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2022 Canadian Cardiovascular Society Guideline for Use of GLP-1 Receptor Agonists and SGLT2 Inhibitors for Cardiorenal Risk Reduction in Adults.

Can J Cardiol 2022 Aug;38(8):1153-1167

Division of Nephrology, Department of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.

This guideline synthesizes clinical trial data supporting the role of glucagon-like peptide-1 receptor agonists and sodium-glucose co-transporter 2 inhibitors (SGLT2i) for treatment of heart failure (HF), chronic kidney disease, and for optimizing prevention of cardiorenal morbidity and mortality in patients with type 2 diabetes. It is on the basis of a companion systematic review and meta-analysis guided by a focused set of population, intervention, control, and outcomes (PICO) questions that address priority cardiorenal end points. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system and a modified Delphi process were used. Read More

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Case of idiopathic multicentric Castleman's disease: the master mimicker.

BMJ Case Rep 2022 Aug 12;15(8). Epub 2022 Aug 12.

Internal Medicine, Albany Medical Center, Albany, New York, USA.

A woman in her 20s with no medical history presented with progressive abdominal distension, right-sided abdominal discomfort, fatigue and nausea. Examination showed multifocal lymphadenopathy and hepatomegaly with tense ascites. Investigations revealed a multisystem inflammatory condition characterised by elevated acute phase reactants, anaemia, thrombocytopenia, acute kidney injury, lymphocytic ascites, hypoalbuminaemia and hypergammaglobulinaemia. Read More

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Systemic Exposure to Hydroxychloroquine and its relationship with outcome in severely ill COVID-19 patients in New York City.

Br J Clin Pharmacol 2022 Aug 12. Epub 2022 Aug 12.

Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, United States of America.

Aim: To investigate the relationship between systemic exposure to Hydroxychloroquine (HCQ) and its metabolite Desethylhydroxychloroquine (DHCQ) and clinical outcome in severely ill patients treated with a standard oral dose regimen of HCQ during the first wave of COVID-19 in New York City.

Methods: We correlated retrospective clinical data with drug exposure prospectively assessed from convenience samples using population pharmacokinetics and Bayesian estimation. Systemic exposure was assessed in 215 patients admitted to ICU or COVID-ward for whom an interleukin-6 level was requested and who were still alive 24h after the last dose of HCQ. Read More

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Urinary CD163 is a marker of active kidney disease in childhood-onset lupus nephritis.

Rheumatology (Oxford) 2022 Aug 12. Epub 2022 Aug 12.

Renal Section, Texas Children's Hospital, ; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

Objective: The objective of this study was to evaluate the utility of urine CD163 for detecting disease activity in childhood-onset systemic lupus erythematosus (cSLE) patients.

Methods: Sixty consecutive pediatric patients fulfilling ≥ 4 ACR criteria for SLE and twenty healthy controls were recruited for testing of urinary CD163 using enzyme linked immunosorbent assay. SLE disease activity was assessed using SLEDAI-2000. Read More

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The Effects of Social and Demographic Factors on High-Volume Hospital and Surgeon Care in Shoulder Arthroplasty.

J Am Acad Orthop Surg Glob Res Rev 2022 Aug 12;6(8). Epub 2022 Aug 12.

From the Department of Orthopaedic Surgery, Brown University, Warren Alpert School of Medicine, Providence, RI.

Introduction: This study seeks to evaluate (1) the relationship between hospital and surgeon volumes of shoulder arthroplasty and complication rates and (2) patient demographics/socioeconomic factors that may affect access to high-volume shoulder arthroplasty care.

Methods: Adults older than 40 years who underwent shoulder arthroplasty between 2011 and 2015 were identified in the New York Statewide Planning and Research Cooperative System database using International Classification of Disease 9/10 and Current Procedural Terminology codes. Medical/surgical complications were compared across surgeon and facility volumes. Read More

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Bioinspired large Stokes shift small molecular dyes for biomedical fluorescence imaging.

