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Anxiety and depressive symptoms in U.S. Census Bureau assessments of adults: Trends from 2019 to fall 2020 across demographic groups.

J Anxiety Disord 2021 Jul 23;83:102455. Epub 2021 Jul 23.

Florida State University, United States.

Background: Events from spring to fall 2020, including the COVID-19 pandemic, hate crimes, and social unrest, may have impacted mental health, particularly mood and anxiety disorders. This study compares rates of positive screens for anxiety and depressive disorders in separate U.S. Read More

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Prevalence and risk factors for acute stress disorder and posttraumatic stress disorder after burn injury.

Am J Surg 2021 Jul 26. Epub 2021 Jul 26.

Firefighters' Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, DC, USA; The Burn Center, Department of Surgery, MedStar Washington Hospital Center, USA; Department of Surgery, Georgetown University School of Medicine, Washington, DC, USA. Electronic address:

Background: Psychological consequences of burn injury can be profound. Acute stress disorder (ASD) and posttraumatic stress disorder (PTSD) are known sequelae, but routine identification is challenging. This study aims to identify patient characteristics associated with outpatient positive screens. Read More

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Impact of vitamin D deficiency on COVID-19.

Clin Nutr ESPEN 2021 Aug 29;44:372-378. Epub 2021 May 29.

Queensland University of Technology, School of Exercise & Nutrition Sciences, Brisbane, Queensland, Australia; Department of Physiology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. Electronic address:

Background & Aims: COVID-19 has emerged as a global pandemic affecting millions of people. Vitamin D deficiency is one of the risk factors for increased susceptibility to COVID-19. This study aimed to examine the correlation between the prevalence of vitamin D deficiency and COVID-19 infection and mortality rates among the adult population in European and Asian continents. Read More

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Surveillance of ceftobiprole against Gram-positive and Gram-negative Clinical Isolates from 2018 from different European territories.

J Glob Antimicrob Resist 2021 Jul 27. Epub 2021 Jul 27.

Correvio International Sàrl, Geneva, Switzerland.

Background: Ceftobiprole is approved for use in treatment of hospital-associated and community-acquired pneumonia in 17 different European countries and is currently undergoing clinical trials in the USA.

Methods: Isolates were collected from hospital laboratories from 15 European countries during 2018 as part of an ongoing post-marketing surveillance study. MICs were determined using EUCAST broth microdilution methodology and interpreted using 2019 EUCAST breakpoints. Read More

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Classifying and Predicting Surgical Complications After Laryngectomy: A Novel Approach to Diagnosing and Treating Patients.

Ear Nose Throat J 2021 Jul 30:1455613211029749. Epub 2021 Jul 30.

Department of Otolaryngology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Objectives: The total laryngectomy is one of the most standardized major surgical procedures in otolaryngology. Several studies have proposed the Clavien-Dindo classification (CDC) as a solution to classifying postoperative complications into 5 grades from less severe to severe. Yet more data on classifying larger patient populations undergoing major otolaryngologic surgery according to the CDC are needed. Read More

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[Development of the inpatient quality of care of surgically treated patients with a proximal femoral fracture in North Rhine-Westphalia : Analysis of 61,249 treatment courses based on data from external inpatient quality assurance].

Unfallchirurg 2021 Jul 30. Epub 2021 Jul 30.

Klinik für Unfallchirurgie und Orthopädie, Knappschaftskrankenhaus Bochum-Langendreer, Universitätsklinikum der Ruhr-Universität Bochum, In der Schornau 23-25, 44892, Bochum, Deutschland.

Background And Objective: Every year in Germany over 100,000 people, mostly of older age, suffer a proximal femoral fracture. Increasing case numbers in connection with an aging population and a relatively large number of concomitant diseases requiring treatment make everyday care more difficult. It is therefore of great importance to observe the quality of care for these patients using relevant quality parameters in order to be able to derive implications for everyday treatment practice. Read More

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Occurrence of Crown Gall Disease on Japanese Spindle (Euonymus japonicas var. Green Rocket) Caused by Agrobacterium rosae in Iran.

Plant Dis 2021 Jul 30. Epub 2021 Jul 30.

