29,344 results match your criteria release probability


Interventions for the discharge of older people to their home from the emergency department: a systematic review.

Australas Emerg Care 2021 Jun 8. Epub 2021 Jun 8.

Nursing and Midwifery Research Centre, Nursing and Midwifery Directorate, Northern Sydney Local Health District, St Leonards, NSW 2065, Australia; Faculty of Health, University of Technology Sydney, Ultimo, 2007 NSW, Australia.

Background: Clinicians have limited evidence on which to base their practice to effectively discharge older people from emergency. The aim of the review was to assess the effectiveness of interventions used for the discharge of older people from the emergency department to their home in the community by emergency clinicians.

Methods: The PRISMA guidelines were followed. Read More

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Integrated use of inverse and biotic ligand modelling for lake water quality resilience estimation: A case of Ramsar wetland, (Deepor Beel), Assam, India.

Environ Res 2021 Jun 7:111397. Epub 2021 Jun 7.

Discipline of Earth Sciences, Indian Institute of Technology, Gandhinagar, 382355, India. Electronic address:

The present study evaluates the vulnerability of a lake system due to the combined exposure of toxic metals, major ions and mineral dissociation. The hydro-chemistry of the Deepor Beel lake reveals the dominance of carbonate weathering with strong evidences of ion-exchange reaction occurring throughout the monsoon season of 2014 and 2015. Through an integrated application of multivariate analysis, the occurrence of albite weathering was confirmed, though as an isolated incidence only, along-with substantial evidence of waste intrusion from fertilizer industries. Read More

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Small-scale dissolution test screening tool to select potentially substandard and falsified (SF) medicines requiring full pharmacopoeial analysis.

Sci Rep 2021 Jun 9;11(1):12145. Epub 2021 Jun 9.

Medi-Quality Security Institute, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.

The purpose of this study was to design a convenient, small-scale dissolution test for extracting potential substandard and falsified (SF) medicines that require full pharmacopoeial analysis. The probability of metronidazole samples complying with the US Pharmacopoeia (USP) dissolution test for immediate-release tablet formulations was predicted from small-scale dissolution test results using the following criteria: (1) 95% confidence interval lower limit (95% CI) of the average dissolution rate of any n = 3 of n = 24 units of each sample, and (2) average and minimum dissolution rates for any n = 3 of n = 24 units. Criteria values were optimized via bootstrap sampling with Thinkeye data-mining software. Read More

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Frailty is associated with increased mortality in older adults 12 months after discharge from post-acute care in Swiss nursing homes.

J Frailty Aging 2021 ;10(3):233-236

Michael Gagesch, MD, Dept. of Geriatrics and Aging Research, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland,

Frail older adults with ongoing care needs often require post-acute care (PAC) following acute hospitalization when not eligible for specific rehabilitation. Long-term outcomes of PAC in this patient group have not been reported for Switzerland so far. In the present report, we investigated 12-month mortality in regard to frailty status upon admission to PAC in a nursing home setting. Read More

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The modified frailty index and patient outcomes following transforaminal lumbar interbody fusion surgery for single-level degenerative spine disease.

J Neurosurg Spine 2021 Jun 4:1-7. Epub 2021 Jun 4.

Objective: The modified frailty index (mFI) is a simple tool that measures physiological reserve based on a thorough history and physical examination. Its use has been validated in several surgical specialties, including spinal deformity surgery. Prior research has suggested no significant differences in clinical outcomes between elderly and nonelderly patients undergoing posterior lumbar interbody fusion. Read More

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Potential role of free-radical processes in biomolecules damage during COVID-19 and ways of their regulation.

Free Radic Res 2021 Jun 4:1-27. Epub 2021 Jun 4.

Belarusian State Medical University, Dzerzhinski av., 83, 220116, Minsk, Republic of Belarus.

It has been shown that the development of coronavirus infection (COVID-19), especially in severe cases, is accompanied by hypoxia as a result of several pathological processes: alveolar blood supply disorders, hemolysis, COVID-associated coagulopathy. Under these conditions, the level of reactive oxygen species is increased and it is more likely that free-radical damage to biomolecules is caused by the process of free-radical fragmentation than oxidation. In contrast to the oxidation process, free-radical fragmentation reactions are more effectively inhibited by oxidizing agents than reducing agents. Read More

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Population pharmacokinetics of immediate-release and modified-release paracetamol and its major metabolites in a supratherapeutic dosing study.

Clin Toxicol (Phila) 2021 Jun 3:1-8. Epub 2021 Jun 3.

School of Pharmacy, University of Otago, Dunedin, New Zealand.

Objectives: Overdose with paracetamol modified-release (MR) formulation, a bilayer tablet containing 69% slow-release component, has been increasing since its introduction to the market. However, little evidence exists for the management of MR paracetamol overdose. We aimed to develop a population pharmacokinetic (PK) model for immediate-release (IR) and MR paracetamol and its major metabolism, and quantitatively understand the formulation difference in toxicity assessment based on the nomogram line. Read More

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Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation.

