep 26.

BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Objectives: To assess the precision of MRI radiomics features in hepatocellular carcinoma (HCC) tumors and liver parenchyma.

Methods: The study population consisted of 55 patients, including 16 with untreated HCCs, who underwent two repeat contrast-enhanced abdominal MRI exams within 1 month to evaluate: (1) test-retest repeatability using the same MRI system (n = 28, 10 HCCs); (2) inter-platform reproducibility between different MRI systems (n = 27, 6 HCCs); (3) inter-observer reproducibility (n = 16, 16 HCCs). Shape and 1st- and 2nd-order radiomics features were quantified on pre-contrast T1-weighted imaging (WI), T1WI portal venous phase (pvp), T2WI, and ADC (apparent diffusion coefficient), on liver regions of interest (ROIs) and HCC volumes of interest (VOIs). Read More

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September 2021

Reliability of MRI radiomics features in MR-guided radiotherapy for prostate cancer: Repeatability, reproducibility, and within-subject agreement.

Med Phys 2021 Nov 25;48(11):6976-6986. Epub 2021 Sep 25.

Medical Physics and Research Department, Hong Kong Sanatorium & Hospital, Hong Kong, Hong Kong, SAR, China.

Purpose: The MR-guided radiotherapy (MRgRT) images on the integrated MRI and linear accelerator (MR-LINAC) might facilitate radiomics analysis for longitudinal treatment response assessment. However, the reliability of MRgRT radiomics features is largely unknown. This study aims to investigate MRgRT radiomics feature reliability acquired using a standardized 3D-T2W-TSE sequence in terms of repeatability, reproducibility, and within-subject feature agreement on a 1. Read More

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November 2021

Reliability of performing ultrasound derived SWE and fat fraction in adult livers.

Clin Imaging 2021 Dec 17;80:424-429. Epub 2021 Sep 17.

Rocky Vista University, Ivins, UT, USA.

Purpose: The aim of the study was to test the reproducibility of performing conventional point shear wave elastography (pSWE), auto-pSWE, and ultrasound derived fat fraction (UDFF) in adult livers.

Methods: The Institutional Review Board approved the study and all participants provided written informed consent. Conventional pSWE (obtaining 10 measurements through 10 acquisitions), auto-pSWE (automatically obtaining 15 measurements by a single acquisition), and UDFF (one measurement obtained by one acquisition) of the liver were prospectively performed in 21 participants (10 men, 11 women, mean age 63y) by senior and junior operators in February-May 2021. Read More

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December 2021

Novel method of transpulmonary pressure measurement with an air-filled esophageal catheter.

Intensive Care Med Exp 2021 Sep 17;9(1):47. Epub 2021 Sep 17.

Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.

Background: There is a strong rationale for proposing transpulmonary pressure-guided protective ventilation in acute respiratory distress syndrome. The reference esophageal balloon catheter method requires complex in vivo calibration, expertise and specific material order. A simple, inexpensive, accurate and reproducible method of measuring esophageal pressure would greatly facilitate the measure of transpulmonary pressure to individualize protective ventilation in the intensive care unit. Read More

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September 2021

Comparing the results of manual and automated quantitative corneal neuroanalysing modules for beginners.

Sci Rep 2021 09 14;11(1):18208. Epub 2021 Sep 14.

Department of Ophthalmology, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, Taiwan.

This study aimed to evaluate the reliability of in vivo confocal microscopic neuroanalysis by beginners using manual and automated modules. Images of sub-basal corneal nerve plexus (SCNP) from 108 images of 18 healthy participants were analyzed by 7 beginner observers using manual (CCMetrics, [CCM]) and automated (ACCMetrics, [ACCM]) module. SCNP parameters analyzed included corneal nerve fiber density (NFD), corneal nerve branch density (NBD), corneal nerve fiber length (NFL), and tortuosity coefficient (TC). Read More

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September 2021

Artificial intelligence-assisted system for precision diagnosis of PD-L1 expression in non-small cell lung cancer.

Mod Pathol 2021 Sep 13. Epub 2021 Sep 13.

Genome Wisdom Inc, Beijing, China.

Standardized programmed death-ligand 1 (PD-L1) assessment in non-small cell lung cancer (NSCLC) is challenging, owing to inter-observer variability among pathologists and the use of different antibodies. There is a strong demand for the development of an artificial intelligence (AI) system to obtain high-precision scores of PD-L1 expression in clinical diagnostic scenarios. We developed an AI system using whole slide images (WSIs) of the 22c3 assay to automatically assess the tumor proportion score (TPS) of PD-L1 expression based on a deep learning (DL) model of tumor detection. Read More

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September 2021

Computer-Aided Fracture Size Measurement in Orbital Fractures-An Alternative to Manual Evaluation.

