266,434 results match your criteria renal failure

Re-operative aortic arch surgery in a contemporary series.

Semin Thorac Cardiovasc Surg 2021 May 7. Epub 2021 May 7.

Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, GA. Electronic address:

Re-operative aortic arch operations (REDO) following previous cardiac surgery are challenging procedures associated with significant morbidity and mortality. We investigated post-operative outcomes for patients undergoing REDO and identified risk-factors for mortality in a contemporary series. From 1/2005-6/2018, 365 consecutive patients at an academic center underwent REDO: 257 HEMIARCH and 108 COMPLETE arch (45 stage I elephant trunk, 63 total arch) replacements. Read More

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Cardio- and reno-protective effects of dipeptidyl peptidase III in diabetic mice.

J Biol Chem 2021 May 7:100761. Epub 2021 May 7.

Division of Molecular Medical Biochemistry, Department of Biochemistry and Molecular Biology, Shiga University of Medical Science, Otsu, Japan. Electronic address:

Diabetes mellitus (DM) causes injury to tissues and organs, including to the heart and kidney, resulting in increased morbidity and mortality. Thus, novel potential therapeutics are continuously required to minimize DM-related organ damage. We have previously shown that dipeptidyl peptidase III (DPPIII) has beneficial roles in a hypertensive mouse model, but it is unknown whether DPPIII has any effects on DM. Read More

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Sex Differences in Ascending Aortic and Arch Surgery: A Propensity-matched Comparison of 1153 Pairs.

Ann Thorac Surg 2021 May 7. Epub 2021 May 7.

Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine; Section of Adult Cardiac Surgery, Department of Cardiovascular Surgery, Texas Heart Institute; Department of Cardiovascular Surgery, CHI St Luke's Health-Baylor St Luke's Medical Center; Cardiovascular Research Institute, Baylor College of Medicine, Houston, Texas.

Background: We investigated the relationship of sex with clinical outcomes after proximal aortic (ascending and arch) operations, and whether sex-specific preoperative factors are associated with mortality.

Methods: Of 3745 patients who underwent elective, urgent, and emergency proximal aortic operations over a 20-year period, 1153 pairs of men and women were propensity-matched, and their early and long-term outcomes were compared. Kaplan-Meier survival analysis was used to estimate late survival. Read More

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Case Report: Acute Kidney Failure due to Massive Envenomation of a Two-Year-Old Child Caused by Killer Bee Stings.

Am J Trop Med Hyg 2021 May 10. Epub 2021 May 10.

1Service de Médecine et Chirurgie Pédiatrique, Cayenne Hospital, Cayenne, French Guiana.

A hybrid species of Brazilian bee has proliferated on the South American continent since 1956. We describe a "killer bee" swarm attack on a 2-year-old girl in French Guiana. The patient weighed 10 kg, and approximately hundreds of bees' stingers were removed, that is, 10 stings/kg. Read More

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Mortality among Hospitalized Dengue Patients with Comorbidities in Mexico, Brazil, and Colombia.

Am J Trop Med Hyg 2021 May 10. Epub 2021 May 10.

4Sanofi Pasteur, Lyon, France.

Dengue patients with comorbidities may be at higher risk of death. In this cross-sectional study, healthcare databases from Mexico (2008-2014), Brazil (2008-2015), and Colombia (2009-2017) were used to identify hospitalized dengue cases and their comorbidities. Case fatality rates (CFRs), relative risk, and odds ratios (OR) for in-hospital mortality were determined. Read More

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Clinical and pathological analysis of renal biopsies of elderly patients in Northeast China: a single-center study.

Ren Fail 2021 Dec;43(1):851-859

The Department of Nephropathy, The Second Hospital of Jilin University, Changchun, China.

Purpose: To identify the clinical characteristics, histopathological features, and prognosis of kidney disease in a large cohort of elderly patients from Northeast China.

