70,939 results match your criteria remodeling proteins

Actin filament alignment causes mechanical hysteresis in cross-linked networks.

Soft Matter 2021 May 14. Epub 2021 May 14.

James Franck Institute, University of Chicago, Chicago, IL 60637, USA. and Department of Physics, University of Chicago, Chicago, IL 60637, USA and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA and Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.

Cells dynamically control their material properties through remodeling of the actin cytoskeleton, an assembly of cross-linked networks and bundles formed from the biopolymer actin. We recently found that cross-linked networks of actin filaments reconstituted in vitro can exhibit adaptive behavior and thus serve as a model system to understand the underlying mechanisms of mechanical adaptation of the cytoskeleton. In these networks, training, in the form of applied shear stress, can induce asymmetry in the nonlinear elasticity. Read More

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Metformin Carbon Dots for Promoting Periodontal Bone Regeneration via Activation of ERK/AMPK Pathway.

Adv Healthc Mater 2021 May 14:e2100196. Epub 2021 May 14.

Hospital of Stomatology, Jilin University, Changchun, 130021, P. R. China.

The osteogenic potential of mesenchymal stem cells (MSCs) is severely impaired under persistent inflammation of periodontitis. A highly efficient way to promote or rescue osteogenic potential of MSCs under inflammation remains an unmet goal. Herein, metformin carbon dots (MCDs) with excellent biocompatibility are prepared from metformin hydrochloride and citric acid via a hydrothermal method. Read More

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SET knockdown attenuated phenotype modulation and calcium channel associated markers of airway smooth muscle cells in asthmatic mice.

Ann Transl Med 2021 Apr;9(8):657

Key Laboratory of Shenzhen Respiratory Disease, Shenzhen Institute of Respiratory Disease, Shenzhen People's Hospital (The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University), Shenzhen, China.

Background: Dysfunctional phenotype modulation and calcium channels in airway smooth muscle cells (ASMCs) are important characteristics of airway remodeling in chronic asthma. However, the mechanisms underlying these pathological processes remain unclear. SET (I2PP2A, inhibitor-2 of protein phosphatase 2A) has many significant functions and is involved in various physiological and pathological processes. Read More

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Anti-VEGF treatment suppresses remodeling factors and restores epithelial barrier function through the E-cadherin/β-catenin signaling axis in experimental asthma models.

Exp Ther Med 2021 Jul 29;22(1):689. Epub 2021 Apr 29.

Department of Pediatric Allergy and Immunology, Celal Bayar University Medical Faculty, Manisa 45030, Turkey.

Besides maintaining a physical barrier with adherens junctional (AJ) and tight junctional proteins, airway epithelial cells have important roles in modulating the inflammatory processes of allergic asthma. E-cadherin and β-catenin are the key AJ proteins that are involved in airway remodeling. Various mediators such as transforming growth factor-β (TGF-β), epidermal growth factor (EGF), fibroblast growth factor (FGF), platelet derived growth factor (PDGF), insulin-like growth factor (IGF), tumor necrosis factor-α (TNF-α) and angiogenic factors, such as vascular endothelial growth factor (VEGF), are released by the airway epithelium in allergic asthma. Read More

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Yu-Ping-Feng Formula Exerts Antilung Cancer Effects by Remodeling the Tumor Microenvironment through Regulating Myeloid-Derived Suppressor Cells.

Evid Based Complement Alternat Med 2021 20;2021:6624461. Epub 2021 Apr 20.

Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China.

Yu-Ping-Feng (YPF) formula is a classical prescription used for enhancing the body's immunity function in traditional Chinese medicine (TCM). In clinical practice, the YPF formula has been reported to exhibit antilung cancer and immunomodulatory effect. However, the relationship between them remains unclear. Read More

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Regulation of macrophage functions by FABP-mediated inflammatory and metabolic pathways.

Biochim Biophys Acta Mol Cell Biol Lipids 2021 May 10;1866(8):158964. Epub 2021 May 10.

Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA. Electronic address:

Macrophages are almost everywhere in the body, where they serve pivotal functions in maintaining tissue homeostasis, remodeling, and immunoregulation. Macrophages are traditionally thought to differentiate from bone marrow-derived hematopoietic stem cells (HSCs). Emerging studies suggest that some tissue macrophages at steady state originate from embryonic precursors in the yolk sac or fetal liver and are maintained in situ by self-renewal, but bone marrow-derived monocytes can give rise to tissue macrophages in pathogenic settings, such as inflammatory injuries and cancer. Read More

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RANKL and RANK in extracellular vesicles: surprising new players in bone remodeling.

Extracell Vesicles Circ Nucl Acids 2021 30;2:18-28. Epub 2021 Mar 30.

Department of Orthodontics and Pediatric Dentistry, Stony Brook School of Dental Medicine, Stony Brook, NY 11794, USA.

Receptor activator of nuclear factor kappa B-ligand (RANKL), its receptor RANK, and osteoprotegerin which binds RANKL and acts as a soluble decoy receptor, are essential controllers of bone remodeling. They also play important roles in establishing immune tolerance and in the development of the lymphatic system and mammary glands. In bone, RANKL stimulates osteoclast formation by binding RANK on osteoclast precursors and osteoclasts. Read More

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Resistin-Like Molecule α Dysregulates Cardiac Bioenergetics in Neonatal Rat Cardiomyocytes.

Front Cardiovasc Med 2021 26;8:574708. Epub 2021 Apr 26.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, United States.

Heart (right) failure is the most frequent cause of death in patients with pulmonary arterial hypertension. Although historically, increased right ventricular afterload has been considered the main contributor to right heart failure in such patients, recent evidence has suggested a potential role of load-independent factors. Here, we tested the hypothesis that resistin-like molecule α (RELMα), which has been implicated in the pathogenesis of vascular remodeling in pulmonary artery hypertension, also contributes to cardiac metabolic remodeling, leading to heart failure. Read More

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Role of Chromodomain-Helicase-DNA-Binding Protein 4 (CHD4) in Breast Cancer.

Front Oncol 2021 26;11:633233. Epub 2021 Apr 26.

Institute of Rare Diseases Research, Instituto de Salud Carlos III (ISCIII), Madrid, Spain.

Chromodomain-helicase-DNA-binding protein 4 (CHD4) is an epigenetic regulator identified as an oncogenic element that may provide a novel therapeutic target for the treatment of breast cancer (BC). CHD4-the core component of the nucleosome remodeling and deacetylase (NuRD) complex-may be mutated in patients with this disease. However, information on mutants that might allow their use as biomarkers of therapeutic success and prognosis is lacking. Read More

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Endogenous and Borrowed Proteolytic Activity in the .

Microbiol Mol Biol Rev 2021 May 12;85(2). Epub 2021 May 12.

Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA

SUMMARYThe spp. are tick-borne pathogenic spirochetes that include the agents of Lyme disease and relapsing fever. As part of their life cycle, the spirochetes traffic between the tick vector and the vertebrate host, which requires significant physiological changes and remodeling of their outer membranes and proteome. Read More

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Dilemmas in management of osteoporosis in patients with complete androgen insensitivity syndrome.

BMJ Case Rep 2021 May 12;14(5). Epub 2021 May 12.

Department of Endocrinology, Diabetes & Metabolism, Walter Reed National Military Medical Center, Bethesda, Maryland, USA

Complete androgen insensitivity syndrome (CAIS)-resulting in 46,XY karyotype, but female phenotype-is a disorder of sex development and primary amenorrhea, but its effect on bone mineral density (BMD) is singular and difficult to manage. Androgens are an important modulator of bone remodeling and health, and the androgen receptor (AR) is pivotal for signaling within the bone cells. CAIS results in a severely disrupted AR throughout the body, causing an elevated risk of early osteoporosis. Read More

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Glutathione S-transferases and their implications in the lung diseases asthma and chronic obstructive pulmonary disease: Early life susceptibility?