Craniomaxillofac Trauma Reconstr 2021 Sep 7;14(3):209-217. Epub 2020 Oct 7.

Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Objective: We aimed to present a novel semiautomated tool for orbital fracture size measurement and to compare the variability of the proposed method with traditional manual measurements.

Methods: Maximal anteroposterior (AP) and mediolateral (ML) dimensions of orbital fractures from computed tomography images were measured for 15 patients with unilateral orbital fractures by 2 surgeons manually and with a semiautomatic software. Variability was assessed with Bland-Altman limits of agreement plots and intra-class correlation coefficients (ICCs). Read More

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September 2021

Polarization properties of retinal blood vessel walls measured with polarization sensitive optical coherence tomography.

Biomed Opt Express 2021 Jul 23;12(7):4340-4362. Epub 2021 Jun 23.

Optical+Biomedical Engineering Laboratory, Department of Electrical, Electronic and Computer Engineering, The University of Western Australia, Perth WA 6009, Australia.

A new method based on polarization-sensitive optical coherence tomography (PS-OCT) is introduced to determine the polarization properties of human retinal vessel walls, . Measurements were obtained near the optic nerve head of three healthy human subjects. The double pass phase retardation per unit depth (DPPR/UD), which is proportional to the birefringence, is higher in artery walls, presumably because of the presence of muscle tissue. Read More

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Reliability and agreement of the central and mid-peripheral corneal thickness measured by a new Scheimpflug based imaging.

Ann Transl Med 2021 Jul;9(14):1136

Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China.

Background: To assess the intra-observer repeatability and inter-observer reproducibility of central corneal thickness (CCT) and mid-peripheral corneal thickness (MPCT) measurements using a new Scheimpflug imaging instrument (Scansys) and compare the agreement with the rotating Scheimpflug corneal tomographer (Pentacam HR).

Methods: The same well-trained operator performed the measuring using the two devices, after which Scansys measurements were repeated by another operator. Both instruments required three consecutive measurements per subject. Read More

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Transepicondylar Distance Can Predict Graft and Tunnel Length for Different Pediatric Anterior Cruciate Ligament Reconstruction Techniques: A Magnetic Resonance Imaging Study.

Arthroscopy 2021 Aug 21. Epub 2021 Aug 21.

AO Ordine Mauriziano Hospital, Department of Orthopaedics and Traumatology, University of Torino, Torino, Italy.

Purpose: To find a correlation and mathematical formulas between a linear 2-dimensional (2D) magnetic resonance imaging (MRI) measurement around the knee and the length of the grafts and tunnels required for both all-inside-all-epiphyseal and Kocher-Micheli pediatric anterior cruciate ligament (ACL) reconstruction techniques.

Methods: At time 0 and 30 days after, 2 observers measured: (1) on standard 2D knee MRI, 7 linear distances, representing morphologic measurements, such as transepicondylar distance (TD), and (2) on 3-dimensional (3D) MRI, 5 curved distances, corresponding to Kocher-Micheli and all-epiphyseal ACL reconstruction techniques. Intra- and interobserver reliability was tested for all measurements. Read More

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Scoring system assessing mucosal visibility of upper gastrointestinal tract: The POLPREP scale.

J Gastroenterol Hepatol 2021 Aug 16. Epub 2021 Aug 16.

Department of Gastroenterology and Hepatology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Background And Aim: The proper visibility of mucosa during esophagogastroduodenoscopy (EGD) is crucial for the detection of early upper gastrointestinal tract lesions. In contrast to colonoscopy, no validated scoring system for the assessment of upper gastrointestinal mucosal cleanliness has been developed so far. The aim of the study was to create and validate standardized grading system (POLPREP) to assess the mucosal cleanliness during EGD. Read More

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Repeatability of Apparent Diffusion Coefficient at 3.0 Tesla in Normal Pancreas.

Cureus 2021 Jun 18;13(6):e15734. Epub 2021 Jun 18.

Radiology, Changhai Hospital of Shanghai, Shanghai, CHN.

Purpose: To evaluate the apparent diffusion coefficient (ADC) test-retest repeatability of the normal pancreas based on diffusion-weighted imaging (DWI).

Methods: Twenty-six healthy volunteers (mean 47.6 years; 13 men) were included and scanned twice with reposition for a DWI sequence at 3. Read More

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Repeatability and Reproducibility of Anterior Chamber Angle Measurement with Swept-Source Optical Coherence Tomography in Patients with Primary Angle Closure Suspect.