Methods: We retrospectively analyzed the renal disease spectrum in 7,122 patients who underwent renal biopsies at the Second Hospital of Jilin University from 2006 to 2020. Patients were grouped according to age: below 60 years (non-elderly group,  = 5923) and at least 60 years (elderly group,  = 1199). Read More

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December 2021

Shifting demographics and comorbidity burden in adult Chinese urban patients with chronic hepatitis B, 2013 and 2016.

J Comp Eff Res 2021 May 10. Epub 2021 May 10.

Department of Infectious Diseases, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.

Chronic hepatitis B demographics and comorbidity data are limited in China. The China Health Insurance Association claims database from 2013 and 2016 was used to augment the existing data: the proportion of patients aged >45 years increased significantly from 40.3% in 2013 to 49% in 2016 (p < 0. Read More

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Cardiovascular Toxicities of Antiangiogenic Tyrosine Kinase Inhibitors: A Retrospective, Pharmacovigilance Study.

Target Oncol 2021 May 10. Epub 2021 May 10.

Leviev Heart Center, Sheba Medical Center, Ramat Gan, Israel.

Background: Vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKIs) are an essential therapeutic option in the management of various solid tumors, particularly renal cell carcinoma (RCC). However, post-marketing data regarding their potential cardiovascular toxicities are scant.

Objective: To identify and characterize cardiovascular adverse events (CVAEs) of VEGFR-TKIs indicated for RCC. Read More

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Functional joint models for chronic kidney disease in kidney transplant recipients.

Stat Methods Med Res 2021 May 10:9622802211009265. Epub 2021 May 10.

Division of Nephrology, University of Nebraska Medical Center, NE, USA.

This functional joint model paper is motivated by a chronic kidney disease study post kidney transplantation. The available kidney organ is a scarce resource because millions of end-stage renal patients are on the waiting list for kidney transplantation. The life of the transplanted kidney can be extended if the progression of the chronic kidney disease stage can be slowed, and so a major research question is how to extend the transplanted kidney life to maximize the usage of the scarce organ resource. Read More

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Extracorporeal CO removal and renal replacement therapy in acute severe respiratory failure in COVID-19 pneumonia: Case report.

Semin Dial 2021 May 10. Epub 2021 May 10.

Department of Critical Care, Hospital Clínico Universidad de Chile, Santiago de Chile, Chile.

The COVID-19 pandemic significates an enormous number of patients with pneumonia that get complicated with severe acute respiratory distress syndrome (ARDS), some of them with refractory hypercapnia and hypoxemia that need mechanical ventilation (MV). Those patients who are not candidate to extracorporeal membrane oxygenation (ECMO), the extracorporeal removal of CO (ECCO R) can allow ultra protective MV to limit the transpulmonary pressures and avoid ventilatory induced lung injury (VILI). We report a first case of prolonged ECCO R support in 38 year male with severe COVID-19 pneumonia refractory to conventional support. Read More

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Induction of renal tumor necrosis factor-alpha and other autacoids and the beneficial effects of hypertonic saline in acute decompensated heart failure.

Am J Physiol Renal Physiol 2021 May 10. Epub 2021 May 10.

Department of Pharmacology, New York Medical College, United Statesgrid.260917.b.

While administration of Hypertonic Saline (HSS) in combination with diuretics has yielded improved weight loss, preservation of renal function, and reduction in hospitalization time in the clinical setting of patients with acute decompensated heart failure (ADHF), the mechanisms that underlie these beneficial effects remain unclear and additional studies are needed before this approach can be adopted on a more consistent basis. As high salt conditions stimulate production of several renal autacoids that exhibit natriuretic effects, renal physiologists can contribute to the understanding of mechanisms by which HSS leads to increased diuresis both as an individual therapy, as well as in combination with loop diuretics. For instance, since HSS increases TNF-α production by proximal tubule (PT) and thick ascending limb of Henle's loop (TAL) epithelial cells, this 'Perspective article' is aimed at highlighting how the effects of TNF-α produced by these cell types may contribute to the beneficial effects of HSS in patients with ADHF. Read More

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Disseminated cutaneous mycobacteria abscessus infection in a patient with chronic renal failure.

