Biomacromolecules 2021 May 6. Epub 2021 May 6.
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao 266100, China.
Peptide/protein therapeutics have been significantly applied in the clinical treatment of various diseases such as cancer, diabetes, . owing to their high biocompatibility, specificity, and therapeutic efficacy. However, due to their immunogenicity, instability stemming from its complex tertiary and quaternary structure, vulnerability to enzyme degradation, and rapid renal clearance, the clinical application of protein/peptide therapeutics is significantly confined. Read More