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Dental Pulp Stem Cell Polarization: Effects of Biophysical Factors.

J Dent Res 2021 Jul 30:220345211028850. Epub 2021 Jul 30.

Department of Biomedical Sciences, College of Dentistry, Texas A&M University, Dallas, TX, USA.

Dental pulp stem cells (DPSCs) have the potential to polarize, differentiate, and form tubular dentin under certain conditions. However, the factors that initiate and regulate DPSC polarization and its underlying mechanism remain unclear. Identification of the factors that control DPSC polarization is a prerequisite for tubular dentin regeneration. Read More

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Papillary muscle relocation with a multiloop suture: A proposed surgical technique for ischemic mitral regurgitation.

JTCVS Tech 2020 Dec 12;4:133-135. Epub 2020 Aug 12.

Division of Cardiac Surgery, Queen's University, Kingston, Ontario, Canada.

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December 2020

Navigating climate change adaptation assistance for communities: a case study of Newtok Village, Alaska.

J Environ Stud Sci 2021 Jul 23:1-12. Epub 2021 Jul 23.

Ristroph Law, Planning, and Research, 410 Burgin Ave, Baton Rouge, LA 70808 USA.

Climate change is significantly impacting Alaska Native Villages (federally recognized tribes) as well as other rural and place-based communities that wish to continue their traditional lifeways. While many communities are looking to state and federal governments for assistance with climate change and other emergencies, there are limits to assistance under the current political and legal framework. This article discusses strategies for climate change adaptation that Alaska Native Villages and similarly situated communities may be able to take on their own. Read More

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CAPABLE program improves disability in multiple randomized trials.

J Am Geriatr Soc 2021 Jul 27. Epub 2021 Jul 27.

Johns Hopkins School of Nursing, Baltimore, Maryland, USA.

Background: Programs to reduce disability are crucial to the quality of life for older adults with disabilities. Reducing disability is also important to avert unnecessary and costly hospitalizations, relocation, or nursing home placements. Few programs reduce disability and few have been replicated and scaled beyond initial research settings. Read More

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Natural killer cell immunosuppressive function requires CXCR3-dependent redistribution within lymphoid tissues.

J Clin Invest 2021 Jul 27. Epub 2021 Jul 27.

Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America.

Natural killer (NK) cell suppression of T cells is a key determinant of viral pathogenesis and vaccine efficacy. This process involves perforin-dependent elimination of activated CD4 T cells during the first three days of infection. Although this mechanism requires cell-cell contact, NK cells and T cells typically reside in different compartments of lymphoid tissues at steady state. Read More

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Rice black-streaked dwarf virus P10 promotes phosphorylation of GAPDH (glyceraldehyde-3-phosphate dehydrogenase) to induce autophagy in .

Autophagy 2021 Jul 27:1-20. Epub 2021 Jul 27.

State Key Laboratory of Rice Biology, Institute of Biotechnology, Zhejiang University, Hangzhou, Zhejiang, P.R.China.

Macroautophagy/autophagy is an important innate and adaptive immune response that can clear microbial pathogens through guiding their degradation. Virus infection in animals and plants is also known to induce autophagy. However, how virus infection induces autophagy is largely unknown. Read More

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Correlational nutritional relationships and interactions between expansive holoparasite Orobanche laxissima and woody hosts on metal-rich soils.

Phytochemistry 2021 Jul 23;190:112844. Epub 2021 Jul 23.

Center for Research and Conservation of Biodiversity, Department of Enviromental Biology, Institute of Biology, Jan Kochanowski University, Uniwersytecka 7 Street, PL-25-406, Kielce, Poland. Electronic address:

Plant parasitism by other plants, combined with abiotic environmental stress, offers a unique opportunity to study correlational nutritional relationships in terms of parasite-host interactions and their functional roles in nutrient cycling in ecosystems. Our study analysed the transfer of selected mineral elements, including heavy metals, from soil to different organs in hosts (Punica granatum and Fraxinus angustifolia) and from hosts to the expansive holoparasite (Orobanche laxissima) in cinnamonic soil habitats in Georgia (Caucasus). We also identified other correlated trophic and bioactive effects in the parasite-host relationship. Read More

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Plasmalogens regulate the AKT-ULK1 signaling pathway to control the position of the axon initial segment.

