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Oculomotor Paresis with Cyclic Spasms in Chinese Populations: A Review of the Chinese Literature and a Case Report.

Pediatr Neurosurg 2021 May 4:1-8. Epub 2021 May 4.

Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Introduction: Oculomotor paresis with cyclic spasms (OPCS) is a rare disorder in which the muscles innervated by the third cranial nerve undergo alternating rhythmic spasm and paralysis. This disease is usually noticeable at birth or developing during the first year of life. To date, most of the OPCS cases reported in the English-language literature were Caucasians. Read More

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Primary healthcare workers at risk during COVID-19: An analysis of infections in HIV service providers in five districts of South Africa.

S Afr Med J 2021 01 18;111(4):309-314. Epub 2021 Jan 18.

Anova Health Institute, South Africa; Department of Community Health, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Protecting healthcare workers (HCWs) from COVID-19 is a global priority. Anova Health Institute (Anova) is the PEPFAR (US President's Emergency Plan for AIDS Relief) District Support Partner for the Johannesburg, Cape Town, Sedibeng, Capricorn and Mopani districts in South Africa, operating in public sector primary healthcare facilities. At the time of the emergence of COVID-19, Anova employed close to 4 000 people: 41% community health workers (CHWs), 23% data staff, 20% nurses and doctors, 12% management/support and 5% allied HCWs. Read More

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January 2021

Posterior vertebral column resection as a safe procedure leading to solid bone fusion in metastatic epidural spinal cord compression.

Neurosurg Focus 2021 May;50(5):E8

1Division of Spine Surgery, Department of Trauma and Orthopedic Surgery, and.

Objective: Cancer is one of the leading causes of death and greatly decreases a patient's quality of life. Vertebral metastases often lead to epidural spinal cord compression (ESCC) requiring surgical therapy. It has previously been shown that in patients with metastatic ESCC (MESCC), a surgical intervention leads to an improved outcome. Read More

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Management of thumb carpometacarpal joint dislocations: A systematic review.

J Orthop 2021 May-Jun;25:59-63. Epub 2021 Apr 1.

Department of Orthopaedic Surgery, Detroit Medical Center, Detroit, MI, 48201, USA.

Although rare, thumb Carpometacarpal (CMC) joint dislocations can have significant complications which impact hand function. Optimal management is crucial in restoring pinch and grasp strength, but no agreement exists regarding treatment due to a paucity of literature on this subject. Systematic review was conducted involving non-operative and operative management of the CMC joint. Read More

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Long-Term Results of the Modular Physiological Wrist Prosthesis (MPW) in Patients with Inflammatory Diseases.

Life (Basel) 2021 Apr 18;11(4). Epub 2021 Apr 18.

Department of Trauma, Hand and Reconstructive Surgery, University Hospital Giessen, 35392 Giessen, Germany.

The wrist is among the predilection sites of over 90% of cases of rheumatoid arthritis (RA). In advanced cases, total wrist arthroplasty (TWA) is an alternative to arthrodesis. The aim of this study is to present the long-term results of the modular physiological wrist prosthesis (MPW) and to match them in context with the results of a standard population survey. Read More

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Convalescent plasma transfusion a promising therapy for coronavirus diseases 2019 (COVID-19): current updates.

Antib Ther 2020 Apr 27;3(2):115-125. Epub 2020 May 27.

Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, 495009, India.

While there is no proven treatment available for coronavirus disease 2019 (COVID-19), convalescent plasma (CP) may provide therapeutic relief as the number of cases escalate steeply world-wide. At the time of writing this review, vaccines, monoclonal antibodies or drugs are still lacking for the recent large COVID-19 outbreak, which restores the interest in CP as an empirical life-saving treatment. However, formal proof of efficacy is needed. Read More

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Hospital in the home-based management of acute diverticulitis: a safe and effective alternative to inpatient care.

ANZ J Surg 2021 Apr 27. Epub 2021 Apr 27.

Epworth Healthcare, Melbourne, Victoria, Australia.

Background: The traditional approach to management of acute uncomplicated diverticulitis involves admission to hospital, antibiotic therapy, gut rest and monitoring for the development of complications. Despite evidence to suggest this can safely be performed in an outpatient setting, inpatient care remains standard practice in Australia potentially due to a variety of factors (van Dijk et al. 2018; Cirocchi et al. Read More

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Stereotactic radiofrequency thalamotomy for cancer pain: a systematic review.

World Neurosurg 2021 Apr 24. Epub 2021 Apr 24.

Neurosciences Research Centre, Molecular and Clinical Sciences Institute, St George's University of London, London, United Kingdom; St. George's University Hospital, London, United Kingdom.