Redox Biol 2021 May 2;43:101995. Epub 2021 May 2.

Department of Respiratory Medicine, Maastricht University Medical Center+, Maastricht, the Netherlands. Electronic address:

Our lungs are exposed daily to airborne pollutants, particulate matter, pathogens as well as lung allergens and irritants. Exposure to these substances can lead to inflammatory responses and may induce endogenous oxidant production, which can cause chronic inflammation, tissue damage and remodeling. Notably, the development of asthma and Chronic Obstructive Pulmonary Disease (COPD) is linked to the aforementioned irritants. Read More

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Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes.

Cell Rep 2021 May;35(6):109100

Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Germany. Electronic address:

RNA-binding proteins (RBPs) control critical aspects of cardiomyocyte function, but the repertoire of active RBPs in cardiomyocytes during the growth response is largely unknown. We define RBPs in healthy and diseased cardiomyocytes at a system-wide level by RNA interactome capture. This identifies 67 cardiomyocyte-specific RBPs, including several contractile proteins. Read More

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Loss of dystrophin expression in skeletal muscle is associated with senescence of macrophages and endothelial cells.

Am J Physiol Cell Physiol 2021 May 12. Epub 2021 May 12.

Department of Applied Human Sciences, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canadagrid.139596.1.

Cellular senescence is the irreversible arrest of normally dividing cells and is driven by cell cycle inhibitory proteins such as p16, p21 and p53. When cells enter senescence, they secrete a host of proinflammatory factors known as the senescence associated secretory phenotype which has deleterious effects on surrounding cells and tissues. Little is known of the role of senescence in Duchenne Muscular Dystrophy (DMD), the fatal X-linked neuromuscular disorder typified by chronic inflammation, extracellular matrix remodeling and a progressive loss in muscle mass and function. Read More

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Identification of retinoblastoma binding protein 7 (Rbbp7) as a mediator against tau acetylation and subsequent neuronal loss in Alzheimer's disease and related tauopathies.

Acta Neuropathol 2021 May 12. Epub 2021 May 12.

Arizona State University-Banner Neurodegenerative Disease Research Center at the Biodesign Institute, Arizona State University, Tempe, AZ, USA.

Evidence indicates that tau hyper-phosphorylation and subsequent neurofibrillary tangle formation contribute to the extensive neuronal death in Alzheimer's disease (AD) and related tauopathies. Recent work has identified that increased tau acetylation can promote tau phosphorylation. Tau acetylation occurs at lysine 280 resulting from increased expression of the lysine acetyltransferase p300. Read More

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Increased substance P and synaptic remodeling occur in the trigeminal sensory system with sustained osteoarthritic temporomandibular joint sensitivity.

Pain Rep 2021 1;6(1):e911. Epub 2021 Apr 1.

Department of Bioengineering, School of Engineering and Applied Science,University of Pennsylvania, Philadelphia, PA, USA.

Introduction: Temporomandibular joint (TMJ) pain is among the most prevalent musculoskeletal conditions and can result from atypical joint loading. Although TMJ pain is typically self-resolving, 15% of patients develop chronic TMJ pain that is recalcitrant to therapy and may be attributed to changes in pain processing centers. Although TMJ overloading induces pain and osteoarthritis, whether neuronal modifications in the trigeminal sensory system contribute to persistent TMJ pain is unknown. Read More

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Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO.

Nat Commun 2021 May 11;12(1):2628. Epub 2021 May 11.

Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

Thoracic aortic aneurysm, as occurs in Marfan syndrome, is generally asymptomatic until dissection or rupture, requiring surgical intervention as the only available treatment. Here, we show that nitric oxide (NO) signaling dysregulates actin cytoskeleton dynamics in Marfan Syndrome smooth muscle cells and that NO-donors induce Marfan-like aortopathy in wild-type mice, indicating that a marked increase in NO suffices to induce aortopathy. Levels of nitrated proteins are higher in plasma from Marfan patients and mice and in aortic tissue from Marfan mice than in control samples, indicating elevated circulating and tissue NO. Read More

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Mycobacteria Tolerate Carbon Monoxide by Remodeling Their Respiratory Chain.

mSystems 2021 May 11;6(3). Epub 2021 May 11.

Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia

Carbon monoxide (CO) gas is infamous for its acute toxicity. This toxicity predominantly stems from its tendency to form carbonyl complexes with transition metals, thus inhibiting the heme-prosthetic groups of proteins, including respiratory terminal oxidases. While CO has been proposed as an antibacterial agent, the evidence supporting its toxicity toward bacteria is equivocal, and its cellular targets remain poorly defined. Read More

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Proteomic and Transcriptomic Analysis of φX174 Infection Reveals Broad Upregulation of Host Escherichia coli Membrane Damage and Heat Shock Responses.

mSystems 2021 May 11;6(3). Epub 2021 May 11.

Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia

Measuring host-bacteriophage dynamics is an important approach to understanding bacterial survival functions and responses to infection. The model bacteriophage φX174 is endemic to the human gut and has been studied for over 70 years, but the host response to infection has never been investigated in detail. To address this gap in our understanding of this important interaction within our microbiome, we have measured host C proteomic and transcriptomic response to φX174 infection. Read More

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The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains.

Elife 2021 May 11;10. Epub 2021 May 11.

Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, United States.

Sigma 1 receptor (S1R) is a 223-amino-acid-long transmembrane endoplasmic reticulum (ER) protein. S1R modulates activity of multiple effector proteins and is a well-established drug target. However, signaling functions of S1R in cells are poorly understood. Read More

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Structural and functional characteristics of plant PHD domain-containing proteins.

Yi Chuan 2021 Apr;43(4):323-339

Institute of Plant Science, College of Life Science, Fudan University, Shanghai 200433, China.

Plant homeodomain (PHD) is a class of transcription factor in the Zinc finger domain family. The most important function of which is to recognize various histone modifications, including histone methylation and acetylation, etc. They can also bind to DNA. Read More

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Muscarinic acetylcholine receptor M5 is involved in spermatogenesis through the modification of cell-cell junctions.

Reproduction 2021 May 1. Epub 2021 May 1.

Y Zhao, Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.

Muscarinic acetylcholine receptor (mAChR) antagonists have been reported to decrease male fertility, however the roles of mAChRs in spermatogenesis and the underlying mechanisms are not understood yet. During spermatogenesis, extensive remodeling between Sertoli cells and/or germ cells interfaces takes place to accommodate the transport of developing germ cells across the blood-testis barrier (BTB) and adluminal compartment. The cell-cell junctions play vital role in the spermatogenesis process. Read More

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Vascular Control of Kidney Epithelial Transporters.

Am J Physiol Renal Physiol 2021 May 10. Epub 2021 May 10.

Division of Nephrology, Duke University School of Medicine, United Statesgrid.471396.e.

A major pathway in hypertension pathogenesis involves direct activation of Ang II (AT) receptors in the kidney, stimulating sodium reabsorption. AT receptors in tubular epithelia control expression and stimulation of sodium transporters and channels. Recently, we found reduced blood pressure and enhanced natriuresis in mice with cell-specific deletion of AT receptors in smooth muscle (SMKOs). Read More

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The Cell Origin and Role of Osteoclastogenesis and Osteoblastogenesis in Vascular Calcification.

Front Cardiovasc Med 2021 23;8:639740. Epub 2021 Apr 23.

Department of Vascular Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Arterial calcification refers to the abnormal deposition of calcium salts in the arterial wall, which results in vessel lumen stenosis and vascular remodeling. Studies increasingly show that arterial calcification is a cell mediated, reversible and active regulated process similar to physiological bone mineralization. The osteoblasts and chondrocytes-like cells are present in large numbers in the calcified lesions, and express osteogenic transcription factor and bone matrix proteins that are known to initiate and promote arterial calcification. Read More

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Extracellular Matrix: Emerging Roles and Potential Therapeutic Targets for Breast Cancer.

