7,655 results match your criteria repair involves

Molecular Mechanisms of Chondrocyte Proliferation and Differentiation.

Front Cell Dev Biol 2021 28;9:664168. Epub 2021 May 28.

Hunan University of Chinese Medicine & Hunan Academy of Chinese Medicine, Changsha, China.

Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood vessels, lymph, and nerve tissues. Repair of cartilage injury is mainly achieved by stimulating chondrocyte proliferation and extracellular matrix (ECM) synthesis. Read More

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Cell-Free Biological Approach for Corneal Stromal Wound Healing.

Front Pharmacol 2021 28;12:671405. Epub 2021 May 28.

Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, United States.

Corneal opacification is the fourth most common cause of blindness globally behind cataracts, glaucoma, and age-related macular degeneration. The standard treatment of serious corneal scarring is corneal transplantation. Though it is effective for restoring vision, the treatment outcome is not optimal, due to limitations such as long-term graft survival, lifelong use of immunosuppressants, and a loss of corneal strength. Read More

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Iliac-femoral stent-graft infection after hybrid procedure redo: Case report.

Int J Surg Case Rep 2021 Jun 8;84:106096. Epub 2021 Jun 8.

Vascular Surgery Unit, AOUP Policlinico 'P. Giaccone', Palermo, Italy; Department of Surgical, Oncological and Oral Sciences, University of Palermo, Italy.

Introduction: Stent-graft infection in peripheral arteries is rare and potentially dangerous. The use of hybrid procedures, in complicated patients previously treated, involves an increase of infective risk especially in no collaborative patients.

Presentation Of Case: We report a case of rare stent-graft infection in a patient treated for a Rutherford IV Multiple Peripheral Arterial Disease (MPAD) involving the right iliac-femoral axis with stenosis on deep femoral artery due to a previously stenting procedure for Superficial Femoral artery (SFA) stenosis. Read More

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Toward a Better Regeneration through Implant-Mediated Immunomodulation: Harnessing the Immune Responses.

Adv Sci (Weinh) 2021 Jun 12:e2100446. Epub 2021 Jun 12.

Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, 11794, USA.

Tissue repair/regeneration, after implantation or injury, involves comprehensive physiological processes wherein immune responses play a crucial role to enable tissue restoration, amidst the immune cells early-stage response to tissue damages. These cells break down extracellular matrix, clear debris, and secret cytokines to orchestrate regeneration. However, the immune response can also lead to abnormal tissue healing or scar formation if not well directed. Read More

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Perspectives on formaldehyde dysregulation: Mitochondrial DNA damage and repair in mammalian cells.

DNA Repair (Amst) 2021 May 11;105:103134. Epub 2021 May 11.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA. Electronic address:

Maintaining genome stability involves coordination between different subcellular compartments providing cells with DNA repair systems that safeguard against environmental and endogenous stresses. Organisms produce the chemically reactive molecule formaldehyde as a component of one-carbon metabolism, and cells maintain systems to regulate endogenous levels of formaldehyde under physiological conditions, preventing genotoxicity, among other adverse effects. Dysregulation of formaldehyde is associated with several diseases, including cancer and neurodegenerative disorders. Read More

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Pathophysiological Aspects of the Development of Abdominal Aortic Aneurysm with a Special Focus on Mitochondrial Dysfunction and Genetic Associations.

Biomol Concepts 2021 Jun 11;12(1):55-67. Epub 2021 Jun 11.

Department of Basic Research, Institute for Atherosclerosis Research, Moscow121609, Russia.

Abdominal aortic aneurysm (AAA) is a complex degenerative vascular disease, with considerable morbidity and mortality rates among the elderly population. The mortality of AAA is related to aneurysm expansion (the enlargement of the aortic diameter up to 30 mm and above) and the subsequent rupture. The pathogenesis of AAA involves several biological processes, including aortic mural inflammation, oxidative stress, vascular smooth muscle cell apoptosis, elastin depletion, and degradation of the extracellular matrix. Read More

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Set2-mediated H3K36 methylation states redundantly repress the production of antisense transcripts: role in transcription regulation.

