217 results match your criteria removal nets


Neutrophil Extracellular Traps in the Autoimmunity Context.

Front Med (Lausanne) 2021 22;8:614829. Epub 2021 Mar 22.

Laboratory of Molecular Nephrology, Scientific Institute for Research and Health Care, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

The formation of neutrophil extracellular traps (NETs) is a strategy utilized by neutrophils for capturing infective agents. Extracellular traps consist in a physical net made of DNA and intracellular proteins externalized from neutrophils, where bacteria and viruses are entrapped and killed by proteolysis. A complex series of events contributes to achieving NET formation: signaling from infectious triggers comes first, followed by decondensation of chromatin and extrusion of the nucleosome components (DNA, histones) from the nucleus and, after cell membrane breakdown, outside the cell. Read More

View Article and Full-Text PDF

Neutrophil Extracellular Traps Promote the Development of Intracranial Aneurysm Rupture.

Hypertension 2021 Apr 5:HYPERTENSIONAHA12016252. Epub 2021 Apr 5.

Barrow Aneurysm and AVM Research Center, Barrow Neurological Institute, Phoenix, AZ. (M.K., J.P., Y.K., K.M., H.F., K.Y., T.M., Hitomi Sato, Hiroki Sato, J.A., M.T.L., T.H.).

Potential roles for neutrophils in the pathophysiology of intracranial aneurysm have long been suggested by clinical observations. The presence of neutrophil enzymes in the aneurysm wall has been associated with significant increases in rupture risk. However, the mechanisms by which neutrophils may promote aneurysm rupture are not well understood. Read More

View Article and Full-Text PDF

TEMPORARY REMOVAL: Re Pathways and factors that influence time to definitive trauma care for injured children in New South Wales, Australia by Curtis et al. published in 2021.

Injury 2021 Mar 12. Epub 2021 Mar 12.

New South Wales Newborn & paediatric Emergency Transport Service, Australia.

The Publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at http://www. Read More

View Article and Full-Text PDF

Effect of fast restoration of aquatic vegetation on phytoplankton community after removal of purse seine culture in Huayanghe Lakes.

Sci Total Environ 2021 May 15;768:144024. Epub 2021 Jan 15.

School of Resources and Environmental Engineering, Anhui University, Hefei 230601, PR China.

The disappearance of submerged aquatic vegetation caused by the use of purse seine in productive fishery has aroused the attention of the national government. In order to restore aquatic vegetation, the government has removed the seine nets on the Huayanghe Lake's surface. Here, fourteen cruises were conducted in the Huayanghe Lakes from 2016 to 2019 to study the response of water quality and phytoplankton communities to rapidly recovering aquatic vegetation. Read More

View Article and Full-Text PDF

Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress.

Cancer Res 2021 Mar 9. Epub 2021 Mar 9.

Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio.

Surgical removal of malignant tumors is a mainstay in controlling most solid cancers. However, surgical insult also increases the risk of tumor recurrence and metastasis. Tissue trauma activates the innate immune system locally and systemically, mounting an inflammatory response. Read More

View Article and Full-Text PDF

But They Told Us It Was Safe! Carbon Dioxide Removal, Fracking, and Ripple Effects in Risk Perceptions.

Risk Anal 2021 Mar 2. Epub 2021 Mar 2.

School of Psychology, Cardiff University, Cardiff, Wales, UK.

Reaching net-zero for global greenhouse gas emissions by the year 2050 will require a portfolio of new technologies and approaches, potentially requiring direct removal and sequestration of atmospheric carbon dioxide using negative emissions technologies (NETs). Since energy and climate systems are fundamentally interconnected it is important that we understand the impacts of policy decisions and their associated controversies in other related technologies and sectors. Using a secondary analysis of data from a series of deliberative workshops conducted with lay publics in the United Kingdom, we suggest that perceptions of CO removal technologies were negatively impacted by risk perceptions and recent policy decisions surrounding shale gas and fracking. Read More

View Article and Full-Text PDF

Detailed histological analysis of a thrombectomy-resistant ischemic stroke thrombus: a case report.

Thromb J 2021 Feb 22;19(1):11. Epub 2021 Feb 22.

Laboratory for Thrombosis Research, KU Leuven Campus Kulak Kortrijk, E. Sabbelaan 53, 8500, Kortrijk, Belgium.

