33,804 results match your criteria remodeling factors


Structural and functional characteristics of plant PHD domain-containing proteins.

Yi Chuan 2021 Apr;43(4):323-339

Institute of Plant Science, College of Life Science, Fudan University, Shanghai 200433, China.

Plant homeodomain (PHD) is a class of transcription factor in the Zinc finger domain family. The most important function of which is to recognize various histone modifications, including histone methylation and acetylation, etc. They can also bind to DNA. Read More

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The Association between Lung Hyperinflation and Coronary Artery Disease in Smokers.

Chest 2021 May 7. Epub 2021 May 7.

Departments of Medicine. Electronic address:

Background: Smokers manifest varied phenotypes of pulmonary impairment.

Research Question: Which pulmonary phenotypes are associated with coronary artery disease (CAD) in smokers?

Study Design: & Methods: We analyzed data from the Pittsburgh SCCOR cohort (n=481), and the COPDGene cohort (n=2580). Participants were current and former smokers with >10 pack-years of tobacco exposure. Read More

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Sleep duration and vascular inflammation using hybrid positron emission tomography/magnetic resonance imaging: results from the Multi-Ethnic Study of Atherosclerosis (MESA).

J Clin Sleep Med 2021 May 10. Epub 2021 May 10.

Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

Study Objectives: Short sleep duration (SD) is associated with cardiovascular disease (CVD). We investigated the relationship between objective SD and subclinical atherosclerosis employing hybrid PET/MRI with F-FDG tracer in the MESA cohort.

Methods: We utilized data from MESA-SLEEP and MESA-PET ancillary studies. Read More

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Formation of Low Voltage Zones on the Anterior Left Atrial Wall Due to Mechanical Compression by the Ascending Aorta.

J Cardiovasc Electrophysiol 2021 May 9. Epub 2021 May 9.

Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Ohyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.

Background: Although low voltage zones (LVZs) in the left atrium (LA) are considered arrhythmogenic substrates in some patients with atrial fibrillation (AF), the pathophysiologic factors responsible for LVZ formations remain unclear.

Objective: To elucidate the anatomical relationship between the LA and ascending aorta responsible for anterior LA wall remodeling.

Methods: We assessed the relationship between existence of LVZs on the anterior LA wall and the 3-dimensional computed tomography image measurements in 102 patients who underwent AF ablation. Read More

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Epigenetic Regulation of Cardiac Neural Crest Cells.

Front Cell Dev Biol 2021 21;9:678954. Epub 2021 Apr 21.

Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL, United States.

The cardiac neural crest cells (cNCCs) is a transient, migratory cell population that contribute to the formation of major arteries and the septa and valves of the heart. Abnormal development of cNCCs leads to a spectrum of congenital heart defects that mainly affect the outflow region of the hearts. Signaling molecules and transcription factors are the best studied regulatory events controlling cNCC development. Read More

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A narrative review of research progress on the relationship between hypoxia-inducible factor-2α and wound angiogenesis.

Ann Palliat Med 2021 Apr;10(4):4882-4888

Department of Burns and Plastic, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.

Objective: This article aims to pay attention to the latest research on the expression, activation and function of hypoxia-inducible factor-2α (HIF-2α) under hypoxia and non-hypoxia conditions, and summarizes the current knowledge about the interaction between hypoxia-inducible factor-2 and angiogenesis, hoping to understand its actions in physiology and disease, with the goal of providing a new strategy for the diagnosis and treatment of wounds.

Background: Wound healing is a complex and continuous process, involving coagulation, inflammation, angiogenesis, new tissue formation and extracellular matrix remodeling. Of these, angiogenesis is an essential step. Read More

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Novel facets of glioma invasion.

Int Rev Cell Mol Biol 2021 17;360:33-64. Epub 2020 Oct 17.

NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg; Department of Biomedicine, University of Bergen, Bergen, Norway. Electronic address:

Malignant gliomas including Glioblastoma (GBM) are characterized by extensive diffuse tumor cell infiltration throughout the brain, which represents a major challenge in clinical disease management. While surgical resection is beneficial for patient outcome, it is well recognized that tumor cells at the invasive front or beyond stay behind and constitute a major source of tumor recurrence. Invasive glioma cells also represent a difficult therapeutic target since they are localized within normal functional brain areas with an intact blood brain barrier (BBB), thereby excluding most systemic drug treatments. Read More

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October 2020

Sweet Melody or Jazz? Transcription Around DNA Double-Strand Breaks.

Front Mol Biosci 2021 20;8:655786. Epub 2021 Apr 20.

Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.

Genomic integrity is continuously threatened by thousands of endogenous and exogenous damaging factors. To preserve genome stability, cells developed comprehensive DNA damage response (DDR) pathways that mediate the recognition of damaged DNA lesions, the activation of signaling cascades, and the execution of DNA repair. Transcription has been understood to pose a threat to genome stability in the presence of DNA breaks. Read More

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Sodium Valproate-Induced Chromatin Remodeling.

Front Cell Dev Biol 2021 20;9:645518. Epub 2021 Apr 20.

Department of Structural and Functional Biology, University of Campinas (Unicamp), Campinas, Brazil.

Valproic acid/sodium valproate (VPA), a drug originally prescribed as an anticonvulsant, has been widely reported to act on epigenetic marks by inducing histone acetylation, affecting the DNA and histone methylation status, and altering the expression of transcription factors, thus leading to modulation of gene expression. All these epigenetic changes have been associated with chromatin remodeling effects. The present minireview briefly reports the main effects of VPA on chromatin and image analysis and Fourier transform infrared (FTIR) microspectroscopy in association with molecular biology methodological approaches to investigate the VPA-induced changes in chromatin structure and at the higher-order supraorganizational level. Read More

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Stem cell therapy for heart failure: Medical breakthrough, or dead end?

World J Stem Cells 2021 Apr;13(4):236-259

Division of Cardiac Surgery, Health Sciences North, Northern Ontario School of Medicine, Sudbury P3E 3Y9, Ontario, Canada.

Heart failure continues to be one of the leading causes of morbidity and mortality worldwide. Myocardial infarction is the primary causative agent of chronic heart failure resulting in cardiomyocyte necrosis and the subsequent formation of fibrotic scar tissue. Current pharmacological and non-pharmacological therapies focus on managing symptoms of heart failure yet remain unable to reverse the underlying pathology. Read More

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Fibroblast Growth Factor Type 2 (FGF2) Administration Attenuated the Clinical Manifestations of Preeclampsia in a Murine Model Induced by L-NAME.

Front Pharmacol 2021 20;12:663044. Epub 2021 Apr 20.

Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y C.S, Universidad Autonoma de Zacatecas, Zacatecas, Mexico.

In preeclampsia, a hypertensive disorder of pregnancy, the poor remodeling of spiral arteries leads to placental hypoperfusion and ischemia, provoking generalized maternal endothelial dysfunction and, in severe cases, death. Endothelial and placental remodeling is important for correct pregnancy evolution and is mediated by cytokines and growth factors such as fibroblast growth factor type 2 (FGF2). In this study, we evaluated the effect of human recombinant FGF2 (rhFGF2) administration in a murine model of PE induced by NG-nitro-L-arginine methyl ester (L-NAME) to test if rhFGF2 administration can lessen the clinical manifestations of PE. Read More

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Interplay of two transcription factors for recruitment of the chromatin remodeling complex modulates fungal nitrosative stress response.

Nat Commun 2021 May 6;12(1):2576. Epub 2021 May 6.

State Key Laboratory of Rice Biology, Zhejiang University, Hangzhou, China.

Nitric oxide (NO) is a diffusible signaling molecule that modulates animal and plant immune responses. In addition, reactive nitrogen species derived from NO can display antimicrobial activities by reacting with microbial cellular components, leading to nitrosative stress (NS) in pathogens. Here, we identify FgAreB as a regulator of the NS response in Fusarium graminearum, a fungal pathogen of cereal crops. Read More

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Ellagic acid induces beige remodeling of white adipose tissue by controlling mitochondrial dynamics and SIRT3.