Commun Biol 2021 Jun 2;4(1):666. Epub 2021 Jun 2.

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Calcium dynamics control synaptic transmission. Calcium triggers synaptic vesicle fusion, determines release probability, modulates vesicle recycling, participates in long-term plasticity and regulates cellular metabolism. Mitochondria, the main source of cellular energy, serve as calcium signaling hubs. Read More

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Workplace bullying increases the risk of anxiety through a stress-induced β2-adrenergic receptor mechanism: a multisource study employing an animal model, cell culture experiments and human data.

Int Arch Occup Environ Health 2021 Jun 2. Epub 2021 Jun 2.

Department of Psychosocial Science, University of Bergen, Bergen, Norway.

Objectives: Several studies show that severe social stressors, e.g., in the form of exposure to workplace bullying in humans, is associated with negative mental health effects such as depression and anxiety among those targeted. Read More

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Timing of Home Health Care Initiation and 30-Day Rehospitalizations among Medicare Beneficiaries with Diabetes by Race and Ethnicity.

Int J Environ Res Public Health 2021 May 25;18(11). Epub 2021 May 25.

School of Nursing, Rutgers, The State University of New Jersey, Newark, NJ 07108, USA.

Older adults with diabetes are at elevated risk of complications following hospitalization. Home health care services mitigate the risk of adverse events and facilitate a safe transition home. In the United States, when home health care services are prescribed, federal guidelines require they begin within two days of hospital discharge. Read More

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X-ROS Signaling Depends on Length-Dependent Calcium Buffering by Troponin.

Cells 2021 May 13;10(5). Epub 2021 May 13.

School of Systems Biology and The Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA 22030, USA.

The stretching of a cardiomyocyte leads to the increased production of reactive oxygen species that increases ryanodine receptor open probability through a process termed X-ROS signaling. The stretching of the myocyte also increases the calcium affinity of myofilament Troponin C, which increases its calcium buffering capacity. Here, an integrative experimental and modeling study is pursued to explain the interplay of length-dependent changes in calcium buffering by troponin and stretch-activated X-ROS calcium signaling. Read More

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The Host Range and Risk Assessment of the Stem-Boring Weevil, (Coleoptera: Curculionidae) Proposed for the Biological Control of (Asteraceae) in Pakistan.

Insects 2021 May 17;12(5). Epub 2021 May 17.

Centre for Agriculture and Biosciences International (CABI), Opposite 1-A, Data Gunj Baksh Road Satellite Town, Rawalpindi 43600, Pakistan.

Parthenium, or , has extended its range in Pakistan throughout Punjab and into Khyber Pakhtunkhwa, the Federally Administrated Tribal Areas, Azad Jammu and Kashmir, and Sindh Provinces. Without control measures against parthenium, the negative impacts of this weed will go unchecked having deleterious effects on native biodiversity, human and animal health, as well as crop productivity. The weevil was obtained and imported from the Plant Health and Protection of the Agricultural Research Council (ARC-PHP), in Cedara, South Africa, in April 2019. Read More

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A Rational Evaluation of the Syncope Patient: Optimizing the Emergency Department Visit.

Medicina (Kaunas) 2021 May 21;57(6). Epub 2021 May 21.

Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB T2N 4Z6, Canada.

Syncope accounts for up to 2% of emergency department visits and results in the hospitalization of 12-86% of patients. There is often a low diagnostic yield, with up to 50% of hospitalized patients being discharged with no clear diagnosis. We will outline a structured approach to the syncope patient in the emergency department, highlighting the evidence supporting the role of clinical judgement and the initial electrocardiogram (ECG) in making the preliminary diagnosis and in safely identifying the patients at low risk of short- and long-term adverse events or admitting the patient if likely to benefit from urgent intervention. Read More

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Short-Stay Hospitalizations for Patients with COVID-19: A Retrospective Cohort Study.

J Clin Med 2021 May 3;10(9). Epub 2021 May 3.

Center for Emergency Care Policy and Research, Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Objective: Patients requiring hospital care for COVID-19 may be stable for discharge soon after admission. This study sought to describe patient characteristics associated with short-stay hospitalization for COVID-19.

Methods: We performed a retrospective cohort study of patients with COVID-19 admitted to five United States hospitals from March to December 2020. Read More

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Acute kidney injury in children with COVID-19: a retrospective study.

BMC Nephrol 2021 05 31;22(1):202. Epub 2021 May 31.

Pediatrics Department, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Background: Acute kidney injury (AKI) is a complication of coronavirus disease 2019 (COVID-19). The reported incidence of AKI, however, varies among studies. We aimed to evaluate the incidence of AKI and its association with mortality and morbidity in children infected with severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) who required hospital admission. Read More

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Preoperative risk stratification minimizes 90-day complications in morbidly obese patients undergoing primary total knee arthroplasty.