Curr Eye Res 2021 Jul 12:1-8. Epub 2021 Jul 12.

Department of Ophthalmology, University of California, San Francisco, California, USA.

: To evaluate the inter- and intra-observer reliability of anterior chamber (AC) angle measurements obtained by swept-source optical coherence tomography (SS-OCT). Forty-eight consecutive patients diagnosed with primary angle closure suspect (PACS) were included. Three masked observers at different training levels (one glaucoma specialist, one ophthalmology resident, and one pre-medical college student) measured 192 SS-OCT images of the PACS patients. Read More

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Improving 3D-3D facial registration methods: potential role of three-dimensional models in personal identification of the living.

Int J Legal Med 2021 Nov 9;135(6):2501-2507. Epub 2021 Jul 9.

Dipartimento Di Scienze Biomediche Per La Salute, LABANOF, Laboratorio Di Antropologia E Odontologia Forense, Università Degli Studi Di Milano, Via Mangiagalli 37, 20133, Milano, Italy.

Personal identification of the living from video surveillance systems usually involves 2D images. However, the potentiality of three-dimensional facial models in gaining personal identification through 3D-3D comparison still needs to be verified. This study aims at testing the reliability of a protocol for 3D-3D registration of facial models, potentially useful for personal identification. Read More

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November 2021

Volk eye check ocular measurement device for objective periorbital measurements: A prospective study.

J Cosmet Dermatol 2021 Jul 1. Epub 2021 Jul 1.

Clinical Epidemiology & Biostatistics Service, LV Prasad Eye Institute, Hyderabad, India.

Background: Volk Eye Check (VEC) is a portable digital ocular measurement device that automatically captures clinical photographs with facial measurements in real time (Volk Optical Inc), claiming to reduce measurement errors. The accuracy and repeatability of this ocular measurement device in the periorbital region has not been reported.

Aim: To report the reproducibility and repeatability of periocular biometric measurements using Volk Eye Check Ocular measurement device. Read More

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Repeatability of PDA diameter measurements on echocardiography.

Eur J Pediatr 2021 Jun 29. Epub 2021 Jun 29.

Neonatal Intensive Care Unit, St George's University Hospital NHS Trust, Blackshaw Road, London, SW17 0QT, UK.

Diameter of the patent ductus arteriosus (PDA) on transthoracic echocardiography (TTE) is used as a marker of haemodynamic significance. We aimed to assess the intra- and inter-observer variability in PDA diameter in babies born at ≤ 30 weeks' gestation. TTEs for 56 infants were performed by a single neonatologist. Read More

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Repeatability and inter-observer variation of choroidal thickness measurements using swept-source optical coherence tomography in myopic danish children aged 6-14 years.

Acta Ophthalmol 2021 Jun 14. Epub 2021 Jun 14.

Department of Ophthalmology, Lillebaelt Hospital, University Hospital of Southern Denmark, Odense, Denmark.

Purpose: To estimate repeatability and inter-observer variation of choroidal thickness measurements in myopic Danish children aged 7-14 years using swept-source optical coherence tomography (SS-OCT).

Methods: Thirty-nine children were enrolled. Optical correction was single-vision spectacles (SVS) or orthokeratology lenses (OKL). Read More

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Inter-observer and intra-observer reliability of the myopic traction maculopathy staging system.

Eur J Ophthalmol 2021 Jun 6:11206721211023319. Epub 2021 Jun 6.

Eyecare Clinic, Brescia, Italy.

Aim: The aim of this study is to evaluate the inter-observer and intra-observer agreement of the myopic traction maculopathy (MTM) staging system (MSS).

Methods: The agreement test for MSS was based on the evaluation of 104 optical coherence tomography (OCT) scans from 104 myopic eyes. According to the MSS, six observers were asked to identify, in each image, one among four retinal patterns and one among three foveal patterns of MTM, the presence of an outer lamellar macular hole (OLMH) and an epiretinal membrane (ERM). Read More

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Quantitative T2* imaging of iron overload in a non-dedicated center - Normal variation, repeatability and reader variation.

Eur J Radiol Open 2021 24;8:100357. Epub 2021 May 24.

Department of Medical Physics, Faculty of Medicine and Health, Örebro University, Sweden.

Background: Patients with transfusion dependent anemia are at risk of complications from iron overload. Quantitative T2* magnetic resonance imaging (MRI) is the best non-invasive method to assess iron deposition in the liver and heart and to guide chelation therapy.

Purpose: To investigate the image quality and inter-observer variations in T2* measurements of the myocardium and the liver, and to obtain the lower limit of cardiac and hepatic quantitative T2* values in patients without suspicion of iron overload. Read More

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Test-retest assessment of non-contrast MRI sequences to characterise and quantify the small bowel wall in healthy participants.