FASEB J 2021 Jun;35(6):e21548

Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea.

To determine whether ellagic acid (EA) induces the "beige remodeling" of white adipose tissue (WAT), we treated cold-exposed mice and mouse stromal vascular fraction (SVF) cells with EA, a phytochemical abundant in fruits and vegetables, in particular berries. We then investigated the mechanism of EA in beige remodeling with a particular focus on DRP1-mediated mitochondrial fission and SIRT3. EA induced the trans-differentiation of white adipocytes to beige adipocytes by promoting the expression of UCP1 and other brown and beige adipocytes/fat factors (PRDM16, UCP1, PGC1α, CD137, and TBX1) and mitochondrial dynamics-related factors (SIRT3, NRF1, CPT1β, DRP1, and FIS1) in 3T3-L1/SVF cells, and these were confirmed in the inguinal WAT of a cold-exposed mouse model. Read More

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The role of autophagy in cardiovascular pathology.

Cardiovasc Res 2021 May 6. Epub 2021 May 6.

Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.

Macroautophagy/autophagy is a conserved catabolic recycling pathway in which cytoplasmic components are sequestered, degraded, and recycled to survive various stress conditions. Autophagy dysregulation has been observed and linked with the development and progression of several pathologies, including cardiovascular diseases, the leading cause of death in the developed world. In this review, we aim to provide a broad understanding of the different molecular factors that govern autophagy regulation and how these mechanisms are involved in the development of specific cardiovascular pathologies, including ischemic and reperfusion injury, myocardial infarction, cardiac hypertrophy, cardiac remodeling, and heart failure. Read More

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Cell death of hippocampal CA1 astrocytes during early epileptogenesis.

Epilepsia 2021 May 6. Epub 2021 May 6.

Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Bonn, Germany.

Objective: Growing evidence suggests that dysfunctional astrocytes are crucial players in the development of mesial temporal lobe epilepsy (MTLE). Using a mouse model closely recapitulating key alterations of chronic human MTLE with hippocampal sclerosis, here we asked whether death of astrocytes contributes to the initiation of the disease and investigated potential underlying molecular mechanisms.

Methods: Antibody staining was combined with confocal imaging and semiquantitative real-time polymerase chain reaction analysis to identify markers of different cellular death mechanisms between 4 h and 3 days after epilepsy induction. Read More

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[Roles of growth factors on vascular remodeling in pulmonary hypertension].

Nihon Yakurigaku Zasshi 2021 ;156(3):161-165

Department of Physiology, Aichi Medical University.

Pulmonary hypertension (PH) is defined as mean pulmonary arterial pressure at rest ≥25 mmHg. Pulmonary arterial hypertension (PAH) is classified as group 1 of PH and is a progressive and fatal disease of the pulmonary artery. The pathogenesis is sustained pulmonary vasoconstriction and pulmonary vascular remodeling, which cause progressive elevations in pulmonary vascular resistance and pulmonary arterial pressure. Read More

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The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling.

Elife 2021 May 5;10. Epub 2021 May 5.

School of Life Science and Technology, ShanghaiTech University, Shanghai, China.

Neural circuits develop through a plastic phase orchestrated by genetic programs and environmental signals. We have identified a leucine-rich-repeat domain transmembrane protein PAN-1 as a factor required for synaptic rewiring in . PAN-1 localizes on cell membrane and binds with MYRF, a membrane-bound transcription factor indispensable for promoting synaptic rewiring. Read More

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Echocardiography Predictors of Survival in Hypertensive Patients With Left Ventricular Hypertrophy.

Am J Hypertens 2021 May 5. Epub 2021 May 5.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

Background: Left ventricular hypertrophy (LVH) is a well-known target organ damage. Concentric hypertrophy is the strongest predictor of increased risk of cardiovascular events, but the predictive value of individual echocardiographic parameters remains unclear.The aim of this study was to search for echocardiographic and hemodynamic variables associated with concentric and eccentric remodeling and their association with long-term cardiovascular outcomes. Read More

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Usnic Acid Treatment Changes the Composition of Mycobacterium tuberculosis Cell Envelope and Alters Bacterial Redox Status.

mSystems 2021 May 4;6(3). Epub 2021 May 4.