Sci Adv 2022 Aug 12;8(32):eabo3289. Epub 2022 Aug 12.

State Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Long Stokes shift dyes that minimize cross-talk between the excitation source and fluorescent emission to improve the signal-to-background ratio are highly desired for fluorescence imaging. However, simple small molecular dyes with large Stokes shift (more than 120 nanometers) and near-infrared (NIR) emissions have been rarely reported so far. Here, inspired by the chromophore chemical structure of fluorescent proteins, we designed and synthesized a series of styrene oxazolone dyes (SODs) with simple synthetic methods, which show NIR emissions (>650 nanometers) with long Stokes shift (ranged from 136 to 198 nanometers) and small molecular weight (<450 daltons). Read More

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Effect of once-weekly dulaglutide on renal function in patients with chronic kidney disease.

PLoS One 2022 12;17(8):e0273004. Epub 2022 Aug 12.

Department of Internal Medicine & Kidney Research Institute, Hallym University Sacred Heart Hospital, Anyang, Korea.

Background: Dulaglutide is associated with improved cardiovascular and kidney outcomes and can be a good therapeutic option for patients with type 2 diabetes with chronic kidney disease (CKD). In this study, the effects of dulaglutide on glucose-lowering efficacy and changes in renal function were analyzed.

Methods: This retrospective study involved 197 patients with type 2 diabetes with mild-to-severe CKD treated with dulaglutide for at least 3 months between January 2017 and December 2020 at two tertiary hospitals in Korea. Read More

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Effects of sea salt intake on metabolites, steroid hormones, and gut microbiota in rats.

PLoS One 2022 12;17(8):e0269014. Epub 2022 Aug 12.

Department of Food Science and Technology, and Institute of Agriculture and Life Science, Gyeongsang National University, Jinju, Gyeongsang, Republic of Korea.

High salt intake is positively linked to many health problems, but the effect of mineral-rich sea salt (SS) has rarely been studied. To better understand the physiological effects of SS intake, the changes in general characteristics, metabolites, steroid hormones, and gut microbiota of SS-fed rats were investigated. Male rats were fed either a normal diet (ND, control) or ND containing 1% SS or 4% SS for 5 weeks. Read More

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Association between serum uric acid to serum creatinine ratio and poor functional outcomes in patients with acute ischemic stroke.

Eur J Neurol 2022 Aug 12. Epub 2022 Aug 12.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: The role of serum uric acid (SUA) in prognosis is controversial because SUA levels largely depend on renal clearance function. This study aimed to investigate the association between renal function-normalized SUA (SUA to serum creatinine ratio, SUA/SCr) and poor functional outcomes in patients with acute ischemic stroke (AIS).

Methods: All patients were recruited from the Third China National Stroke Registry. Read More

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The importance of biological sex in cardiac cachexia.

Am J Physiol Heart Circ Physiol 2022 Aug 12. Epub 2022 Aug 12.

Trent University, Peterborough, Ontario, Canada.

Cardiac cachexia is a catabolic muscle wasting syndrome observed in approximately 1 in 10 heart failure patients. Increased skeletal muscle atrophy leads to frailty and limits mobility which impacts quality of life, exacerbates clinical care, and is associated with higher rates of mortality. Heart failure is known to exhibit a wide range of prevalence and severity when examined across individuals of different ages and with co-morbidities related to diabetes, renal failure and pulmonary dysfunction. Read More

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Isorhapontigenin ameliorates high glucose-induced podocyte and vascular endothelial cell injuries via mitigating oxidative stress and autophagy through the AMPK/Nrf2 pathway.

Int Urol Nephrol 2022 Aug 12. Epub 2022 Aug 12.

Department of Thoracic Vascular Surgery, Beijing Daxing District People's Hospital, No. 26 Huangcun West Street, Daxing District, Beijing, 102600, China.