Background: Mechanical removal of a thrombus by thrombectomy can be quite challenging. For reasons that are not fully understood, some thrombi require multiple passes to achieve successful recanalization, whereas other thrombi are efficiently removed in a single pass. Since first pass success is associated with better clinical outcome, it is important to better understand the nature of thrombectomy resistant thrombi. Read More

View Article and Full-Text PDF
February 2021

Clinical utility of endoscopic submucosal dissection using the pocket-creation method with a HookKnife and preoperative evaluation by endoscopic ultrasonography for the treatment of rectal neuroendocrine tumors.

Surg Endosc 2021 Jan 25. Epub 2021 Jan 25.

Department of Gastroenterology and Hepatology, Mie University Hospital, Tsu, Japan.

Background: Various endoscopic methods have been developed to remove small rectal neuroendocrine tumors (NETs). This study aimed to evaluate the clinical utility of endoscopic submucosal dissection using the pocket-creation method (ESD-PCM) with a HookKnife, following preoperative evaluation by endoscopic ultrasonography (EUS), for the treatment of rectal NETs.

Methods: We analyzed retrospectively consecutive patients who underwent ESD-PCM with a HookKnife for the removal of rectal NETs, with a size less than 10 mm, at Mie University Hospital between June 2015 and December 2019. Read More

View Article and Full-Text PDF
January 2021

Perineuronal nets stabilize the grid cell network.

Nat Commun 2021 01 11;12(1):253. Epub 2021 Jan 11.

Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Grid cells are part of a widespread network which supports navigation and spatial memory. Stable grid patterns appear late in development, in concert with extracellular matrix aggregates termed perineuronal nets (PNNs) that condense around inhibitory neurons. It has been suggested that PNNs stabilize synaptic connections and long-term memories, but their role in the grid cell network remains elusive. Read More

View Article and Full-Text PDF
January 2021

A lightweight convolutional neural network for assessing an EEG risk marker for sudden unexpected death in epilepsy.

BMC Med Inform Decis Mak 2020 12 24;20(Suppl 12):329. Epub 2020 Dec 24.

Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.

Background: Convolutional neural network (CNN) has achieved state-of-art performance in many electroencephalogram (EEG) related studies. However, the application of CNN in prediction of risk factors for sudden unexpected death in epilepsy (SUDEP) remains as an underexplored area. It is unclear how the trade-off between computation cost and prediction power varies with changes in the complexity and depth of neural nets. Read More

View Article and Full-Text PDF
December 2020

Monoclonal antibody 2C5 specifically targets neutrophil extracellular traps.

MAbs 2020 Jan-Dec;12(1):1850394

Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University , Boston, MA, USA.

Neutrophils can release DNA and granular cytoplasmic proteins that form smooth filaments of stacked nucleosomes (NS). These structures, called neutrophil extracellular traps (NETs), are involved in multiple pathological processes, and NET formation and removal are clinically significant. The monoclonal antibody 2C5 has strong specificity toward intact NS but not to individual NS components, indicating that 2C5 could potentially target NS in NETs. Read More

View Article and Full-Text PDF
December 2020

Chondroitinase and Antidepressants Promote Plasticity by Releasing TRKB from Dephosphorylating Control of PTPσ in Parvalbumin Neurons.

J Neurosci 2021 Feb 8;41(5):972-980. Epub 2020 Dec 8.

Neuroscience Center, HiLIFE, University of Helsinki, Helsinki 00290, Finland

Perineuronal nets (PNNs) are an extracellular matrix structure rich in chondroitin sulfate proteoglycans (CSPGs), which preferentially encase parvalbumin-containing (PV) interneurons. PNNs restrict cortical network plasticity but the molecular mechanisms involved are unclear. We found that reactivation of ocular dominance plasticity in the adult visual cortex induced by chondroitinase ABC (chABC)-mediated PNN removal requires intact signaling by the neurotrophin receptor TRKB in PV neurons. Read More

View Article and Full-Text PDF
February 2021

Low-grade Rectal Neuroendocrine Tumor Recurring as Multiple Hepatic Metastasis after Complete Endoscopic Removal: A Case Report.

Korean J Gastroenterol 2020 11;76(5):251-255

Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.

The World Health Organization classified rectal neuroendocrine tumors (NETs) as malignant in 2010 owing to their distant metastasis potential. On the other hand, in cases of small rectal NETs (<10 mm), which have a low risk of metastasis, endoscopic removal is the first-line therapeutic option, and regular surveillance is not recommended. The authors report a case of a small, well-differentiated rectal NET, which recurred as multiple hepatic metastases 5 years after apparent complete removal using endoscopic methods. Read More

View Article and Full-Text PDF
November 2020

The role of the right posterior parietal cortex in prism adaptation and its aftereffects.

