50 results match your criteria renal oncocytosis


Morphological and Molecular Study of Hybrid Oncocytic/Chromophobe Tumor of the Kidney Associated with Sporadic Renal Oncocytosis and Chronic B-Cell Lymphocytic Leukemia: The Possible Contribution of Lymphoma to Renal Oncocytosis.

Pathobiology 2021 Apr 21:1-10. Epub 2021 Apr 21.

Pathology, University Hospital Virgen Macarena, University of Seville, Sevilla, Spain.

Hybrid oncocytic/chromophobe tumor (HOCT) of the kidney arising from a precursor oncocytosis not associated with the Birt-Hogg-Dubé (BHD) syndrome is an unusual and highly interesting neoplasm. Immunohistochemical and molecular findings suggest that HOCT is an entity distinct from both oncocytoma and chromophobe carcinoma. Although uncertainty persists regarding the factors predisposing to the development of HOCT, experimental findings suggest that it may arise due to the effect of toxins or in association with chronic kidney failure. Read More

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Single-center study: the diagnostic performance of contrast-enhanced ultrasound (CEUS) for assessing renal oncocytoma.

Scand J Urol 2020 Apr 12;54(2):135-140. Epub 2020 Mar 12.

Department of Radiology, Ludwig-Maximilians-University Munich - Grosshadern Campus, Munich, Germany.

The aim of the present retrospective single-center study is to evaluate the diagnostic performance of contrast-enhanced ultrasound (CEUS) in the evaluation of renal oncocytoma. Thirteen patients with histopathologically confirmed renal oncocytoma and 26 patients with histopathologically confirmed renal cell carcinoma were included in this retrospective single-center study on whom CEUS was performed between 2005 and 2015. The applied contrast agent was a second-generation blood pool agent. Read More

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[A Case of Renal Oncocytosis with Bilateral Multiple Renal Masses].

Hinyokika Kiyo 2019 Apr;65(4):111-116

The Department of Pathology, Kobe City Medical Center General Hospital.

A 63-year-old man with microscopic hematuria underwent contrast-enhanced CT, which showed multiple bilateral renal masses. Percutaneous biopsy results indicated renal oncocytosis. The tumors remained unchanged for 3 years. Read More

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Hybrid oncocytic/chromophobe renal cell tumor: An integrated genetic and epigenetic characterization of a case.

Exp Mol Pathol 2018 12 18;105(3):352-356. Epub 2018 Oct 18.

Department of Pathology, Portuguese Oncology Institute of Porto, Portugal; Cancer Biology & Epigenetics Group, Research Center, Portuguese Oncology Institute of Porto, Portugal; Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Portugal. Electronic address:

Introduction: Hybrid oncocytic/chromophobe tumor (HOCT) is a renal cell neoplasm displaying overlapping cellular and architectural features of both renal oncocytoma (RO) and chromophobe renal cell carcinoma (chRCC). It has been described in the context of oncocytosis, Birt-Hogg-Dubé syndrome, and also sporadically. Thus far, HOCT immunohischemical profile and cytogenetic alterations have been reported, but not epigenetic alterations. Read More

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December 2018

Renal hybrid oncocytic/chromophobe tumor associated with multiple schwannomas: Case report and literature review.

Medicine (Baltimore) 2017 Dec;96(48):e8939

Department of Urology Department of Pathology, Peking Union Medical College Hospital, Beijing, China.

Rationale: Renal hybrid oncocytic/chromophobe tumors (HOCTs) are benign tumors containing a mixture of cells with features of chromophobe renal cell carcinoma (CHRCC) and renal oncocytoma (RO). Sporadic HOCT, which means HOCT occurs in patients without Birt-Hogg-Dubé syndrome (BHDS) or renal oncocytosis, is extremely rare. In this article, we would report a new case of a patient with both sporadic HOCT and multiple Schwannomas, which is even rarer than simplex sporadic HOCT. Read More

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December 2017

Emerging entities in renal cell neoplasia: thyroid-like follicular renal cell carcinoma and multifocal oncocytoma-like tumours associated with oncocytosis.

