12,162 results match your criteria renal scintigraphy

High renin hypertension in focal renal fibromuscular dysplasia: turn off of renin system angiotensin overactivation by renal angioplasty cured high blood pressure and quickly reversed myocardial hypertrophy.

Acta Biomed 2021 Apr 30;92(S1):e2021162. Epub 2021 Apr 30.

University of Parma.

Background Fibromuscolar dysplasia (FMD) is an idiopathic, non-atherosclerotic and non-inflammatory stenotic lesion of renal arteries causing renovascular hypertension up-regulating renin-angiotensin-aldosterone system. Case report: A 18-year-old man was referred to our Hypertension Center (Clinica e Terapia Medica) for the recent onset of hypertension, poorly controlled on calcium channel blockers, already associated to electrocardiographic and echocardiography signs of left ventricular hypertrophy and significant albuminuria (728 mg/24 h). An increased plasma renin activity (PRA), aldosterone level and a mild hypokalemia raised the suspicion of renovascular hypertension. Read More

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[Evaluation of ischemia-modified albumin in obstructive renal injury.]

Arch Esp Urol 2021 May;74(4):427-434

SBU Haydarpasa Numune SUAM. Department of Urology. Istanbul. Turkey.

Objectives: This study was aimed at assessing the ability of ischemia-modified albumin (IMA) to predict renal injury by associating biochemical, functional, and pathological findings with various degrees of ureteral obstruction.

Methods: Twenty-four rats were randomized into three groups, and their blood was sampled to determine the creatinine and IMA values and renal scintigraphy was done at the start and on postoperative day 7. In the sham group, the ureter was untouched; in the partial group, the ureter was gently embedded into the psoas muscle; and in the complete group, the ureter was compathologically, and all parameters were statistically evaluated. Read More

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Superselective Ischemia in Robotic Partial Nephrectomy Does Not Provide Better Long-term Renal Function than Renal Artery Clamping in a Randomized Controlled Trial (EMERALD): Should We Take the Risk?

Eur Urol Focus 2021 Apr 27. Epub 2021 Apr 27.

Urology Department, Grenoble University Hospital, Grenoble, France.

Background: Superselective clamping of tumor-targeted arteries aims to eliminate ischemia of the remnant kidney while keeping tumor bed bloodless during excision.

Objective: To evaluate the impact of superselective clamping on long-term renal function, compared with renal artery early unclamping.

Design, Setting, And Participants: A randomized monocentric single-blind trial (1:1) was conducted from February 2018 to August 2019. Read More

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Current and future perspectives on functional molecular imaging in nephro-urology: theranostics on the horizon.

Theranostics 2021 7;11(12):6105-6119. Epub 2021 Apr 7.

Department of Nuclear Medicine, University Hospital Wuerzburg, Wuerzburg, Germany.

In recent years, a paradigm shift from single-photon-emitting radionuclide radiotracers toward positron-emission tomography (PET) radiotracers has occurred in nuclear oncology. Although PET-based molecular imaging of the kidneys is still in its infancy, such a trend has emerged in the field of functional renal radionuclide imaging. Potentially allowing for precise and thorough evaluation of renal radiotracer urodynamics, PET radionuclide imaging has numerous advantages including precise anatomical co-registration with CT images and dynamic three-dimensional imaging capability. Read More

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Living-Donor Kidney Transplantation With Laparoscopic Nephrectomy From a Donor With Horseshoe Kidney: A Case Report.

Transplant Proc 2021 Apr 20. Epub 2021 Apr 20.

Department of Surgery, Japan Community Health Care Organization Sendai Hospital, Sendai, Miyagi, Japan.

Background: In living-donor kidney transplantation, laparoscopic nephrectomy from a donor has become widespread. However, more careful treatment is required for nephrectomy from a donor with horseshoe kidney. This report presents an interesting surgical case of laparoscopic nephrectomy from a donor with horseshoe kidney. Read More

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Laparoscopic transposition for crossing vessels (vascular hitch) in pure extrinsic pelvic-ureteric junction obstruction: a successful case report of a 2-year-old infant with horseshoe kidney.

