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Management and Outcomes after Upper Versus Lower Extremity Vascular Trauma.

Ann Vasc Surg 2021 Jun 18. Epub 2021 Jun 18.

Department of Surgery, Division of Vascular Surgery, Emory University, Atlanta, GA. Electronic address:

Objectives: While significant literature exists regarding peripheral vascular injury management, the vast majority focuses on lower extremity arterial injury. As a result, clinical management of arterial injury in the upper extremities is often guided by literature specific to lower extremity vessel injury. The purpose of this study is to use the largest series of patients reported in the literature to compare management and outcomes of upper and lower extremity traumatic vascular injuries. Read More

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High Mortality and Venous Thromboembolism Risk Following Major Penetrating Abdominal Venous Injuries.

Ann Vasc Surg 2021 Jun 18. Epub 2021 Jun 18.

Division of Vascular Surgery, University of Massachusetts Medical Center, Worcester, MA. Electronic address:

Introduction: Penetrating injuries to the inferior vena cava (IVC) and/or iliac veins are a source of hemorrhage but may also predispose patients to venous thromboembolism (VTE). We sought to determine the relationship between iliocaval injury, VTE and mortality.

Methods: The National Trauma Data Bank was queried for penetrating abdominal trauma from 2015-2017. Read More

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Early Results of Popliteal Vein External Banding for Treatment of Chronic Venous Insufficiency.

Ann Vasc Surg 2021 Jun 18. Epub 2021 Jun 18.

Emory University Hospital, Department of Surgery, Division of Vascular Surgery, 1364 Clifton Rd, NE, Atlanta, GA, USA, 30322; Grady Health, Department of Surgery, Division of Vascular Surgery, 80 Jesse Hill Jr Dr SE, Atlanta, GA, USA, 30303. Electronic address:

Introduction: Chronic venous insufficiency (CVI) encompasses a myriad of clinical manifestations including lower extremity swelling and pain, ulcerations and chronic skin changes such as stasis dermatitis, and lipodermatosclerosis. CVI effects greater than 25 million Americans and has a significant socioeconomic and psychosocial impact. Treatment of CVI varies depending on the etiology. Read More

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The Long Road to Understanding RNAPII Transcription Initiation and Related Syndromes.

Annu Rev Biochem 2021 Jun;90:193-219

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, Université de Strasbourg, 67404 Illkirch CEDEX, Commune Urbaine de Strasbourg, France; email:

In eukaryotes, transcription of protein-coding genes requires the assembly at core promoters of a large preinitiation machinery containing RNA polymerase II (RNAPII) and general transcription factors (GTFs). Transcription is potentiated by regulatory elements called enhancers, which are recognized by specific DNA-binding transcription factors that recruit cofactors and convey, following chromatin remodeling, the activating cues to the preinitiation complex. This review summarizes nearly five decades of work on transcription initiation by describing the sequential recruitment of diverse molecular players including the GTFs, the Mediator complex, and DNA repair factors that support RNAPII to enable RNA synthesis. Read More

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Tracheal Macrophages During Regeneration and Repair of Long-Segment Airway Defects.

Laryngoscope 2021 Jun 21. Epub 2021 Jun 21.

Center of Regenerative Medicine, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.

Objectives/hypothesis: Tissue-engineered tracheal grafts (TETGs) offer a potential solution for repair of long-segment airway defects. However, preclinical and clinical TETGs have been associated with chronic inflammation and macrophage infiltration. Macrophages express great phenotypic heterogeneity (generally characterized as classically activated [M1] vs. Read More

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Analysis of Later Stage Morbidity and Mortality after Pancreatic Surgery Because of Abdominal Trauma.

Surg Infect (Larchmt) 2021 Jun 21. Epub 2021 Jun 21.

Department of General Surgery, Jinling Hospital, Jiangsu Nanjing, China.

Pancreatic trauma surgery is a complicated surgical procedure for severe pancreatic injuries, accompanied by a high incidence of complications and mortality. This study was designed to explore the long-term prognosis of pancreatic surgery because of abdominal trauma. The clinical data of 103 patients who were admitted to Jinling Hospital between August 2012 and August 2019 who had pancreatic trauma surgery were analyzed retrospectively. Read More

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Genomic basis of deep-water adaptation in Arctic Charr (Salvelinus alpinus) morphs.

