33,525 results match your criteria renal toxicity


Local ablation of gastric cancer by reconstituted apolipoprotein B lipoparticles carrying epigenetic drugs.

Nanomedicine 2021 Jul 28:102450. Epub 2021 Jul 28.

Department of Surgery, National Cheng Kung University, Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Epigenetic inhibitors have shown anticancer effects. Combination chemotherapy with epigenetic inhibitors has shown high effectiveness in gastric cancer clinical trials, but severe side effect and local progression are the causes of treatment failure. Therefore, we sought to develop an acidity-sensitive drug delivery system to release drugs locally to diminish unfavorable outcome of gastric cancer. Read More

View Article and Full-Text PDF

Ameliorative mechanisms of turmeric-extracted curcumin on arsenic (As)-induced biochemical alterations, oxidative damage, and impaired organ functions in rats.

Environ Sci Pollut Res Int 2021 Jul 31. Epub 2021 Jul 31.

Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresource, College of Tropical Crops, Hainan University, Haikou, Hainan, 570228, People's Republic of China.

Arsenic (As) is known for its carcinogenic and hepatorenal toxic effects causing serious health problems in human beings. Turmeric (Curcuma longa L.) extracted curcumin (Cur) is a polyphenolic antioxidant which has ability to combat hazardous environmental toxicants. Read More

View Article and Full-Text PDF

Carbon monoxide releasing molecule A1 reduces myocardial damage after acute myocardial infarction in a porcine model.

J Cardiovasc Pharmacol 2021 May 20. Epub 2021 May 20.

Cardiology department, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Infarct size is a major determinant of outcomes after acute myocardial infarction (AMI). Carbon monoxide releasing molecules (CORMs), which deliver nano-molar concentrations of carbon monoxide to tissues, have been shown to reduce infarct size in rodents. We evaluated efficacy and safety of CORM-A1 to reduce infarct size in a clinically relevant porcine model of AMI. Read More

View Article and Full-Text PDF

Systematic review of sirolimus in dermatological conditions.

Australas J Dermatol 2021 Jul 30. Epub 2021 Jul 30.

Department of Dermatology, Sir Charles Gairdner Hospital, Nedlands, Australia.

Sirolimus is a mammalian target of rapamycin inhibitor (mTORI) with anti-proliferative, antiangiogenic and immunosuppressive properties. While approved in Australia as an anti-rejection medication for renal transplant patients, there is mounting evidence regarding the utility of oral and topical sirolimus in treating a plethora of dermatological conditions or conditions with cutaneous manifestations. Our aim was to present an overview of the evidence for current usage and breadth of the application of sirolimus in dermatology. Read More

View Article and Full-Text PDF

Erythropoietin-Resistant Anemia Secondary to Zinc-Induced Hypocupremia in a Hemodialysis Patient.

Case Rep Nephrol Dial 2021 May-Aug;11(2):167-175. Epub 2021 Jul 1.

East Georgia Kidney and Hypertension, Augusta, Georgia, USA.

Excessive intake of zinc is a known but often forgotten cause of copper deficiency, and its consequences in the context of end-stage renal disease (ESRD) are not widely discussed. Zinc-induced copper deficiency (ZICD) can result in erythropoietin (EPO)-resistant anemia and may not be considered as a possible etiology when conducting the work-up. We present a case wherein an ESRD patient had been receiving excess zinc for several months and subsequently experienced EPO-resistant anemia. Read More

View Article and Full-Text PDF

A Rare Presentation of Checkpoint Inhibitor Induced Distal RTA.

Case Rep Oncol Med 2021 15;2021:7406911. Epub 2021 Jul 15.

Department of Internal Medicine, State University of New York-Downstate Health Sciences University, Brooklyn, New York, USA 11203.

Immune checkpoint inhibitors have opened a new era in treating advanced malignancies, resulting in a rapid increase in utilization, given the remarkable clinical outcomes. The incidence of immune-related adverse events increased due to the immunologic effects of these therapeutic agents. However, immune-related renal adverse events remain low, representing only a small incidence of reported cases. Read More

View Article and Full-Text PDF

Population Pharmacokinetics of High-Dose Methotrexate in Chinese Pediatric Patients With Acute Lymphoblastic Leukemia.

Front Pharmacol 2021 13;12:701452. Epub 2021 Jul 13.