Pathology 2018 Jan 11;50(1):24-36. Epub 2017 Nov 11.

Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand.

The list of accepted entities of renal cell neoplasia has burgeoned since the turn of the century through recognition of rare tumour types and the discovery of genetic mutations driving renal neoplasia syndromes. This growth has not finished and in this report we present examples of each of these types which were not included in the 2016 World Health Organization classification of renal neoplasia, but are candidates for inclusion in the next edition of the classification. Thyroid-like follicular renal cell carcinoma is a rare tumour type with a distinctive microscopic appearance resembling follicles of the thyroid gland. Read More

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January 2018

A novel heterozygous mutation in the Birt-Hogg-Dubé Syndrome.

Arch Esp Urol 2017 Sep;70(7):675-678

Department of Urology. La Paz University Hospital. Madrid. Spain.

Objetive: Our aim is to present a novel mutation of the Birt-Hogg-Dubé Syndrome.

Methods: We present a case report of a 70-year-old male with three solid nodulary lesions of 4, 2.6, and 3 cm each in the right kidney, and two lesions of 1. Read More

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September 2017

Renal oncocytosis: a clinicopathological and cytogenetic study of 42 tumours occurring in 11 patients.

Pathology 2016 Jan 18;48(1):41-6. Epub 2015 Dec 18.

Division of Pathology of the University of Turin at San Luigi Hospital, Orbassano, Turin, Italy.

Renal oncocytosis is a rare pathological condition characterised by the presence of multiple oncocytic tumours with a spectrum of histological features ranging from renal oncocytoma, hybrid oncocytic tumour and rarely chromophobe renal cell carcinoma, sometimes overlapping. Here we retrospectively analysed histological, immunohistochemical (IHC), and cytogenetic features of 42 lesions in 11 patients with renal oncocytosis, not associated with Birt-Hogg-Dubé syndrome. The histology of all the lesions was blindly reviewed by three dedicated genitourinary pathologists. Read More

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January 2016

[The diagnostic and therapeutic challenges of bilateral renal oncocytosis : Illustrative case presentations and a review of the literature].

Urologe A 2016 Jul;55(7):941-8

Urologische Klinik, St. Elisabeth Klinikum Straubing, St. Elisabeth-Str. 23, 94315, Straubing, Deutschland.

Bilateral oncocytosis along with multiple tumours in both kidneys represents a very rare pathology that is accompanied by diagnostic and therapeutic challenges. We report the case of a 60-year old male patient who underwent computer tomography with incidental detection of multiple bilateral and contrast enhancing renal tumours of different size. Subsequently the patient underwent nephron-sparing tumor resection, first on the right side and 4 weeks later on the left side. Read More

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Mitochondrial DNA mutations distinguish bilateral multifocal renal oncocytomas from familial Birt-Hogg-Dubé tumors.

Mod Pathol 2015 Nov 2;28(11):1458-69. Epub 2015 Oct 2.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Oncocytomas are mostly benign tumors characterized by accumulation of defective mitochondria, and in sporadic cases, are associated with disruptive mitochondrial DNA (mtDNA) mutations. However, the role mtDNA mutations have in renal tumors of Birt-Hogg-Dubé (BHD) patients and other renal oncocytomas with an apparent genetic component has not been investigated to date. Here we characterize the mitochondrial genome in different renal tumors and investigate the possibility of employing mtDNA sequencing analyses of biopsy specimens to aid in the differential diagnosis of oncocytomas. Read More

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November 2015

[Renal oncocytosis is a diagnostic challenge].

Ugeskr Laeger 2015 01;177(2A):122-3

Radiologisk Afdeling, Holstebro Sygehus, Lægårdvej 12 C, 7500 Holstebro.

Renal oncocytosis is a rare variant of renal oncocytoma with multiple, often bilateral oncocytomas. This case report discusses radiological and pathological aspects of renal oncocytoma and oncocytosis. Read More

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January 2015

Review of renal tumors associated with Birt-Hogg-Dubé syndrome with focus on clinical and pathobiological aspects.