Surg Case Rep 2021 Apr 23;7(1):103. Epub 2021 Apr 23.

Department of Pediatric Surgery, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Pediatric hydronephrosis induced by pelvic-ureteric junction obstruction (PUJO) is treated by dismembered pyeloplasty (DP) via open and laparoscopic surgery. The etiology of PUJO involves both intrinsic stenosis and extrinsic compression of crossing vessels (CVs). PUJO owing to CVs is also treated by DP, as there is no consensus concerning this vascular condition. Read More

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Sequential Bone Scintigraphy and the Evolution of Warfarin-Mediated Calcific Uremic Arteriolopathy.

Case Rep Nephrol Dial 2021 Jan-Apr;11(1):78-86. Epub 2021 Mar 1.

Division of Nephrology, Hennepin County Medical Center, Minneapolis, Minnesota, USA.

Calcific uremic arteriolopathy (CUA), also known as calciphylaxis, is a complex syndrome of deranged mineral metabolism and vascular calcification leading to tissue ischemia that primarily occurs in end-stage renal disease (ESRD) patients on maintenance hemodialysis (HD). We report a case illustrating a temporal relationship between long-term warfarin anticoagulation and development of CUA in a patient with pre-dialysis chronic kidney disease (CKD) who progressed to ESRD. Serial Tc-methylene diphosphonate bone scintigraphy documented the evolution of metastatic CUA over a 5-month period following HD initiation. Read More

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Preparation of Heat-Denatured Macroaggregated Albumin for Biomedical Applications Using a Microfluidics Platform.

ACS Biomater Sci Eng 2021 Apr 7. Epub 2021 Apr 7.

Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada.

Albumin is widely used in pharmaceutical applications to alter the pharmacokinetic profile, improve efficacy, or decrease the toxicity of active compounds. Various drug delivery systems using albumin have been reported, including microparticles. Macroaggregated albumin (MAA) is one of the more common forms of albumin microparticles, which is predominately used for lung perfusion imaging when labeled with radionuclide technetium-99m (Tc). Read More

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Determination of split renal function in voluntary renal donors by multidetector computed tomography and nuclear renography: How well do they correlate?

SA J Radiol 2021 5;25(1):2009. Epub 2021 Mar 5.

Department of Radiology, Faculty of Health Sciences, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Background: The use of computed tomography (CT) for estimation of split renal function (SRF) has been reported previously. However, most of these studies have small samples, and many do not account for the renal attenuation at CT.

Objective: The aim of this study was to compare multidetector computed tomography (MDCT) volumetry-attenuation-based SRF with that obtained via Tc99m-diethylenetriaminepentaacetic acid (DTPA) renal scintigraphy in voluntary renal donors. Read More

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U.S. Diagnostic Reference Levels and Achievable Administered Activities for Adult Renal Scintigraphy: An Analysis of the Intersocietal Accreditation Committee Nuclear Laboratories.

J Nucl Med Technol 2021 Apr 5. Epub 2021 Apr 5.

Medical University of South Carolina, United States.

The goal of this work was to determine U.S. diagnostic reference levels (DRLs) and achievable administered activities (AAAs) for adult renal scintigraphy. Read More

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[Comparison of functional magnetic resonance urography and dynamic renal scintigraphy in the functional assessment of ureteropelvic junction obstruction in children].

Urologiia 2021 Mar(1):90-94

Rostov Medical State University, Rostov-on-Don, Russia.

Purpose: In order to determine the role and significance of functional magnetic resonance urography (fMRU) in the diagnosis of ureteropelvic junction obstruction (UPJO), a comparative analysis of the results of fMRU and dynamic renal scintigraphy (DRS) was carried out.

