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Crosstalk of DNA Methylation Triggered by Pathogen in Poplars With Different Resistances.

Front Microbiol 2021 28;12:750089. Epub 2021 Dec 28.

National Engineering Laboratory for Tree Breeding, College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing, China.

DNA methylation plays crucial roles in responses to environmental stimuli. Modification of DNA methylation during development and abiotic stress responses has been confirmed in increasing numbers of plants, mainly annual plants. However, the epigenetic regulation mechanism underlying the immune response to pathogens remains largely unknown in plants, especially trees. Read More

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December 2021

Impact of the COVID-19 pandemic on neonatal admissions in a tertiary children's hospital in southwest China: An interrupted time-series study.

PLoS One 2022 13;17(1):e0262202. Epub 2022 Jan 13.

Department of Neonatology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China.

Background: The unprecedented coronavirus disease 2019 (COVID-19) pandemic has caused millions of infections worldwide and represents a significant challenge facing modern health care systems. This study was conducted to investigate the impact of lockdown measures in a tertiary Children's Hospital in southwest China, which might be used to predict long-term effects related to health-seeking behavior of parents/caregivers.

Methods: This study included newborns enrolled over a span of 86 weeks between January 4, 2019, and August 27, 2020. Read More

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January 2022

The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut.

J Exp Med 2022 Feb 13;219(2). Epub 2022 Jan 13.

Institute of Anatomy, University of Zurich, Zurich, Switzerland.

Gut innate lymphoid cells (ILCs) show remarkable phenotypic diversity, yet microenvironmental factors that drive this plasticity are incompletely understood. The balance between NKp46+, IL-22-producing, group 3 ILCs (ILC3s) and interferon (IFN)-γ-producing group 1 ILCs (ILC1s) contributes to gut homeostasis. The gut mucosa is characterized by physiological hypoxia, and adaptation to low oxygen is mediated by hypoxia-inducible transcription factors (HIFs). Read More

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February 2022

Oil-Infused Silicone Prevents Zebra Mussel Adhesion.

ACS Appl Bio Mater 2019 Dec 3;2(12):5841-5847. Epub 2019 Dec 3.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Room 407, Toronto, ON M5S 3G9, Canada.

The remarkable underwater adhesion capacity of the invasive freshwater mussel species (zebra mussel) causes extensive damage each year. The adhesive interface between the substrate surface and the mussels' adhesive plaques plays a key role in zebra mussel biofouling. Silicone-oil-infused polydimethylsiloxane (iPDMS), an omniphobic material in the class of liquid-infused slippery surfaces, has been shown to develop a uniform, microscale, antifouling surface oil layer, which we hypothesized would be effective against zebra mussel fouling. Read More

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December 2019

Transpelvic Magnetic Stimulation Enhances Penile Microvascular Perfusion in a Rat Model: A Novel Interventional Strategy to Prevent Penile Fibrosis after Cavernosal Nerve Injury.

World J Mens Health 2022 Jan 2. Epub 2022 Jan 2.

Department of Urology, VA San Diego Health Care System, University of California, San Diego, CA, USA.

Purpose: Penile microvascular dysfunction is a known contributor to erectile dysfunction (ED) and penile fibrosis has been shown to impair microvascular perfusion (MVP). Our objectives were to: (i) determine beneficial effects of TPMS to modulate penile MVP, (ii) determine its mechanism, (iii) evaluate impact of cavernosal nerve injury (CNI) on penile MVP, and (iv) determine time-course of cavernosal tissue elastin changes after CNI in rats.

Materials And Methods: Adult male rats (n=5) were anesthetized and subjected to TPMS (13%, 15%, and 17%) and MVP changes were recorded using laser speckle contrast imaging (LSCI). Read More

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January 2022

Size-Dependent Plasmonic Resonance Scattering Characteristics of Gold Nanorods for Highly Sensitive Detection of microRNA-27a.

ACS Appl Bio Mater 2021 Apr 11;4(4):3469-3475. Epub 2021 Mar 11.

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, P. R. China.

MicroRNAs, as one kind of significant biomarkers, play indispensable roles in the diagnosis and treatment of cancers. Yet, owing to low expression and high sequence homology, high sensitivity and specificity for microRNA detection are greatly challenging. Herein, a sensitive sensing platform with high specificity was developed for microRNA-27a (miRNA-27a) based on the miRNA-27a-triggered chemical etching of gold nanorods to a smaller size, which was accompanied by a significant blue shift and a large decrease of intensity in the localized surface plasmon resonance (LSPR) scattering and remarkable color variability from red to green. Read More

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Does ( -)-epigallocatechin-3-gallate protects the neurotoxicity induced by bisphenol A in vivo?

