235,975 results match your criteria repair techniques


Effect of Nimodipine and Botulinum Toxin A on Peripheral Nerve Regeneration in Rats: A Pilot Study.

J Surg Res 2021 Apr 7;264:208-221. Epub 2021 Apr 7.

University of Wisconsin School of Medicine and Public Health, Division of Plastic Surgery, Department of Surgery, Madison, Wisconsin. Electronic address:

Background: Peripheral nerve damage is a frequent problem, with an estimated 2.8%-5.0% of trauma admissions involving peripheral nerve injury. Read More

View Article and Full-Text PDF

Onlay Poly-4-Hydroxybutyrate (P4HB) Mesh for Complex Hernia: Early Clinical and Patient Reported Outcomes.

J Surg Res 2021 Apr 7;264:199-207. Epub 2021 Apr 7.

Division of Plastic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA. Electronic address:

Background: While mesh re-enforcement and advanced surgical techniques are cornerstones of complex ventral hernia repair (CVHR), the risk of complications and recurrence is common. We aim to evaluate the efficacy, safety, and patient reported outcomes (PROs) of patients undergoing CVHR with onlay Poly-4-hydroxybutyrate (P4HB).

Methods: Adult (>18 y old) patients undergoing VHR with P4HB (Phasix) in the onlay plane by a single surgeon from 01/2015 to 05/2020 were reviewed. Read More

View Article and Full-Text PDF

Isolation and culture of adult murine cardiac atrial and ventricular fibroblasts and myofibroblasts.

Methods 2021 Apr 7. Epub 2021 Apr 7.

Montreal Heart Institute, 5000 Belanger, Montréal, Québec, H1T 1C8, Canada; Departments of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Québec, H3C 3J7, Canada; Pharmacology and Physiology, Université de Montréal, Montréal, Québec, H3C 3J7, Canada; Université de Montréal, Montréal, Québec, H3C 3J7, Canada. Electronic address:

Cardiac fibroblasts play a critical role in extracellular matrix homeostasis, wound healing, and cardiac interstitial fibrosis: the latter being a pathophysiological response to a chronic increase in afterload. Using a standard protocol to isolate cardiac fibroblasts and maintain them in their quiescent phenotype in vitro will enable a better understanding of cardiac fibroblast biology and their role in the response to profibrotic stimuli. Here, we describe an enzymatic method for isolating cardiac fibroblasts. Read More

View Article and Full-Text PDF

Stent Graft Oversizing is Associated with an Increased Risk of Long-Term Left Ventricular Wall Thickening in Young Patients Following Thoracic Endovascular Aortic Repair.

Ann Vasc Surg 2021 Apr 7. Epub 2021 Apr 7.

Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, Emory University School of Medicine, Atlanta, GA.

Introduction: Left ventricular (LV) wall thickening occurs in patients following thoracic endovascular aortic repair (TEVAR). Clinical consequences of cardiovascular (CV) remodeling may be more significant younger patients with longer anticipated life spans. Risk factors for CV remodeling following TEVAR are unknown but may be related to graft size. Read More

View Article and Full-Text PDF

Update of a model to predict outcomes after endovascular aneurysm repair.

Ann Vasc Surg 2021 Apr 7. Epub 2021 Apr 7.

Discipline of Surgery, The University of Adelaide, The Queen Elizabeth Hospital, Woodville South, South Australia 5011, Australia; Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville South, Australia, 5011. Electronic address:

Objectives: Risk assessment models must be continuously validated and updated to ensure that predictions remain valid. Here, the Endovascular Aneurysm Repair Risk Assessment Model, developed in 2008, is updated and improved.

Methods: We used prospectively collected data from Australian patients who underwent elective endovascular aneurysm repair between 2009 and 2013 (n=695). Read More

View Article and Full-Text PDF

Use of Indocyanine Green During Repair of a Superior Mesenteric Artery Aneurysm.