Prog Neurobiol 2021 Jul 21:102123. Epub 2021 Jul 21.

Neurolipid Biology, Instituto de Investigação e Inovação em Saúde da Universidade do Porto - i3S, Portugal; Instituto de Biologia Molecular e Celular - IBMC, Porto, Portugal. Electronic address:

The axon initial segment (AIS) is a specialized region in neurons that encompasses two essential functions, the generation of action potentials and the regulation of the axodendritic polarity. The mechanism controlling the position of the axon initial segment to allow plasticity and regulation of neuron excitability is unclear. Here we demonstrate that plasmalogens, the most abundant ether-phospholipid, are essential for the homeostatic positioning of the AIS. Read More

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Productivity, Satisfaction, Work Environment and Health after Relocation to an Activity-Based Flex Office-The Active Office Design Study.

Int J Environ Res Public Health 2021 Jul 18;18(14). Epub 2021 Jul 18.

Department of Public Health and Clinical Medicine, Section of Sustainable Health, Umeå University, 901 87 Umeå, Sweden.

Implementation of activity-based flex offices (AFOs) are becoming increasingly common. The aim of this study was to evaluate the effects of an AFO on perceived productivity, satisfaction, work environment and health. Questionnaire data from the longitudinal, quasi-experimental Active Office Design Study was used. Read More

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Facing the COVID-19 pandemic inside maternities in Brazil: A mixed-method study within the REBRACO initiative.

PLoS One 2021 23;16(7):e0254977. Epub 2021 Jul 23.

Department of Obstetrics and Gynecology, University of Campinas, Campinas/SP, Brazil.

Introduction: COVID-19 pandemic posed major challenges in obstetric health care services. Preparedness, development, and implementation of new protocols were part of the needed response. This study aims to describe the strategies implemented and the perspectives of health managers on the challenges to face the pandemic in 16 different maternity hospitals that comprise a multicenter study in Brazil, called REBRACO (Brazilian network of COVID-19 during pregnancy). Read More

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Preventive behaviours and family inequalities during the COVID-19 pandemic: a cross-sectional study in China.

Infect Dis Poverty 2021 Jul 20;10(1):100. Epub 2021 Jul 20.

School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, China.

Background: The coronavirus disease 2019 (COVID-19) pandemic is an international public health threat, and people's participation in disease-related preventive behaviours is the key to controlling infectious diseases. This study aimed to assess the differences in adopting preventive behaviours among populations to explore potential individual and household factors and inequalities within families.

Methods: This online survey was conducted in April 2020. Read More

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Evaluation of In Vitro Phototoxicity of a Minibody-IR700 Conjugate Using Cell Monolayer and Multicellular Tumor Spheroid Models.

Cancers (Basel) 2021 Jul 4;13(13). Epub 2021 Jul 4.

Division of Laboratory Medicine, Department of Pathology, Oslo University Hospital-Radiumhospitalet, Ullernchausseen 70, 0379 Oslo, Norway.

Photodynamic therapy (PDT) is a treatment strategy that utilizes photosensitizers (PSs) and light of a specific wavelength to kill cancer cells. However, limited tumor specificity is still a drawback for the clinical application of PDT. To increase the therapeutic efficacy and specificity of PDT, a novel human minibody (MS5) that recognizes a cell surface receptor expressed on various cancer cells was labeled with the hydrophilic phthalocyanine PS IR700 to generate an MS5-IR700 conjugate that is activated by near-infrared (NIR) light. Read More

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Assessing Residents' Perceptions of Their Relocation to Long-Term Care: Psychometric Validation of the View of Relocation Scale.

J Am Med Dir Assoc 2021 Jul 12. Epub 2021 Jul 12.

Swinburne University of Technology, Hawthorn, VIC, Australia.

Objectives: Relocation to long-term care is a major challenge for older people. The View of Relocation Scale (VRS) was developed to address the need for a brief instrument to assess residents' perceptions of the relocation.