Mol Ecol 2021 Jun 21. Epub 2021 Jun 21.

Fisheries and Oceans Canada, Northwest Atlantic Fisheries Centre, St. John's, Newfoundland and Labrador, Canada.

The post-glacial colonization of Gander Lake in Newfoundland, Canada, by Arctic Charr (Salvelinus alpinus) provides the opportunity to study the genomic basis of adaptation to extreme deep-water environments. Colonization of deep-water (> 50 m) habitats often requires extensive adaptation to cope with novel environmental challenges from high hydrostatic pressure, low temperature, and low light, but the genomic mechanisms underlying evolution in these environments are rarely known. Here, we compare genomic divergence between a deep-water morph adapted to depths of up to 288m and a larger, piscivorous pelagic morph occupying shallower depths. Read More

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[Homologous recombination repair deficiency as a predictive biomarker : Basic mechanisms and detection methods].

Pathologe 2021 Jun 21. Epub 2021 Jun 21.

Institut für Pathologie, Universitätsklinikum Köln, Köln, Deutschland.

Background: DNA double-strand breaks may evoke cell death or cancer. Cells have developed two fundamentally different mechanisms of DNA double-strand repair: the accurate mechanism of homologous recombination repair and the error-prone nonhomologous end joining. The deficiency of homologous recombination repair (HRD) is a frequent feature of several solid tumor entities and is associated with sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitor therapy. Read More

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Roles of Angioplasty With Drug-Coated Balloon for Chronic Ischemia in Wound Healing.

J Endovasc Ther 2021 Jun 21:15266028211025023. Epub 2021 Jun 21.

Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Hyogo, Japan.

Purpose: Clinical trials have demonstrated sustained benefits of drug-coated balloon (DCB) angioplasty compared with noncoated balloon angioplasty in symptomatic peripheral artery disease (PAD) presenting with femoropopliteal (FP) artery disease. However, there is still controversy whether particulate embolization caused by crystalline paclitaxel, the so-called "downstream effect," is adversely associated with clinical outcomes after use of FP DCB among chronic limb-threatening ischemia (CLTI) patients. The current RADISH (Roles of Angioplasty with Drug-coated balloon for chronic ISchemia in wound Healing) study investigated wound healing following DCB therapy vs non-DCB therapy for real-world CLTI patients presenting with FP lesions. Read More

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Hemorrhagic Transformation and Stroke Recurrence in Children with Cardiac Disease Receiving Antithrombotic Therapy for Secondary Stroke Prevention.

J Thromb Haemost 2021 Jun 21. Epub 2021 Jun 21.

Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.

Background: Antithrombotic therapy is currently recommended for stroke prevention in pediatric cardioembolic stroke where the recurrence risk is high. However, safety concerns remain. The primary objective of this study was to evaluate clinical and radiographic predictors of hemorrhagic transformation and stroke recurrence in children with cardiac disease to ascertain the safety and failure rates for secondary stroke prevention. Read More

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Influence of Arg399Gln, Arg280His and Arg194Trp XRCC1 gene polymorphisms of Base Excision Repair pathway on the level of 8-oxo-guanine and risk of head and neck cancer in the Polish population.

Cancer Biomark 2021 Jun 12. Epub 2021 Jun 12.

Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, Łodz, Poland.

Background: Reduced efficiency of DNA repair systems has long been a suspected factor in increasing the risk of cancer.

Objective: In this work we investigate influence of three selected polymorphisms of DNA repair gene XRCC1 and level of oxidative damage (measured as level of 8-oxo-guanine) on modulation of the risk of HNSCC.

Methods: In group of 359 patients with HNSCC (diagnosed with OSCC) the occurrence of polymorphic variants in Arg399Gln, Arg280His and Arg194Trp of XRCC1 were studied with TaqMan technique. Read More

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New insights on the role of vascular endothelial growth factor in biliary pathophysiology.