Materials And Methods: From January 2017 to December 2019, fMRU and diuretic DRS were performed in 36 patients (mean age 89+/-63 months). Boys - 26 (72. Read More

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Preclinical Evaluation of Tc-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake.

Int J Mol Sci 2021 Mar 9;22(5). Epub 2021 Mar 9.

Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.

Radionuclide imaging of HER2 expression in tumours may enable stratification of patients with breast, ovarian, and gastroesophageal cancers for HER2-targeting therapies. A first-generation HER2-binding affibody molecule [Tc]Tc-ZHER2:V2 demonstrated favorable imaging properties in preclinical studies. Thereafter, the affibody scaffold has been extensively modified, which increased its melting point, improved storage stability, and increased hydrophilicity of the surface. Read More

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Dynamic Contrast Enhanced-MR CEST Urography: An Emerging Tool in the Diagnosis and Management of Upper Urinary Tract Obstruction.

Tomography 2021 Mar 2;7(1):80-94. Epub 2021 Mar 2.

The Russell H. Morgan Department of Radiology and Radiological Science, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA.

Upper urinary tract obstructions (UTOs) are blockages that inhibit the flow of urine through its normal course, leading to impaired kidney function. Imaging plays a significant role in the initial diagnosis of UTO, with anatomic imaging (primarily ultrasound (US) and non-contrast computed tomography (CT)) serving as screening tools for the detection of the dilation of the urinary collecting systems (i.e. Read More

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A Novel Method for Accurate Quantification of Split Glomerular Filtration Rate Using Combination of Tc-99m-DTPA Renal Dynamic Imaging and Its Plasma Clearance.

Dis Markers 2021 13;2021:6643586. Epub 2021 Mar 13.

The Second Hospital of Anhui Medical University, Hefei, China.

Purpose: To precisely quantify split glomerular filtration rate by Tc-99m-DTPA renal dynamic imaging and plasma clearance in order to increase its consistency among doctors.

Methods: Tc-99m-DTPA renal dynamic imaging was performed according to the conventional radionuclide renal dynamic imaging by five double-blinded doctors independently and automatically calculated split GFR, namely, gGFR. Moreover, the conventional radionuclide renal dynamic imaging was assessed to only outline the kidney, blank background, and automatically calculated split GFR, gGFR'. Read More

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Feasibility and Therapeutic Potential of Combined Peptide Receptor Radionuclide Therapy With Intensive Chemotherapy for Pediatric Patients With Relapsed or Refractory Metastatic Neuroblastoma.

Clin Nucl Med 2021 Mar 16. Epub 2021 Mar 16.

From the Division of Hematology/Oncology, Department of Pediatrics, School of Medicine Hematology Research Center, Amir Oncology Hospital, Shiraz University of Medical Sciences, Shiraz The Persian Gulf Nuclear Medicine Research Center, Department of Molecular Imaging and Radionuclide Therapy, Bushehr Medical University Hospital, Bushehr University of Medical Sciences, Bushehr Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad Hematology Research Center, Shiraz University of Medical Sciences, Shiraz Department of Pediatric Hematology and Oncology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada Department of Nuclear Medicine, Klinikum Westfalen, Dortmund, Germany.

Background: Recent evidence has demonstrated high expression of somatostatin receptors in neuroblastoma (NB) cells. Because of this, we endeavored to evaluate the diagnostic performance and clinical efficacy of 68Ga-DOTATATE PET/CT and peptide receptor radionuclide therapy (PRRT) using 177Lu-DOTATATE combined with chemotherapy in pediatric NB patients.

Patients And Methods: In total, 14 pediatric patients with histopathologically confirmed NB underwent 68Ga-DOTATATE PET/CT. Read More

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Preoperative Imaging in Renal Transplant Patients with Tertiary Hyperparathyroidism.

World J Surg 2021 Mar 27. Epub 2021 Mar 27.

