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J Pharmacol Exp Ther 2022 Jul 2. Epub 2022 Jul 2.

Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals, Inc, United States

Diabetic nephropathy is a leading cause of end stage renal disease, characterized by endothelial dysfunction and compromised glomerular permeability barrier. Dysregulation of the ANGPT1/ANGPT2 signaling axis is implicated in disease progression. We recently described the discovery of an IgG antibody, O010, with therapeutic potential to elevate circulating endogenous ANGPT1, a TIE2 agonist. Read More

J Trace Elem Med Biol 2022 Jun 24;73:127030. Epub 2022 Jun 24.

Food Toxicology & Contaminants Department, National Research Center, Dokki, Cairo, Egypt. Electronic address:

Background: Zinc (Zn) is an essential trace element required for the function of the immune system. However, Zn fortification of food has faced some challenges, although excess Zn may be induced obesity and other related. This study aimed to use Zn-loaded whey protein nanoparticles (Zn-WPNPs) to enhance the immunomodulatory activity of Zn in rats treated with CCl. Read More

J Clin Endocrinol Metab 2022 Jul 2. Epub 2022 Jul 2.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.

Context: Due to its rare incidence, molecular features of PA in young adults are largely unknown. Recently developed targeted mutational analysis identified aldosterone-driver somatic mutations in aldosterone-producing lesions, including aldosterone-producing adenomas (APAs), aldosterone-producing nodules (APNs), and aldosterone-producing micronodules, formerly known as aldosterone-producing cell clusters.

Objective: To investigate histologic and genetic characteristics of lateralized PA in young adults. Read More

Support Care Cancer 2022 Jul 2. Epub 2022 Jul 2.

Division of Medical Oncology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 73, Goryeodae-ro, Seongbuk-gu, Seoul, 02841, Korea.

Purpose: First-line choice of therapy is critical as it affects treatment decisions in later lines in patients with metastatic colorectal cancer (mCRC). We assessed changes in renal function for 1 year among patients diagnosed with mCRC who received first-line chemotherapy. We aimed to analyze the prognostic factors and effect of each chemotherapy regimen on the renal function of the patients. Read More

Pediatr Surg Int 2022 Jul 2. Epub 2022 Jul 2.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China.

Objectives: To analyze the mid-short-term risk factors for chronic renal failure (CRF) in children with posterior urethral valve (PUV) after valve ablation.

Materials And Methods: A retrospective study of 143 patients with PUV who underwent operation was performed. Patients were divided into CRF group (n = 39) and non-CRF group (n = 104). Read More

Microscopy (Oxf) 2022 Jul 2. Epub 2022 Jul 2.

X-ray Research Laboratory, Rigaku Corporation, Akishima, Tokyo, Japan.

X-ray microscopes adopting computed tomography (CT) enable nondestructive 3D visualization of biological specimens at micron-level resolution without conventional 2D serial sectioning that is a destructive/laborious method and is routinely used for analyzing renal biopsy in clinical diagnosis of kidney diseases. Here we applied a compact commercial system of laboratory-based X-ray microscope to observe a resin-embedded osmium-stained 1 mm strip of a mouse kidney piece as a model of renal biopsy, toward more efficient diagnosis of kidney diseases. A reconstructed CT image from several hours of data collection using CCD detector allowed us to unambiguously segment a single nephron connected to a renal corpuscle, which was consistent with previous reports using serial sectioning. Read More

BMC Nephrol 2022 Jul 1;23(1):233. Epub 2022 Jul 1.

Research Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Investigating the effect of metabolic disorders on chronic kidney disease (CKD) in the presence or the absence of obesity is of great importance. This study aimed to examine the independent and joint relationships of obesity and metabolic syndrome (MetS) with CKD.  METHODS : The present study was performed on 9,762 participants from the baseline phase of the Ravansar non- communicable diseases (RaNCD) study. Read More

Heart Vessels 2022 Jul 1. Epub 2022 Jul 1.

Emergency Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng District, Beijing, People's Republic of China.