University of Tehran, 48425, Department of Plant Protection, Tehran, Tehran, Iran (the Islamic Republic of);

Crown gall disease caused by diverse Agrobacterium species is one of the main biotic constraints in the ornamental plants industry in Iran (Mafakheri et al. 2017). In August 2019, Japanese spindle (Euonymus japonicus var. Read More

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Heroin Relapse "Strikes a Nerve": A Rare Case of Drug-Induced Acute Myelopathy.

Cureus 2021 Jun 23;13(6):e15865. Epub 2021 Jun 23.

Internal Medicine, Texas Tech University Health Sciences Center School of Medicine at the Permian Basin, Odessa, USA.

Opioid addiction is a major public health problem. Through a commitment to individualized treatment plans meant to help patients meet personal goals, behavioral therapy can encourage abstinence and help prevent relapses that can have debilitating consequences. This case describes a 31-year-old male with heroin relapse who presented with flaccid quadriparesis as well as loss of sensation below the T2-3 spinal level, loss of rectal tone, and urinary retention. Read More

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Relapse of Anterior Open Bite: A Case Report.

Int J Clin Pediatr Dent 2021 Jan-Feb;14(1):140-144

Department of Orthodontics, University of North Paraná, Londrina, Brazil.

The aim and objective of this study is to report the recurrence of the treatment of the anterior open bite after 5 years of treatment. A female patient aged 8 years 6 months old had a negative vertical crossing of -4.7 mm. Read More

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Infiltration of thyroid papillary cancer tissue with myeloid leukemic cells: a case report.

World J Surg Oncol 2021 Jul 29;19(1):225. Epub 2021 Jul 29.

Department of Endocrinology and Metabolism, Kocaeli University Faculty of Medicine, İzmit, Kocaeli, Turkey.

Background: Extramedullary leukemia, also known as myeloid sarcoma, is a rare form of acute myeloid leukemia and often accompanies bone marrow involvement. Myeloid infiltration of the thyroid gland is extremely rare. Here, a unique case in which thyroid cancer tissue was infiltrated with myeloid cells is presented. Read More

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PTEN Expression and Morphologic Patterns in Prostatic Adenocarcinoma.

Histopathology 2021 Jul 29. Epub 2021 Jul 29.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.

Aims: Cribriform morphology, which includes intraductal carcinoma (IDCP) and invasive cribriform carcinoma, is an indicator of poor prognosis in prostate cancer. PTEN loss is a predictor of adverse clinical outcomes. The association between PTEN expression and morphologic patterns of prostate cancer is unclear. Read More

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Can Deep Learning Replace Gadolinium in Neuro-Oncology?: A Reader Study.

Invest Radiol 2021 Jul 28. Epub 2021 Jul 28.

From the Imaging Department, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif BioMaps (UMR1281), Université Paris-Saclay, CNRS, Inserm, CEA, Villejuif Guerbet Research, Villepinte Center for Visual Computing, CentraleSupélec, Inria, Université Paris-Saclay, Gif-sur-Yvette, France.

This study proposes and evaluates a deep learning method that predicts surrogate images for contrast-enhanced T1 from multiparametric magnetic resonance imaging (MRI) acquired using only a quarter of the standard 0.1 mmol/kg dose of gadolinium-based contrast agent. In particular, the predicted images are quantitatively evaluated in terms of lesion detection performance. Read More

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Donor-Derived CD7 Chimeric Antigen Receptor T Cells for T-Cell Acute Lymphoblastic Leukemia: First-in-Human, Phase I Trial.

J Clin Oncol 2021 Jul 29:JCO2100389. Epub 2021 Jul 29.

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin China.

Purpose: Patients with relapsed or refractory T-cell acute lymphoblastic leukemia (r/r T-ALL) have few options and poor prognosis. The aim was to assess donor-derived anti-CD7 chimeric antigen receptor (CAR) T-cell safety and efficacy in patients with r/r T-ALL.

Methods: In this single-center, phase I trial, we administered anti-CD7 CAR T cells, manufactured from either previous stem-cell transplantation donors or new donors, to patients with r/r T-ALL, in single infusions at doses of 5 × 10 or 1 × 10 (±30%) cells per kilogram of body weight. Read More

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Association Between Periconceptional Weight of Maternal Grandmothers and Attention-Deficit/Hyperactivity Disorder in Grandchildren.