Pol J Pathol 2014 Jun;65(2):93-9

Naoto Kuroda Department of Diagnostic Pathology Kochi Red Cross Hospital, Shin-honmachi 2-13-51 Kochi City, Kochi 780-8562, Japan tel. +81-88-822-1201 fax +81-88-822-1056 e-mail:

Birt-Hogg-Dubé syndrome (BHDS) is an autosomal dominant inherited disorder characterized by clinical features of skin lesions, pulmonary lesions and renal tumor. The gene responsible for this syndrome is located on chromosome 17p11.2 and designated as FLCN. Read More

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Renal oncocytosis.

J Urol 2014 Oct 18;192(4):1225-6. Epub 2014 Jul 18.

Imaging Institute, Cleveland Clinic, Cleveland, Ohio.

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October 2014

Unilateral renal oncocytosis and combined hybrid tumor: a case report and review of the literature.

Jpn J Radiol 2014 Sep 28;32(9):556-60. Epub 2014 May 28.

Department of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102, Heukseok-ro, Dongjak-gu, Seoul, 156-755, Korea.

Renal oncocytosis is a very rare cause of multiple renal masses. Imaging features of renal oncocytosis and combined tumors have rarely been reported. Here, we describe a case of unilateral left renal oncocytosis and a combined hybrid tumor between chromophobe renal cell carcinoma and oncocytoma, which were depicted on CT and MR imaging as multiple enhancing solid masses with one dominant mass. Read More

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September 2014

Renal cell neoplasm of oncocytosis: a type of unclassified renal cell carcinoma.

CEN Case Rep 2014 May 19;3(1):10-13. Epub 2013 Apr 19.

Department of Pathology, Nara Medical University, Nara, Japan.

A 69-year-old woman was referred to us because a cyst in the lower pole of the left kidney had been pointed out on screening ultrasound. Computed tomography (CT) demonstrated a mural nodule of the wall of the cyst with an enhancement effect, suggesting cystic renal cell carcinoma (cT1aN0M0). The patient underwent retroperitoneoscopic non-ischemic partial nephrectomy using a microwave tissue coagulator. Read More

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[Renal unilateral oncocytis: case report].

Prog Urol 2014 Feb 9;24(2):138-41. Epub 2013 Jul 9.

Département d'urologie, CHU Rangueil, 1, avenue du Pr-Jean-Poulhès, TSA 50032, 31059 Toulouse cedex, France. Electronic address:

The renal oncocytoma tumors are rare (5% of renal tumors). These benign tumors are incidentally diagnosed most often in an asymptomatic form. Sometimes it is multiple bilateral tumors affecting the renal parenchyma and forming a renal oncocytosis. Read More

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February 2014

The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia.

Am J Surg Pathol 2013 Oct;37(10):1469-89

*Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada †Department of Pathology and Molecular Medicine, Wellington School of Medicine, University of Otago, Wellington, New Zealand ‡Department of Pathology, Indiana University School of Medicine, Indianapolis, IN Departments of ∥Pathology, Urology and Oncology §§Pathology and Oncology, Johns Hopkins Medical Institutions, Baltimore, MD ††Memorial Sloan Kettering Cancer Centre, NY ‡‡Department of Pathology, in New York University Medical Centre, New York, NY §Department of Oncology and Pathology, Karolinska University Hospital Solna, Stockholm, Sweden ¶Department of Pathology, University Hospital Plzen, Plzen, Czech Republic #Institute of Surgical Pathology, University of Zurich, Switzerland **Section of Pathological Anatomy, Polytechnic University of Medicine, United Hospitals, Ancona, Italy.

The classification working group of the International Society of Urological Pathology consensus conference on renal neoplasia was in charge of making recommendations regarding additions and changes to the current World Health Organization Classification of Renal Tumors (2004). Members of the group performed an exhaustive literature review, assessed the results of the preconference survey and participated in the consensus conference discussion and polling activities. On the basis of the above inputs, there was consensus that 5 entities should be recognized as new distinct epithelial tumors within the classification system: tubulocystic renal cell carcinoma (RCC), acquired cystic disease-associated RCC, clear cell (tubulo) papillary RCC, the MiT family translocation RCCs (in particular t(6;11) RCC), and hereditary leiomyomatosis RCC syndrome-associated RCC. Read More

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October 2013

Renal hybrid oncocytic/chromophobe tumors - a review.