Background: Diabetic nephropathy (DN) is a severe microvascular complication of diabetes mellitus and a primary reason for end-stage renal disease (ESRD). Isorhapontigenin (ISO), a natural derivative of stilbene, has significant anti-inflammatory and antioxidant effects. Nevertheless, its impact on DN remains elusive. Read More

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Clinical factors associated with outcome in solid tumor patients treated with immune-checkpoint inhibitors: a single institution retrospective analysis.

Discov Oncol 2022 Aug 12;13(1):73. Epub 2022 Aug 12.

Division of Hematology/Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, Third Floor Admin Suite #108 (Hess Building), New York, NY, USA.

Objectives: Response to immune checkpoint inhibitor (ICI) remains limited to a subset of patients and predictive biomarkers of response remains an unmet need, limiting our ability to provide precision medicine. Using real-world data, we aimed to identify potential clinical prognosticators of ICI response in solid tumor patients.

Methods: We conducted a retrospective analysis of all solid tumor patients treated with ICIs at the Mount Sinai Hospital between January 2011 and April 2017. Read More

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Gird your kidneys? A novel approach to ADPKD therapeutics.

Andrew Mallett

J Nephrol 2022 Aug 12. Epub 2022 Aug 12.

Department of Renal Medicine, Townsville University Hospital, Douglas, QLD, 4029, Australia.

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The effect of extended hemodialysis on nutritional parameters: a systematic review.

J Nephrol 2022 Aug 12. Epub 2022 Aug 12.

Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.

Objective: This systematic review provides an up-to-date synthesis on the effects of extended hemodialysis on nutritional outcomes.

Design And Methods: Ten databases were searched. Inclusion criteria were: randomised and non-randomised studies of extended hemodialysis (defined by > 15 h/week) with a comparator group which received conventional in-centre hemodialysis (usually ≤ 12 h per week). Read More

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A Cohort Study of the Surgical Risks and Prediction of Complications in Surgical Tracheostomies.

World J Surg 2022 Aug 12. Epub 2022 Aug 12.

Department of Otolaryngology/Head & Neck Surgery, Hebrew-University Medical Center, Hadassah Ein-Kerem, 91120, Jerusalem, Israel.

Background: Current protocols favor percutaneous tracheostomies over open procedures. We analyzed the effects of this conversion from the open approach to the percutaneous procedure in terms of relevant clinical status, complications, and mortality in surgical open tracheostomies. Relevant laboratory and clinical parameters, potentially associated with complications, were also examined. Read More

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Efficacy and safety of belimumab in systemic lupus erythematosus patients with severe lupus nephritis requiring renal replacement therapy.

Lupus 2022 Aug 12:9612033221119123. Epub 2022 Aug 12.

Department of Nephrology, Nanfang Hospital, 198153Southern Medical University; National Clinical Research Center for Kidney Disease, Nanfang Hospital; State Key Laboratory of Organ Failure Research, Southern Medical University; Guangdong Provincial Institute of Nephrology; Guangdong Provincial Key Laboratory of Renal Failure Research; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China.

Background: Systemic lupus erythematosus is a chronic inflammatory autoimmune disease that has various manifestations. Lupus nephritis is a common and severe presentation, which results in increased morbidity and mortality. Belimumab added on standard therapy has been proved to induce disease remission and improve renal parameters. Read More

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Identification of two novel variants of BCS1L gene in a patient with classical GRACILE syndrome.

Nephrology (Carlton) 2022 Aug 12. Epub 2022 Aug 12.

Laboratory of Nephrology & department of Nephrology, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, China.

BCS1L pathogenic variants cause widely different clinical phenotypes. Disease phenotypes can be as mild as Björnstad syndrome, characterized by pili torti (abnormal flat twisted hair shafts) and sensorineural hearing loss, or as severe as GRACILE syndrome, characterized by growth restriction, aminoaciduria, cholestasis, iron overload, lactic acidosis, and early death. BCS1L pathogenic variants are also linked to an undefined complex III deficiency, a heterogeneous condition generally involving renal and hepatic pathologies, hypotonia, and developmental delays. Read More

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Real-world efficacy of sequential nivolumab for metastatic renal cancer after first-line molecular targeting therapy.