Department of Hematology and Oncology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.

High-dose methotrexate (HD-MTX) is widely used in pediatric acute lymphoblastic leukemia (ALL) treatment regimens. In this study, we aimed to develop a population pharmacokinetic (PK) model of HD-MTX in Chinese pediatric patients with ALL for designing personalized dosage regimens. In total, 4,517 MTX serum concentration data for 311 pediatric patients with ALL, aged 0. Read More

View Article and Full-Text PDF

Immune-Related Meningoencephalitis following Nivolumab in Metastatic Renal Cell Carcinoma.

Case Rep Oncol 2021 May-Aug;14(2):1051-1058. Epub 2021 Jul 1.

Norton Cancer Institute, Norton Healthcare, Louisville, Kentucky, USA.

While immunotherapy with nivolumab is promising for patients with renal cell carcinoma (RCC), overactivation of the immune system can lead to serious side effects. Immune-related meningoencephalitis without a viral or microbial etiology is a rare complication that may occur in patients treated with checkpoint inhibitors (CPI). Herein, we report a 66-year-old man who underwent a partial nephrectomy which revealed a papillary RCC with clear cell component. Read More

View Article and Full-Text PDF

Safety and efficacy of intravenously administered cidofovir in adult haematopoietic cell transplant recipients: a retrospective multicentre cohort study.

J Antimicrob Chemother 2021 Jul 29. Epub 2021 Jul 29.

Division of Infectious Diseases, University Hospital of Geneva, Geneva, Switzerland.

Objectives: To evaluate the safety and efficacy of cidofovir for the treatment of double-stranded DNA (dsDNA) viral infections following allogeneic haematopoietic cell transplant (HCT).

Methods: This was a retrospective multicentre cohort study including adult HCT recipients who received ≥1 dose of IV-administered cidofovir for any dsDNA viral infection from 2006 to 2019. The objectives were to describe the rate of and risk factors for nephrotoxicity and virological response by the end of treatment (EOT). Read More

View Article and Full-Text PDF

Synthetic blood and blood products for combat casualty care and beyond.

J Trauma Acute Care Surg 2021 Aug;91(2S Suppl 2):S26-S32

From the US Army Institute of Surgical Research (A.P.C.), For Sam Houston, Texas; Uniformed Services University (A.P.C., J.W.C.), Bethesda, Maryland; Division of Traumatology, Surgical Critical Care & Emergency Surgery (J.W.C.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; Joint Health Command (M.C.R.), Australian Defence Force, Canberra; Faculty of Medicine (M.C.R.), University of Queensland, Brisbane; and Royal Brisbane and Women's Hospital (M.C.R.), Brisbane, Australia.

Abstract: Synthetic biology adopts an engineering design approach to create innovative treatments that are reliable, scalable, and customizable to individual patients. Interest in substitutes for allogenic blood components, primarily red blood cells and platelets, increased in the 1980s because of concerns over infectious disease transmission. However, only now, with emerging synthetic approaches, are such substitutes showing genuine promise. Read More

View Article and Full-Text PDF

Discovery of polymethoxyflavones as potential cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX) and phosphodiesterase 4B (PDE4B) inhibitors.

J Recept Signal Transduct Res 2021 Jul 29:1-13. Epub 2021 Jul 29.

Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA (UiTM) Selangor Branch, Puncak Alam Campus, Selangor, Malaysia.

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed to treat inflammatory-related diseases, pain and fever. However, the prolong use of traditional NSAIDs leads to undesirable side effects such as gastric, ulceration, and renal toxicity due to lack of selectivity toward respective targets for COX-2, 5-LOX, and PDE4B. Thus, targeting multiple sites can reduce these adverse effects of the drugs and increase its potency. Read More

View Article and Full-Text PDF

An evaluation of a novel nanoformulation of imatinib mesylate in a mouse model of lupus nephritis.

Drug Deliv Transl Res 2021 Jul 28. Epub 2021 Jul 28.

Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA.

Studies have suggested imatinib mesylate (ImM) as a potential treatment for systemic lupus erythematosus nephritis (SLEN). However, ImM has limited renal excretion. The goal of the current research was to develop an ImM containing nanoformulation, conduct studies to evaluate pharmacokinetics, and determine whether kidney deposition can be enhanced in a mouse model of SLEN. Read More

View Article and Full-Text PDF

A Phase I Study of the ALK inhibitor Ceritinib in Combination with Gemcitabine-Based Chemotherapy in Patients with Advanced Solid Tumors.