FEBS Open Bio 2021 Jun 11. Epub 2021 Jun 11.

Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, RNA Institute, Wuhan University, Wuhan, 430072, China.

Methyltransferase Set2-mediated methylation of histone H3 lysine 36 (H3K36), which involves the addition of up to three methyl groups at this site, has been demonstrated to function in many chromatin-coupled events. The methylation of H3K36 is known to recruit different chromatin effector proteins, affecting transcription, mRNA splicing and DNA repair. In this study, we engineered two yeast set2 mutants that lack H3K36 mono/dimethylation (H3K36me1/2) and trimethylation (H3K36me3), respectively, and characterized their roles in the production of antisense transcripts under nutrient-rich conditions. Read More

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Severe baffle leak after Takeuchi repair successfully treated with coronary bypass and percutaneous baffle closure: a case report.

Eur Heart J Case Rep 2021 Mar 21;5(3):ytab074. Epub 2021 Mar 21.

Division of Interventional Cardiology, Department of Cardiology, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA.

Background: Anomalous left coronary artery from the pulmonary artery is a rare congenital abnormality that requires surgical correction.

Case Summary: We describe the case of a 33-year-old female with a history of anomalous left coronary artery of the pulmonary artery who presents with exertional angina. She underwent a Takeuchi repair that was complicated by a baffle leak. Read More

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Transcriptomic analysis of shell repair and biomineralization in the blue mussel, Mytilus edulis.

BMC Genomics 2021 Jun 10;22(1):437. Epub 2021 Jun 10.

British Antarctic Survey, Natural Environment Research Council, High Cross, Madingley Road, CB3 0ET, Cambridge, UK.

Background: Biomineralization by molluscs involves regulated deposition of calcium carbonate crystals within a protein framework to produce complex biocomposite structures. Effective biomineralization is a key trait for aquaculture, and animal resilience under future climate change. While many enzymes and structural proteins have been identified from the shell and in mantle tissue, understanding biomieralization is impeded by a lack of fundamental knowledge of the genes and pathways involved. Read More

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High Resolution View on the Regulation of Recombinase Accumulation in Mammalian Meiosis.

Front Cell Dev Biol 2021 24;9:672191. Epub 2021 May 24.

Department of Developmental Biology, Erasmus MC, Rotterdam, Netherlands.

A distinguishing feature of meiotic DNA double-strand breaks (DSBs), compared to DSBs in somatic cells, is the fact that they are induced in a programmed and specifically orchestrated manner, which includes chromatin remodeling prior to DSB induction. In addition, the meiotic homologous recombination (HR) repair process that follows, is different from HR repair of accidental DSBs in somatic cells. For instance, meiotic HR involves preferred use of the homolog instead of the sister chromatid as a repair template and subsequent formation of crossovers and non-crossovers in a tightly regulated manner. Read More

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Preventing and managing pressure ulcers in patients receiving palliative care.

Lynn Cornish

Nurs Older People 2021 Jun 9. Epub 2021 Jun 9.

St Margaret's Hospice Care, Somerset, England.

Pressure ulcers are more common in patients being cared for in palliative care settings than in the general population. Patients with life-limiting illnesses are living longer than ever before, and many present with multiple co-morbidities. Palliative care involves improving the patient's quality of life by achieving a balance between treatment, comfort and maintaining dignity. Read More

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Arthroscopic Bankart Repair and Open Bristow Procedure in the Treatment of Anterior Shoulder Instability With Osseous Glenoid Lesions in Collision Athletes.

Orthop J Sports Med 2021 May 28;9(5):23259671211008274. Epub 2021 May 28.

Department of Orthopedic Surgery, St Luke's International Hospital, Tokyo, Japan.