Neuropsychologia 2021 01 11;150:107672. Epub 2020 Nov 11.

Department of Psychology, University of Milano-Bicocca, Milan, Italy; Neuropsychological Laboratory, IRCCS Istituto Auxologico Italiano, Milan, Italy. Electronic address:

Adaptation to optical prisms (Prismatic Adaptation, PA) displacing the visual scene laterally, on one side of visual space, is both a procedure for investigating visuo-motor plasticity and a powerful tool for the rehabilitation of Unilateral Spatial Neglect (USN). Two processes are involved in PA: i) recalibration (the reduction of the error of manual pointings toward the direction of the prism-induced displacement of the visual scene); ii) the successive realignment after prisms' removal, indexed by the Aftereffects (AEs, in egocentric straight-ahead pointing tasks, the deviation in a direction opposite to the visual displacement previously induced by prisms). This study investigated the role of the posterior parietal cortex (PPC) of the right hemisphere in PA and AEs, by means of low frequency repetitive Transcranial Magnetic Stimulation (rTMS). Read More

View Article and Full-Text PDF
January 2021

Recycled Nylon Fiber from Waste Fishing Nets as Reinforcement in Polymer Cement Mortar for the Repair of Corroded RC Beams.

Materials (Basel) 2020 Sep 25;13(19). Epub 2020 Sep 25.

Faculty of Engineering, Kagoshima University, Kagoshima 890-0065, Japan.

Waste fishing nets were utilized as recycled nylon (RN) short fiber to improve the mechanical properties of cement mortar. RN and manufactured polyethylene (PE) fibers were added to polymer cement mortar (PCM) as a reinforcement, and fiber-reinforced PCM was sprayed on the section of reinforced concrete (RC) beams. Normal RC beams and the upgraded RC beams were placed in the tidal zone for 14 months to induce rebar corrosion. Read More

View Article and Full-Text PDF
September 2020

Do free radical NETwork and oxidative stress disparities in African Americans enhance their vulnerability to SARS-CoV-2 infection and COVID-19 severity?

Redox Biol 2020 10 15;37:101721. Epub 2020 Sep 15.

Department of Biophysics, Free Radical Research Center, Center for Disease Prevention Research, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, USA. Electronic address:

This review focuses on the hypothetical mechanisms for enhanced vulnerability of African Americans to SARS-CoV-2 infection, COVID-19 severity, and increased deaths. A disproportionately higher number of African Americans are afflicted with autoimmune and inflammatory diseases (e.g. Read More

View Article and Full-Text PDF
October 2020

Polymorphonuclear neutrophil leukocytes in snakebite envenoming.

Toxicon 2020 Nov 18;187:188-197. Epub 2020 Sep 18.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

Polymorphonuclear neutrophils are the most abundant leukocytes in the blood and constitute key components of the innate immunity. Upon infection or tissue damage, neutrophils are recruited to tissues, where they exert a variety of effects, such as microbicidal activity, phagocytosis, degranulation, formation of reactive oxygen species (ROS), release of inflammatory mediators, and formation of neutrophil extracellular traps (NETs). In addition to microbial killing and removal of damaged tissue components, neutrophils play a role in the resolution of inflammation and, in some circumstances, they stimulate chronic inflammation and may contribute to tissue damage. Read More

View Article and Full-Text PDF
November 2020

On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little.

Cells 2020 09 11;9(9). Epub 2020 Sep 11.

Department of Experimental Hematology, Institute of Zoology and Biomedical Research, Jagiellonian University, 31-007 Krakow, Poland.

Although neutrophil extracellular traps (NETs) were discovered only 16 years ago, they have already taken us from heaven to hell as we learned that apart from beneficial trapping of pathogens, they cause, or contribute to, numerous disorders. The latter is connected to their persistent presence in the blood or tissue, and we hardly know how they are removed in mild pathophysiological conditions and why their removal is impaired in multiple severe pathological conditions. Herein, we bring together all data available up till now on how NETs are cleared-from engaged cells, their phenotypes, to involved enzymes and molecules. Read More

View Article and Full-Text PDF
September 2020

Cocaine memory reactivation induces functional adaptations within parvalbumin interneurons in the rat medial prefrontal cortex.

Addict Biol 2020 Aug 4:e12947. Epub 2020 Aug 4.

Neuroscience Graduate Program, University of Wyoming, Laramie, Wyoming, USA.