Int J Cancer 2021 Jul 28. Epub 2021 Jul 28.

Roswell Park Comprehensive Cancer Center, Buffalo, NY.

In this phase I, dose-escalation study, we sought to determine the maximum tolerated dose (MTD) of the ALK/ROS1 inhibitor ceritinib in combination with gemcitabine-based chemotherapy in patients with advanced solid tumors. Secondary objectives were characterization of the safety profile, pharmacokinetics and preliminary efficacy of these combinations, and identification of potential biomarkers of efficacy. Ceritinib was combined with gemcitabine (Arm 1), gemcitabine/nab-paclitaxel (Arm 2), or gemcitabine/cisplatin (Arm 3). Read More

View Article and Full-Text PDF

Flecainide Toxicity Leading to Loss of Pacemaker Capture and Cardiac Arrest.

JACC Case Rep 2021 Apr 27;3(4):586-590. Epub 2021 Jan 27.

Cardiovascular Division, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.

An 86-year-old man with paroxysmal atrial fibrillation on flecainide, a class IC antiarrhythmic, presented with cardiac arrest. The patient had extremely wide QRS complexes with inconsistent pacemaker capture on electrocardiography. Due to cardiac failure and renal failure, the patient developed progressive flecainide toxicity, which led to pacemaker failure, and ultimately, death. Read More

View Article and Full-Text PDF

Role of Radioembolization in the Management of Liver-Dominant Metastatic Renal Cell Carcinoma: A Single-Center, Retrospective Study.

Cardiovasc Intervent Radiol 2021 Jul 26. Epub 2021 Jul 26.

Diagnostic Imaging and Interventional Radiology, H. Lee Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL, USA.

Purpose: The management of Renal cell carcinoma (RCC) patients with liver metastases is challenging. Liver-directed therapy, such as Transarterial radioembolization (TARE), is a reasonable option for these patients; however, its safety and efficacy are not well characterized. This study evaluated the safety and efficacy of TARE in patients with liver-dominant metastatic RCC. Read More

View Article and Full-Text PDF

How will NAFLD change the liver transplant landscape in the 2020s?

Clin Res Hepatol Gastroenterol 2021 Jul 23:101759. Epub 2021 Jul 23.

Hepatology Department, Croix Rousse Hospital, Hospices Civils de Lyon, Lyon, France.

Liver steatosis is the hepatic manifestation of the metabolic syndrome, and is now the leading cause of chronic liver disease worldwide. The treatment of metabolic cirrhosis with liver failure and/or hepatocellular carcinoma is liver transplantation (LT). During the past decade, metabolic cirrhosis represented an increasing cause for LT, especially in the United States. Read More

View Article and Full-Text PDF

Potential toxicity evaluation and comparison within multiple mice organs after repeat injections of linear versus macrocyclic gadolinium-based contrast agents: A comprehensive and time course study.

Toxicol Lett 2021 Jul 24;350:152-161. Epub 2021 Jul 24.

Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Jiangsu, Xuzhou, 221006, PR China. Electronic address:

As nephrogenic systemic fibrosis (NSF) and increased signal intensities in deep cerebellar nuclei (DCN) were successively discovered in renal insufficiency patients and healthy persons after gadolinium-based contrast agents (GBCAs) exposure, an awareness of potential toxicity with GBCAs exposure has been heightening. Herein, we performed a multi-organ/tissue toxicity assessment after different GBCAs administration with a large number of samples, and long-term, time-course schedule investigation. ICR mice were randomized to five exposure groups (n = 42/group) and received intravenous injection of GBCAs (2. Read More

View Article and Full-Text PDF

A renal and hepatic toxicity analysis of remdesivir formulations: Does what is on the inside really count?

Antimicrob Agents Chemother 2021 Jul 26:AAC0104521. Epub 2021 Jul 26.

Yale New Haven Health System, Department of Pharmacy Services, New Haven, CT, United States.