Design: Secondary analysis of data collected in a cluster randomized trial. Read More

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Exploring the Operative Strategy for Secondary Mitral Regurgitation: A Systematic Review.

Biomed Res Int 2021 22;2021:3466813. Epub 2021 Jun 22.

Cardiovascular Surgery, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.

Background: Mitral valve disease surgery is an evolving field with multiple possible interventions. There is an increasing body of evidence regarding the optimal strategy in secondary mitral regurgitation where the pathology lies within the ventricle. We conducted a systematic review to identify the benefits and limitations of each surgical option. Read More

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Use of Corrective Ulnar Osteotomy and Radial Head Relocation Into Preserved Annular Ligament in the Treatment of Radiocapitellar Instability Secondary to Pediatric Chronic Monteggia Fracture-Dislocation.

J Hand Surg Am 2021 Jul 10. Epub 2021 Jul 10.

Baltalimani Bone Diseases Research Hospital Hand Surgery Clinic, University of Health Science Turkey Medical School, İstanbul.

Purpose: Opening-wedge osteotomy of the ulna restores normal ulnar length and corrects the angulation of the ulna in patients with chronic Monteggia fracture-dislocations. In addition, this eases the reduction of the radial head. Morbidity caused by annular ligament reconstruction surgery can be prevented by preserving the intact annular ligament. Read More

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Intraperitoneal extension of the peritoneal dialysis catheter-a new technique for catheter implantation in patients with obesity.

J Nephrol 2021 Jul 8. Epub 2021 Jul 8.

Department of General, Visceral and Transplant Surgery, Tübingen University Hospital, Hoppe-Seyler-Strasse 3, 72076, Tübingen, Germany.

Background: In patients with obesity and end-stage kidney disease, implantation of the peritoneal dialysis (PD) catheter may be complicated by increased abdominal circumference or skin folds. Relocation of the implantation site to the upper abdomen could solve this problem. However, this would require an extended catheter. Read More

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Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway.

Redox Biol 2021 09 23;45:102056. Epub 2021 Jun 23.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China; Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, China. Electronic address:

Ferroptosis is primarily triggered by a failure of the glutathione (GSH)-glutathione peroxidase 4 (GPX4) reductive system and associated overwhelming lipid peroxidation, in which enzymes regulating polyunsaturated fatty acid (PUFA) metabolism, and in particular acyl-CoA synthetase long chain family member 4 (ACSL4), are central. Here, we found that exogenous oxygen radicals generated by photodynamic therapy (PDT) can directly peroxidize PUFAs and initiate lipid autoxidation, coinciding with cellular GSH depletion. Different from canonical ferroptosis induced by RSL3 or erastin, PDT-initiated lipid peroxidation and ferroptotis-like cell death is independent of lipoxygenase (ALOXs) and ACSL4. Read More

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September 2021

The comorbidity of HIV, hypertension and diabetes: a qualitative study exploring the challenges faced by healthcare providers and patients in selected urban and rural health facilities where the ICDM model is implemented in South Africa.

BMC Health Serv Res 2021 Jul 3;21(1):647. Epub 2021 Jul 3.

Perinatal and HIV Research Unit, Chris Hani Baragwanath Hospital, Johannesburg, South Africa.

Background: PLWH are living longer as a result of advancement and adherence to antiretroviral therapy. As the life expectancy of PLWH increases, they are at increased risk of hypertension and diabetes. HIV chronic co-morbidities pose a serious public health concern as they are linked to increased use and need of health services, decreased overall quality of life and increased mortality. Read More

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Facilitators and barriers to HIV pre-exposure prophylaxis (PrEP) uptake through a community-based intervention strategy among adolescent girls and young women in Seme Sub-County, Kisumu, Kenya.

BMC Public Health 2021 Jul 1;21(1):1284. Epub 2021 Jul 1.

Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Background: While the introduction of HIV Pre-Exposure Prophylaxis (PrEP) as an HIV prevention strategy has allowed women to exercise more control over the reduction of HIV transmission rates, adolescent girls and young women in Sub-Saharan Africa continue to experience higher rates of HIV infections and bear the greatest disease burden. Understanding progress in PrEP uptake among adolescent girls and young women would enhance risk reduction in this vulnerable population. The Determined, Resilient, AIDS-Free, Mentored and Safe women (DREAMS) Initiative plays a key role in this risk reduction strategy. Read More

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Integrative Modelling of Gene Expression and Digital Phenotypes to Describe Senescence in Wheat.

Genes (Basel) 2021 Jun 11;12(6). Epub 2021 Jun 11.

The John Bingham Laboratory, NIAB, 93 Lawrence Weaver Road, Cambridge CB3 0LE, UK.

Senescence is the final stage of leaf development and is critical for plants' fitness as nutrient relocation from leaves to reproductive organs takes place. Although senescence is key in nutrient relocation and yield determination in cereal grain production, there is limited understanding of the genetic and molecular mechanisms that control it in major staple crops such as wheat. Senescence is a highly orchestrated continuum of interacting pathways throughout the lifecycle of a plant. Read More

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Transcriptional Stress Induces Chromatin Relocation of the Nucleotide Excision Repair Factor XPG.

Int J Mol Sci 2021 Jun 19;22(12). Epub 2021 Jun 19.

Istituto di Genetica Molecolare "Luigi Luca Cavalli-Sforza", Consiglio Nazionale Delle Ricerche (CNR), Via Abbiategrasso 207, 27100 Pavia, Italy.

Endonuclease XPG participates in nucleotide excision repair (NER), in basal transcription, and in the processing of RNA/DNA hybrids (R-loops): the malfunction of these processes may cause genome instability. Here, we investigate the chromatin association of XPG during basal transcription and after transcriptional stress. The inhibition of RNA polymerase II with 5,6-dichloro-l-β-D-ribofuranosyl benzimidazole (DRB), or actinomycin D (AD), and of topoisomerase I with camptothecin (CPT) resulted in an increase in chromatin-bound XPG, with concomitant relocation by forming nuclear clusters. Read More

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Diel Variations of Extracellular Microcystin Influence the Subcellular Dynamics of RubisCO in PCC 7806.

Microorganisms 2021 Jun 10;9(6). Epub 2021 Jun 10.

Department of Microbiology, Institute for Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Street 24/25, 14476 Potsdam-Golm, Germany.

The ubiquitous freshwater cyanobacterium is remarkably successful, showing a high tolerance against fluctuations in environmental conditions. It frequently forms dense blooms which can accumulate significant amounts of the hepatotoxin microcystin, which plays an extracellular role as an infochemical but also acts intracellularly by interacting with proteins of the carbon metabolism, notably with the CO fixing enzyme RubisCO. Here we demonstrate a direct link between external microcystin and its intracellular targets. Read More

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Assessment of knowledge, attitude, and practice regarding Deep Margin Elevation (DME) among dental practitioners in Riyadh, Saudi Arabia.

J Family Med Prim Care 2021 May 31;10(5):1931-1937. Epub 2021 May 31.

Dental Student, Riyadh Elm University, Riyadh, Saudi Arabia.

Objectives: To evaluate Knowledge, Attitude, and Practice (KAP) regarding deep margin elevation (DME) among dental practitioners in Riyadh city.

Materials And Methodology: A cross-sectional study that comprised a total number of 535 dental practitioners: 255 (47.7%) were males and 280 (52. Read More

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The missing Eusarcus: generic relocation of Pucrolia minuta, with synonymic notes (Opiliones: Laniatores: Gonyleptidae).

Zootaxa 2021 Jun 22;4990(3):587-590. Epub 2021 Jun 22.

2 División Plantas Vasculares, Museo de La Plata, Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata, and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), La Plata, provincia de Buenos Aires, Argentina. .

The harvestmen family Gonyleptidae (Opiliones), the largest one in the Neotropics (Kury 2003), is astonishingly diverse in eastern South America. The species-rich genus Eusarcus Perty, 1833, is characteristic for this area. It is the second largest gonyleptid genus (Kury 2003; Hara Pinto-da-Rocha 2010), with a long taxonomical history beginning in the 19th century, when Perty (1833) described the genus together with four species. Read More

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Chromatin mobility and relocation in DNA repair.