Substance use disorder is a complex disease created in part by maladaptive learning and memory mechanisms following repeated drug use. Exposure to drug-associated stimuli engages prefrontal cortex circuits, and dysfunction of the medial prefrontal cortex (mPFC) is thought to underlie drug-seeking behaviors. Growing evidence supports a role for parvalbumin containing fast-spiking interneurons (FSI) in modulating prefrontal cortical microcircuit activity by influencing the balance of excitation and inhibition, which can influence learning and memory processes. Read More

View Article and Full-Text PDF

Complement activation on endothelium initiates antibody-mediated acute lung injury.

J Clin Invest 2020 11;130(11):5909-5923

Department of Medicine, UCSF, San Francisco, California, USA.

Antibodies targeting human leukocyte antigen (HLA)/major histocompatibility complex (MHC) proteins limit successful transplantation and transfusion, and their presence in blood products can cause lethal transfusion-related acute lung injury (TRALI). It is unclear which cell types are bound by these anti-leukocyte antibodies to initiate an immunologic cascade resulting in lung injury. We therefore conditionally removed MHC class I (MHC I) from likely cellular targets in antibody-mediated lung injury. Read More

View Article and Full-Text PDF
November 2020

Cu-DOTATOC PET-CT in Patients with Neuroendocrine Tumors.

Oncol Ther 2020 Jun 26;8(1):125-131. Epub 2019 Nov 26.

Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.

Introduction: Several radiolabeled somatostatin analogues have been developed for molecular imaging of neuroendocrine tumors (NETs) with single-photon emission computed tomography (SPECT) and positron-emission tomography (PET). The aim of the present study was to report our first results using Cu-DOTATOC in patients with NETs.

Methods: Thirty-three patients with NETs (15 female, 18 male; mean age 64 ± 13 years) were included in this retrospective study. Read More

View Article and Full-Text PDF

Polysialylated - neural cell adhesion molecule (PSA-NCAM) promotes recovery of vision after the critical period.

Mol Cell Neurosci 2020 09 4;107:103527. Epub 2020 Jul 4.

Departments of Surgery (Neurosurgery), Medical Neuroscience, and Ophthalmology & Visual Sciences, Dalhousie University, Life Science Research Institute, 1348 Summer Street, Halifax B3H 4R2, NS, Canada. Electronic address:

Vision loss has long since been considered irreversible after a critical period; however, there is potential to restore limited vision, even in adulthood. This phenomenon is particularly pronounced following complete loss of vision in the dominant eye. Adult neural cell adhesion molecule (NCAM) knockout mice have an age-related impairment of visual acuity. Read More

View Article and Full-Text PDF
September 2020

Dilated conditional GAN for bone suppression in chest radiographs with enforced semantic features.

Med Phys 2020 Dec 20;47(12):6207-6215. Epub 2020 Oct 20.

Rapiscan Systems, 27/6-8 Herbert Street, St Leonards, NSW, 2065, Australia.

Purpose: The purpose of this essay is to improve computer-aided diagnosis of lung diseases by the removal of bone structures imagery such as ribs and clavicles, which may shadow a clinical view of lesions. This paper aims to develop an algorithm to suppress the imaging of bone structures within clinical x-ray images, leaving a residual portrayal of lung tissue; such that these images can be used to better serve applications, such as lung nodule detection or pathology based on the radiological reading of chest x rays.

Methods: We propose a conditional Adversarial Generative Network (cGAN) (Mirza and Osindero, Conditional generative adversarial nets, 2014. Read More

View Article and Full-Text PDF
December 2020

Neutrophils as Main Players of Immune Response Towards Nondegradable Nanoparticles.

Nanomaterials (Basel) 2020 Jun 29;10(7). Epub 2020 Jun 29.

Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nurnberg (FAU), Universitatsklinikum Erlangen, 90154 Erlangen, Germany.

Many nano/microparticles (n/µP), to which our body is exposed, have no physiological way of removal. Our immune system sense these "small particulate objects", and tries to decrease their harmfulness. Since oxidation, phagocytosis and other methods of degradation do not work with small, chemically resistant, and hydrophobic nanoparticles (nP). Read More

View Article and Full-Text PDF

The intriguing commonality of NETosis between COVID-19 & Periodontal disease.

Med Hypotheses 2020 Nov 7;144:109968. Epub 2020 Jun 7.

Panjab University, Chandigarh, India.