Environ Sci Pollut Res Int 2022 Jan 11. Epub 2022 Jan 11.

Pathology, Faculty of Veterinary Medicine, University of Sadat City, Sadat, Egypt.

Bisphenol A (BPA) is one of the chemicals that is firmly accompanied by hippocampal neuronal injury. As oxidative stress appears to be a major contributor to neurotoxicity induced by BPA, antioxidants with remarkable neuroprotective effects can play a valuable protective role. Around the world, ( -)-epigallocatechin-3-gallate (EGCG) was one of the most popular antioxidants that could exert a beneficial neuroprotective role. Read More

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January 2022

Sensitive determination of tobramycin using homocystine capped gold nanoclusters as probe by second-order scattering.

Spectrochim Acta A Mol Biomol Spectrosc 2022 Jan 3;270:120840. Epub 2022 Jan 3.

School of Pharmacy, Lanzhou University, Lanzhou 730000, PR China. Electronic address:

A novel photoluminescent Hcy-AuNCs has been developed through one-pot reduction method, to establish a tobramycin sensing by second-order scattering (SOS). Hcy-AuNCs could spontaneously assemble to small-scaled aggregation, resulting in remarkable intensity enhancement of scattered luminescence signals. The luminescence of Hcy-AuNCs could be clearly observed under ultraviolet lamp, when excited at 365 nm, a significant luminescent intensity at 741 nm was monitored in SOS spectra. Read More

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January 2022

Improved Mesenchymal Stem Cell Proliferation, Differentiation, Epithelial Transition, and Restrained Senescence on Hierarchically Patterned Porous Honey Silk Fibroin Scaffolds.

ACS Appl Bio Mater 2021 May 12;4(5):4328-4344. Epub 2021 Apr 12.

Instability and Soft Patterning Laboratory, Department of Chemical Engineering, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India.

We report a significant improvement of adipose-derived mesenchymal stem cells' (ADMSCs) biocompatibility and proliferation on hierarchically patterned porous honey-incorporated silk fibroin scaffolds fabricated using a combination of soft lithography and freeze-drying techniques. Parametric variations show enhanced surface roughness, swelling, and degradation rate with good pore interconnectivity, porosity, and mechanical strength for soft-lithographically fabricated biomimetic microdome arrays on the 2% honey silk fibroin scaffold (PHSF2) as compared to its other variants, which eventually made PHSF2 more comparable to the native environment required for stem cell adhesion and proliferation. PHSF2 also exhibits sustained honey release with remarkable antibacterial efficacy against methicillin-resistant (MRSA). Read More

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Maltodextrin-Conjugated Gd-Based MRI Contrast Agents for Specific Diagnosis of Bacterial Infections.

ACS Appl Bio Mater 2021 May 24;4(5):3762-3772. Epub 2020 Nov 24.

Cixi Institute of Biomedical Engineering, Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Materials and Devices & Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, People's Republic of China.

Bacterial infections are one of the most serious health risks worldwide, and their rapid diagnosis remains a major challenge in clinic. To enhance the relaxivity and bacterial specificity of magnetic resonance imaging (MRI) contrast agents, here, a kind of gadolinium-based nanoparticles (NPs) of impressive biocompatibility is constructed as a contrast agent for maltodextrin-mediated bacteria-targeted diagnosis. To realize this, positively charged ultrasmall gadolinium oxide (GdO, 2-3 nm) NPs are embedded in mesoporous silica NPs (MSN) with pore size around 6. Read More

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Multi- and transgenerational biochemical effects of low-dose exposure to bisphenol A and 4-nonylphenol on testicular interstitial (Leydig) cells.

Environ Toxicol 2022 Jan 10. Epub 2022 Jan 10.

Department of Obstetrics and Gynecology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, China.

Bisphenol A (BPA) and 4-nonylphenol (NP) are well-known endocrine-disrupting chemicals (EDCs) that have been proven to affect Leydig cell (LC) functions and testosterone production, but whether BPA and NP have multi- and transgenerational biochemical effects on Leydig cells (LCs) is unknown. Fourier transform infrared (FTIR) spectroscopy is a powerful analytical technique that enables label-free and non-destructive analysis of the tissue specimen. Herein we employed FTIR coupled with chemometrics analysis to identify biomolecular changes in testicular interstitial (Leydig) cells of rats after chronic exposure to low doses of BPA and NP. Read More

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January 2022

DCI after Aneurysmal Subarachnoid Hemorrhage Is Related to the Expression of MFG-E8.