Background: Traumatic anterior shoulder instability in collision sports athletes often involves osseous glenoid lesions, which make surgical treatment challenging. High redislocation rates have been seen in collision sports athletes treated using arthroscopic Bankart repair.

Purpose: To investigate the effectiveness of a combined arthroscopic Bankart repair and open Bristow procedure for the treatment of traumatic anterior shoulder instability in collision sports athletes, with a focus on osseous glenoid lesions. Read More

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Micro-RNA-338-3p Promotes the Development of Atherosclerosis by Targeting Desmin and Promoting Proliferation.

Mol Biotechnol 2021 Jun 7. Epub 2021 Jun 7.

Department of Cardiology, Heze Municipal Hospital, No. 2888, Caozhou West Road, Heze, 274000, China.

Atherosclerosis (AS) is a dynamic and multi-stage process that involves various cells types, such as vascular smooth muscle cells (VSMCs) and molecules such as microRNAs. In this study, we investigated how miR-338-3p works in the process of AS. To determine how miR-338-3p was expressed in AS, an AS rat model was established and primary rat VSMCs were cultured. Read More

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A Hybrid Open-Arthroscopic Latarjet Coracoid Bone-Block Technique Using "Hyla" Instrumentation.

Orthop Traumatol Surg Res 2021 Jun 4:102978. Epub 2021 Jun 4.

Polyclinique Les Fleurs, Ollioules, France.

Latarjet coracoid bone-block is a gold-standard procedure for anteroinferior instability of the shoulder. Nowadays, it can be performed as open surgery or entirely under arthroscopy. The pure arthroscopic technique has the advantage of allowing concomitant intra-articular surgery, but involves a long learning curve. Read More

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Musculoskeletal tissue engineering: Regional gene therapy for bone repair.

Biomaterials 2021 May 19;275:120901. Epub 2021 May 19.

Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California, 1520 San Pablo St #2000, Los Angeles, CA, 90033, USA. Electronic address:

Bone loss associated with fracture nonunion, revision total joint arthroplasty (TJA), and pseudoarthrosis of the spine presents a challenging clinical scenario for the orthopaedic surgeon. Current treatment options including autograft, allograft, bone graft substitutes, and bone transport techniques are associated with significant morbidity, high costs, and prolonged treatment regimens. Unfortunately, these treatment strategies have proven insufficient to safely and consistently heal bone defects in the stringent biological environments often encountered in clinical cases of bone loss. Read More

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The effect of multiple freeze-thaw cycles on the viscoelastic properties and microstructure of bovine superficial digital flexor tendon.

J Mech Behav Biomed Mater 2021 Aug 21;120:104582. Epub 2021 May 21.

AGH University of Science and Technology, Faculty of Mechanics and Robotics, Krakow, Poland.

The most common injuries of the human musculoskeletal system are related to soft tissue structures such as tendons or ligaments. To repair torn structures, surgical intervention and application of a biological or synthetic graft may be required. A typical procedure for the processing, storage, and distribution of soft tissue grafts involves at least two freezing/thawing (F/T) cycles. Read More

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Nanotherapeutic approach to tackle chemotherapeutic resistance of cancer stem cells.

Life Sci 2021 Jun 2;279:119667. Epub 2021 Jun 2.

Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64849, Mexico. Electronic address:

Estimates indicate that cancer will become the leading cause of mortality worldwide in the future. Tumorigenesis is a complex process that involves self-sufficiency in signs of growth, insensitivity to anti-growth signals, prevention of apoptosis, unlimited replication, sustained angiogenesis, tissue invasion, and metastasis. Cancer stem cells (CSCs) have an important role in tumor development and resistance. Read More

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Hybrid repair versus conventional open repair for thoracic aortic arch aneurysms.

Cochrane Database Syst Rev 2021 Jun 4;6:CD012923. Epub 2021 Jun 4.

School of Nursing and Midwifery, National University of Ireland Galway, Galway, Ireland.