JAMA Netw Open 2021 Jul 1;4(7):e2118824. Epub 2021 Jul 1.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Importance: Neurodevelopmental disorders have been proposed to involve alterations to epigenetic regulation, and epigenetic effects may extend to germline cells to affect later generations. Weight status may affect DNA methylation, and maternal weight before and during pregnancy has been associated with offspring DNA methylation as well as attention-deficit/hyperactivity disorder (ADHD).

Objective: To assess whether a woman's weight before and during pregnancy is associated with ADHD in her grandchild. Read More

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Systemic inflammation mediates the association of heavy metal exposures with liver injury: A study in general Chinese urban adults.

J Hazard Mater 2021 Jun 29;419:126497. Epub 2021 Jun 29.

Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address:

Heavy metal exposures have been reported to be associated with increased risk for liver injury. However, the potential mechanisms of the association remain unclear. A repeated-measure study of 9367 observations was conducted to quantify the associations of urinary heavy metals with serum alanine aminotransferase (ALT), a biomarker for liver injury, and assess the mediating role of systemic inflammation in such associations among general Chinese adults. Read More

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A Case-Control Study on Dietary Acid Load in Relation to Glioma.

Nutr Cancer 2021 Jul 29:1-8. Epub 2021 Jul 29.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Limited data are available linking dietary factors to glioma. The current study was conducted to investigate the association between Dietary Acid Load (DAL) and odds of glioma in Iranian adults. This case-control study was done on 128 newly diagnosed patients with glioma and 256 healthy controls in Tehran, Iran. Read More

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PGC-1α regulates myonuclear accretion after moderate endurance training.

J Cell Physiol 2021 Jul 28. Epub 2021 Jul 28.

British Heart Foundation Centre of Research Excellence, School of Cardiovascular Medicine and Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.

The transcriptional demands of skeletal muscle fibres are high and require hundreds of nuclei (myonuclei) to produce specialised contractile machinery and multiple mitochondria along their length. Each myonucleus spatially regulates gene expression in a finite volume of cytoplasm, termed the myonuclear domain (MND), which positively correlates with fibre cross-sectional area (CSA). Endurance training triggers adaptive responses in skeletal muscle, including myonuclear accretion, decreased MND sizes and increased expression of the transcription co-activator peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). Read More

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A prospective multicenter study of the magnifying endoscopic evaluation of the invasion depth of superficial esophageal cancers.

Surg Endosc 2021 Jul 28. Epub 2021 Jul 28.

Department of Gastroenterology and Hepatology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, 2-5-1 Shikata, Okayama, 700-8558, Japan.

Background: Treatment strategies for superficial esophageal squamous cell carcinoma (SESCC) are determined mainly on the basis of the invasion depth. The Japan Esophageal Society (JES) developed a simplified magnifying endoscopic classification for estimating the invasion depth of SESCC. We aimed to evaluate its accuracy. Read More

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Psychological Responses of the Patients in Cabin Hospital to the COVID-19 Outbreak: A Comparative Epidemiologic Analysis.

Front Psychol 2021 12;12:641167. Epub 2021 Jul 12.

Department of Internal Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The building of cabin hospitals in Wuhan has been proven to be clinically successful in curing mild-symptom COVID-19 patients shortly after the outbreak of COVID-19 in late 2019. At the same time, the psychological effect of patients being treated in cabin hospitals and the features of the psychological status of the whole society remained ambiguous. This study adopted a self-administrated questionnaire to investigate the stress, depression, and anxiety status of patients in cabin hospitals ( = 212) and healthy participants outside of Hubei province ( = 221) in a population level from February 29 to March 01, 2020. Read More

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A male-ABCD algorithm for hepatocellular carcinoma risk prediction in HBsAg carriers.

Chin J Cancer Res 2021 Jun;33(3):352-363

State Key Lab of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Objective: Hepatocellular carcinoma (HCC) development among hepatitis B surface antigen (HBsAg) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBsAg-positive male adults.

Methods: HBsAg-positive males of 35-69 years old (N=6,153) were included from a multi-center population-based liver cancer screening study. Read More

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Increased sugar-sweetened beverage use tendency in pregnancy positively associates with peripartum Edinburgh postpartum depression scores.

Sci Rep 2021 Jul 28;11(1):15324. Epub 2021 Jul 28.