Histol Histopathol 2013 10 6;28(10):1257-64. Epub 2013 Jun 6.

Department of Pathology, Charles University in Prague, Faculty of Medicine in Plzen, Czech Republic.

Hybrid oncocytic/chromophobe tumors (HOCT) occur in three clinico-pathologic situations; (1) sporadically, (2) in association with renal oncocytomatosis and (3) in patients with Birt-Hogg-Dubé syndrome (BHD). There are no specific clinical symptoms in patients with sporadic or HOCT associated with oncocytosis/oncocytomatosis. HOCT in patients with BHD are usually encountered on characteristic BHD clinicopathologic background. Read More

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October 2013

Review of renal oncocytosis (multiple oncocytic lesions) with focus on clinical and pathobiological aspects.

Histol Histopathol 2012 11;27(11):1407-12

Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi, Japan.

Renal oncocytosis is a recently established disease entity characterized by numerous oncocytic tumors and diffuse involvement of oncocytic changes in renal parenchymal epithelia. In this article, we review this disease with a focus on its clinical and pathobiological aspects. Clinically, renal oncocytosis may occur in a sporadic form without any underlying disease or may be associated with chronic renal failure/long-term hemodialysis. Read More

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November 2012

Incidental detection of oncocytosis in a renal biopsy specimen for idiopathic nephrotic syndrome.

Pathol Res Pract 2011 Nov 13;207(11):733-6. Epub 2011 Oct 13.

Department of Anatomic Pathology, Marqués de Valdecilla University Hospital, Medical Faculty, University of Cantabria, Avda. Valdecilla s/n, ES-39011 Santander, Spain.

Oncocytosis (oncocytomatosis) is a rare condition characterized by the presence of innumerable oncocytic nodules in one or both kidneys, usually associated with the presence of a dominant nodule. An incidental detection of a renal tumor in a renal biopsy performed for the diagnosis of a medical disease of the kidney is exceptional. We report herein a case of a 58-year-old woman presenting with idiopathic nephrotic syndrome. Read More

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November 2011

Renal oncocytosis: management and clinical outcomes.

J Urol 2011 Mar 15;185(3):795-801. Epub 2011 Jan 15.

Department of Surgery, Urology Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

Purpose: Renal oncocytosis is a rare pathological condition in which renal parenchyma is diffusely involved by numerous oncocytic nodules in addition to showing a spectrum of other oncocytic changes. We describe our experience with renal oncocytosis, focusing on management and outcomes.

Materials And Methods: A total of 20 patients with a final pathological diagnosis of renal oncocytosis from July 1995 through June 2009 were included in the analysis. Read More

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Type 2 and clear cell papillary renal cell carcinoma, and tubulocystic carcinoma: a unifying concept.

Anticancer Res 2010 Feb;30(2):641-4

Pathology Queensland, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, QLD 4102, Australia.

The clinical and pathological features of multiple different renal neoplasms arising in a setting of end-stage renal disease in a 72-year-old male are described. The kidney showed features of renal oncocytosis with multiple oncocytomas, hybrid tumours and chromophobe renal carcinoma. In addition, the kidney contained a type 2 papillary renal cell carcinoma, clear cell papillary and cystic renal cell carcinoma, and tubulocystic carcinoma. Read More

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February 2010

Renal cell neoplasms of oncocytosis have distinct morphologic, immunohistochemical, and cytogenetic profiles.

Am J Surg Pathol 2010 May;34(5):620-6

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

This study was undertaken to elucidate the genetic patterns of the renal cell neoplasms of oncocytosis and to compare them with those found in cases with multiple oncocytomas. Three cases of renal oncocytosis and 6 cases of multiple oncocytomas were analyzed. Fluorescence in situ hybridization analysis was performed with centromeric probes for chromosomes 1, 2, 6, 10, and 17 that are typically lost in chromophobe renal cell carcinoma but not in oncocytoma. Read More

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Sporadic hybrid oncocytic/chromophobe tumor of the kidney: a clinicopathologic, histomorphologic, immunohistochemical, ultrastructural, and molecular cytogenetic study of 14 cases.