Medicine (Baltimore) 2022 Aug;101(32):e29510

Department of Urology, Nihon University School of Medicine, Tokyo, Japan.

This study aimed to clarify the real-world efficacy of sequential nivolumab for treating metastatic renal cancer after first-line molecular targeting therapy. Patients were divided into two groups (2014-2016 and 2017-2020) according to the year when they started primary treatment with molecular targeted drugs (MTDs). We compared the overall survival of patients and investigated a contributing factor for survival. Read More

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Effects of resveratrol therapy on glucose metabolism, insulin resistance, inflammation, and renal function in the elderly patients with type 2 diabetes mellitus: A randomized controlled clinical trial protocol.

Nan Ma Youzhi Zhang

Medicine (Baltimore) 2022 Aug;101(32):e30049

Department of Emergency, Affiliated Hospital of Sichuan Nursing Vocational College (The Third People's Hospital of Sichuan Province), Chengdu, China.

Background: Diabetes mellitus is a spectrum of metabolic disorders characterized by hyperglycemia and shows a growing global public health problem in the elderly. Resveratrol presents antiaging, anti-inflammatory, antitumor antioxidant, and cardioprotective activities. The purpose of this study was to investigate the ameliorative effects of resveratrol on blood glucose, insulin metabolism, lipid profile, renal function, inflammation, and nutrient sensing systems in the elderly patients with type 2 diabetes mellitus. Read More

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Novel homozygous nonsense mutation associated with Bardet-Biedl syndrome in fetuses with congenital renal malformation.

Medicine (Baltimore) 2022 Aug;101(32):e30003

Medical Genetic Diagnosis and Therapy Center, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fujian Key Laboratory for Prenatal Diagnosis and Birth Defect, Fuzhou, China.

Background: The Bardet-Biedl syndrome (BBS) is a rare autosomal recessive disorder, characterized by clinical and genetic heterogeneity. BBS is more commonly reported in adults and children than in fetuses. Here, a retrospective study on 210 fetuses with congenital renal malformation was conducted. Read More

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Comparison of mortality and its causes in patients with complicated systemic lupus erythematosus on hemodialysis versus peritoneal dialysis: A meta-analysis.

Medicine (Baltimore) 2022 Aug;101(32):e30090

Department of Nephrology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.

Background: Lupus nephritis is one of the most serious complications of systemic lupus erythematosus (SLE). Ten percent to 20% of patients with SLE progress to end-stage renal disease and would require renal replacement therapy or renal transplantation. In this analysis, we aimed to systematically compare mortality and the causes of mortality in patients with complicated SLE who were treated on hemodialysis (HD) versus peritoneal dialysis (PD). Read More

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Role of T follicular helper and T follicular regulatory cells in antibody-mediated rejection: new therapeutic targets?

Curr Opin Organ Transplant 2022 Aug 10. Epub 2022 Aug 10.

Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: Antibody-mediated rejection (AbMR) after solid organ transplantation is tightly controlled by multiple cells of the immune system. Tfh and Tfr cells are essential controllers of antibody responses making them putative targets for therapeutics. However, the mechanisms of how Tfh and Tfr cells regulate B cell and antibody responses are not completely understood. Read More

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VNN1 contributes to the acute kidney injury-chronic kidney disease transition by promoting cellular senescence via affecting RB1 expression.

FASEB J 2022 Sep;36(9):e22472

Department of Nephrology, Daping Hospital, Army Medical University, Chongqing, China.

The mechanisms underlying acute kidney injury (AKI) and chronic kidney disease (CKD) progression include interstitial inflammation, cellular senescence, and oxidative stress (OS). Although vanin-1 (VNN1) plays an important role in OS, its contribution to the AKI-CKD transition remains unknown. Here, we explored the roles and mechanisms of VNN1 in the progression of the AKI-CKD transition. Read More

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September 2022

Successful use of intra-operative continuous renal replacement therapy in pediatric liver transplant recipients: Single center case series.

