222 results match your criteria relief hyperthermia


Effect and Safety of Remifentanil Patient-Controlled Analgesia Compared with Epidural Analgesia in Labor: An Updated Meta-Analysis of Randomized Controlled Trials.

Gynecol Obstet Invest 2021 30;86(3):231-238. Epub 2021 Jun 30.

Department of Anesthesiology, Tianjin Central Hospital of Gynecology & Obstetrics, Tianjin, China.

Purpose: The study was aimed to systematically assess the effect and safety of remifentanil patient-controlled analgesia (rPCA) versus epidural analgesia (EA) during labor.

Methods: Eligible trials were retrieved from PubMed, EMBASE, ScienceDirect, and Cochrane Library before April 2020. The primary outcomes were patient satisfaction with pain relief and average visual analog scale (VAS) pain scores during labor; the secondary outcomes were rate of spontaneous delivery, oxygen desaturation, maternal hyperthermia, and neonatal Apgar scores <7 at 1 and 5 min. Read More

View Article and Full-Text PDF

Functional Calsequestrin-1 Is Expressed in the Heart and Its Deficiency Is Causally Related to Malignant Hyperthermia-Like Arrhythmia.

Circulation 2021 Jun 24. Epub 2021 Jun 24.

Department of Pharmacology, School of Basic Medical Sciences, Beijing Key Laboratory of Metabolic Disturbance Related Cardiovascular Disease, Capital Medical University, Beijing 100069, P. R. China.

Calsequestrins (Casqs), comprising the Casq1 and Casq2 isoforms, buffer Ca and regulate its release in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle, respectively. Human inherited diseases associated with mutations in or include malignant hyperthermia/environmental heat stroke (MH/EHS) and catecholaminergic polymorphic ventricular tachycardia. However, patients with an MH/EHS event often suffer from arrhythmia for which the underlying mechanism remains unknown. Read More

View Article and Full-Text PDF

Image-guided thermal ablation in the management of symptomatic adenomyosis: a systematic review and meta-analysis.

Int J Hyperthermia 2021 ;38(1):948-962

School of Biomedical Engineering, Health Science Center, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen University, Shenzhen, China.

Objective: To evaluate the clinical effects of image-guided thermal ablation for the treatment of symptomatic adenomyosis (AD).

Data Sources: We searched PubMed, Web of Science, Cochrane Library, EMBASE, ClinicalTrials.gov and Google Scholar for literature from January 2000 to September 2020. Read More

View Article and Full-Text PDF

[COMPLEX TREATMENT OF PATIENTS WITH VENOUS TROPHIC ULCER IN THE CONDITIONS OF COVID-19 HOSPITAL].

Georgian Med News 2021 Mar(312):7-14

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of the Russian Federation.

The aim of the study was to study the effectiveness of complex treatment of decompensated chronic venous insufficiency (CVI) using innovative techniques and proteolysis inhibitors with a wide spectrum of activity in patients with SARS-CoV-2 (COVID-19) in COVID hospital. This study was performed in the surgical department of COVID hospital on the basis of the Clinical Hospital No. 4 of the First Moscow State Medical University named I. Read More

View Article and Full-Text PDF

The efficacy of a new high-intensity focused ultrasound therapy for metastatic pancreatic cancer.

Int J Hyperthermia 2021 ;38(1):288-295

Department of Medical Oncology, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China.

Purpose: To compare the survival benefit, pain control and safety of low-power cumulative and traditional high-intensity focused ultrasound (HIFU) for metastatic pancreatic cancer.

Method: We retrospectively analyzed 55 patients with metastatic pancreatic cancer who received HIFU treatment between January 2008 and April 2014 in our department. 23 patients received low-power cumulative HIFU treatment (L group), 32 received the traditional HIFU treatment (T group). Read More

View Article and Full-Text PDF

High-intensity focused ultrasound ablation in the treatment of recurrent ovary cancer and metastatic pelvic tumors: a feasibility study.

Int J Hyperthermia 2021 ;38(1):282-287

State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.

Objective: To explore the feasibility of high-intensity focused ultrasound (HIFU) ablation for treating metastatic pelvic tumors and recurrent ovary cancer.

Materials And Methods: Eight patients with metastatic pelvic tumors or recurrent ovary cancer were enrolled in this study. Among them, 5 patients had ovarian cancer, 1 had cervical cancer, 1 had endometrial cancer, and 1 had rectal cancer. Read More

View Article and Full-Text PDF

Synergy of hypoxia relief and heat shock protein inhibition for phototherapy enhancement.