Indian J Dermatol Venereol Leprol 2021 Apr 23:1-4. Epub 2021 Apr 23.

Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.

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Rapid Onset Development of Myocardial Calcifications in the Setting of Renal Failure and Sepsis.

Radiol Cardiothorac Imaging 2021 Apr 1;3(2):e200549. Epub 2021 Apr 1.

Department of Radiology, University of Maryland School of Medicine, 655 W Baltimore St, Baltimore, MD 21201.

Myocardial calcifications can arise following damage to myocardial tissue or in the setting of disturbances in the calcium and phosphorus balance. They are associated with a number of cardiac sequelae, as well as higher mortality. Three cases of rapid-onset myocardial calcifications that developed within the course of 5 to 13 weeks in patients who had a history of sepsis and renal failure while undergoing hemodialysis are described. Read More

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Bradycardia, renal failure, atrioventricular nodal blockade, shock, and hyperkalemia: An important syndrome to recognize.

Turk J Emerg Med 2021 Apr-Jun;21(2):86-89. Epub 2021 Feb 12.

Department of Emergency Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

BRASH syndrome is a syndrome characterized by bradycardia, renal failure, usage of atrioventricular (AV) nodal blocker, shock, and hyperkalemia (BRASH). It is more common among patients with multiple comorbidities such as cardiac disease, kidney dysfunction, and hypertension requiring AV nodal blockers. Cardiac conduction abnormalities are frequently caused by severe hyperkalemia. Read More

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February 2021

Perioperative massive cerebral stroke in thoracic patients: Report of three cases.

World J Clin Cases 2021 May;9(13):3170-3176

Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.

Background: Perioperative stroke is a rare but devastating complication. The risk factors for massive cerebral stroke in surgical patients include older age, male sex, prior cerebrovascular disease, hypertension, renal failure, smoking, diabetes mellitus, and atrial fibrillation.

Case Summary: We describe two cases of perioperative massive cerebral stroke following thoracic surgery and one case following bronchoscopy. Read More

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Fabry disease-what cardiologists can learn from the nephrologist: a narrative review.

Cardiovasc Diagn Ther 2021 Apr;11(2):672-682

Department II of Internal Medicine and Center for Rare Diseases Cologne, University Hospital of Cologne, Cologne, Germany.

Fabry disease (FD) is a rare, X-linked lysosomal storage disorder resulting in decreased or absent activity of the lysosomal enzyme alpha-galactosidase A. Subsequent accumulation of storage material can occur in virtually all cells of the body. Organs and structures affected by storage material deposition include the heart, the kidney, the central and peripheral nervous system and the cornea of the eyes. Read More

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Fabry disease: what the cardiologist should consider in non-cardiac screening, diagnosis, and management-narrative review.

Cardiovasc Diagn Ther 2021 Apr;11(2):661-671

Department of Nephrology, Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Munich, Germany.

Fabry disease (FD) is a rare X chromosomally transmitted lysosomal storage disorders with an absence or deficiency of the enzyme alpha-galactosidase. The deposition of globotriaosylceramide (Gb3) may cause damage to all organs, particularly brain, heart and kidney. While acroparaesthesia, hypo- or anhydrosis and diarrhoea are the main symptoms in childhood, cardiac involvement with left ventricular hypertrophy (LVH), renal insufficiency, diffuse pain attacks and apoplexy are the main symptoms in adulthood. Read More

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Narrative review on Morbus Fabry: diagnosis and management of cardiac manifestations.

Cardiovasc Diagn Ther 2021 Apr;11(2):650-660

2nd Department of Internal Cardiovascular Medicine, General University Hospital, Prague, Czech Republic.