Department of Surgery, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

Background: Tertiary hyperparathyroidism following kidney transplantation is most commonly characterized by 4-gland hyperplasia, but single and double adenomatous disease has been demonstrated in this population as well. It is unknown whether preoperative imaging can assist in identifying patients who may qualify for focused surgery for adenomatous disease.

Materials And Methods: We performed a retrospective review of our patient database from 1998-2018 for patients with tertiary hyperparathyroidism following renal transplant. Read More

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Preclinical evaluation of [Ac]Ac-DOTA-TATE for treatment of lung neuroendocrine neoplasms.

Eur J Nucl Med Mol Imaging 2021 Mar 26. Epub 2021 Mar 26.

Department of Cancer Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.

Purpose: There is significant interest in the development of targeted alpha-particle therapies (TATs) for treatment of solid tumors. The metal chelator-peptide conjugate, DOTA-TATE, loaded with the β-particle emitting radionuclide Lu ([Lu]Lu-DOTA-TATE) is now standard care for neuroendocrine tumors that express the somatostatin receptor 2 (SSTR2) target. A recent clinical study demonstrated efficacy of the corresponding [Ac]Ac-DOTA-TATE in patients that were refractory to [Lu]Lu-DOTA-TATE. Read More

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Comparison of Subureteral Endoscopic Injection of Dextranomer/Hyaluronic Acid and Lich-Gregoir Ureteral Reimplantation in the Treatment of Pediatric Primary Vesicoureteral Reflux: A Prospective Randomized Study.

J Laparoendosc Adv Surg Tech A 2021 Mar 22. Epub 2021 Mar 22.

Department of Urology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

The gold standard of surgical intervention of vesicoureteral reflux (VUR) is open ureteral reimplantation with high success and low complication rates. However, in recent years, endoscopic injection, dextranomer/hyaluronic acid (Dx/HA), has become an effective therapy for VUR. It is noted that limited prospective randomized trials compare the different surgical techniques of especially endoscopic injection versus open procedures. Read More

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A new technique in the treatment of ureteroenteric anastomosis stricture: Repair of ureteroenteric anastomosis stricture with low lombotomy incision (retroperitoneal approach).

Int J Clin Pract 2021 Mar 20:e14155. Epub 2021 Mar 20.

Department of Urology, Ege University Faculty of Medicine, Izmir, Turkey.

Introduction And Aim: Ureteroenteric anastomosis stricture (UEAS) is one of the complications of urinary diversion and may lead to serious consequences. In this study, we evaluated our UEAS revision technique outcomes performed with a low lombotomy incision in the lateral decubitus position.

Materials And Methods: Eleven patients who underwent surgical repair due to isolated right UEAS between January 2010 and June 2019 were included in the study. Read More

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[Clinical features of neurogenic bladder with vesicoureteral reflux in children].

Zhongguo Dang Dai Er Ke Za Zhi 2021 Mar;23(3):279-282

Department of Nephrology, Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.

Objective: To study the clinical features of vesicoureteral reflux (VUR) in children with neurogenic bladder (NB), and to provide a reference for its early diagnosis and treatment.

Methods: Clinical data were collected from 26 children with NB and urinary tract infection who were admitted to the Department of Pediatric Nephrology from January 2014 to December 2019. According to the presence or absence of VUR, the children were divided into a VUR group with 11 children and a non-VUR group with 15 children. Read More

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Comparison of Cr-EDTA and Tc-DTPA for glomerular filtration rate measurement.

J Nephrol 2021 Mar 4. Epub 2021 Mar 4.

Université de Paris, Paris, France.