J Nanobiotechnology 2021 Jan 6;19(1). Epub 2021 Jan 6.

Department of Laboratory Medicine, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, 210003, China.

Background: Phototherapy is a promising strategy for cancer therapy by reactive oxygen species (ROS) of photodynamic therapy (PDT) and hyperthermia of photothermal therapy (PTT). However, the therapeutic efficacy was restricted by tumor hypoxia and thermal resistance of increased expression of heat shock protein (Hsp). In this study, we developed albumin nanoparticles to combine hypoxia relief and heat shock protein inhibition to overcome these limitations for phototherapy enhancement. Read More

View Article and Full-Text PDF
January 2021

Suberosin Attenuates the Proliferation of MCF-7 Breast Cancer Cells in Combination with Radiotherapy or Hyperthermi

Curr Drug Res Rev 2020 12 27. Epub 2020 Dec 27.

Departments of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran

Aim: The aim of this study was to determine the proliferation of MCF-7 following irradiation or hyperthermia as alone or pre-treatment with suberosin.

Background: Radiotherapy is a major therapeutic modality for the control of breast cancer. However, hyperthermia can be prescribed for relief of pain or enhancing cancer cell death. Read More

View Article and Full-Text PDF
December 2020

Effects of stereotactic radiofrequency thermocoagulation in the globus pallidus internus on refractory tic disorders.

Int J Hyperthermia 2020 ;37(1):1404-1411

Department of Medical Research, Shijiazhuang People's Hospital, Shijiazhuang, China.

Objective: To investigate the effect of stereotactic radiofrequency thermocoagulation in the globus pallidus internus on refractory tic disorders.

Materials And Methods: Forty patients with refractory tic disorders were enrolled between January 2015 and July 2017 to experience stereotactic radiofrequency thermocoagulation in the globus pallidus internus. All clinical data, Yale Global Tic Severity Scale (YGTSS) scores, serum dopamine (SDA), and 5-hydroxytryptamine (5-HT) were analyzed. Read More

View Article and Full-Text PDF

High Intensity Focused Ultrasound-Responsive and Ultrastable Cerasomal Perfluorocarbon Nanodroplets for Alleviating Tumor Multidrug Resistance and Epithelial-Mesenchymal Transition.

ACS Nano 2020 11 11;14(11):15904-15918. Epub 2020 Nov 11.

Key Laboratory of Protein and Peptide Pharmaceuticals, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, P.R. China.

Hypoxia is a hostile hallmark of most solid tumors, which often leads to multidrug resistance (MDR) and causes the failure of chemotherapy. Hypoxia also promotes epithelial-mesenchymal transition (EMT), leading to acceleration of tumor metastasis. Many chemotherapeutic drugs can further exacerbate hypoxia and thus promote metastasis. Read More

View Article and Full-Text PDF
November 2020

Sevoflurane may not be a complete sigh of relief in COVID-19.

Br J Anaesth 2020 12 16;125(6):e487-e488. Epub 2020 Sep 16.

Academic Unit of Anaesthesia, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.

View Article and Full-Text PDF
December 2020

Optimal Time of Thermotherapy for Reducing Pain, Anxiety, and Side Effects in Arteriovenous Fistula Puncture Patients: A Randomized Controlled Trial.

Int J Environ Res Public Health 2020 09 29;17(19). Epub 2020 Sep 29.

Department of Nursing, Sunchon National University, 255 Jungang-ro, Suncheon, Jeonnam 57922, Korea.

Chronic renal failure patients undergoing hemodialysis complain of moderate pain from repeated punctures of the arteriovenous fistula. This study examined the optimal application time of thermotherapy for reducing pain, anxiety, and side effects during arteriovenous fistula puncture. This study was conducted as a single-blinded randomized controlled trial. Read More

View Article and Full-Text PDF
September 2020

Thermal cycling protects SH-SY5Y cells against hydrogen peroxide and β-amyloid-induced cell injury through stress response mechanisms involving Akt pathway.

PLoS One 2020 1;15(10):e0240022. Epub 2020 Oct 1.

Department of Physics, Lab for Medical Physics & Biomedical Engineering, National Taiwan University, Taipei, Taiwan.

Neurodegenerative diseases (NDDs) are becoming a major threat to public health, according to the World Health Organization (WHO). The most common form of NDDs is Alzheimer's disease (AD), boasting 60-70% share. Although some debates still exist, excessive aggregation of β-amyloid protein (Aβ) and neurofibrillary tangles has been deemed one of the major causes for the pathogenesis of AD. Read More

View Article and Full-Text PDF
November 2020

Long-term follow-up outcome and reintervention analysis of ultrasound-guided high intensity focused ultrasound treatment for uterine fibroids.