It has been postulated that the injectable solution formulation of remdesivir could be more nephrotoxic than the lyophilized powder since it contains twice as much sulfobutylether-β-cyclodextrin (SBECD). Therefore, we evaluated 1000 hospitalized patients with SARS-CoV-2 who received remdesivir lyophilized powder or solution. A logistic regression model accounting for baseline confounders identified that neither the use of the injectable solution (OR = 1. Read More

View Article and Full-Text PDF

Nursing Observation on the Clinical Efficacy and Toxicity of Lobaplatin Compared with Cisplatin in the Treatment of Locally Advanced Hypopharyngeal Carcinoma Based on Intelligent CT Imaging.

J Healthc Eng 2021 30;2021:9982888. Epub 2021 Jun 30.

Department of Radiotherapy, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, Heilongjiang, China.

With the acceleration of people's life rhythm, the incidence of hypopharyngeal cancer has generally increased. This study mainly explores the clinical efficacy and toxicity of lobaplatin compared with cisplatin in the treatment of locally advanced hypopharyngeal carcinoma based on intelligent CT imaging. Group A received lobaplatin combined with docetaxel induction chemotherapy for 2 cycles after cisplatin combined with intensity-modulated radiotherapy. Read More

View Article and Full-Text PDF

Artemisinin-Based Combination Therapy Synergized with Medicinal Plants to Induce Musculotoxic Effects.

Evid Based Complement Alternat Med 2021 8;2021:8861574. Epub 2021 Jul 8.

Institut Pasteur of Côte-d'Ivoire, BP 450 Abidjan 01, Abidjan, Côte d'Ivoire.

Introduction: Multivisceral, neurological, hepatic, and renal damage has been witnessed following the use of artemisinin-based combination therapy (ACT) and herbal medicine. These multiple organ damages make us think of muscle damage. The objective was to study the myotoxicity of the combination of ACTs with medicinal plants. Read More

View Article and Full-Text PDF

Ethyl pyruvate: A newly discovered compound against ischemia-reperfusion injury in multiple organs.

Pharmacol Res 2021 Jul 21:105757. Epub 2021 Jul 21.

Department of Paediatrics, Shenmu Hospital, School of Life Sciences and Medicine, Northwest University, Guangming Road, Shenmu, China. Electronic address:

Ischemia-reperfusion injury (IRI) is a process whereby an initial ischemia injury and subsequent recovery of blood flow, which leads to the propagation of an innate immune response and the changes of structural and functional of multiple organs. Therefore, IRI is considered to be a great challenge in clinical treatment such as organ transplantation or coronary angioplasty. In recent years, ethyl pyruvate (EP), a derivative of pyruvate, has received great attention because of its stability and low toxicity. Read More

View Article and Full-Text PDF

Doxorubicin-Induced Fetal Mesangial Cell Death Occurs Independently of TRPC6 Channel Upregulation but Involves Mitochondrial Generation of Reactive Oxygen Species.

Int J Mol Sci 2021 Jul 15;22(14). Epub 2021 Jul 15.

Department of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Doxorubicin (DOX), a category D pregnancy drug, is a chemotherapeutic agent that has been shown in animal studies to induce fetal toxicity, including renal abnormalities. Upregulation of the transient receptor potential cation (TRPC) 6 channel is involved in DOX-induced podocyte apoptosis. We have previously reported that TRPC6-mediated Ca signaling promotes neonatal glomerular mesangial cell (GMC) death. Read More

View Article and Full-Text PDF

Increased Endocytosis of Cadmium-Metallothionein through the 24p3 Receptor in an In Vivo Model with Reduced Proximal Tubular Activity.

Int J Mol Sci 2021 Jul 6;22(14). Epub 2021 Jul 6.

Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, México CP 07360, Mexico.

Background: The proximal tubule (PT) is the major target of cadmium (Cd) nephrotoxicity. Current dogma postulates that Cd complexed to metallothionein (MT) (CdMT) is taken up through receptor-mediated endocytosis (RME) via the PT receptor megalin:cubilin, which is the predominant pathway for reuptake of filtered proteins in the kidney. Nevertheless, there is evidence that the distal parts of the nephron are also sensitive to damage induced by Cd. Read More

View Article and Full-Text PDF

Efficacy and safety of anti-vascular endothelial growth factor therapies in older patients for first line treatment of metastatic renal cell carcinoma.

Transl Androl Urol 2021 Jun;10(6):2418-2426

Urology Department, Rouen University Hospital, Rouen, France.