Pain is a common occurrence in cancer patients which, in some cases, is not adequately controlled with medical analgesia. Thalamotomy is a treatment option in such circumstances, but synthesis of historical evidence and thalamic stratified data are lacking. We therefore sought to systematically review evidence supporting radiofrequency thalamotomy for intractable cancer pain. Read More

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[Evaluation of the effect of free fibular flap transplantation in repairing mandibular osteoradionecrosis defect in 151 cases].

Zhonghua Kou Qiang Yi Xue Za Zhi 2021 May 9;56(5):428-434. Epub 2021 May 9.

Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou 510120, China.

To investigate the clinical effect of free fibula flap transplantation in repairing the defect of mandibular osteoradionecrosis (ORN). A total of 151 mandibular ORN patients undergoing free fibular flap transplantation were selected from August 2005 to September 2020 in the Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University. Among them, 109 patients were males and 42 patients were females, aged (54. Read More

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Clinical features of multiple spinal schwannomas without vestibular schwannomas.

J Orthop Sci 2021 Apr 23. Epub 2021 Apr 23.

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Multiple spinal cord tumors in a single patient are very rare and most often seen in cases of neurofibromatosis and associated disorders. Schwannomatosis, which is characterized by the development of multiple schwannomas without vestibular schwannomas, has been newly defined as a distinct form of neurofibromatosis. The purpose of the present study was to describe and review the clinical and radiological features and the management of patients with multiple spinal schwannomas without vestibular schwannomas. Read More

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Clinical and Radiographic Outcomes of Lateral Interbody Fusion for Adjacent Segment Degeneration.

Int J Spine Surg 2021 Feb 18;15(1):74-81. Epub 2021 Feb 18.

Department of Orthopedics and Rehabilitation, University of Wisconsin School of Medicine, Madison, Wisconsin.

Study Design: Retrospective cohort study.

Objective: Assessment of outcomes in patients undergoing lateral interbody fusion as part of the surgical treatment of adjacent segment deterioration after previous lumbar spine fusion.

Methods: Adult patients with previous lumbar posterior spinal fusion who presented with adjacent segment degeneration and stenosis refractory to nonoperative treatment and who underwent lateral lumbar interbody fusion were retrospectively analyzed. Read More

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February 2021

Fingertip injuries managed by a thenar flap: follow-up and long-term outcomes of 32 cases.

Hand Surg Rehabil 2021 Apr 22. Epub 2021 Apr 22.

Epidemiology Laboratory of the Faculty of Medicine and Pharmacy of Casablanca, Rue Tarik Ibnou Ziad, 20250 Casablanca, Morocco.

While various techniques are used for the reconstruction of fingertip injuries, the main goals remain the same: preserve finger length, sensation, and function. The thenar flap is a well-described technique and simple procedure in fingertip amputations. This study aimed to evaluate the long-term functional and esthetic outcomes along with patient satisfaction of thenar flaps done for fingertip defects. Read More

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Neuralgia-inducing cavitational osteonecrosis - A systematic review.

Oral Dis 2021 Apr 24. Epub 2021 Apr 24.

Department of Oral and Maxillofacial Surgery, University Hospital Heidelberg, Heidelberg, Germany.

Objective: To assess the aetiologic factors, proposed diagnostic means and treatment strategies for neuralgia-inducing cavitational osteonecrosis.

Methods: A search of the literature published up to June 2020 was conducted using Medline, the Cochrane Library, PsycINFO, CINAHL and Web of Science. The scientific quality of the evidence was rated according to NIH Quality Assessment Tools. Read More

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Outcomes of Rotator Cuff Repair with Concurrent Microfracture of Focal Glenohumeral Osteoarthritis.

J Shoulder Elbow Surg 2021 Apr 20. Epub 2021 Apr 20.

Department of Orthopaedic Surgery, The Rothman Orthopaedic Institute, Thomas Jefferson University Hospitals, Philadelphia, PA, USA. Electronic address:

Background: The benefit of rotator cuff repair (RCR) in patients with concurrent osteoarthritic changes remains unclear. Rotator cuff repair has the theoretical potential to increase the compressive force across the glenohumeral joint, further exacerbating osteoarthritis pain. The purpose of this study is to investigate pain relief and patient reported outcomes of patients undergoing simultaneous RCR and microfracture of focal glenohumeral osteoarthritis. Read More

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Probing stress relaxation behavior in glassy methacrylate networks containing thio-carbamate additives.

J Mater Chem B 2021 Apr 22;9(13):3015-3024. Epub 2021 Mar 22.