Department of Obstetrics and Gynecology, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

The association among sugar sweetened beverages (SSB) consumption, addiction and depression in adults, children and adolescents is widely reported. Dieting patterns during pregnancy is complicated by maternal fetal concerns. Specifically, restrained use of SSB might be potentially a source of perinatal distress. Read More

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Expansion of patient eligibility for virtual glaucoma clinics: a long-term strategy to increase the capacity of high-quality glaucoma care.

Br J Ophthalmol 2021 Jul 28. Epub 2021 Jul 28.

Glaucoma Service, Moorfields Eye Hospital NHS Foundation Trust, London, UK.

Aims: The virtual glaucoma clinic (VGC) is a well-established diagnostic pathway for delivery of glaucoma care. Current UK national guidance recommends VGCs for patients with ocular hypertension, glaucoma suspects or early glaucoma. This study evaluates whether expanded eligibility criteria, including other glaucoma phenotypes and disease stages, can deliver safe and effective care with a positive patient experience. Read More

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Duration of Adjuvant Aromatase-Inhibitor Therapy in Postmenopausal Breast Cancer.

N Engl J Med 2021 Jul;385(5):395-405

From the Comprehensive Cancer Center (M.G., C.F.S., C.D., F.F., K.W., S.K.-S.), the Department of General Surgery (F.F., K.W., S.K.-S.), the Department of Internal Medicine I, Division of Oncology (G.G.S., R.B.), and the Department of Obstetrics and Gynecology (C.F.S., C.D.), Medical University of Vienna, Austrian Breast and Colorectal Cancer Study Group (M.G., R.J., L.S., C.F.), Breast Care Center, Hanusch Hospital (U.W.), the Department of Gynecology, Hospital Hietzing, and Karl Landsteiner Institute for Gynecological Oncology and Senology (P.S.), Vienna, the Department of Internal Medicine III and Salzburg Cancer Research Institute-Center for Clinical Cancer and Immunology Trials, Paracelsus Medical University Salzburg, Salzburg (G.R., S.G.-R., S.P.G., R.G.), the Departments of Oncology (M.B., C.S.) and Gynecology (V.B.-R.), Medical University Graz, Graz, the Department of Surgery, Ordensklinikum Linz, Linz (D.H.), the Department of Internal Medicine IV, Klinikum Wels-Grieskirchen, Wels (J.T.), the Department of Gynecology, Medical University Innsbruck, Innsbruck (D.E., C.B.), Doctor's Office Manfreda, Klagenfurt (D.M.), the Department of Surgery, Hospital Wolfsberg, Wolfsberg (E.M.-Z.), the Department of Internal Medicine, Hospital Vöcklabruck, Vöcklabruck (F.H.), the Department of Surgery, General Hospital Baden, Baden (H.T.), and the Breast Center, Doctor's Office Wette, Sankt Veit an der Glan (V.W.) - all in Austria; and the Breast Unit, University Hospital Helios, University Witten Herdecke, Wuppertal, Germany (V.B.-R.).

Background: For postmenopausal women with hormone-receptor-positive breast cancer, the most effective duration for adjuvant therapy with an aromatase inhibitor remains unclear.

Methods: In this prospective, phase 3 trial, we randomly assigned postmenopausal women with hormone-receptor-positive breast cancer who had received 5 years of adjuvant endocrine therapy to receive the aromatase inhibitor anastrozole for an additional 2 years (2-year group, receiving a total of 7 years) or an additional 5 years (5-year group, receiving a total of 10 years). The primary end point was disease-free survival. Read More

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Efficacy of the Chinese version interpretation bias modification training in an unselected sample: A randomized trial.

PLoS One 2021 28;16(7):e0255224. Epub 2021 Jul 28.

Faculty of Psychology, Naval Medical University, Shanghai, China.

Training individuals to interpret ambiguous information in positive ways might be an effective method of reducing social anxiety. However, little research had been carried out in Chinese samples, and the effect of interpretation training on other processes such as attentional bias also remained unclear. This study examined the effect of interpretation bias modification program (IMP) on interpretation bias, social anxiety and attentional bias, and the possible mediation effects. Read More

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First Report of New Bacterial Leaf Blight of Rice Caused by Pantoea ananatis in Southeast China.

Plant Dis 2021 Jul 28. Epub 2021 Jul 28.