Trends Cell Biol 2021 Jun 26. Epub 2021 Jun 26.

Children's Medical Research Institute, University of Sydney, Westmead, New South Wales, 2145, Australia. Electronic address:

The nucleus is a dynamic environment containing chromatin, membraneless organelles, and specialized molecular structures at the nuclear membrane. Within the spectrum of DNA repair activities are observations of increased mobility of damaged chromatin and the displacement of DNA lesions to specific nuclear environments. Here, we focus on the role that nuclear-specific filamentous actin plays in mobilizing damaged chromatin in response to DNA double-strand breaks and replication stress. Read More

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Assessing the perceived changes in neighborhood physical and social environments and how they are associated with Chinese internal migrants' mental health.

BMC Public Health 2021 06 28;21(1):1240. Epub 2021 Jun 28.

Department of Human Geography and Spatial Planning, Faculty of Geosciences, Utrecht University, Princetonlaan 8A, Utrecht, CB, 3584, The Netherlands.

Background: Migrants experience substantial changes in their neighborhood physical and social environments along their migration journeys, but little is known about how perceived changes in their neighborhood environment pre- and post-migration correlate with their mental health. Our aim was to examine the associations between recalled changes in the perceived neighborhood physical and social environments and migrants' mental health in the host city.

Methods: We used cross-sectional data on 591 migrants in Shenzhen, China. Read More

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Estimating the impact of state cigarette tax rates on smoking behavior: Addressing endogeneity using a natural experiment.

Drug Alcohol Depend 2021 Aug 18;225:108807. Epub 2021 Jun 18.

RAND Corporation, 1776 Main Street, Santa Monica, CA, 90407, USA.

Introduction: Cigarette excise taxes are a well-established policy lever for reducing tobacco use. However, estimating the effect of taxes on smoking behavior can be confounded by endogeneity concerns such as selection. This study leverages a unique natural experiment -compulsory relocation of U. Read More

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Structure and function of Shark Bay microbial communities following tropical cyclone Olwyn: A metatranscriptomic and organic geochemical perspective.

Geobiology 2021 Jun 28. Epub 2021 Jun 28.

WA-Organic Isotope Geochemistry Centre, The Institute for Geoscience Research, School of Earth and Planetary Sciences, Curtin University, Perth, WA, Australia.

Shark Bay, Western Australia, is episodically impacted by tropical cyclones. During 2015, the region was hit by a category 3 cyclone, "severe tropical cyclone Olywn," leading to the formation of a black sludge in an intertidal zone harboring microbial mats and microbialites. Upon returning to the impacted site 12 months later, the black sludge deposit was still recognizable between the microbialite columns and mucilaginous cobbles near the shoreline in the impacted area. Read More

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Phase IIB Randomized Trial on the Use of 4-Aminopyridine in Guillain-Barré Syndrome.

Arch Rehabil Res Clin Transl 2021 Jun 8;3(2):100123. Epub 2021 Apr 8.

Department of Physical Medicine and Rehabilitation-Oakwood, Wayne State University School of Medicine, Vestavia Hills, Alabama.

Objective: To determine the safety and efficacy of orally delivered 4-aminopyridine (4-AP) in persons with Guillain-Barré Syndrome (GBS) >6 months from initial diagnosis.

Design: A randomized, double-blind, placebo-controlled, crossover study.

Setting: Tertiary care clinical outpatient program. Read More

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Assessment of transportation system disruption and accessibility to critical amenities during flooding: Iowa case study.

Sci Total Environ 2021 Jun 18;793:148476. Epub 2021 Jun 18.

Department of Civil and Environmental Engineering, University of Iowa, Iowa City, IA, USA; IIHR, Hydroscience and Engineering, University of Iowa, Iowa City, IA, USA.

Natural disasters, such as flooding, can cause severe social, environmental, and economic damage to a community. Transportation infrastructure plays an essential role in flood response and recovery efforts. However, flooding may disturb road functionality and generate direct and indirect adverse impacts, including the loss of access to essential services. Read More

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