Oregon Health & Science University, Biomaterials and Biomechanics, Oregon Health & Science University, 2730 SW Moody Ave, 6N036, Portland, OR, USA.

The incorporation of thiourethane prepolymer (TU) into either the organic phase or as a surface treatment for filler particles in composites reduces polymerization stress and improves fracture toughness. The aim of this study was to gain insight into the influence of the inclusion of thiourethanes on the resulting network of methacrylate-based materials polymerized via free-radical mechanisms. Dynamic mechanical analysis was used to elucidate network parameters and potential stress relaxation behavior of these networks. Read More

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Effectiveness of Intrathecal Baclofen for Intractable Stiffperson Syndrome: a Case Report.

J Rehabil Med Clin Commun 2021 3;4:1000052. Epub 2021 Mar 3.

MossRehab, Elkins Park, PA, USA.

Background: Intrathecal baclofen is considered an adjuvant therapy for patients with intractable spasms due to stiff-person syndrome. There is increasing evidence to support the use of intrathecal baclofen in the management of symptomatic stiffperson syndrome, with improvement in function.

Case Report: A 38-year-old woman with stiff- person syndrome initially presented to inpatient rehabilitation for intractable muscle spasms. Read More

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Spermatic Cord Block Series as a Minimally Invasive Therapy for Chronic Scrotal Content Pain.

J Urol 2021 Apr 19:101097JU0000000000001777. Epub 2021 Apr 19.

Rush University Medical Center, Chicago, Illinois.

Purpose: The primary aim of our study was to evaluate relief of chronic scrotal content pain after a series of spermatic cord blocks with a combination of local anesthetic and a steroid. Secondary aims were to assess factors associated with a positive response and complications.

Materials And Methods: We performed a retrospective chart review of patients who underwent spermatic cord block series for chronic scrotal content pain at our practice between 2012 and 2019. Read More

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Acute esophageal necrosis complicated by refractory stricture formation.

JGH Open 2021 Apr 1;5(4):528-530. Epub 2021 Mar 1.

Department of Gastroenterology and Hepatology University of California Fresno California USA.

Acute esophageal necrosis (AEN) is a rare presentation of severe esophageal injury. The optimal long-term management of complications related to AEN, particularly stricture formation, are not well defined. We report a case of AEN in a patient who presented with diabetic ketoacidosis (DKA) and had dysphagia due to refractory stricture formation after mucosal healing occurred. Read More

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Amniotic membrane extract eye drops for ocular surface diseases: use and clinical outcome in real-world practice.

Int Ophthalmol 2021 Apr 17. Epub 2021 Apr 17.

Hospital Clinic de Barcelona, Institut Clinic D'Oftalmologia (ICOF), Sabino de Arana s/n, 08028, Barcelona, Spain.

Purpose: To study the indications and clinical outcomes, in a real-word setting, of amniotic membrane extract eye drops (AMEED) use for ocular surface disease (OSD).

Methods: A retrospective study of patients treated with topical AMEED between January 2018 and January 2020 was conducted. Patients were classified in two groups according to specific OSD-dry eye disease (DED) and wound healing delay (WHD) groups. Read More

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Response To Celiac Plexus Block Confirms Neurogenic Etiology of Median Arcuate Ligament Syndrome.

J Vasc Interv Radiol 2021 Apr 13. Epub 2021 Apr 13.

Purpose: To evaluate the response of Median Arcuate Ligament Syndrome (MALS) symptoms, including postprandial pain, nausea, and vomiting to celiac plexus block (CPB) and to correlate response with arterial anatomy.

Materials And Methods: In a single-institution, retrospective cohort of clinically diagnosed MALS patients, 96 patients (75 female, 21 male, mean age 27 years) underwent 103 CT-guided percutaneous CPB procedures. Imaging, procedural, and clinical reports were reviewed. Read More

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Management of Esophageal Dysphagia in Chagas Disease.

Dysphagia 2021 Apr 14. Epub 2021 Apr 14.

Department of Medicine, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes, 3900 - Campus da USP, Ribeirão Preto, SP, Brazil.

Chagas disease, caused by the infection of the protozoan parasite Trypanosoma cruzi, has clinical consequences in the heart and digestive tract. The most important changes in the digestive tract occur in the esophagus (megaesophagus) and colon (megacolon). Esophageal dysfunction in Chagas disease results from damage of the esophageal myenteric plexus, with loss of esophageal peristalsis, partial or absent lower esophageal sphincter relaxation, and megaesophagus, which characterizes secondary esophageal achalasia. Read More

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Expert consensus of the Chinese Association for the Study of Pain on ion channel drugs for neuropathic pain.