JHEP Rep 2021 Jun 4;3(3):100251. Epub 2021 Feb 4.

Section of Digestive Diseases, Liver Center, Yale University, New Haven, CT, USA.

The family of vascular endothelial growth factors (VEGFs) includes 5 members (VEGF-A to -D, and placenta growth factor), which regulate several critical biological processes. VEGF-A exerts a variety of biological effects through high-affinity binding to tyrosine kinase receptors (VEGFR-1, -2 and -3), co-receptors and accessory proteins. In addition to its fundamental function in angiogenesis and endothelial cell biology, VEGF/VEGFR signalling also plays a role in other cell types including epithelial cells. Read More

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Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes.

Bone Rep 2021 Dec 7;15:101098. Epub 2021 Jun 7.

Department of Medical Sciences, Uppsala University, SE-751 85 Uppsala, Sweden.

Myeloma bone disease is a major complication in multiple myeloma affecting quality of life and survival. It is characterized by increased activity of osteoclasts, bone resorbing cells. Myeloma microenvironment promotes excessive osteoclastogenesis, a process of production of osteoclasts from their precursors, monocytes. Read More

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December 2021

Joining soft tissues to bone: Insights from modeling and simulations.

Bone Rep 2021 Jun 23;14:100742. Epub 2020 Dec 23.

Mechanics of Biological and Bioinspired Materials Laboratory, Department of Aerospace and Mechanical Engineering, University of Liège, Liège, Belgium.

Entheses are complex multi-tissue regions of the musculoskeletal system serving the challenging task of connecting highly dissimilar materials such as the compliant tendon to the much stiffer bone, over a very small region. The first aim of this review is to highlight mathematical and computational models that have been developed to investigate the many attachment strategies present at entheses at different length scales. Entheses are also relevant in the medical context due to the high prevalence of orthopedic injuries requiring the reattachment of tendons or ligaments to bone, which are associated with a rather poor long-term clinical outcome. Read More

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Comparison Between Cultivation and Sequencing Based Approaches for Microbiota Analysis in Swabs and Biopsies of Chronic Wounds.

Front Med (Lausanne) 2021 4;8:607255. Epub 2021 Jun 4.

National Laboratory for Health, Environment, and Food, Department for Microbiological Research, Maribor, Slovenia.

Chronic wounds are a prominent health concern affecting 0.2% of individuals in the Western population. Microbial colonization and the consequent infection contribute significantly to the healing process. Read More

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Overexpression of PTPRN Promotes Metastasis of Lung Adenocarcinoma and Suppresses NK Cell Cytotoxicity.

Front Cell Dev Biol 2021 2;9:622018. Epub 2021 Jun 2.

Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.

Background: Lung adenocarcinoma (LUAD) is the most common diagnostic histologic subtype of non-small cell lung cancer, but the role of receptor-type tyrosine-protein phosphatase-like N (PTPRN) in LUAD has not been studied.

Methods: We conducted a bioinformatic analysis to identify the expression of PTPRN on LUAD data from the Cancer Genome Atlas (TCGA) and the relationship between PTPRN and overall survival of LUAD patients. The effects of PTPRN on the migration ability of LUAD cells and the underlying mechanisms were investigated by and assays (i. Read More

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Environmental Tobacco Smoke in Occupational Settings: Effect and Susceptibility Biomarkers in Workers From Lisbon Restaurants and Bars.

Front Public Health 2021 4;9:674142. Epub 2021 Jun 4.

Department of Human Genetics, Instituto Nacional de Saúde Doutor Ricardo Jorge, Lisbon, Portugal.

Environmental tobacco smoke (ETS) has been recognized as a major health hazard by environmental and public health authorities worldwide. In Portugal, smoke-free laws are in force for some years, banning smoking in most indoor public spaces. However, in hospitality venues such as restaurants and bars, owners can still choose between a total smoke-free policy or a partial smoking restriction with designated smoking areas, if adequate reinforced ventilation systems are implemented. Read More

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S100A9 Derived From Myeloma Associated Myeloid Cells Promotes TNFSF13B/TNFRSF13B-Dependent Proliferation and Survival of Myeloma Cells.