Ann Vasc Surg 2021 Apr 7. Epub 2021 Apr 7.

Division of Vascular and Endovascular Surgery, University of Louisville, Louisville, Kentucky, USA. Electronic address:

Superior mesenteric artery (SMA) aneurysms are rare and associated with a high risk of rupture, with resultant significant morbidity and mortality. During open operative repair of a superior mesenteric artery aneurysm, perfusion of the involved small bowel must be evaluated when determining need for and/or extent of vascular reconstruction. We present a case of a 51-year-old woman who underwent open repair of a non-ruptured superior mesenteric artery aneurysm with ligation and excision, in whom no revascularization was determined to be needed and the involved small bowel was able to be preserved, with intraoperative evaluation of perfusion using indocyanine green (ICG) fluorescence imaging, as an adjunct to more traditional methods of perfusion assessment. Read More

View Article and Full-Text PDF

Adjunctive False Lumen Intervention for Chronic Aortic Dissections is Safe but Offers Unclear Benefit.

Ann Vasc Surg 2021 Apr 7. Epub 2021 Apr 7.

Division of Vascular Surgery, Department of Surgery, NYU Langone Health, New York, NY. Electronic address:

Objective: Adjunctive false lumen embolization (FLE) with thoracic endovascular aortic repair (TEVAR) in patients with chronic aortic dissection is thought to induce FL thrombosis and favorable aortic remodeling. However, these data are derived from small single-institution experiences and the potential benefit of FLE remains unproven. In this study, we examined perioperative and midterm outcomes of patients with aortic dissection undergoing concomitant TEVAR and FLE. Read More

View Article and Full-Text PDF

Pharmacological inhibition of HSP90 radiosensitizes HNSCC xenograft by inhibition of DNA damage repair, nucleotide metabolism, and radiation-induced tumor vasculogenesis.

Int J Radiat Oncol Biol Phys 2021 Apr 7. Epub 2021 Apr 7.

Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD. Electronic address:

Purpose: Recent pre-clinical studies suggest combining the HSP90 inhibitor AT13387 (Onalespib) with radiation (IR) against colon cancer and HNSCC. These studies emphasized that AT13387 down-regulates HSP90 client proteins involved in oncogenic signaling and DNA repair mechanisms as major drivers of enhanced radiosensitivity. Given the large array of client proteins HSP90 directs, we hypothesized that other key proteins or signaling pathways may be inhibited by AT13387 and contribute to enhanced radiosensitivity. Read More

View Article and Full-Text PDF

Combining chitin biological conduits with small autogenous nerves and platelet-rich plasma for the repair of sciatic nerve defects in rats.

CNS Neurosci Ther 2021 Apr 10. Epub 2021 Apr 10.

Department of Orthopedics and Trauma, Key Laboratory of Trauma and Neural Regeneration (Ministry of Education/Peking University, Peking University People's Hospital, Beijing, 100044, China.

Aims: Peripheral nerve defects are often difficult to recover from, and there is no optimal repair method. Therefore, it is important to explore new methods of repairing peripheral nerve defects. This study explored the efficacy of nerve grafts constructed from chitin biological conduits combined with small autogenous nerves (SANs) and platelet-rich plasma (PRP) for repairing 10-mm sciatic nerve defects in rats. Read More

View Article and Full-Text PDF

What is the reality in epigastric hernia repair?-a trend analysis from the Herniamed Registry.

Hernia 2021 Apr 10. Epub 2021 Apr 10.

Pius Hospital, Department of General and Visceral Surgery, University Hospital of Visceral Surgery, Georgstrasse 12, 26121, Oldenburg, Germany.

Introduction: The proportion of epigastric hernias in the total collective of all operated abdominal wall hernias is 3.6-6.9%. Read More

View Article and Full-Text PDF

Inguinal hernia repair in Spain. A population-based study of 263,283 patients: factors associated with the choice of laparoscopic approach.