Fabry disease (FD) is an X-linked lysosomal storage disorder due to reduced or undetectable α-galactosidase A (AGAL-A) enzyme activity caused by pathogenic variants in the AGAL-A gene (). Tissue and organ changes are caused by widespread progressive accumulation of globotriaosylceramide (Gb) and globotriaosylsphingosine (lysoGb). The classical form of FD is multisystemic with cutaneous (angiokeratomas), neurological (peripheral neuropathy, premature stroke), renal (proteinuria and renal insufficiency), and cardiac involvement. Read More

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Suvorexant Poisoning in a Patient With Cirrhosis and Renal Failure.

Cureus 2021 Apr 6;13(4):e14329. Epub 2021 Apr 6.

Division of Hospital Medicine, University of Tsukuba Hospital, Tsukuba, JPN.

Suvorexant is a novel hypnotic that acts as an orexin-1 receptor and orexin-2 receptor antagonist. Owing to its safety and tolerability, suvorexant has recently become widely used. However, little is known about the presentation of suvorexant poisoning. Read More

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Abdominal compartment syndrome among surgical patients.

World J Gastrointest Surg 2021 Apr;13(4):330-339

Department of Medicine, Texas A&M University, Corpus Christi, TX 78405, United States.

Abdominal compartment syndrome (ACS) develops when organ failure arises secondary to an increase in intraabdominal pressure. The abdominal pressure is determined by multiple factors such as blood pressure, abdominal compliance, and other factors that exert a constant pressure within the abdominal cavity. Several conditions in the critically ill may increase abdominal pressure compromising organ perfusion that may lead to renal and respiratory dysfunction. Read More

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Angiotensin II Receptor Blockers but Not Angiotensin-Converting Enzyme Inhibitors Are Associated With a Reduced Risk of Acute Kidney Injury After Major Surgery.

Front Pharmacol 2021 23;12:662301. Epub 2021 Apr 23.

Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.

We investigated the respective effects of preoperative angiotensin-converting-enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) on the incidence of postoperative acute kidney injury (AKI) and mortality. In this nested case-control study, we enrolled 20,276 patients who received major surgery. We collected their baseline demographic data, comorbidities and prescribed medication, the outcomes of postoperative AKI and mortality. Read More

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Review of acute kidney injury and continuous renal replacement therapy in pediatric extracorporeal membrane oxygenation.

Indian J Thorac Cardiovasc Surg 2021 Apr 23;37(Suppl 2):254-260. Epub 2020 Nov 23.

Children's of Dallas, Department of Pediatrics, Section of Critical Care, University of Texas Southwestern Medical Center, Dallas, TX USA.

Purpose: To review the relevant literature of acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) as it relates to pediatric extracorporeal membrane oxygenation (ECMO).

Methods: Available online relevant literature.

Results: ECMO is a therapeutic modality utilized to support patients with refractory respiratory and/or cardiac failure. Read More

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[A case of hemolysis and acute kidney disease caused by rectal damage due to glycerin enema].

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(5):473-479

Department of Gastroenterology and Oncology, Tokushima University of Biochemical Sciences.

A male patient in his sixties with a long-term history of schizophrenia had been received glycerin enema once or twice a week in a mental hospital. He was emergently transferred to our hospital due to fever, vomiting, hematuria, and dyspnea. Laboratory findings on admission showed an elevation of white blood cells indicating inflammation, hemolysis, and renal dysfunction. Read More

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January 2021

Effects of intensive blood pressure control on mortality and cardiorenal function in chronic kidney disease patients.

Ren Fail 2021 Dec;43(1):811-820

Department of Nephrology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Blood pressure (BP) variability is highly correlated with cardiovascular and kidney outcomes in patients with chronic kidney disease (CKD). However, appropriate BP targets in patients with CKD remain uncertain.

Methods: We searched PubMed, Embase, and the Cochrane Library for randomized controlled trials (RCTs) of CKD patients who underwent intensive BP management. Read More

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December 2021

Hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against renal ischemia/reperfusion injury by inhibiting inflammation.