Int J Hyperthermia 2020 ;37(1):1046-1051

Department of Obstetrics and Gynecology, The Third Xiangya Hospital, Central South University, Changsha, China.

Objective: To investigate the long-term reintervention of ultrasound-guided high intensity focused ultrasound (USgHIFU) treatment for uterine fibroids and analyze the factors affecting reintervention rate after USgHIFU.

Materials And Methods: Three hundred and eight-one patients with uterine fibroids treated by USgHIFU at the third Xiangya Hospital of Central South University from April 2012 to December 2014 were retrospectively reviewed. The factors that affect the reintervention rate were analyzed. Read More

View Article and Full-Text PDF

Pre- and post-irradiation mild hyperthermia enabled by NIR-II for sensitizing radiotherapy.

Biomaterials 2020 10 14;257:120235. Epub 2020 Jul 14.

Intelligent Nanomedicine Institute, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China; The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China. Electronic address:

The clinical application of cancer radiotherapy is critically impeded by hypoxia-induced radioresistance, insufficient DNA damage, and multiple DNA repair mechanisms. Herein we demonstrate a dual-hyperthermia strategy to potentiate radiotherapy by relieving tumor hypoxia and preventing irradiation-induced DNA damage repair. The tumor hyperthermia temperature was well-controlled by a near infrared laser with minimal side effects using PEGylated nanobipyramids (PNBys) as the photo-transducer. Read More

View Article and Full-Text PDF
October 2020

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for colorectal and appendiceal peritoneal metastases - The Hong Kong experience and literature review.

Asian J Surg 2021 Jan 27;44(1):221-228. Epub 2020 Jun 27.

Division of Colorectal Surgery, Department of Surgery, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Introduction: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is increasingly used to treat peritoneal metastases from appendiceal or colorectal origin. We evaluate our institution's experience and survival outcomes with this procedure, and its efficacy in symptom relief.

Methods: This is a single-centre retrospective observational study on patients with peritoneal metastases (PM) from appendiceal neoplasm or colorectal cancer who underwent CRS/HIPEC in Queen Mary Hospital. Read More

View Article and Full-Text PDF
January 2021

Oxygen self-enriched nanoplatform combined with US imaging and chemo/photothermal therapy for breast cancer.

Nanomedicine 2020 10 18;29:102238. Epub 2020 Jun 18.

Breast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

Oxygen-saturated perfluorohexane-cored, cisplatin (Pt)-decorated hollow gold nanospheres ([email protected]) have been synthesized for ultrasound (US) imaging-guided tumor treatment depending on chemo/photothermal therapy, relief of hypoxia, and photothermal induced US contrast signal. Both NIR laser-induced hyperthermia generation by gold nanospheres and acidity triggered release of Pt resulted in high toxicity after internalization by breast cancer cells. According to ex vivo immunofluorescence investigation and in vivo pharmacodynamic studies on MDA-MB-231 tumor bearing mice, the susceptibility of tumors to [email protected] was improved by the relief of hypoxia. Read More

View Article and Full-Text PDF
October 2020

Multidisciplinary management and outcome in pancreatic cancer patients treated with high-intensity focused ultrasound.

Int J Hyperthermia 2020 ;37(1):456-462

Clinic for Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany.

High-intensity focused ultrasound (HIFU) for pancreatic cancer is a growing therapeutic field which has been proven to reduce cancer pain and provide a local tumor control additionally to standard palliative care. However, less is known about the multidisciplinary and especially anesthesiological management of HIFU treatment although an interdisciplinary approach is crucial for treatment success. Anesthesiological and radiological records of 71 HIFU-treated pancreatic cancer patients were analyzed with regard to the following items: intervention time, sonication time, total energy, anesthesia time, peri-interventional medication, body temperature maximum and minimum, pain scores before and 1 day, 6 weeks and 3 months after intervention, peri-interventional complications. Read More

View Article and Full-Text PDF
November 2020

Thermal ablation of biological tissues in disease treatment: A review of computational models and future directions.

Electromagn Biol Med 2020 Apr 1;39(2):49-88. Epub 2020 Apr 1.

MS2Discovery Interdisciplinary Research Institute, Wilfrid Laurier University, Waterloo, Ontario, Canada.