Bulgarian Academy of Sciences, The Stephan Angeloff Institute of Microbiology, Laboratory of Metabolomics, Plovdiv, Bulgaria.

developed efficient adaptation mechanisms in response to different environmental conditions. This resulted in the ability to survive in human macrophages and in resistance to numerous antibiotics. To get insight into bacterial responses to potent antimycobacterial natural compounds, we tested how usnic acid, a lichen-derived secondary metabolite, would influence mycobacteria at transcriptomic and metabolomic levels. Read More

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Structure and Development of the Legume-Rhizobial Symbiotic Interface in Infection Threads.

Cells 2021 Apr 29;10(5). Epub 2021 Apr 29.

Laboratory of Molecular and Cellular Biology, All-Russia Research Institute for Agricultural Microbiology, 196608 Saint Petersburg, Russia.

The intracellular infection thread initiated in a root hair cell is a unique structure associated with -legume symbiosis. It is characterized by inverted tip growth of the plant cell wall, resulting in a tunnel that allows invasion of host cells by bacteria during the formation of the nitrogen-fixing root nodule. Regulation of the plant-microbial interface is essential for infection thread growth. Read More

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Immunohistochemical analysis of thrombomodulin expression in myocardial tissue from autopsy cases of ischemic heart disease.

Leg Med (Tokyo) 2021 Apr 24;51:101897. Epub 2021 Apr 24.

Division of Legal Medicine, Department of Community Medicine and Social Healthcare Science, Kobe University Graduate School of Medicine, Kobe, Japan.

Thrombomodulin is a transmembrane glycoprotein that is ubiquitously expressed on the surface of vascular endothelial cells. Thrombomodulin exerts its anticoagulant effects by combining with thrombin, activating protein C, and inactivating the coagulation factors FVa and FVIIIa. Clinically, thrombomodulin is also known as a marker of vascular injury because it circulates freely in response to endothelial injury. Read More

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Alleviative Effects of Exercise on Bone Remodeling in Fluorosis Mice.

Biol Trace Elem Res 2021 May 3. Epub 2021 May 3.

Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, College of Veterinary Medicine, Shanxi Agricultural University, 030801, Taigu, Shanxi, China.

Fluorine is widely present in nature in the form of fluoride. Prolonged high-dose fluoride exposure can cause skeletal fluorosis, resulting in osteosclerosis, osteoporosis or osteomalacia. It has been proved that exercise is one of the important factors affecting the health of the bone and promoting bone formation. Read More

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Isolation of Human Primary Valve Cells for In vitro Disease Modeling.

J Vis Exp 2021 Apr 16(170). Epub 2021 Apr 16.

Division of Cardiology, Department of Medicine, and the Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh; Department of Bioengineering, University of Pittsburgh;

Calcific aortic valve disease (CAVD) is present in nearly a third of the elderly population. Thickening, stiffening, and calcification of the aortic valve causes aortic stenosis and contributes to heart failure and stroke. Disease pathogenesis is multifactorial, and stresses such as inflammation, extracellular matrix remodeling, turbulent flow, and mechanical stress and strain contribute to the osteogenic differentiation of valve endothelial and valve interstitial cells. Read More

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Mitochondrial cytochrome c shot towards histone chaperone condensates in the nucleus.

FEBS Open Bio 2021 May 3. Epub 2021 May 3.

Institute for Chemical Research (IIQ), Scientific Research Centre Isla de la Cartuja (cicCartuja), University of Seville - CSIC, Avda. Américo Vespucio 49, Sevilla, 41092, Spain.

Despite mitochondria being key for the control of cell homeostasis and fate, their role in DNA damage response (DDR) is usually just regarded as an apoptotic trigger. However, growing evidence points to mitochondrial factors modulating nuclear functions. Remarkably, after DNA damage, cytochrome c (Cc) interacts in the cell nucleus with a variety of well-known histone chaperones, whose activity is competitively inhibited by the hemeprotein. Read More

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Effects of lifestyle interventions on epigenetic signatures of liver fat: CENTRAL randomized controlled trial.