The present study aimed to evaluate sex-specific association between admission systolic blood pressure (SBP) and in-hospital prognosis in patients with acute decompensated heart failure (ADHF) admitted to intensive care unit (ICU). In this retrospective, observational study, 1268 ADHF patients requiring intensive care were consecutively enrolled and divided by sex. Patients were divided into three subgroups according to SBP tertiles: high (≥ 122 mmHg), moderate (104-121 mmHg) and low (< 104 mmHg). Read More

Sci Rep 2022 Jul 1;12(1):11161. Epub 2022 Jul 1.

Department of Hematology, The Second Affiliated Hospital of Dalian Medical University, Liaoning, Dalian, People's Republic of China.

Topoisomerase IIα (TOP2A) plays an oncogenic role in multiple tumor types. However, no pan-cancer analysis about the function and the upstream molecular mechanism of TOP2A is available. For the first time, we analyzed potential oncogenic roles of TOP2A in 33 cancer types via The Cancer Genome Atlas (TCGA) database. Read More

Clin Transplant 2022 Jul 1:e14759. Epub 2022 Jul 1.

Department of Medicine, Division of Nephrology, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213, USA.

High kidney-donor profile index (KDPI) kidneys have a shorter survival than grafts with lower KDPI values. It is still unclear, however, whether their shorter longevity depends on an inferior baseline function, faster functional decline, or the combination of both. To clarify this issue, we analyzed the estimated glomerular filtration rate (eGFR) of 605 consecutive recipients of deceased donor kidney transplants (KT) at 1, 3, 6, 12, 18, 24, 36, 48, and 60 months. Read More

Clin Genitourin Cancer 2022 Jun 9. Epub 2022 Jun 9.

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH. Electronic address:

Introduction: The American-Urological-Association(AUA) Guidelines for renal cancer(2017) recommend consideration for radical-nephrectomy(RN) over partial(PN) whenever there is increased oncologic-risk; and RN should be prioritized if three other criteria are all also met: 1) increased tumor-complexity; 2) no preexisting chronic-kidney-disease/ proteinuria, and 3) normal contralateral kidney that will likely provide estimated glomerular-filtration-rate (eGFR) >45ml/min/1.73m even if RN is performed. Our objective was to assess the complexity of decision-making about RN/PN and utility of AUA Guidelines statements regarding this issue. Read More

Clin Radiol 2022 Jun 28. Epub 2022 Jun 28.

Department of Radiology, Central Hospital Affiliated to Shandong First Medical University, Jinan 250013, China; Department of Radiology, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250013, China. Electronic address:

Aim: To evaluate the feasibility of an ultra-low volume contrast media (CM) protocol for coronary computed tomography angiography (CTA).

Materials And Methods: In total, 214 patients receiving coronary CTA were enrolled prospectively and divided into group A (n=107) receiving a conventional dose of CM and group B (n=107) receiving an ultra-low dose. CT values of the right coronary artery (RCA), left anterior descending artery (LAD), and left circumflex artery (LCX) were measured and radiation doses recorded. Read More

Clin J Am Soc Nephrol 2022 Jul 1. Epub 2022 Jul 1.

Department for Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London, London, United Kingdom

Background And Objectives: C3 glomerulopathy and idiopathic Ig-associated membranoproliferative GN are kidney diseases characterized by abnormal glomerular complement C3 deposition. These conditions are heterogeneous in outcome, but approximately 50% of patients develop kidney failure within 10 years.

Design, Setting, Participants, & Measurements: To improve identification of patients with poor prognosis, we performed a detailed analysis of percutaneous kidney biopsies in a large cohort of patients. Read More

Clin J Am Soc Nephrol 2022 Jul 1. Epub 2022 Jul 1.

Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland.

Background And Objectives: Mitochondrial DNA copy number is a biomarker of mitochondrial function, which has been hypothesized to contribute to pathogenesis of CKD through podocyte injury, tubular epithelial cell damage, and endothelial dysfunction. The prospective association of mitochondrial DNA copy number with CKD progression has not been previously evaluated.

Design, Setting, Participants, & Measurements: Chronic Renal Insufficiency Cohort study participants had serum levels of mitochondrial DNA copy number calculated from probe intensities of mitochondrial single nucleotide polymorphisms genotyped on the Illumina HumanOmni 1-Quad Array. Read More

Clin J Am Soc Nephrol 2022 Jul 1. Epub 2022 Jul 1.

Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

AKI is a potential complication of intravascular iodinated contrast exposure. Contrast-associated AKI, which typically manifests as small and transient decrements in kidney function that develop within several days of contrast administration, is associated with serious adverse outcomes, including progressive kidney dysfunction and death. However, a causal link between the small increases in serum creatinine that characteristically occur with contrast-associated AKI and serious adverse outcomes remains unproven. Read More

Ann Clin Lab Sci 2022 May;52(3):367-373

Department of Nephrology and Wenzhou Central Hospital, Wenzhou, China.

Objective: Matrix metallopeptidase 7 (MMP7) can promote renal fibrosis in diabetic kidney disease (DKD). A study found that LINC01510 overexpression inhibits MMP7 to play a role in renal cancer, but the relationship between the two in DKD had not been revealed, and the function of LINC01510 also needed to be explored, which was also the focus of this study.

Methods: The morphological changes of HK-2 cells induced by high glucose were observed by an inverted microscope, and fluorescence hybridization was used to determine the subcellular localization of LINC01510. Read More

J Am Soc Nephrol 2022 Jul 1. Epub 2022 Jul 1.

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin, Germany

Background: Volume-regulated anion channels (VRACs) are heterohexamers of LRRC8A with LRRC8B, -C, -D, or -E in various combinations. Depending on the subunit composition, these swelling-activated channels conduct chloride, amino acids, organic osmolytes, and drugs. Despite VRACs' role in cell volume regulation, and large osmolarity changes in the kidney, neither the localization nor the function of VRACs in the kidney is known. Read More

J Am Soc Nephrol 2022 Jul 1. Epub 2022 Jul 1.

Renal Division, Peking University First Hospital; Institute of Nephrology, Peking University; Key Laboratory of Renal Disease, Ministry of Health of China; Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China; Beijing, China.

Background: The complement system is highly activated in primary membranous nephropathy (MN). Identifying the complement components that damage podocytes has important therapeutic implications. This study investigated the role of C3a and the C3a receptor (C3aR) in the pathogenesis of MN. Read More

Transpl Immunol 2022 Jun 28:101649. Epub 2022 Jun 28.

Department of Neurology, Sanjay Gandhi Post Graduate institute of Medical Science, Lucknow, India.

Introduction: Living kidney donation is a complex psychological experience for donors. The present study examined the psychosocial impact of kidney donation on donors.

Methods: The retrospective study included 506 donors who donated a kidney between 2010 and 2018 at a transplant centre in India. Read More

Int J Cardiol 2022 Jun 28. Epub 2022 Jun 28.

Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Japan.

Background: Blood urea nitrogen (BUN) reflects decreased glomerular filtration rate (GFR). The effect of BUN on clinical outcomes, excluding the impact of GFR, in heart failure with preserved ejection fraction (HFpEF) patients remains unknown.

Methods: We enrolled HFpEF (left ventricular ejection fraction ≥50%) patients hospitalized due to acute decompensated heart failure (HF) from PURSUIT-HFpEF registry which was prospective, multicenter and observational study. Read More

J Pharmacokinet Pharmacodyn 2022 Jul 1. Epub 2022 Jul 1.

School of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, USA.

Plasma potassium regulation within a narrow range is vital for life. The risk for hyperkalemia increases when kidney function is impaired and with therapeutic interventions such as mineralocorticoid receptor antagonists (MRAs). The kidney maintains potassium homeostasis by matching potassium intake and excretion, in part through the action of aldosterone. Read More

Abdom Radiol (NY) 2022 Jul 1. Epub 2022 Jul 1.

Division of Abdominal Imaging, Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, White Building, Room 270, Boston, MA, 02114, USA.

Purpose: Prior case reports have noted an increase in renal size and perinephric stranding accompanying immunotherapy-related renal toxicity due to checkpoint-inhibitor therapy. The purpose of this investigation was to systematically evaluate if immunotherapy-related renal toxicity affects renal size and possible associated imaging findings.

Methods: This retrospective multi-hospital study included 25 patients (13 men), mean age 67 years (range 46-83) who received immune-checkpoint inhibitors for cancer treatment, developed biopsy-proven immunotherapy-related nephritis, and who also had abdominal imaging before, during, and after nephritis was diagnosed. Read More

Clin Transplant 2022 Jul 1:e14764. Epub 2022 Jul 1.

Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.

Acute kidney injury (AKI) in deceased organ donors is increasing due to the escalation in anoxic brain-deaths. The management of an organ donor with oligoanuric AKI is frequently curtailed due to hemodynamic and electrolyte instability. Although continuous renal replacement therapy (CRRT) corrects the effects of AKI, it is rarely started after the diagnosis of brain-death (BD). Read More

Lupus 2022 Jul 1:9612033221111958. Epub 2022 Jul 1.

Department of Medicine, Division of Rheumatology, 1500Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Objective: Proteinuria is the clinical expression of lupus nephritis and despite recent advances in the therapeutic armamentarium for lupus nephritis, morbidity and mortality rates remain high. Therefore, the identification of factors that predict lupus nephritis is paramount in preventing damage accrual and disease progression. Lipoprotein (a) (Lp[a]) is a primarily genetically inherited plasma lipoprotein with pro-thrombotic and pro-atherosclerotic effects. Read More

Exp Biol Med (Maywood) 2022 Jul 1:15353702221106479. Epub 2022 Jul 1.

School of Life Sciences, Anhui University, Hefei 230601, China.

Epigallocatechin-3-gallate (EGCG), an essential polyphenolic constituent found in tea leaves, possesses various potent biological activities. This research was undertaken to investigate the impact of EGCG against endoplasmic reticulum (ER) stress-mediated inflammation and to clarify the underlying molecular mechanism in type 2 diabetic kidneys. The male rats were randomized into four groups: normal, diabetic, low-dose EGCG, and high-dose EGCG. Read More

Int J Mycobacteriol 2022 Apr-Jun;11(2):205-207

Department of General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India.

Weil's syndrome, a severe form of the disease, may present with symptoms such as jaundice, renal dysfunction, and hemorrhagic diathesis and it can progress to multi-organ failure leading to death. In patients with coinfection of tuberculosis with leptospirosis, there may be severe hepatic and renal dysfunction rendering the standard antitubercular therapy (ATT) regimen useless, thus requiring alternate drug selection and dose modification of antitubercular drugs. We present a case of a 57-year-old female who presented with high-grade fever and yellowish discoloration of the eyes. Read More

Arch Ital Urol Androl 2022 Jun 30;94(2):232-236. Epub 2022 Jun 30.

Portuguese Institute of Oncology, Coimbra.

Introduction: Cycling is a popular means of transport and recreational activity; bicycles are also a source of genitourinary injuries and there is the idea that cycling may have a significant impact on sexual function. The objective of this study was to evaluate the effect of amateur cycling on erectile function.

Methods: We used a questionnaire comparing amateur cyclists (n = 199) and footballers (n = 43), regarding sexual related comorbidities and hours of practice per week. Read More

Arch Ital Urol Androl 2022 Jun 29;94(2):144-149. Epub 2022 Jun 29.

Department of Urology, Hospitals of Legnano and Magenta, Milan.

Introduction And Objectives: Radical cystectomy (RC) continues to be standard of care for muscle-invasive bladder cancer and recurrent or refractory nonmuscle invasive bladder cancer. Unfortunately, it has high rates of perioperative morbidity and mortality. One of the most important predictors of postoperative outcomes is frailty, while the majority of complications are diversion related. Read More

J Clin Pharm Ther 2022 Jun 30. Epub 2022 Jun 30.

Department of Pharmacy, Tokyo Women's Medical University, Yachiyo Medical Center, Yachiyo, Chiba, Japan.

What Is Known And Objective: High doses of vancomycin are required early in the treatment of nosocomial meningitis. However, the dosage is often reduced later during treatment, irrespective of renal function. This study was designed to investigate the pharmacokinetic variability of vancomycin and the associated factors throughout the treatment course for patients with nosocomial bacterial meningitis. Read More

Drugs Context 2022 14;11. Epub 2022 Jun 14.

Department of Nursing Administration, Spartanburg Regional Healthcare System, Spartanburg, SC, USA.

Background: Chronic kidney disease (CKD) is a prevalent and progressive condition worldwide, and diabetes is a leading risk factor of this renal disorder. People with diabetes and CKD are at high risk of complications such as cardiovascular events and death. CKD is often unrecognized and undiagnosed amongst people with diabetes. Read More