Biomed Res Int 2021 31;2021:6568477. Epub 2021 Dec 31.

Department of Neurosurgery, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi 330006, China.

Objective: To explore the predictive value of milk fat globule epidermal growth factor 8 (MFG-E8) in the occurrence of delayed cerebral ischemia (DCI) after an aneurysmal subarachnoid hemorrhage (aSAH).

Methods: We recruited 32 patients with aSAH as the case group and 24 patients with unruptured aneurysms as the control group. Serum MFG-E8 levels were measured by western blot and enzyme-linked immunosorbent assay. Read More

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January 2022

mTOR Signaling Regulates the Development and Therapeutic Efficacy of PMN-MDSCs in Acute GVHD.

Front Cell Dev Biol 2021 23;9:741911. Epub 2021 Dec 23.

Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Myeloid-derived suppressor cells (MDSCs) represent a population of heterogeneous myeloid cells, which are characterized by their remarkable ability to suppress T cells and natural killer cells. MDSCs have been proven to play a positive role in protecting acute graft-versus-host disease (aGVHD). Here, we aimed to describe the mechanism behind how mTOR signaling regulates MDSCs' generation and explore its prophylactic and therapeutic potential in aGVHD. Read More

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December 2021

Effectiveness of Empagliflozin With Vitamin D Supplementation in Peripheral Neuropathy in Type 2 Diabetic Patients.

Cureus 2021 Dec 6;13(12):e20208. Epub 2021 Dec 6.

Department of Pathology, St. Matthew's University, George Town, CYM.

Background: Neuropathy is the most prevalent broad-spectrum microvascular complication of diabetes. The present study aims to evaluate the effect of empagliflozin with vitamin D supplementation on diabetic peripheral neuropathy.

Methods: A prospective, randomized, controlled study was conducted for six months including 150 type 2 diabetic patients, divided into three groups (n=50/group): Group 1, patients on oral hypoglycemic agents; Group 2, patients on empagliflozin and Group 3, patients on empagliflozin with vitamin D. Read More

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December 2021

Plasmonic biosensor for the highly sensitive detection of microRNA-21 via the chemical etching of gold nanorods under a dark-field microscope.

Biosens Bioelectron 2021 Dec 31;201:113942. Epub 2021 Dec 31.

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, And Key Laboratory of Luminescent and Real-Time Anal. Chem. (Southwest University), Chongqing Science and Technology Bureau, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, PR China. Electronic address:

MicroRNAs involved in tumor-related tissues at abnormal expression level present tremendous potential in the early diagnosis of cancers. However, their intrinsic shortcomings, for instance, low abundance and high sequence homology, make it challengeable to quantify them with high sensitivity and selectivity. Herein, a highly sensitive platform with great specificity was developed for microRNA-21 based on the produced-I triggered chemical etching of gold nanorods to a smaller size, resulting in a significant blue shift and a great intensity decrease in the localized surface plasmon resonance (LSPR) scattering. Read More

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December 2021

Pharmacological Management of Atrial Fibrillation: A Century of Expert Opinions in Cecil Textbook of Medicine.

Am J Ther 2022 Jan-Feb 01;29(1):e18-e25

Department of Cardiology, Colentina Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

Background: Advances in drug therapy for atrial fibrillation (AF) have had a significant impact on the quality of life of a substantial majority of affected persons, which has contributed to a remarkable decrease in the frequency and severity of thromboembolic complications, hospitalizations, and mortality.

Study Question: What are the milestones of the changes in the expert approach to the pharmacological management of AF in the past century?

Study Design: To determine the changes in the experts' approach to the management of AF, as presented in a widely used textbook in the United States.

Data Sources: The chapters presenting the management of AF in the 26 editions of Cecil Textbook of Medicine published from 1927 through 2020. Read More

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January 2022

The modulatory effect of bee honey against diethyl nitrosamine and carbon tetrachloride instigated hepatocellular carcinoma in Wistar rats.

Toxicol Res (Camb) 2021 Dec 14;10(6):1092-1103. Epub 2021 Oct 14.

Biochemistry Department, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.

 : Hepatocellular carcinoma (HCC) is a serious threat to human health that has attracted substantial interest. The purpose of this study was to investigate the modulatory effect of bee honey against induced HCC by diethylnitrosamine/carbon tetrachloride (DEN/CCl4) in rats. HCC was induced by a single intraperitoneal dose of DEN (200 mg/kg B. Read More

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December 2021

Network pharmacology analysis and experimental validation to explore the mechanism of Shenlian extract on myocardial ischemia.