Liver Int 2021 May 3. Epub 2021 May 3.

Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105, Beer-Sheva, Israel.

Background And Aims: In the CENTRAL trial context, we found diverse liver fat dynamics in response to different dietary interventions. Epigenetic mechanisms may contribute to the intraindividual variation. Moreover, genetic factors are involved in developing non-alcoholic fatty-liver disease (NAFLD), a disease reflected by an increase in intrahepatic fat (IHF). Read More

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An Update on Cardiovascular Risk Factors After Kawasaki Disease.

Front Cardiovasc Med 2021 16;8:671198. Epub 2021 Apr 16.

Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, China.

First described in Japan 50 years ago, Kawasaki disease is a worldwide multisystem disease. It is an acute self-limited vasculitis of unknown etiology that can lead to coronary artery lesions, such as dilatation, aneurysms, and stenosis in children. It is one of the common causes of acquired heart disease among children in developed countries. Read More

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The Charming World of the Extracellular Matrix: A Dynamic and Protective Network of the Intestinal Wall.

Front Med (Lausanne) 2021 16;8:610189. Epub 2021 Apr 16.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

The intestinal extracellular matrix (ECM) represents a complex network of proteins that not only forms a support structure for resident cells but also interacts closely with them by modulating their phenotypes and functions. More than 300 molecules have been identified, each of them with unique biochemical properties and exclusive biological functions. ECM components not only provide a scaffold for the tissue but also afford tensile strength and limit overstretch of the organ. Read More

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Effect of resveratrol on abnormal bone remodeling and angiogenesis of subchondral bone in osteoarthritis.

Int J Clin Exp Pathol 2021 15;14(4):417-425. Epub 2021 Apr 15.

Experimental Center, The First Subsidiary Hospital of Tianjin TCM University Tianjin 300385, China.

Purpose: The effect of resveratrol on subchondral bone in osteoarthritis was explored by constructing a mouse model of osteoarthritis and giving resveratrol as intervention.

Methods: The degree of proteoglycan loss in articular cartilage was assessed by safranine fast green staining. The expressions of Lubricin and Aggrecan, COLX, and MMP-13, the co-expression of CD31 and Endomucin, and the expression of angiogenesis-related factors were determined by immunohistochemistry. Read More

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Hepatic SENP2 Controls Systemic Metabolism via SUMOylation-dependent Regulation of Liver-Adipose Tissue Crosstalk.

Hepatology 2021 May 2. Epub 2021 May 2.

Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences, Department of Endocrinology and Metabolism of Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

Background & Aims: Nonalcoholic fatty liver disease (NAFLD), characterized by aberrant triglycerides accumulation in liver, affects the metabolism remodeling of hepatic and non-hepatic tissues by secreting altered hepatokines. SUMO-specific protease 2 (SENP2) is responsible for de-SUMOylation of target protein, with broad effects on cell growth, signal transduction and developmental process. However, role of SENP2 in hepatic metabolism remains unclear. Read More

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The 2020 ESPEN Arvid Wretlind lecture: Metabolic response in bariatric surgery - Mechanisms and clinical implications.

Authors:
Anders Thorell

Clin Nutr 2021 Apr 20;40(5):2602-2608. Epub 2021 Apr 20.

Karolinska Institutet, Department of Clinical Science, Danderyd Hospital & Department of Surgery, Ersta Hospital, 116 91 Stockholm, Sweden. Electronic address:

Background & Aims: Owing to the "obesity-pandemic", an increasing number of individuals are in need of treatment for obesity and obesity-related disorders. For patients with severe disease, results with conventional treatment modalities such as diet regimens, physical activity, and pharmacologic agents most often lack satisfactory efficacy and/or sustainability. In contrast, bariatric surgery has been demonstrated to be associated with marked, long-term weight loss as well as resolution or improvement of co-morbid disease, in particular metabolic aberrations such as insulin resistance and type 2 diabetes. Read More

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