Pediatr Transplant 2022 Aug 12:e14377. Epub 2022 Aug 12.

University of Colorado School of Medicine, Aurora, Colorado, USA.

Background: Acute kidney injury (AKI) is common in pediatric patients undergoing liver transplantation (LT), with an incidence 17%-55%. Fluid, metabolic, and acid-base aberrancies are often pronounced pre-operatively and further worsened by events during LT, making intra-operative continuous renal replacement therapy (CRRT) an option for critically ill LT recipients.

Methods: All pediatric LT performed at our institution who underwent intra-operative CRRT between January 2017 and August 2021 were included. Read More

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Food for healthier aging: power on your plate.

Crit Rev Food Sci Nutr 2022 Aug 12:1-14. Epub 2022 Aug 12.

Wolfson Wohl Translational Research Centre, University of Glasgow, Glasgow, UK.

Inflammageing is a persistent low-level inflammatory burden that accompanies age-related dysregulation of the immune system during normative aging and within the diseasome of aging. A healthy diet containing a balanced amount of macronutrients, vitamins and minerals, adequate in calories and rich in poly(phenols), has an essential role in mitigating the effects of inflammageing and extending healthspan through modulation of the activity of a range of factors. These include transcription factors, such as nuclear factor erythroid-derived 2 related factor 2 (Nrf2) and nuclear factor-κB (NF-kB), the inflammasome and the activities of the gut microbiota. Read More

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Indications for Left Atrial Appendage Occlusion in the United States and Associated In-Hospital Outcomes: Results From the NCDR LAAO Registry.

Circ Cardiovasc Qual Outcomes 2022 Aug 12:101161CIRCOUTCOMES121008418. Epub 2022 Aug 12.

Center for Outcomes Research and Evaluation Yale New Haven Health Services Corporation, New Haven, CT (Y.W., D.J.F., C.D., J.P.C., J.V.F.).

Background: The Food and Drug Administration approved left atrial appendage occlusion with the Watchman device for patients who are at increased stroke risk and are suitable for oral anticoagulation but who have an appropriate reason to seek a nondrug alternative. These broad criteria raise the question of their interpretation in clinical practice. There is a lack of studies comprehensively evaluating the indications for Watchman implantation among a large series of patients from contemporary, real-world practice in the United States. Read More

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Evolving Concepts in Uromodulin Biology, Physiology, and Its Role in Disease: a Tale of Two Forms.

Hypertension 2022 Aug 12:101161HYPERTENSIONAHA12218567. Epub 2022 Aug 12.

Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, VA, Medical Center.

Uromodulin (or Tamm-Horsfall protein) is a glycoprotein uniquely produced in the kidney by tubular cells of the thick ascending limb of the loop of Henle and early distal tubules. This protein exhibits bidirectional secretion in the urine and in the renal interstitium and circulation. The role of this protein in maintaining renal and systemic homeostasis is becoming increasingly appreciated. Read More

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Pan-cancer Landscape of the RUNX Protein Family Reveals their Potential as Carcinogenic Biomarkers and the Mechanisms Underlying their Action.

J Transl Int Med 2022 Jun 10;10(2):156-174. Epub 2022 Jul 10.

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.

Background: The RUNX family of transcription factors plays an important regulatory role in tumor development. Although the importance of RUNX in certain cancer types is well known, the pan-cancer landscape remains unclear.

Materials And Methods: Data from The Cancer Genome Atlas (TCGA) provides a pan-cancer overview of the genes. Read More

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Endoplasmic Reticulum Stress-Related Signature Predicts Prognosis and Drug Response in Clear Cell Renal Cell Carcinoma.

Front Pharmacol 2022 26;13:909123. Epub 2022 Jul 26.

Department of Urology, West China Hospital of Sichuan University, Chengdu, China.

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. The maximum number of deaths associated with kidney cancer can be attributed to ccRCC. Disruption of cellular proteostasis results in endoplasmic reticulum (ER) stress, which is associated with various aspects of cancer. Read More

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