J Ethnopharmacol 2022 Jan 3:114973. Epub 2022 Jan 3.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing, 100700, China. Electronic address:

Ethnopharmacological Relevance: Shenlian extract (SL), extracted from Salvia miltiorrhiza Bunge and Andrographis paniculata (Burm. f.) Nees, has been proved to be effective in the prevention and treatment of atherosclerosis. Read More

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January 2022

Effect of Electroacupuncture on Reproductive Disorders and Insulin Resistance in a Murine Polycystic Ovary Syndrome Model.

Evid Based Complement Alternat Med 2021 26;2021:9968463. Epub 2021 Dec 26.

South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, University of Chinese Medicine, Guangzhou 510006, China.

Polycystic ovarian syndrome (PCOS) is a common, complex, and heterogeneous endocrine and metabolic disorder. There is no standardized treatment, and it therefore requires individualized therapies according to the symptoms and pathogenesis of each patient. The present study aimed to determine the effect of electroacupuncture at the acupoints Zusanli (ST36), Sanyinjiao (SP6), and Neiguan (PC6) on reproductive disorders and insulin resistance in a murine model of PCOS induced by dehydroepiandrosterone (DHEA). Read More

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December 2021

Complex formation of lactic acid by atmospheric pressure chemical ionization.

J Mass Spectrom 2022 Jan;57(1):e4805

Department of Chemistry, Sejong University, Seoul, Republic of Korea.

Oligomers and polymers of lactic acid are generally synthesized through condensation reactions by dehydration at high emperature under catalysis. In the present work, ionization behaviors of lactic acid produced by atmospheric pressure chemical ionization were investigated. Influence of the sample concentration, the heating zone temperature, and the source fragmentor voltage on kinds and abundances of the product ions was examined. Read More

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January 2022

Epidemic of cutaneous fowlpox in a naïve population of chickens and turkeys in Austria: Detailed phylogenetic analysis indicates co-evolution of Fowlpox virus with reticuloendotheliosis virus.

Transbound Emerg Dis 2022 Jan 2. Epub 2022 Jan 2.

Clinic for Poultry and Fish Medicine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, Veterinaerplatz 1, Vienna, 1210, Austria.

Cutaneous fowlpox is a disease of chickens and turkeys caused by the Fowlpox virus (FWPV), characterized by the development of proliferative lesions and scabs on unfeathered areas. FWPVs regularly carry an integrated, active copy of the reticuloendotheliosis virus (REV) and it has been hypothesized that such FWPVs are more problematic in the field. Extensive outbreaks are usually observed in tropical and sub-tropical climates, where biting insects are more difficult to control. Read More

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January 2022

Moringa oleifera polysaccharide regulates colonic microbiota and immune repertoire in C57BL/6 mice.

Int J Biol Macromol 2021 Dec 30;198:135-146. Epub 2021 Dec 30.

College of Animal Science, South China Agricultural University, Guangzhou 510642, China. Electronic address:

This study investigated the effects of Moringa oleifera polysaccharide (MOP) on serum immune indices, immune organ indices, colonic microflora and immune repertoire of mice. Forty male SPF C57BL/6 mice were randomly divided into four groups and subjected to gavage of 0, 20, 40 and 60 mg/kg MOP for 28 days. Mice were sacrificed on the last day of the experiment and their thymus, spleen, blood and colon contents were collected for further detection. Read More

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December 2021

[Randomized controlled trial on cervical spondylotic radiculopathy of wind-cold-damp type treated with acupuncture and thunder-fire moxibustion].

Zhen Ci Yan Jiu 2021 Dec;46(12):1036-42

Department of Acupuncture and Moxibustion, Lianyungang Hospital of Traditional Chinese Medicine Affi-liated to Kangda College of Nanjing Medical University, Lianyungang 222000, Jiangsu Province, China.

Objective: To explore the therapeutic effect of acupuncture combined with thunder-fire moxibustion on cervical spondylotic radiculopathy of wind-cold-damp type and its impacts on the conduction velocity of F wave of median nerve and ulnar nerve, as well as hypersensitive C-responsive protein (hs-CRP), interleukin 6 (IL-6), IL-1β and tumor necrosis factor α (TNF-α) in serum.