China National Rice Research Institute, 98439, State Key Laboratory of Rice Biology, 28 Shuidaosuo Road, Fuyang, Hangzhou, China, 311400;

In autumn 2020, leaf blight was observed on rice (Oryza sativa L., variety Zhongzao39, Yongyou9, Yongyou12, Yongyou15, Yongyou18, Yongyou1540, Zhongzheyou8, Jiafengyou2, Xiangliangyou900 and Jiyou351) in the fields of 17 towns in Zhejiang and Jiangxi Provinces, China. The disease incidence was 45%-60%. Read More

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Interplay of clear, demanding, and important goals on project performance in community-academic health partnerships.

Health Care Manage Rev 2021 Jul 23. Epub 2021 Jul 23.

Choiwai M. Chak, MSc, Research Associate, Change Management & Organizational Behavior, University of Twente, Enschede, the Netherlands, and Research Associate, Science-to-Business Marketing Research Centre, Münster University of Applied Sciences, Münster, Germany. E-mail: Lara Carminati, PhD, Assistant Professor, Change Management & Organizational Behavior, University of Twente, Enschede, the Netherlands. Celeste P. M. Wilderom, PhD, Professor, Change Management & Organizational Behavior, University of Twente, Enschede, the Netherlands.

Background: Community-academic health partnerships (CAHPs) have become increasingly common to bridge the knowledge-to-practice gap in health care. Because working in such partnerships can be excessively challenging, insights into the individual-level enablers of high performance will enable better management of CAHPs.

Purpose: Steered by the goal-setting theory, this study examined the relations between goal clarity, goal stress, goal importance, and their interactions on perceived project performance among individuals working in CAHPs' constituting projects. Read More

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Seroreversion of Hepatitis B Surface Antigen among Subjects with Resolved HBV Infection: A Community Based Cohort Study.

J Gastroenterol Hepatol 2021 Jul 28. Epub 2021 Jul 28.

Hepatitis Center and Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Background & Aims: Hepatitis B virus (HBV) surface antigen (HBsAg) seroreversion usually occurs during immunosuppressive therapy. The risk and factors of HBsAg seroreversion from resolved HBV infection in general population remained unclear.

Methods: This retrospective study enrolled subjects with resolved HBV infection, and who had received at least two times of screen in a longitudinal community screen program. Read More

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Large-scale reanalysis of refrigerated antemortem blood samples for ethanol content at random intervals.

J Forensic Sci 2021 Jul 27. Epub 2021 Jul 27.

Scottsdale Police Department Crime Laboratory, Scottsdale, Arizona, USA.

Ethanol stability in antemortem blood stored under various conditions has been widely studied. Most such studies have somewhat limited sample size (<50) and limited variation in the length of time between the blood draw and the first analysis and between the first analysis and the reanalysis. In the work presented here, the antemortem blood drawn for forensic purposes and stored refrigerated (~4°C) in 371 cases was analyzed for ethanol concentration using headspace gas chromatography at various times after the blood draw based on routine case flow and then also analyzed at various times within approximately 1 year after the first analysis. Read More

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Diagnostic accuracy of rapid antigen tests in asymptomatic and presymptomatic close contacts of individuals with confirmed SARS-CoV-2 infection: cross sectional study.

BMJ 2021 Jul 27;374:n1676. Epub 2021 Jul 27.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands

Objective: To assess the diagnostic test accuracy of two rapid antigen tests in asymptomatic and presymptomatic close contacts of people with SARS-CoV-2 infection on day 5 after exposure.

Design: Prospective cross sectional study.

Setting: Four public health service covid-19 test sites in the Netherlands. Read More

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HCV Positive Allograft Use in Heart Transplant is Associated With Increased Access to Overdose Donors and Reduced Waitlist Mortality Without Compromising Outcomes.

J Card Fail 2021 Jul 24. Epub 2021 Jul 24.

Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104. Electronic address:

Background: Despite ongoing donor shortages in heart transplant, donor candidates arising from drug overdose (OD) are increasingly prevalent. These donors carry a high preponderance of now curable Hepatitis C virus (HCV). This study investigates temporal trends and regional variability in HCV+ allograft use in heart transplant, assessing the relation of HCV+ graft use on OD donor usage as well as waitlist and post-transplant outcomes. Read More

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