World J Clin Cases 2021 Mar;9(9):2100-2109

Department of Algology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.

Neuropathic pain (NPP) is a kind of pain caused by disease or damage impacting the somatosensory system. Ion channel drugs are the main treatment for NPP; however, their irregular usage leads to unsatisfactory pain relief. To regulate the treatment of NPP with ion channel drugs in clinical practice, the Chinese Association for the Study of Pain organized first-line pain management experts from China to write an expert consensus as the reference for the use of ion channels drugs . Read More

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Treatment of Localized Vulvar Pain with Neural Therapy: A Case Series and Literature Review.

Complement Med Res 2021 Apr 12:1-7. Epub 2021 Apr 12.

Campus Docent de Sant Joan de Déu, Barcelona, Spain.

Background: Localized vulvar pain (LVP) is a common condition among fertile women, with physical and psychosexual implications. Treatment is complex with limited benefits. Neural therapy is a regulatory therapy that uses injections of local anesthetics in low concentrations in specific points to treat different conditions. Read More

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Kyphoplasty versus percutaneous posterior instrumentation for osteoporotic vertebral fractures with posterior wall injury: a propensity score matched cohort study.

J Spine Surg 2021 Mar;7(1):68-82

Department of Spine Surgery, Cantonal Hospital of Lucerne, Spitalstrasse, 6000 Lucerne, Switzerland.

Background: Osteoporotic vertebral fractures (OVFs) that present with posterior wall cortical injury pose a higher risk for instability. Surgical management includes standard cement augmentation techniques like balloon kyphoplasty (BKP) or percutaneous posterior instrumentation with pedicle screws (PS) or both. Neither treatment has yet demonstrated superiority, and posterior cement leakage is of special concern in these fractures. Read More

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Assessment and prediction of restless leg syndrome (RLS) in patients with diabetes mellitus type II through artificial intelligence (AI).

Pak J Pharm Sci 2020 Sep;33(5(Special)):2399-2403

Department of Medicine, King Edward Medical University (KEMU), Mayo Hospital Lahore Pakistan.

This study aimed to diagnose the incidence of restless leg syndrome (RLS) in patients with diabetes mellitus (DM) type-2, thorough artificial intelligence based multilayer perceptron (MLP). 300 cases of diabetes mellitus type-2, of age between 18-80 years were included. Point-biserial correlation/Pearson Chi-Square correlations were conducted between RLS and risk factors. Read More

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September 2020

Complications of primary total hip arthroplasty in human immunodeficiency virus-positive patients with femoral head osteonecrosis.

Hip Int 2021 Apr 8:11207000211005750. Epub 2021 Apr 8.

Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Background: Femoral head osteonecrosis (FHON) is a well-recognised complication in patients with human immunodeficiency virus (HIV) infection. Total hip arthroplasty (THA) is a reliable solution to FHON and has provided functional improvement and pain relief in these patients. Higher complication rates, in particular infections, have been reported in the series of THAs done in the HIV-positive patients. Read More

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Management of post-operative urinary incontinence after midurethral sling explantation for pelvic or perineal pain.

Int Urogynecol J 2021 Apr 6. Epub 2021 Apr 6.

Department of Urology, Centre Hospitalier Universitaire de Nantes, Nantes, France.

Introduction And Hypothesis: The objective was to report the management of post-operative urinary incontinence after midurethral sling (MUS) revision for chronic pelvic pain (CPP), and to report functional outcomes.

Methods: From November 2004 to February 2018, a total of 89 women who underwent removal or section of MUS for CPP, were enrolled. Patients were divided into the transobturator tape (TOT) group (50 patients) and the tension-free vaginal tape (TVT) group (37 patients); 2 patients had had both slings implanted. Read More

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Percutaneous Endoscopic Lumbar Discectomy via Transforaminal Approach Combined with Interlaminar Approach for L4/5 and L5/S1 Two-Level Disc Herniation.

Orthop Surg 2021 Apr 5. Epub 2021 Apr 5.

Orthopaedics Department, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Objective: The purpose of the present study was to discuss a new surgical strategy that combines percutaneous endoscopic transforaminal discectomy (PETD) with percutaneous endoscopic interlaminar discectomy (PEID) for L4/5 and L5/S1 two-level disc herniation.

Methods: This was a retrospective study. A total of 19 patients with L4/5 and L5/S1 two-level lumbar disc herniation (LDH) who underwent percutaneous endoscopic lumbar discectomy (PELD) in our hospital from January 2015 to June 2016 were retrospectively examined. Read More

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