Background: Thoracic aortic arch aneurysms (TAAs) can be a life-threatening condition due to the potential risk of rupture. Treatment is recommended when the risk of rupture is greater than the risk of surgical complications. Depending on the cause, size and growth rate of the TAA, treatment may vary from close observation to emergency surgery. Read More

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A three-dimensional-printed SPION/PLGA scaffold for enhanced palate-bone regeneration and concurrent alteration of the oral microbiota in rats.

Mater Sci Eng C Mater Biol Appl 2021 Jul 6;126:112173. Epub 2021 May 6.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu 210029, China. Electronic address:

Scaffold implantation for the repair of oral bone defects involves an interplay between the scaffold biomaterial and the microenvironment. However, previous studies on this subject have only considered the effects of the immune system and largely ignored those of the oral microbiota. Accordingly, in the present study, we prepared composite scaffolds comprising a three-dimensional poly(l-lactide-co-glycolide) matrix with a superparamagnetic iron oxide nanoparticle (SPION) coating and used a rat model to evaluate their palate-bone-regenerating effects and their interaction with the oral microbiota. Read More

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Association of hemodynamic factors and progressive aortic dilatation following type A aortic dissection surgical repair.

Sci Rep 2021 Jun 1;11(1):11521. Epub 2021 Jun 1.

Department of Chemical Engineering, Imperial College London, London, SW7 2AZ, UK.

Type A aortic dissection (TAAD) involves the ascending aorta or the arch. Acute TAAD usually requires urgent replacement of the ascending aorta. However, a subset of these patients develops aortic rupture due to further dilatation of the residual dissected aorta. Read More

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Optimizing Graft Extraction From the Femoral Condyle for Fresh Osteochondral Allograft Transplantation in Treating Osteochondritis Dissecans of the Capitellum: Best Fit Based on Radius of Curvature.

J Pediatr Orthop 2021 Jun 2. Epub 2021 Jun 2.

Department of Orthopaedics and Rehabilitation, Oregon Health & Science University, Portland, OR.

Background: Osteochondritis dissecans (OCD) of the capitellum is a common cause of pain and dysfunction in adolescents that engage in repetitive elbow loading. For large, unstable lesions fresh osteochondral allograft transplantation (FOCAT) from the femoral condyle has been described as an effective treatment. Current practice involves significant guesswork in obtaining an appropriately sized graft, with anatomic variations resulting in poor graft fit. Read More

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Ubiquitination and Deubiquitination in Oral Disease.

Int J Mol Sci 2021 May 23;22(11). Epub 2021 May 23.

Divisions of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo 173-8610, Japan.

Oral health is an integral part of the general health and well-being of individuals. The presence of oral disease is potentially indicative of a number of systemic diseases and may contribute to their early diagnosis and treatment. The ubiquitin (Ub) system has been shown to play a role in cellular immune response, cellular development, and programmed cell death. Read More

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A Novel Method for Effective Cell Segmentation and Tracking in Phase Contrast Microscopic Images.

Sensors (Basel) 2021 May 18;21(10). Epub 2021 May 18.

Department of Biomedical Engineering, College of Software and Digital Healthcare Convergence, Yonsei University, Wonju 26493, Korea.

Cell migration plays an important role in the identification of various diseases and physiological phenomena in living organisms, such as cancer metastasis, nerve development, immune function, wound healing, and embryo formulation and development. The study of cell migration with a real-time microscope generally takes several hours and involves analysis of the movement characteristics by tracking the positions of cells at each time interval in the images of the observed cells. Morphological analysis considers the shapes of the cells, and a phase contrast microscope is used to observe the shape clearly. Read More

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Whole-Genome Doubling Affects Pre-miRNA Expression in Plants.

Plants (Basel) 2021 May 18;10(5). Epub 2021 May 18.

Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy.

Whole-genome doubling (polyploidy) is common in angiosperms. Several studies have indicated that it is often associated with molecular, physiological, and phenotypic changes. Mounting evidence has pointed out that micro-RNAs (miRNAs) may have an important role in whole-genome doubling. Read More

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Wound Repair and Extremely Low Frequency-Electromagnetic Field: Insight from In Vitro Study and Potential Clinical Application.