Purpose: The production of Cr-labelled ethylenediaminetetraacetic acid (Cr-EDTA), a validated and widely used radio-isotopic tracer for glomerular filtration rate (GFR) measurement in Europe, was recently halted by the manufacturer. Technetium-99m-diethylenetriaminepentaacetic acid (Tc-DTPA) clearance has so far mostly been restricted to assessment of separate renal function by scintigraphy, but scarcely used and validated for GFR measurement. We compared the performances of Cr-EDTA and Tc-DTPA for GFR and extracellular fluid measurement. Read More

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Clinical advantages of robot-assisted partial nephrectomy versus laparoscopic partial nephrectomy in terms of global and split renal functions: A propensity score-matched comparative analysis.

Int J Urol 2021 Mar 3. Epub 2021 Mar 3.

Department of Urology, Kyushu University, Fukuoka, Japan.

Objectives: To identify predictors of renal function preservation, and to compare the global and split renal function outcomes of robot-assisted partial nephrectomy and laparoscopic partial nephrectomy.

Methods: Demographic, operative and pathological data, as well as renal function outcomes, of 251 patients who underwent laparoscopic (n = 104) and robot-assisted (n = 147) partial nephrectomy between 2008 and 2018 were retrospectively analyzed. Propensity score matching (1:1) was carried out to adjust for potential baseline confounders. Read More

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Metabolomic profiling identifies a novel mechanism for heat stroke‑related acute kidney injury.

Mol Med Rep 2021 04 28;23(4). Epub 2021 Jan 28.

Department of Nephrology, Sichuan Clinical Research Center for Nephropathy, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

Heat stroke can induce a systemic inflammatory response, which may lead to multi‑organ dysfunction including acute kidney injury (AKI) and electrolyte disturbances. To investigate the pathogenesis of heat stroke (HS)‑related AKI, a mouse model of HS was induced by increasing the animal's core temperature to 41˚C. Blood samples obtained from the tail vein were used to measure plasma glucose and creatinine levels. Read More

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Types of Parenchymal Changes Diagnosed on DMSA Scans of Kidneys Affected by Different Grades of Vesicoureteral Reflux.

Med Sci Monit 2021 Mar 1;27:e929617. Epub 2021 Mar 1.

Department of Pediatrics, University Hospital in Split, Split, Croatia.

BACKGROUND Renal parenchymal damage and scarring usually is associated with urinary tract infection (UTI), whereas the impact of vesicoureteral reflux (VUR) on the kidneys is unclear. We aimed to compare kidneys with all grades of VUR (grades Io-V) and those without VUR by using direct radionuclide cystography, voiding cystourethrography, and findings from 99mTc-DMSA scintigraphy (DMSA scan). MATERIAL AND METHODS The present analysis included 253 renal ureteral units (RUU) from 129 children with VUR and recurrent UTI and children with a single febrile UTI associated with abnormal ultrasonographic findings. Read More

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A Rare Case of a Pediatric Patient Affected by Crossed Fused Renal Ectopia: The usefulness of Dual TracerTc-Diethylenetriamine Pentaacetic Acid/Tc-Dimercaptosuccinic Acid Scintigraphy.

Indian J Nucl Med 2020 Oct-Dec;35(4):374-376. Epub 2020 Oct 21.

Department of Maternal and Child Health, UOC of Latina, University of La Sapienza Roma, Roma, Italy.

A 9-year-old male patient, with an ultrasonography diagnosis of horseshoe kidney condition, was referred to our hospital for recurrent urinary tract infection. He was submitted to Tc-diethylenetriamine pentaacetic acid sequential scintigraphy that demonstrated urine stasis in the calyces of both kidneys and was also suggestive for 8-shaped right-to-left crossed-fused renal ectopia. A subsequently performed Tc-dimercaptosuccinic acid scan confirmed the diagnosis of crossed renal ectopia, also disclosing, through single-photon emission computed tomography (SPECT) acquisition, cortical uptake defects in both kidneys, and indicative of renal scarring due to recurrent pyelonephritis. Read More

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October 2020

An Unusual Case of Anterior Abdominal wall Dialysate Leak Diagnosed with Tc99m-Sulfur Colloid Single-Photon Emission Computed Tomography/Computed Tomography Peritoneal Scintigraphy.