Ren Fail 2021 Dec;43(1):803-810

Department of Nephrology, Taizhou People's Hospital, Fifth Affiliated Hospital to Nantong University, Taizhou, Jiangsu, China.

Hypoxia-induced inflammation is the critical pathological feature of acute kidney injury (AKI). Activation of hypoxia-inducible factor (HIF) signaling is considered as a central mechanism of body adapting to hypoxia. Hypoxia-inducible factor prolyl hydroxylase inhibitor FG-4592 (Roxadustat) is a first-in-class HIF stabilizer for the treatment of patients with renal anemia. Read More

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December 2021

Extracellular water/total body water ratio as predictor of mortality in hemodialysis patients.

Ren Fail 2021 Dec;43(1):821-829

Nephrology Department, Hospital Universitario Nuestra Señora de Candelaria (HUNSC), Santa Cruz de Tenerife, Spain.

Background: Overhydration is a predictor of mortality in hemodialysis (HD) patients. Bioimpedance spectroscopy (BIS) is used to determine the body composition. Extracellular Water/Total Body Water (ECW/TBW) ratio has been proposed to predict mortality. Read More

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December 2021

New Devices and Technologies for Hemodialysis Vascular Access: A Review.

Am J Kidney Dis 2021 May 5. Epub 2021 May 5.

Department of Nephrology and Hypertension, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH; Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH.

In the United States, hemodialysis remains the most common treatment modality for kidney failure, chosen by almost 90% of incident patients. A functioning vascular access is key to providing adequate hemodialysis therapy. Recently, major innovations in devices and technology for hemodialysis vascular access care have rapidly changed the landscape. Read More

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Flumazenil therapy for a gabapentin-induced coma: a case report.

J Med Case Rep 2021 May 9;15(1):242. Epub 2021 May 9.

Spinal Cord Unit, IRCCS S. Lucia Foundation, Rome, Italy.

Background: Spasticity and neuropathic pain are common in patients after spinal cord injury and negatively affect patients' quality of life. Gabapentin and baclofen are frequently used to treat these conditions. We present a flumazenil-reversed gabapentin-induced coma case, which, to our knowledge, is the second one described in scientific literature. Read More

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Lefamulin efficacy and safety in a pooled phase 3 clinical trial population with community-acquired bacterial pneumonia and common clinical comorbidities.

BMC Pulm Med 2021 May 8;21(1):154. Epub 2021 May 8.

Olive View-UCLA Medical Center, Los Angeles, CA, USA.

Background: Lefamulin, a first-in-class pleuromutilin antibiotic approved for intravenous and oral use in adults with community-acquired bacterial pneumonia (CABP), was noninferior to moxifloxacin in the Lefamulin Evaluation Against Pneumonia (LEAP) 1 intravenous-to-oral switch study and the LEAP 2 oral-only study. Using pooled LEAP 1/2 data, we examined lefamulin efficacy/safety overall and within subgroups of patients presenting with comorbidities typical in CABP management.

Methods: In LEAP 1, adults with CABP were randomized to receive intravenous lefamulin (150 mg every 12 h) for 5‒7 days or moxifloxacin (400 mg every 24 h) for 7 days, with optional intravenous-to-oral switch if predefined improvement criteria were met. Read More

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Cumulative exposure to melphalan chemotherapy and subsequent risk of developing acute myeloid leukemia and myelodysplastic syndromes in patients with multiple myeloma.

Eur J Haematol 2021 May 9. Epub 2021 May 9.

Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

Objectives: The aim of this study was to determine risk factors for development of acute myeloid leukemia/myelodysplastic syndromes (AML/MDS) in patients with multiple myeloma (MM).

Methods: We identified all patients diagnosed with MM in Sweden from January 1 , 1958 to December 31 , 2011. A total of 26,627 patients were diagnosed with MM with during the study period. Read More

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