NETosis, being an alternative form of cell death is the creation of web-like chromatin decondensates by suitably primed neutrophils as a response to stimulus aimed at containing and eliminating the same. In certain situations, it causes more harm than benefit in the form of bystander damage directly or via activation of autoimmune mechanisms. Such pathophysiology finds evidence in both Periodontal disease and COVID-19. Read More

View Article and Full-Text PDF
November 2020

Estimation of spatiotemporal trends in bat abundance from mortality data collected at wind turbines.

Conserv Biol 2021 Feb 3;35(1):227-238. Epub 2020 Jul 3.

Environment and Climate Change Canada, Canadian Wildlife Service, 351 St. Joseph Boulevard, Gatineau, QC, K1A 0H3, Canada.

Renewable energy sources, such as wind energy, are essential tools for reducing the causes of climate change, but wind turbines can pose a collision risk for bats. To date, the population-level effects of wind-related mortality have been estimated for only 1 bat species. To estimate temporal trends in bat abundance, we considered wind turbines as opportunistic sampling tools for flying bats (analogous to fishing nets), where catch per unit effort (carcass abundance per monitored turbine) is a proxy for aerial abundance of bats, after accounting for seasonal variation in activity. Read More

View Article and Full-Text PDF
February 2021

Prognostic importance of lymph node yield after curative resection of gastroenteropancreatic neuroendocrine tumours.

World J Clin Oncol 2020 Apr;11(4):205-216

Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester M20 4BX, United Kingdom.

Background: The prognostic significance of lymph nodes (LNs) metastases and the optimum number of LN yield in gastroenteropancreatic neuroendocrine tumours (GEP NETs) undergoing curative resection is still debatable. Many studies have demonstrated that cure rate for patients with GEP NETs can be improved by the resection of the primary tumour and regional lymphadenectomy.

Aim: To evaluate the effect of lymph node (LN) status and yield on relapse-free survival (RFS) and overall survival (OS) in patients with resected GEP NETs. Read More

View Article and Full-Text PDF

Serial in-solution digestion protocol for mass spectrometry-based glycomics and proteomics analysis.

Mol Omics 2020 08 20;16(4):364-376. Epub 2020 Apr 20.

Boston University School of Medicine, Boston University, Department of Biochemistry, Boston, 02118, USA.

Advancement in mass spectrometry has revolutionized the field of proteomics. However, there remains a gap in the analysis of protein post-translational modifications (PTMs), particularly for glycosylation. Glycosylation, the most common form of PTM, is involved in most biological processes; thus, analysis of glycans along with proteins is crucial to answering important biologically relevant questions. Read More

View Article and Full-Text PDF

Polymeric Coatings Based on Water-Soluble Trimethylammonium Copolymers for Antifouling Applications.

Molecules 2020 Apr 6;25(7). Epub 2020 Apr 6.

Department of Chemistry, University of Patras, GR-26504 Patras, Greece.

Crosslinked polymeric materials based on a quaternary trimethylammonium compound were developed and evaluated as potential antifouling coatings. For this purpose, two water-soluble random copolymers, poly(4-vinylbenzyltrimethylammonium chloride-co-acrylic acid) P(VBCTMAM-co-AAx) and poly(N,N-dimethylacrylamide-co-glycidylmethacrylate) P(DMAm-co-GMAx), were synthesized via free radical polymerization. A water based approach for the synthesis of P(VBCTMAM-co-AAx) copolymer was used. Read More

View Article and Full-Text PDF

H and L Chain Affinity Maturation and/or Fab -Glycosylation Influence Immunoreactivity toward Neutrophil Extracellular Trap Antigens in Rheumatoid Arthritis Synovial B Cell Clones.

J Immunol 2020 05 27;204(9):2374-2379. Epub 2020 Mar 27.

Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, United Kingdom; and

We previously showed that anti-neutrophil extracellular trap (NET) rheumatoid arthritis (RA)-rmAbs derived from CD19 B cells within RA human synovial tissues frequently react against NETs. In this study, we aimed to characterize the importance of affinity maturation via somatic hypermutation (SHM) within the Ig variable H (VH) and variable L (VL) chains and Fab--linked glycosylation in RA synovial B cell clones reactive to NETs and NET-derived Ags such as citrullinated histones. Selected anti-NET RA-rmAbs derived from synovial RA CD19 B cells were subjected to overlap-PCR to generate germline (GL; VH and VL reverted into GL), hybrid clones (VH/VL region reverted into GL), and -glycosylation mutants (N→Q) and analyzed for anti-NETs and citrullinated histones (cit-H2B) immunoreactivity. Read More

View Article and Full-Text PDF