Hernia 2021 Apr 10. Epub 2021 Apr 10.

Department of General and Digestive Surgery, Hospital Plató, c/ Plató 21, 08006, Barcelona, Spain.

Purpose: The objective of this study is to evaluate the laparoscopic inguinal hernia repair (IHR) rate in Spain and identify the factors associated with the choice of this surgical approach.

Methods: A retrospective cohort study of 263,283 patients who underwent IHR from January 2016 to December 2018 was conducted. Data were extracted from the Spanish Minimum Basic Data Set (MBDS) of the Health Ministry database. Read More

View Article and Full-Text PDF

Cell lines of the same anatomic site and histologic type show large variability in intrinsic radiosensitivity and relative biological effectiveness to protons and carbon ions.

Med Phys 2021 Apr 10. Epub 2021 Apr 10.

The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.

Purpose: To show that intrinsic radiosensitivity varies greatly for protons and carbon (C) ions in addition to photons, and that DNA repair capacity remains important in governing this variability.

Methods: We measured or obtained from the literature clonogenic survival data for a number of human cancer cell lines exposed to photons, protons (9.9 keV/μm), and C-ions (13. Read More

View Article and Full-Text PDF

Pre-surgical Prediction of Ischemic Mitral Regurgitation Recurrence Using In Vivo Mitral Valve Leaflet Strains.

Ann Biomed Eng 2021 Apr 9. Epub 2021 Apr 9.

James T. Willerson Center for Cardiovascular Modeling and Simulation, Oden Institute for Computational Engineering and Sciences, Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.

Ischemic mitral regurgitation (IMR) is a prevalent cardiac disease associated with substantial morbidity and mortality. Contemporary surgical treatments continue to have limited long-term success, in part due to the complex and multi-factorial nature of IMR. There is thus a need to better understand IMR etiology to guide optimal patient specific treatments. Read More

View Article and Full-Text PDF

A long-term follow-up study of minimally invasive Ivor Lewis esophagectomy with linear stapled anastomosis.

Surg Endosc 2021 Apr 9. Epub 2021 Apr 9.

Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: Minimally invasive esophagectomy (MIE) is increasingly performed to expect lower complication rate compared to open esophagectomy. Studies of minimally invasive Ivor Lewis esophagectomy (MIILE) with circular staplers have reported better outcomes compared to MIE with cervical anastomosis, but frequent anastomotic complications have also been reported. MIILE with linear staplers is a promising alternative, but the long-term functional and oncological outcomes are uncertain. Read More

View Article and Full-Text PDF

PASCAL mitral valve repair system versus MitraClip: comparison of transcatheter edge-to-edge strategies in complex primary mitral regurgitation.

Clin Res Cardiol 2021 Apr 10. Epub 2021 Apr 10.

Clinic for General and Interventional Cardiology/Angiology, Herz- Und Diabeteszentrum NRW, Ruhr-Universität Bochum, Georgstraße 11, 32545, Bad Oeynhausen, Germany.

Background: The PASCAL system is a novel device for edge-to-edge treatment of mitral regurgitation (MR). The aim of this study was to compare the safety and efficacy of the PASCAL to the MitraClip system in a highly selected group of patients with complex primary mitral regurgitation (PMR) defined as effective regurgitant orifice area (MR-EROA) ≥ 0.40 cm, large flail gap (≥ 5 mm) or width (≥ 7 mm) or Barlow's disease. Read More

View Article and Full-Text PDF

Dosimetric evaluation of receptor-heterogeneity on the therapeutic efficacy of peptide receptor radionuclide therapy: correlation with DNA damage induction and survival.

J Nucl Med 2021 Apr 9. Epub 2021 Apr 9.

Erasmus MC, Netherlands.