Indian J Nucl Med 2020 Oct-Dec;35(4):370-371. Epub 2020 Oct 21.

Department of Urology, Princess Esra Hospital, Hyderabad, Telangana, India.

Peritoneal dialysis (PD) was commonly used renal replacement therapy for treating end-stage renal failure patients leading to various infectious and mechanical complications. We present a case of a 50-year-old female patient who presented with reduced dialysate return and abdominal wall edema following continuous ambulatory PD. Peritoneal scintigraphy done on suspicion of dialysate leak shows tracer accumulation in the anterior abdominal wall below the insertion of the peritoneal catheter. Read More

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October 2020

A Resuscitated Case of Acute Myocardial Infarction with both Familial Hypercholesterolemia Phenotype Caused by Possibly Oligogenic Variants of the PCSK9 and ABCG5 Genes and Type I CD36 Deficiency.

J Atheroscler Thromb 2021 Feb 27. Epub 2021 Feb 27.

Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine.

A 56-year-old postmenopausal woman with out-of-hospital cardiac arrest caused by acute myocardial infraction was successfully resuscitated by intensive treatments and recovered without any neurological disability. She was diagnosed as having familial hypercholesterolemia (FH) based on a markedly elevated low-density lipoprotein cholesterol (LDL-C) level and family history of premature coronary artery disease. Genetic testing in her family members showed that a variant of the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene (c. Read More

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February 2021

Surgical feasibility, Determinants and overall Efficacy assessment of Neoadjuvant PRRT with Lu-DOTATATE for Locally Advanced Unresectable Gastroenteropancreatic Neuroendocrine Tumors.

J Nucl Med 2021 Feb 26. Epub 2021 Feb 26.

Radiation Medicine Centre (BARC), India.

The aim of the study was to assess Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) in neoadjuvant setting in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). In addition, we also evaluated the variables associated with resectability of the primary following PRRT. A total of 57 GEP-NETs with unresectable primary due to vascular involvement as defined using the National Comprehensive Cancer Network (NCCN) criteria given for pancreatic ductal adenocarcinoma (PDAC), who underwent Lu-DOTATATE without any prior surgery were included in this study. Read More

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February 2021

Clinical utility of FDG PET/CT for primary and recurrent papillary renal cell carcinoma.

Cancer Imaging 2021 Feb 25;21(1):25. Epub 2021 Feb 25.

Department of Nuclear Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

Purpose: Papillary renal cell carcinoma (RCC) is the second most common subtype of RCC, after clear cell RCC. This study aimed to investigate the usefulness of FDG PET/CT in primary and recurrent papillary RCC, and the role of staging FDG PET/CT in predicting survival.

Methods: A total of 66 patients with histopathologically confirmed papillary RCC who underwent either staging or restaging FDG PET/CT scans (30 had staging scans only, 28 had restaging scans only, 8 had both) were retrospectively included in this study. Read More

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February 2021

Lu-DOTATATE Peptide Receptor Radionuclide Therapy: Indigenously Developed Freeze Dried Cold Kit and Biological Response in In-Vitro and In-Vivo Models.

Dose Response 2021 Jan-Mar;19(1):1559325821990147. Epub 2021 Feb 12.

Department of Chemistry, Government College University, Faisalabad, Pakistan.

Somatostatin receptors (SStR) based Lu-DOTATATE therapy is known as one of the highly effective neuroendocrine tumors (NETs) treatment strategy. Development of DOTATATE freeze-dried kit for imaging and therapy of SStR positive NETs is a prime goal in neuroendocrine cancer research. The present work describes the development of Lu-DOTATATE freeze dried cold kit for indigenous needs, through technology development fund (TDF) program offered by Higher Education Commission (HEC) Pakistan. Read More

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February 2021