Front Oncol 2021 3;11:691705. Epub 2021 Jun 3.

Department of Radiation Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Multiple myeloma (MM) is a lethal hematological malignancy characterized by abundant myeloid cells in the microenvironment that fuel tumor progression. But the mechanism by which myeloid cells support myeloma cells has not been fully explored. We aimed to examine their effect on bone marrow cells of MM patients by scRNA-seq transcriptome analysis and reveal a high-resolution gene profile of myeloma cells and myeloma-associated myeloid cells. Read More

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High Expression of Cancer-IgG Is Associated With Poor Prognosis and Radioresistance PI3K/AKT/DNA-PKcs Pathway Regulation in Lung Adenocarcinoma.

Front Oncol 2021 2;11:675397. Epub 2021 Jun 2.

Department of Radiation Oncology, Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China.

Background: Lung adenocarcinoma (LUAD) is the dominant type of lung neoplasms, and radiotherapy is its mainstay treatment, yet poor prognosis caused by radioresistance remains problematic. Cancer-derived immunoglobulin G (cancer-IgG) has been detected in multiple cancers and plays important roles in carcinogenesis. This study aimed to demonstrate that cancer-IgG is associated with poor prognosis of LUAD and to identify its role in radioresistance. Read More

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EMT and Cancer Cell Stemness Associated With Chemotherapeutic Resistance in Esophageal Cancer.

Front Oncol 2021 3;11:672222. Epub 2021 Jun 3.

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.

Drug resistance often occurs after chemotherapy in esophageal cancer patients, leading to cancer metastasis and recurrence. However, the relationship among cancer cell migration, recurrence and drug resistance in esophageal cancer drug-resistant cells has not been clearly explained. In this study, we constructed paclitaxel (PTX)-resistant esophageal cancer cells to explore the causes of drug resistance and poor prognosis after chemotherapy in esophageal cancer. Read More

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Identification of Methylation-Regulated Differentially Expressed Genes and Related Pathways in Hepatocellular Carcinoma: A Study Based on TCGA Database and Bioinformatics Analysis.

Front Oncol 2021 3;11:636093. Epub 2021 Jun 3.

Department of Internal Oncology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.

Background: In recent years, DNA methylation modification has been shown to be a critical mechanism in the field of epigenetics.

Methods: Hepatocellular carcinoma (HCC) data were obtained from The Cancer Genome Atlas project, including RNA expression profiles, Illumina Human Methylation 450K BeadChip data, clinical information, and pathological features. Then, differentially expressed genes (DEGs) and differentially methylated genes were identified using R software. Read More

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Extraperitoneal laparoscopic repair of huge inguinoscrotal bladder hernia: A case report and literature review.

Urol Case Rep 2021 Sep 30;38:101735. Epub 2021 May 30.

Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Inguinal herniation of urinary bladder is a rare condition which might associated with significant complication. Exact pre-operative diagnosis is extremely important. We reported a case of huge inguinoscrotal bladder hernia, associated with bilateral hydronephrosis and kidney injuries, managed by laparoscopy technique. Read More

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September 2021

CRISPR-Cas system enables fast and simple genome editing of industrial strains.

Metab Eng Commun 2015 Dec 20;2:13-22. Epub 2015 Mar 20.

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Allé 6, 2970 Hørsholm, Denmark.

There is a demand to develop 3rd generation biorefineries that integrate energy production with the production of higher value chemicals from renewable feedstocks. Here, robust and stress-tolerant industrial strains of will be suitable production organisms. However, their genetic manipulation is challenging, as they are usually diploid or polyploid. Read More

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December 2015

Diabetes as a Risk Factor for Orthopedic Implant Surface Performance: A Retrieval and Study.

J Bio Tribocorros 2021 Jun 22;7(2). Epub 2021 Feb 22.

Department of Biomedical Engineering, University of Texas at Dallas, Richardson, TX, USA.