To build a refined dosimetry model for [Lu]Lu-DOTA-[Tyr]octreotate (Lu-DOTATATE) experiments enabling the correlation of absorbed dose with double strand breaks (DSBs) induction and cell death. Somatostatin receptor type-2 (SSTR) expression of NCI-H69 xenografted mice, injected with Lu-DOTATATE, was imaged at 0, 2, 5, 11 days. This was used as input to reconstruct realistic 3 dimensional heterogeneous activity distributions and tissue geometries of both cancer and heathy cells. Read More

View Article and Full-Text PDF

Intratumoral OH2, an oncolytic herpes simplex virus 2, in patients with advanced solid tumors: a multicenter, phase I/II clinical trial.

J Immunother Cancer 2021 Apr;9(4)

Binhui Biopharmaceutical Co., Ltd, Wuhan, China.

Background: OH2 is a genetically engineered oncolytic herpes simplex virus type 2 designed to selectively amplify in tumor cells and express granulocyte-macrophage colony-stimulating factor to enhance antitumor immune responses. We investigated the safety, tolerability and antitumor activity of OH2 as single agent or in combination with HX008, an anti-programmed cell death protein 1 antibody, in patients with advanced solid tumors.

Methods: In this multicenter, phase I/II trial, we enrolled patients with standard treatment-refractory advanced solid tumors who have injectable lesions. Read More

View Article and Full-Text PDF

Rotator Cuff Repair and Reconstruction.

J Hand Surg Am 2021 Apr 6. Epub 2021 Apr 6.

Orthopaedics and Sports Medicine Institute, University of Florida, Gainesville, FL.

Rotator cuff pathology is the most common shoulder condition for which patients seek treatment. Schmidt et al covered the relevant anatomy, natural history, nonsurgical and surgical treatment, biological augmentation, and postoperative rehabilitation in their comprehensive review published in 2015. This current review builds upon the last update, discussing the most recent evidence-based medicine regarding rotator cuff repair: primary repair, revision repair, and reconstructive techniques for superior capsular reconstruction, subacromial balloon spacers, tendon transfer options (pectoralis major, latissimus dorsi, and lower trapezius), and reverse total shoulder arthroplasty. Read More

View Article and Full-Text PDF

An exploratory focus group study on experiences with snakebites: health-seeking behaviour and challenges in rural communities of Kenya.

Trans R Soc Trop Med Hyg 2021 Apr 9. Epub 2021 Apr 9.

Health Action International, Overtoom 60 (2), 1054 HK Amsterdam, the Netherlands.

Background: Snakebite envenoming is a long-hidden public health threat in the rural communities of Kenya. This study aimed to shed light on the health-seeking behaviour of people bitten by snakes, views on prevention measures and community needs and the consequences for snakebite patients in these areas.

Methods: Six focus group interviews were conducted in communities in the Kajiado (n=3) and Kilifi (n=3) counties. Read More

View Article and Full-Text PDF

The Administrative Risk Analysis Index (RAI-A) Does Not Predict Reintervention or Mortality Within 30 Days in Patients Who Undergo Elective Open or Endovascular Abdominal Aortic Aneurysm Repair.

Authors:
Jeanette Man Jun Xu

J Surg Res 2021 Apr 6;264:179-185. Epub 2021 Apr 6.

Department of Surgery, Division of Vascular Surgery, University of Iowa, Iowa City, Iowa. Electronic address:

Objective: Frailty scores are increasingly utilized to predict postoperative complications. The purpose of this study is to determine whether the administrative risk analysis index (RAI-A) can be used to predict reintervention or mortality within 30 days in patients who undergo elective open or endovascular abdominal aortic aneurysm (AAA) repair.

Methods: The American College of Surgeons National Surgical Quality Improvement Program database was used to query data from elective open or endovascular aortic aneurysm repairs from 2011 to 2018. Read More

View Article and Full-Text PDF

PILP remineralization of artificial and natural dentin carious lesions evaluated by nanoindentation and microcomputed tomography.

J Dent 2021 Apr 6:103659. Epub 2021 Apr 6.