Methods: A total of 94 patients with cervical spondylotic radiculopathy of wind-cold-damp type were randomly divided into a control group and a combined therapy group, 47 cases in each group. In the control group, acupuncture was applied to Fengchi (GV20), Tianzhu (BL10), Neck-Jiaji (EX-B5), Dazhui (GV14) and others, 30 min each time, once daily, 5 times a week, totally for 4 weeks. Read More

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December 2021

Interferon-gamma induced APOBEC3B contributes to Merkel cell polyomavirus genome mutagenesis in Merkel cell carcinoma.

J Invest Dermatol 2021 Dec 27. Epub 2021 Dec 27.

Department of Molecular Genetics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan; Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.

Merkel cell polyomavirus (MCPyV) is the causative agent of an aggressive skin tumor, Merkel cell carcinoma (MCC). The viral genome is integrated into the tumor genome and harbors nonsense mutations in the helicase domain of large T antigen (LTAg). However, the molecular mechanisms by which the viral genome gains the tumor-specific mutations remain to be elucidated. Read More

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December 2021

The transport and retention of CQDs-doped TiO in packed columns and 3D printed micromodels.

J Environ Sci (China) 2022 Mar 10;113:365-375. Epub 2021 Jul 10.

Environment Research Institute, Shandong University, Qingdao 266237, China; Shenzhen Research Institute, Shandong University, Shenzhen 518057, China. Electronic address:

CQDs-doped TiO (C-TiO) has drawn increased attention in recent because of its excellent catalytic performance. Understanding the transport of C-TiO in porous media is necessary for evaluating the environmental process of this new nanomaterial. Column experiments were used in this study to investigate ionic strength (IS), dissolved organic matter (DOM) and sand grain size on the transport of C-TiO. Read More

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Synergistic Combination of AS101 and Azidothymidine against Clinical Isolates of Carbapenem-Resistant .

Pathogens 2021 Nov 29;10(12). Epub 2021 Nov 29.

Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Owing to the over usage of carbapenems, carbapenem resistance has become a vital threat worldwide, and, thus, the World Health Organization announced the carbapenem-resistant Enterobacteriaceae (CRE) as the critical priority for antibiotic development in 2017. In the current situation, combination therapy would be one solution against CRE. Azidothymidine (AZT), a thymidine analog, has demonstrated its synergistically antibacterial activities with other antibiotics. Read More

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November 2021

Preparation and Characterization of Fenofibrate Microparticles with Surface-Active Additives: Application of a Supercritical Fluid-Assisted Spray-Drying Process.

Pharmaceutics 2021 Dec 2;13(12). Epub 2021 Dec 2.

Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Korea.

In this study, supercritical fluid-assisted spray-drying (SA-SD) was applied to achieve the micronization of fenofibrate particles possessing surface-active additives, such as d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), sucrose mono palmitate (Sucroester 15), and polyoxyethylene 52 stearate (Myrj 52), to improve the pharmacokinetic and pharmacodynamic properties of fenofibrate. For comparison, the same formulation was prepared using a spray-drying (SD) process, and then both methods were compared. The SA-SD process resulted in a significantly smaller mean particle size (approximately 2 μm) compared to that of unprocessed fenofibrate (approximately 20 μm) and SD-processed particles (approximately 40 μm). Read More

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December 2021

Predictive value of lncRNA ZFAS1 in patients with lumbar disc degeneration.

Am J Transl Res 2021 15;13(11):12549-12556. Epub 2021 Nov 15.

Department of Orthopaedics, Lanzhou University Second Hospital Lanzhou 730000, Gansu, China.

Background: Increasing evidences have indicated the association of non-coding RNAs with the progression of lumbar disc degeneration (LDD), but the role of lncRNA ZFAS1 in LDD remains undefined. Therefore, this study was designed to determine the predictive value of lncRNA ZFAS1 in patients with LDD.

Methods: A total of 80 patients with LDD confirmed and treated in the Gansu Provincial Hospital from May 2018 to May 2020 were enrolled into the patient group, and 50 healthy controls who concurrently underwent physical examination in our hospital were enrolled into the control group. Read More

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November 2021

Optic Nerve Head Microcirculation in Eyes with Vogt-Koyanagi-Harada Disease Accompanied by Anterior Ischemic Optic Neuropathy.

Case Rep Ophthalmol 2021 Sep-Dec;12(3):899-908. Epub 2021 Nov 8.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Anterior ischemic optic neuropathy (AION) is infrequently complicated with Vogt-Koyanagi-Harada (VKH) disease. We quantitatively examined sequential changes in the morphology and circulation hemodynamics, using a C-scan of optical coherence tomography (OCT) and laser speckle flowgraphy (LSFG) in a patient with VKH disease accompanied by AION. A 65-year-old female complained of blurred vision in both of her eyes. Read More

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November 2021