Int J Mol Sci 2021 May 10;22(9). Epub 2021 May 10.

Department of Medicine and Aging Science, Dermatology Clinic, University "G. D'Annunzio", Via dei Vestini, 66100 Chieti, Italy.

Wound healing is a complex, staged process. It involves extensive communication between the different cellular constituents of various compartments of the skin and its extracellular matrix (ECM). Different signaling pathways are determined by a mutual influence on each other, resulting in a dynamic and complex crosstalk. Read More

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Molecular Mechanisms Associated with ROS-Dependent Angiogenesis in Lower Extremity Artery Disease.

Antioxidants (Basel) 2021 May 7;10(5). Epub 2021 May 7.

Department of Vascular and Endovascular Surgery, Angiology and Phlebology, Poznan University of Medical Sciences, 60-848 Poznan, Poland.

Currently, atherosclerosis, which affects the vascular bed of all vital organs and tissues, is considered as a leading cause of death. Most commonly, atherosclerosis involves coronary and peripheral arteries, which results in acute (e.g. Read More

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The Effects of Insulin-Like Growth Factor I and BTP-2 on Acute Lung Injury.

Int J Mol Sci 2021 May 15;22(10). Epub 2021 May 15.

Department of Medicine, Division of Regenerative Medicine, Loma Linda University, Loma Linda, CA 92354, USA.

Acute lung injury (ALI) afflicts approximately 200,000 patients annually and has a 40% mortality rate. The COVID-19 pandemic has massively increased the rate of ALI incidence. The pathogenesis of ALI involves tissue damage from invading microbes and, in severe cases, the overexpression of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Read More

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Endoscopic Approach to Proximal Hamstring Avulsion Repair.

JBJS Essent Surg Tech 2020 Oct-Dec;10(4). Epub 2020 Dec 24.

Division of Sports Medicine, Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois.

Background: Endoscopic repair of a proximal hamstring avulsion promotes precise anatomical repair and lowers the risk of neurovascular injury.

Description: Indications for proximal endoscopic repair of the proximal part of the hamstrings include acute tears of 2 tendons with >2 cm of retraction in young active patients, acute complete tears of 3 tendons with >2 cm of retraction, or failed conservative treatment of tears of ≥2 tendons with ≤2 cm of retraction. Repair of a proximal hamstring avulsion is performed using 2 portals. Read More

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December 2020

IL-1 Impaired Diabetic Wound Healing by Regulating MMP-2 and MMP-9 through the p38 Pathway.

Mediators Inflamm 2021 18;2021:6645766. Epub 2021 May 18.

Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Diabetes mellitus is one of the most prominent metabolic disorders in the world, and insulin resistance in diabetic patients leads to several complications including increased inflammation and delayed wound healing. Fibroblast migration and reepithelialization play a significant role in wound healing. In this study, we explored the effects of IL-1 signaling on proliferation and migration of human fibroblasts from diabetic wound tissues. Read More

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Effect of Preoperative Imaging and Patient Factors on Clinically Meaningful Outcomes and Quality of Life After Osteochondral Allograft Transplantation: A Machine Learning Analysis of Cartilage Defects of the Knee.

Am J Sports Med 2021 May 28:3635465211015179. Epub 2021 May 28.

Sports Medicine and Shoulder Service, Institute for Cartilage Repair Hospital for Special Surgery, New York, New York, USA.

Background: Fresh osteochondral allograft transplantation (OCA) is an effective method of treating symptomatic cartilage defects of the knee. This restoration technique involves the single-stage implantation of viable, mature hyaline cartilage into a chondral or osteochondral lesion. The extent to which preoperative imaging and patient factors predict achieving clinically meaningful outcomes among patients undergoing OCA for cartilage lesions of the knee remains unknown. Read More

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