Eur J Neurol 2021 Mar 27. Epub 2021 Mar 27.
University Institute of Molecular Pathology Biomarkers, UNEx, ARADyAL Instituto de Salud Carlos III, Cáceres, Spain.
Background: The coexistence of peripheral neuropathy (PN) and restless legs syndrome/Ekbom disease (RLS/WED) is relatively frequent, but its prevalence has shown a high variability across studies. In addition, several reports have shown data suggesting the presence of PN in patients with idiopathic RLS.
Methods: We undertook a search using the PubMed, EMBASE, and Web of Science Databases, from 1966 until December 6,2020, crossing the search term "Restless legs syndrome" with "neuropathy", "polyneuropathy" (PNP), and "peripheral neuropathy", and identified the references of interest for this topic, and performed a meta-analysis, according to PRISMA guidelines, and a calculation of pooled prevalences, where appropriate, using standard methods. Read More