MAGMA 2021 Dec 5;34(6):791-804. Epub 2021 Jun 5.

Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK.

Objective: Quantitative Magnetic Resonance Imaging sequences have been investigated as objective imaging biomarkers of fibrosis and inflammation in Crohn's disease.

Aim: To determine the repeatability and inter- and intra-observer agreement of these measures in the prepared small bowel wall.

Methods: Ten healthy participants were scanned at 3 T on 2 separate occasions using T1 and T2 relaxometry, IVIM-DWI and MT sequences. Read More

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December 2021

Development and evaluation of a method to define a tibial coordinate system through the fitting of geometric primitives.

Int Biomech 2021 12;8(1):12-18

Alliance for Research in Exercise, Nutrition and Activity (ARENA), School of Health Sciences, University of South Australia, Adelaide, SA, Australia.

Coordinate system definition is a critical element of biomechanical modeling of the knee, and cases of skeletal trauma present major technical challenges. This paper presents a method to define a tibial coordinate system by fitting geometric primitives to surface anatomy requiring minimal user input. The method presented here utilizes a conical fit to both the tibial shaft and femoral condyles to generate independent axes forming the basis of a tibial coordinate system. Read More

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December 2021

Reliability of Performing Multiparametric Ultrasound in Adult Livers.

J Ultrasound Med 2021 May 13. Epub 2021 May 13.

Rocky Vista University, Ivins, Utah, USA.

Purpose: The aim of the study was to test inter-observer and intra-observer reliability of measuring multiparametric ultrasound in adult livers.

Methods: We prospectively measured shear wave velocity (SWV, m/s), shear wave dispersion slope (SWD, m/s/kHz), attenuation coefficient (ATI, dB/cm/MHz), normalized local variance (NLV), and echo intensity ratio of liver to kidney (L/K ratio) in 21 adults who underwent liver magnetic resonance imaging-proton density fat fraction (MRI-PDFF). Intraclass correlation coefficient and 95% Bland-Altman limits of agreement (95% LOA) were used to analyze intra- and inter-observer reproducibility. Read More

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Nailfold videocapillaroscopic changes in patients with pulmonary arterial hypertension associated with connective tissue diseases.

Rheumatol Int 2021 07 12;41(7):1289-1298. Epub 2021 May 12.

Fourth Department of Internal Medicine, Hippokration University Hospital, Medical School, Aristotle University of Thessaloniki, 49 Konstantinoupoleos Street, 54642, Thessaloníki, Greece.

Pulmonary arterial hypertension (PAH) represents one of the most devastating complications in connective tissue diseases (CTDs). The aim of this study was to investigate the presence of peripheral microangiopathy in patients with PAH associated with CTDs (CTD-PAH) by exploring nailfold videocapillaroscopic (NVC) changes and identify possible associations of NVC characteristics with markers of disease severity. Α cross-sectional study was performed in 18 CTD-PAH patients [13 PAH due to systemic sclerosis (SSc-PAH) and 5 with other types of CTD-PAH], 14 patients with SSc without PAH (SSc-non-PAH) and 20 healthy controls. Read More

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Effect of ECG-gating Retinal Photographs on Retinal Vessel Caliber Measurements in Subjects with and without Type 2 Diabetes.

Curr Eye Res 2021 11 26;46(11):1742-1750. Epub 2021 May 26.

Department of Cardiology, Westmead Hospital, Sydney, Australia.

: Retinal vessel caliber is an independent risk marker of cardiovascular disease risk. However, variable mechanical delays in capturing retinal photographs and cardiac cycle-induced retinal vascular changes have been shown to reduce the accuracy of retinal vessel caliber measurements, but this has only ever been investigated in healthy subjects. This cross-sectional study is the first study to investigate this issue in type 2 diabetes. Read More

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November 2021

Attenuation parameter and liver stiffness measurement using FibroTouch vs Fibroscan in patients with chronic liver disease.

PLoS One 2021 3;16(5):e0250300. Epub 2021 May 3.

Faculty of Medicine, Department of Medicine, Gastroenterology and Hepatology Unit, University of Malaya, Kuala Lumpur, Malaysia.

Background & Aim: We studied FibroTouch (FT) and Fibroscan (FS) examination results and their repeatability when performed by healthcare personnel of different background.

Methods: FT and FS examinations were performed on patients with chronic liver disease by two operators, a doctor and a nurse, twice on each patient, at two different time points, independent of each other.

Results: The data for 163 patients with 1304 examinations was analyzed. Read More

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October 2021