Percutaneous thermal ablation has proven to be an effective modality for treating both benign and malignant tumours in various tissues. Among these modalities, radiofrequency ablation (RFA) is the most promising and widely adopted approach that has been extensively studied in the past decades. Microwave ablation (MWA) is a newly emerging modality that is gaining rapid momentum due to its capability of inducing rapid heating and attaining larger ablation volumes, and its lesser susceptibility to the heat sink effects as compared to RFA. Read More

View Article and Full-Text PDF

A comparison of reproductive outcomes of patients with adenomyosis and infertility treated with High-Intensity focused ultrasound and laparoscopic excision.

Int J Hyperthermia 2020 ;37(1):301-307

Department of Gynecology, Third Xiangya Hospital of Central South University, Changsha, China.

The aim of this study was to compare the treatment effects of high-intensity focused ultrasound (HIFU) and laparoscopic excision (LE) in patients with adenomyosis and infertility. A total of 93 patients with adenomyosis and infertility who were treated with HIFU (50 patients) or LE (43 patients) from January 2012 to January 2017 at the Third Xiangya Hospital of Central South University were retrospectively analyzed. Clinical characteristics including dysmenorrhea severity pain score, menorrhagia severity scores, reproductive outcomes, complications during pregnancy and delivery, adverse effects, surgical complications, and other clinical variables were compared between the HIFU and LE groups. Read More

View Article and Full-Text PDF
October 2020

Percutaneous ultrasound-guided 'three-step' radiofrequency ablation for giant hepatic hemangioma (5-15 cm): a safe and effective new technique.

Int J Hyperthermia 2020 ;37(1):212-219

Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, PR China.

To evaluate the safety and efficacy of percutaneous ultrasound-guided 'three-step' radiofrequency ablation (RFA) for the treatment of giant hepatic hemangioma. Patients with giant hepatic hemangioma who underwent percutaneous ultrasound-guided 'three-step' RFA ( = 52) and conventional RFA ( = 54) at our center from June 2013 to December 2017 were retrospectively analyzed. The 'three-step' RFA proceeds as follows. Read More

View Article and Full-Text PDF
October 2020

On-Demand Printing of Wearable Thermotherapy Pad.

Adv Healthc Mater 2020 02 16;9(4):e1901575. Epub 2020 Jan 16.

Center for Nanotechnology, NASA Ames Research Center, Mountain View, CA, 94035, USA.

Thermotherapy is an effective method for pain relief, recovery from injury, and general healthcare. The ordinary heat pad used for thermotherapy at home is not usually tailored to the individual but supplied in a few different pre-fixed sizes and shapes for mass marketing. A customized wearable heat pad often requires expert support. Read More

View Article and Full-Text PDF
February 2020

[Electrical muscle stimulation in combination with heat for patients with chronic, nonspecific low back pain : A randomized, double-blind, stratified, placebo-controlled clinical trial].

Schmerz 2020 Feb;34(1):65-73

Zentrum für interdisziplinäre Schmerztherapie, Onkologie und Palliativmedizin, Klinikum Klagenfurt am Wörthersee, Feschnigstraße 11, 9020, Klagenfurt am Wörthersee, Österreich.

Background: Chronic non-specific low back pain (LBP) causes more disability than any other medical condition worldwide. Electrical muscle stimulation in combination with heat (EMS/H) for management of LBP has yet not been properly studied. Our hypothesis was that EMS/H provides better pain relief and improves subjective and objective data compared to standard treatment. Read More

View Article and Full-Text PDF
February 2020

Water vapor thermal therapy to alleviate catheter-dependent urinary retention secondary to benign prostatic hyperplasia.

Prostate Cancer Prostatic Dis 2020 06 18;23(2):303-308. Epub 2019 Nov 18.

Minnesota Urology, Woodbury, MN, USA.

Background: Water vapor thermal therapy utilizes convectively delivered thermal energy to target ablation of obstructive prostatic tissue. We report results of this thermal therapy for relief of nonneurogenic complete urinary retention associated with BPH.

Patients And Methods: We conducted a retrospective analysis of 38 catheter-dependent men with complete urinary retention consecutively enrolled in a registry in two centers: median age 75. Read More

View Article and Full-Text PDF

Responsive agarose hydrogel incorporated with natural humic acid and MnO nanoparticles for effective relief of tumor hypoxia and enhanced photo-induced tumor therapy.

Biomater Sci 2020 Jan 14;8(1):353-369. Epub 2019 Nov 14.

Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, School of Materials and Energy, Southwest University, Chongqing 400715, China. and Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Chongqing 400715, China.

In spite of widespread applications of nano-photosensitizers, poor tumor penetration and severe hypoxia in the tumor microenvironment (TME) always result in an undesirable therapeutic outcome of photodynamic therapy (PDT). Herein, a biocompatible agarose-based hydrogel incorporated with sodium humate (SH), manganese oxide (MnO) and chlorin e6 (Ce6) was synthesized as [email protected]/MnO/Ce6 through a "co-trapped" strategy during a sol-gel process and employed for combined photothermal therapy (PTT) and enhanced PDT. NIR-induced local hyperthermia is responsible for not only activating Ce6 release, but also triggering the catalytic decomposition of HO mediated by MnO to relieve hypoxia. Read More

View Article and Full-Text PDF
January 2020

Mild hyperthermia by MR-guided focused ultrasound in an ex vivo model of osteolytic bone tumour: optimization of the spatio-temporal control of the delivered temperature.

J Transl Med 2019 10 24;17(1):350. Epub 2019 Oct 24.

Image Guided Interventions Laboratory (GR-949), Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Background: Magnetic resonance guided focused ultrasound was suggested for the induction of deep localized hyperthermia adjuvant to radiation- or chemotherapy. In this study we are aiming to validate an experimental model for the induction of uniform temperature elevation in osteolytic bone tumours, using the natural acoustic window provided by the cortical breakthrough.

Materials And Methods: Experiments were conducted on ex vivo lamb shank by mimicking osteolytic bone tumours. Read More

View Article and Full-Text PDF
October 2019

Evaluating the effectiveness of combined radiotherapy and hyperthermia for the treatment response of patients with painful bony metastases: A phase 2 clinical trial.

J Therm Biol 2019 Aug 27;84:129-135. Epub 2019 Jun 27.

Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Introduction: Since the survival time of patients with bony metastases has noticeably improved in recent years, these patients are at high risk of complications associated with this metastasis. Hence, the appropriate choice of treatment modality or combination of therapeutic approaches can lead to increasing bone pain relief, improving quality of life, etc. This study is aimed to evaluate the effectiveness of combined radiotherapy and hyperthermia for the treatment response of patients with painful bony metastases. Read More

View Article and Full-Text PDF

Experimental methodology for quantitative assessment of heat-wrap thermal transient behavior.

Med Eng Phys 2019 07 27;69:72-84. Epub 2019 May 27.

Dipartimento di Ingegneria "Enzo Ferrari", Università degli Studi di Modena e Reggio Emilia, Via P. Vivarelli 10, 41125 Modena, Italy.

Among the numerous thermotherapy methods, heat wraps have been largely used over the last 2 decades as a self-administered practice for pain relief. Therefore, understanding their performance has become instrumental within the healthcare industry. However, the majority of the available studies have been focused on in vivo clinical performance, whereas a standardized, quantitative approach to evaluate and compare the various heat-wrap types against each other is lacking. Read More

View Article and Full-Text PDF

Epidural analgesia? A prospective analysis of perioperative coagulation in cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.

Am J Surg 2019 05 1;217(5):887-892. Epub 2019 Feb 1.

Department of Surgery, Division of Surgical Oncology, University of Calgary, Canada.

Background: Cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) is beneficial in peritoneal carcinomatosis. Epidurals provide excellent pain relief for laparotomies. Coagulopathy (platelet count <100 × 10/L, INR>1. Read More

View Article and Full-Text PDF

Rezūm Water Vapor Thermal Therapy for Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia: 4-Year Results From Randomized Controlled Study.

Urology 2019 04 21;126:171-179. Epub 2019 Jan 21.

Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX.

Objective: To report 4-year outcomes of the randomized controlled trial of water vapor thermal therapy for treatment of moderate to severe lower urinary tract symptoms due to benign prostatic hyperplasia.

Materials And Methods: Total 188 subjects; 135 men ≥50years old, International Prostate Symptom Score ≥ 13, maximum flow rate (Qmax) ≤15 mL/s and prostate volume 30 to 80 cc treated with Rezūm System thermal therapy were followed 4 years; subset of 53 men who requalified for crossover from control to active treatment were followed 3years.

Results: Lower urinary tract symptoms were significantly improved within ≤3 months after thermal therapy and remained consistently durable (International Prostate Symptom Score 47%, quality of life 43%, Qmax 50%, Benign Prostatic Hyperplasia Impact Index 52%) throughout 4years (P <. Read More

View Article and Full-Text PDF