Virchows Arch 2010 Apr 19;456(4):355-65. Epub 2010 Mar 19.

Department of Pathology, National University Hospital System, Singapore, Singapore.

Hybrid oncocytic/chromophobe tumors (HOCT) of the kidney have been described in patients with Birt-Hogg-Dubé syndrome (BHD) and in association with renal oncocytosis without BHD. HOCT in patients without evidence of BHD or renal oncocytosis is exceedingly rare, and these cases have been poorly characterized. We have identified and studied 14 cases of HOCT from previously diagnosed renal oncocytomas (398 cases) and chromophobe renal cell carcinomas (351 cases) without evidence of BHD or renal oncocytosis. Read More

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Dysplastic ("in-situ") Lesions in multofocal renal oncocytomas (oncocytosis).

Int J Clin Exp Pathol 2009 Jun 18;2(6):583-7. Epub 2009 Jun 18.

Department of Pathology, David Geffen School of Medicine, University of California at Los Angeles Los Angeles, CA, USA.

Preneoplastic lesions for renal oncocytosis have not been well defined. We have attempted to identify the putative in-situ or dysplastic change in nephrectomy specimens with oncocytosis. Cases of multiple oncocytoma previously identified in radical nephrectomy specimens (n = 5) were reviewed for early lesions of renal oncocytosis by light microscopic analysis and by immunohistochemical studies for p53, bcl2 and MIB-1. Read More

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[Hereditary renal cancer].

Actas Urol Esp 2009 Feb;33(2):127-33

Servicio de Anatomía Patológica, Hospital Clínico San Carlos, Madrid, España.

Kidney cancer is the tenth most common cause of cancer death. There are a growing number of genes known to be associated with an increased risk of specific types of kidney cancer. People with Von Hippel-Lindau syndrome have about a 40% risk of developing multiple bilateral clear cell kidney cancers. Read More

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February 2009

Two consecutive cases of renal oncocytomatosis in a single-center experience.

Clin Nephrol 2009 Apr;71(4):433-40

First Department of Internal Medicine and Nephrology, St. Lukas Hospital, Tarnów, Poland.

Renal oncocytoma is a rare finding and represents the small percentage of all kidney tumors. This kind of tumor is benign and diagnosed accidentally (on autopsy or during nephrectomy performed for other reasons). On rare occasions, truly multiple tumors are seen, affecting the entire renal parenchyma; this condition is called oncocytosis or oncocytomatosis. Read More

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[Renal oncocytosis: case report].

Prog Urol 2009 Feb 20;19(2):142-4. Epub 2008 Nov 20.

Service d'urologie, université Paris-Sud, CHU Le Kremlin-Bicêtre, AP-HP, 78, rue Général-Leclerc, 94275 Le Kremlin-Bicêtre, France.

Renal oncocytoma represent 5% of kidney tumors. Oncocytoma is a benign tumor, usually asymptomatic and fortuitous discovery. Standard treatment is tumorectomy when technically feasible. Read More

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February 2009

Hybrid tumour 'oncocytoma-chromophobe renal cell carcinoma' of the kidney: a report of seven sporadic cases.

BJU Int 2009 May 20;103(10):1381-4. Epub 2009 Jan 20.

Department of Pathology, Necker Hospital, University of Paris-René Descartes, Paris, France.

Objectives: To determine whether renal hybrid tumours (HT) appear as a specific clinical and radiological entity, as HT are characterized by the association of both oncocytes and chromophobe cells within the same tumour, and have been described in patients with oncocytosis and Birt-Hogg-Dube syndrome.

Patients And Methods: We reviewed the medical charts of 67 patients who had a partial or radical nephrectomy in our institution for renal oncocytoma (RO, 24), chromophobe renal cell carcinoma (CRCC, 36) and HT (seven), from January 2006 to October 2007. We report the clinical, radiological and pathological characteristics of the seven cases of HT. Read More

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