Department of Preventative and Restorative Dental Sciences, UCSF School of Dentistry, San Francisco, CA, USA. Electronic address:

Objectives: The study evaluates the efficacy to remineralize artificial and natural dentin lesions through restorative dental procedures that include the Polymer-Induced Liquid Precursor (PILP) method comprising polyaspartic acid (pAsp).

Methods: Novel ionomeric cement compositions based on bioglass 45S5 and pAsp mixtures, as well as conditioning solutions (conditioner) containing 5 mg/ml pAsp, were developed and tested on demineralized dentin blocks (3-4 mm thick) on shallow and deep lesions with the thickness of 150 µm ± 50 and 700 µm ± 50, respectively. In the first treatment group, 20 µl of conditioner was applied to demineralized shallow (n = 3) and deep (n = 3) lesion specimens for 20 s before restoration with glass ionomer cement (RMGIC). Read More

View Article and Full-Text PDF

OFF-LABEL USE OF A FLARED ENDOGRAFT LIMB FOR TREATMENT OF A COMPLICATED ANASTOMOTIC ABDOMINAL AORTIC PSEUDOANEURYSM: REVERSE DEPLOYMENT THROUGHT AXILLARY ARTERY.

Ann Vasc Surg 2021 Apr 6. Epub 2021 Apr 6.

Angiology and Vascular Surgery Department. Hospital Clínico Universitario de Valladolid. Universidad de Valladolid, C/ Ramón y Cajal S/N. CP 47005. Valladolid. Spain.

A case of complicated abdominal aortic pseudoaneurysm not suitable for open repair is described. It was treated by means of endovascular methods with a flared endograft limb. The uniqueness of this case is the absence of a suitable femoral access, requiring the deployment of the graft in a reversed configuration through axillary artery. Read More

View Article and Full-Text PDF

Unique Complications and Failure Modes of Iliac Branch Devices.

Ann Vasc Surg 2021 Apr 6. Epub 2021 Apr 6.

Department of Surgery, Division of Vascular & Endovascular Surgery, Stanford University School of Medicine, Stanford, CA.

Objectives: Iliac branch devices (IBDs) are modular, bifurcated endografts designed to preserve hypogastric flow during endovascular aortoiliac aneurysm repair. We report our single center outcomes, and describe the unique complications of these devices: inability to cannulate the hypogastric artery (technical failure), occlusion of the internal branch, and type III endoleak from separation of components between the main body and IBD.

Methods: A prospectively maintained institutional database of patients undergoing IBD implantation between 2014 and 2019 was reviewed. Read More

View Article and Full-Text PDF

Multiple Chimney Endografts (ChEVAR) for Ruptured Pararenal Aortic Aneurysm.

Ann Vasc Surg 2021 Apr 6. Epub 2021 Apr 6.

Division of Vascular Surgery, University of Missouri, Columbia, MO, USA. Electronic address:

We present a ruptured pararenal abdominal aortic aneurysm (AAA) repaired with a complex three-vessel chimney EVAR (ChEVAR). This technique allows for rapid sealing of the aneurysm with branch preservation and avoids complex open aortic surgery. This case report highlights techniques and pitfalls from ChEVAR repair in the emergency setting. Read More

View Article and Full-Text PDF

Chlamydomonas POLQ is necessary for CRISPR/Cas9-mediated gene targeting.

G3 (Bethesda) 2021 Apr 9. Epub 2021 Apr 9.

Institute of Biology, Experimental Biophysics, Humboldt University of Berlin, Berlin, Germany, D-10099.

The use of CRISPR/Cas endonucleases has revolutionized gene editing techniques for research on Chlamydomonas reinhardtii. To better utilize the CRISPR/Cas system, it is essential to develop a more comprehensive understanding of the DNA repair pathways involved in genome editing. In this study, we have analyzed contributions from canonical KU80/KU70-dependent non-homologous end-joining and polymerase theta (POLQ)-mediated end-joining on SpCas9-mediated untemplated mutagenesis and homology-directed repair/gene inactivation in Chlamydomonas. Read More

View Article and Full-Text PDF

Matrix Metalloproteinase MMP-12 promotes macrophage transmigration across intestinal epithelial tight junctions and increases severity of experimental colitis.