Front Oncol 2021 22;11:650453. Epub 2021 Apr 22.

Department of Pharmacy, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Increasing evidence shows that the extracellular matrix (ECM) is an important regulator of breast cancer (BC). The ECM comprises of highly variable and dynamic components. Compared with normal breast tissue under homeostasis, the ECM undergoes many changes in composition and organization during BC progression. Read More

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A narrative review of research progress on the relationship between hypoxia-inducible factor-2α and wound angiogenesis.

Ann Palliat Med 2021 Apr;10(4):4882-4888

Department of Burns and Plastic, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.

Objective: This article aims to pay attention to the latest research on the expression, activation and function of hypoxia-inducible factor-2α (HIF-2α) under hypoxia and non-hypoxia conditions, and summarizes the current knowledge about the interaction between hypoxia-inducible factor-2 and angiogenesis, hoping to understand its actions in physiology and disease, with the goal of providing a new strategy for the diagnosis and treatment of wounds.

Background: Wound healing is a complex and continuous process, involving coagulation, inflammation, angiogenesis, new tissue formation and extracellular matrix remodeling. Of these, angiogenesis is an essential step. Read More

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The influence of progesterone and prostaglandin F on decorin and the adhesion of caruncular epithelial cells of bovine placenta at early-mid pregnancy - part II.

Reprod Domest Anim 2021 May 9. Epub 2021 May 9.

Department of Biochemistry, Faculty of Veterinary Medicine, University of Life Science, Lublin, Poland.

One of the most important processes determining the proper course of gestation and its physiological termination in cows is the adhesion of epithelial cells allowing for direct contact of maternal and fetal parts of the placenta. Throughout pregnancy, placental cells are under strict hormonal control, which among others regulates the concentration and activity of specific proteins participating in the extracellular matrix remodeling of fetal membranes. The aim of the study was to evaluate the influence of progesterone and prostaglandin F on the adhesion of epithelial cells at early-mid pregnancy in cows. Read More

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Repurposing Nintedanib for Pathological Cardiac Remodeling and Dysfunction.

Pharmacol Res 2021 May 6:105605. Epub 2021 May 6.

Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, AL 35294-1913, USA. Electronic address:

Heart Failure (HF) is the leading cause of death worldwide. Myocardial fibrosis, one of the clinical manifestations implicated in almost every form of heart disease, contributes significantly to HF development. However, there is no approved drug specifically designed to target cardiac fibrosis. Read More

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Quantitative proteomic analysis of scleras in guinea pig exposed to wavelength defocus.

J Proteomics 2021 May 5:104248. Epub 2021 May 5.

Department of Ophthalmology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China; Clinical Research Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China. Electronic address:

Myopia is the most common optical disorder in the world, and wavelength defocus induced ametropia and myopia have attracted great attention. The objective was to identify and quantify scleral proteins involved in the response to the wavelength defocus. Guinea pigs were randomly divided into 3 groups that received different lighting conditions for 8 weeks: white light, short wavelength light, and long wavelength light. Read More

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Energy management and mitochondrial dynamics in cerebral cortex during endotoxemia.

Arch Biochem Biophys 2021 May 6;705:108900. Epub 2021 May 6.

Universidad de Buenos Aires, CONICET, Instituto de Bioquímica y Medicina Molecular (IBIMOL), Facultad de Farmacia y Bioquímica, Junín 946, C1113AAD, CABA, Argentina; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Química Analítica y Fisicoquímica, Cátedra de Fisicoquímica, Junín 946, C1113AAD, CABA, Argentina. Electronic address:

Mitochondria play an essential role in inflammatory processes such as sepsis or endotoxemia, contributing to organ-cellular redox metabolism, emerging as the energy hub of the cell, and as an important center of action of second messengers. In this work, we aimed to elucidate the energy state, redox balance, and mitochondrial remodeling status in cerebral cortex in an experimental model of endotoxemia. Female Sprague-Dawley rats were subjected to a single dose of LPS (ip 8 mg kg body weight) for 6 h. Read More

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