Orthopedic devices are often associated with increased risk for diabetic patients due to impaired wound healing capabilities. Adverse biological responses for immunocompromised patients at the implant-tissue interface can lead to significant bone resorption that may increase failure rates. The goal of this study was to characterize the surface of implants removed from diabetic patients to determine underlying mechanisms of diabetes-induced impaired osseointegration. Read More

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Ramp lesion of the medial meniscus.

EFORT Open Rev 2021 May 4;6(5):372-379. Epub 2021 May 4.

Department of Orthopaedics, the Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, China.

Ramp lesion of the medial meniscus used to be completely disregarded in the past.Ramp lesion has been now put under the spotlight by orthopaedic and sport medicine surgeons and requires attention.It is closely associated with anterior cruciate ligament injury. Read More

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CXCR4 is a prognostic marker that inhibits the invasion and migration of gastric cancer by regulating VEGF expression.

Oncol Lett 2021 Aug 4;22(2):587. Epub 2021 Jun 4.

Institute of Combining Chinese Traditional and Western Medicine, Medical College, Yangzhou University, Jiangsu, Yangzhou 225001, P.R. China.

Metastasis is the main cause of poor prognosis of patients with gastric cancer (GC). Thus, current research is focused on identifying biomarkers that can predict the prognosis of patients with GC. C-X-C motif chemokine receptor 4 (CXCR4) and vascular endothelial growth factor (VEGF) have been reported to play important roles in different types of malignancies; however, their role in the prognosis of GC remains unknown. Read More

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Long non-coding RNA TPT1-AS1 alleviates cell injury and promotes the production of extracellular matrix by targeting the microRNA-324-5p/CDK16 axis in human dermal fibroblasts after thermal injury.

Exp Ther Med 2021 Aug 6;22(2):843. Epub 2021 Jun 6.

Department of Burns, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

Long non-coding RNAs (lncRNAs) are associated with the healing of burn wounds in the dermis. The present study aimed to probe the role and regulatory network of the lncRNA TPT1 antisense RNA 1 (TPT1-AS1) in human dermal fibroblasts (HDFs) following thermal injury. A model of thermally injured cells was constructed with HDFs. Read More

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lncRNA ZFAS1 promotes the ox-LDL induced proliferation, invasion and migration of vascular smooth muscle cells.

Exp Ther Med 2021 Aug 4;22(2):835. Epub 2021 Jun 4.

Department of Clinical Laboratory, Lianyungang Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Lianyungang, Jiangsu 222004, P.R. China.

Atherosclerosis is a chronic progressive inflammatory vascular disease. The dysfunction of vascular smooth muscle cells (VSMCs) induced by oxidized low-density lipoprotein (ox-LDL) contributes to the formation of atherosclerotic lesions. Additionally, upregulation of the long non-coding RNA zinc finger antisense 1 (ZFAS1) was observed in the plaques of patients with atherosclerosis. Read More

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Prognostic Implication of the mA RNA Methylation Regulators in Rectal Cancer.

Front Genet 2021 3;12:604229. Epub 2021 Jun 3.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.

N6-methyladenosine (mA) is a very common and abundant RNA modifications occurring in nearly all types of RNAs. Although the dysregulated expression of mA regulators is implicated in cancer progression, our understanding of the prognostic value of the mA regulators in rectal cancer is still quite limited. In this study, we analyzed the RNA expression levels of the 17 mA regulator genes of 95 rectal cancer and 10 normal rectal samples from the The Cancer Genome Atlas Rectum Adenocarcinoma (TCGA-READ) dataset. Read More

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Raising the 'Good' Oxidants for Immune Protection.

Front Immunol 2021 4;12:698042. Epub 2021 Jun 4.

Conway Institute, School of Medicine, University College Dublin, Dublin, Ireland.

Redox medicine is a new therapeutic concept targeting reactive oxygen species (ROS) and secondary reaction products for health benefit. The concomitant function of ROS as intracellular second messengers and extracellular mediators governing physiological redox signaling, and as damaging radicals instigating or perpetuating various pathophysiological conditions will require selective strategies for therapeutic intervention. In addition, the reactivity and quantity of the oxidant species generated, its source and cellular location in a defined disease context need to be considered to achieve the desired outcome. Read More

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