Background: immunotherapy became the first line treatment of metastatic renal cell carcinoma (mRCC). Nevertheless, a better understanding of the specificities of targeted therapies (TT) in the elderly population could be helpful in order to improve the management of mRCC in this population. The aim of this retrospective study was to assess efficacy and safety of sunitinib and sorafenib used as first-line TT in 70 years older patients compared to younger patients. Read More

View Article and Full-Text PDF

Alleviated the Hemotoxicity, Oxidative Damage and Histopathological Alterations of Hydroxychloroquine in Catfish ().

Front Physiol 2021 6;12:683669. Epub 2021 Jul 6.

Department of Zoology, Faculty of Science, Sohag University, Sohag, Egypt.

The current study aims at evaluating the toxicity of hydroxychloroquine (HCQ) as a pharmaceutical residue in catfish () and the protective role of (SP). Four groups were used in this study: (1) a control group, (2) a group exposed to 3.16 mg/l of HCQ, (3) a group exposed to 3. Read More

View Article and Full-Text PDF

Potential Privilege of Maltodextrin-α-Tocopherol Nano-Micelles in Seizing Tacrolimus Renal Toxicity, Managing Rheumatoid Arthritis and Accelerating Bone Regeneration.

Int J Nanomedicine 2021 14;16:4781-4803. Epub 2021 Jul 14.

Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt.

Background: Tacrolimus (TAC) is a powerful immunosuppressive agent whose therapeutic applicability is confined owing to its systemic side effects.

Objective: Herein, we harnessed a natural polymer based bioconjugate composed of maltodextrin and α-tocopherol (MD-α-TOC) to encapsulate TAC as an attempt to overcome its biological limitations while enhancing its therapeutic anti-rheumatic efficacy.

Methods: The designed TAC loaded maltodextrin-α-tocopherol nano-micelles ([email protected]α-TOC) were assessed for their physical properties, safety, toxicological behavior, their ability to combat arthritis and assist bone/cartilage formation. Read More

View Article and Full-Text PDF

A case report of RccHan: WIST rat with multiple neoplastic and non-neoplastic proliferative lesions.

J Toxicol Pathol 2021 Jul 30;34(3):251-259. Epub 2021 Apr 30.

Toxicology and Environmental Science Department, Biological Research Laboratories, Nissan Chemical Corporation, 1470 Shiraoka, Shiraoka-shi, Saitama 349-0294, Japan.

It is extremely rare to have multiple spontaneous proliferative lesions in young adult rats. Here, we report the occurrence of different proliferative lesions in multiple tissues of a 7-week-old female rat in a 1-week repeated toxicity study. Grossly, multiple white patches and nodules in the bilateral kidneys, femoral and subcutaneous masses, and a nodule in the liver were observed. Read More

View Article and Full-Text PDF

N-Terminal pro-brain natriuretic peptide (NTproBNP) in patients with symptomatic multiple myeloma: report from a single institution.

Ann Hematol 2021 Jul 21. Epub 2021 Jul 21.

Department of Medical Oncology and Hematology, Tom Baker Cancer Center, 1331 29th St, NW, Calgary, AB, T2N 4N2, Canada.

Elevated levels of serum cardiovascular markers including natriuretic peptides (NPs) such as amino terminal pro-brain natriuretic peptide (NTproBNP) have been associated with disease severity and survival in cancer patients and more recently in multiple myeloma (MM). In the present study, we retrospectively reviewed 87 consecutive symptomatic TEMM (transplant-eligible) and 126 TIMM (transplant-ineligible) patients treated at our institution that did undergo NTproBNP testing from 2017 to 2020. Median age at diagnosis was 59. Read More

View Article and Full-Text PDF

[Achilles tendinopathy in a hemodialysis patient complicated by rupture of the Achilles tendon due to self-medication with ciprofloxacin: about a case].

Pan Afr Med J 2021 29;38:312. Epub 2021 Mar 29.

Service de Traumatologie-Orthopédie B4, Centre Hospitalier Universitaire Hassan II, Fès, Maroc.

This study aims to remind clinicians of fluoroquinolone-related tendinopathies. They are rare side effects, but which can result in functional disability. We report the case of a 79-year-old woman with a 11-year history of haemodialysis who had sudden left ankle pain and functional impairment in the ipsilateral member on day 5 after self-medication with ciprofloxacin. Read More

View Article and Full-Text PDF