J Crohns Colitis 2021 Apr 9. Epub 2021 Apr 9.

Department of Medicine, College of Medicine, Penn State University, Hershey, PA.

Background And Aims: Matrix Metalloproteinases (MMPs) play an important role in extracellular matrix regulation during cell growth and wound healing. Increased expression of MMP-12 (human macrophage elastase) has been reported in inflammatory bowel disease (IBD) which is characterized by the loss of epithelial tight junction (TJ) barrier function and an excessive inflammatory response. The aim of this study was to investigate the role of MMP-12 in intestinal TJ barrier function and inflammation. Read More

View Article and Full-Text PDF

Histochemical and Morphometrical Analyses of Scarless Wound Healing in Mouse Fetal Model.

Tokai J Exp Clin Med 2021 Apr 20;46(1):33-43. Epub 2021 Apr 20.

Department of Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-Ku, Tokyo 113-0033, Japan.

Objective: Scar formation is an inevitable outcome after craniofacial surgery in the congenital facial anomaly. Scarless healing is the ultimate treatment after the surgery. Therefore, we elucidate the mechanism underlying scarless healing during fetal development. Read More

View Article and Full-Text PDF

Lower reoperation rates after open and laparoscopic groin hernia repair when performed by high-volume surgeons: a nationwide register-based study.

Hernia 2021 Apr 9. Epub 2021 Apr 9.

Center for Perioperative Optimization, Department of Surgery, Herlev Hospital, University of Copenhagen, Borgmester Ib Juuls Vej 1, 2730, Herlev, Denmark.

Purpose: Previous studies have shown a correlation between surgeons with high annual volume and better outcomes after various surgical procedures. However, the preexisting literature regarding groin hernia repair and annual surgeon volume is limited. The aim was to investigate how annual surgeon volume affected the reoperation rates for recurrence after primary groin hernia repair. Read More

View Article and Full-Text PDF

Operating costs, fiscal impact, value analysis and guidance for the routine use of robotic technology in abdominal surgical procedures.

Surg Endosc 2021 Apr 9. Epub 2021 Apr 9.

PSJH Finance Institute, Renton, WA, USA.

Background: This study was designed to define the value, cost, and fiscal impact of robotic-assisted procedures in abdominal surgery and provide clinical guidance for its routine use.

Methods: 34,984 patients who underwent an elective cholecystectomy, colectomy, inguinal hernia repair, hysterectomy, or appendectomy over a 24-month period were analyzed by age, BMI, risk class, operating time, LOS and readmission rate. Average Direct and Total Cost per Case (ADC, TCC) and Net Margin per Case (NM) were produced for each surgical technique, i. Read More

View Article and Full-Text PDF

Non-anatomic repair of medial meniscus posterior root tears to the posterior capsule provided favourable outcomes in middle-aged and older patients.

Knee Surg Sports Traumatol Arthrosc 2021 Apr 9. Epub 2021 Apr 9.

Department of Orthopedic Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No.1665 Kongjiang Road, Shanghai, People's Republic of China.

Purpose: To describe a non-anatomic arthroscopic all-inside repair technique for middle-aged and older patients with medial meniscus posterior root tears (MMPRTs) and to evaluate the short- to mid-term clinical and radiologic results. The hypothesis was that this procedure would yield good clinical outcome results and structural healing in middle- and older-aged patients.

Methods: This was a retrospective study evaluating patients who had undergone MMPRT repair by suturing the meniscal root directly to the capsule, rather than by the transtibial technique, between 2013 and 2016. Read More

View Article and Full-Text PDF