Biomaterials 2021 May 19;275:120901. Epub 2021 May 19.
Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California, 1520 San Pablo St #2000, Los Angeles, CA, 90033, USA. Electronic address:
Bone loss associated with fracture nonunion, revision total joint arthroplasty (TJA), and pseudoarthrosis of the spine presents a challenging clinical scenario for the orthopaedic surgeon. Current treatment options including autograft, allograft, bone graft substitutes, and bone transport techniques are associated with significant morbidity, high costs, and prolonged treatment regimens. Unfortunately, these treatment strategies have proven insufficient to safely and consistently heal bone defects in the stringent biological environments often encountered in clinical cases of bone loss. Read More