Bone Joint J 2021 Jun;103-B(6 Supple A):45-50

Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Aims: It has been shown that the preoperative modification of risk factors associated with obesity may reduce complications after total knee arthroplasty (TKA). However, the optimal method of doing so remains unclear. The aim of this study was to investigate whether a preoperative Risk Stratification Tool (RST) devised in our institution could reduce unexpected intensive care unit (ICU) transfers and 90-day emergency department (ED) visits, readmissions, and reoperations after TKA in obese patients. Read More

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In vivo flow cytometry reveals a circadian rhythm of circulating tumor cells.

Light Sci Appl 2021 May 28;10(1):110. Epub 2021 May 28.

State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, 200030, Shanghai, China.

Circulating tumor cells (CTCs) is an established biomarker of cancer metastasis. The circulation dynamics of CTCs are important for understanding the mechanisms underlying tumor cell dissemination. Although studies have revealed that the circadian rhythm may disrupt the growth of tumors, it is generally unclear whether the circadian rhythm controls the release of CTCs. Read More

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Acute Kidney Injury Requiring Dialysis and Incident Dialysis Patient Outcomes in US Outpatient Dialysis Facilities.

Clin J Am Soc Nephrol 2021 May 27. Epub 2021 May 27.

J Messana, Internal Medicine, Nephrology, University of Michigan Medical School, Ann Arbor, United States.

Background And Objectives: About 30% of patients with acute kidney injury (AKI) may require ongoing dialysis in the outpatient setting after hospital discharge. A 2017 CMS policy change allows Medicare beneficiaries with AKI requiring dialysis to receive outpatient treatment in dialysis facilities. Outcomes for these patients have not been reported. Read More

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Incidence of COVID-19 After Nonelective Hip and Knee Surgery During the Peak of the Pandemic: The New Jersey Experience.

Orthopedics 2021 May-Jun;44(3):180-186. Epub 2021 May 1.

In an attempt to preserve essential equipment and health care system capacity and slow the spread of coronavirus disease 2019 (COVID-19) infection, Governor Murphy suspended all elective surgeries performed in New Jersey from March 27, 2020, through May 25, 2020. The objective of this study was to determine the incidence of postoperative COVID-19 infection following nonelective hip and knee surgery during the peak of the COVID-19 pandemic in New Jersey during this time. A retrospective cohort of 149 patients who underwent nonelective hip and knee surgery from March 27, 2020, through May 25, 2020, at 2 institutions was identified. Read More

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[Next-day discharge after minimalist transcatheter aortic valve replacement: a case report].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 May;49(5):510-512

Department of Cardiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.

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[Left ventricular guidewire pacing during transcatheter aortic valve replacement].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 May;49(5):461-466

Structure Heart Disease Center, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

To investigate the safety and efficacy of left ventricular guidewire pacing during transcatheter aortic valve replacement (TAVR). This is a retrospective study. Thirteen patients, who underwent TAVR with left ventricular guidewire pacing from October 2019 to December 2019 in Fuwai Hospital, were included. Read More

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Robotic-assisted, laparoscopic, and open incisional hernia repair: early outcomes from the Prospective Hernia Study.

Hernia 2021 May 24. Epub 2021 May 24.

Vanderbilt University Medical Center, Nashville, TN, USA.

Purpose: To provide a comparative analysis of short-term outcomes after open, laparoscopic, and robotic-assisted (RAS) ventral incisional hernia (VIH) repairs that include subject-reported pain medication usage and hernia-related quality of life (QOL).

Methods: Subjects were ≥ 18 years old and underwent elective open, laparoscopic or RAS VIH repair without myofascial release. Perioperative clinical outcomes through 30 days were analyzed as were prescription pain medication use and subject-reported responses to the HerQLes Abdominal QOL questionnaire. Read More

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Rapid assessment of silver nanoparticle migration from food containers into food simulants using a qualitative method.

Food Chem 2021 May 13;361:130091. Epub 2021 May 13.

Environmental Sciences Institute (ICAM), Department of Analytical Chemistry and Food Technology, University of Castilla-La Mancha, Avda. Carlos III s/n, 45071 Toledo, Spain. Electronic address:

Migration of silver nanoparticles (AgNPs) from food containers (FCs) has been assessed for the first time using a screening method previously validated. Migration was evaluated using water and 3% acetic acid as food simulants (FSs), from 20 to 70 °C at contact times of 2 h and 10 days. Total and migrated Ag were determined by inductively coupled plasma-mass spectrometry (ICP-MS) in the FCs and FSs, respectively. Read More

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Evaluation of recurrent dislocation of the patella in children with MRI: Goldthwait technique combined with lateral release, and VMO advancement-a retrospective study of 85 knees.

Musculoskelet Surg 2021 May 23. Epub 2021 May 23.

A' Surgical Department, Sismanogleio General Hospital, Athens, Greece.

Purpose: There are certain risk factors responsible for patella instability that should be identified before choosing the most appropriate treatment.

Methods: We evaluated 83 skeletally immature patients who, after two or more patellar dislocation episodes, underwent surgical treatment to address the condition of patellar instability. Each patient was evaluated for patellar instability risk factors using the Balcarek patellar instability severity score. Read More

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Microvascular imaging and monitoring of hemodynamic changes in the skin during arterial-venous occlusion using multispectral raster-scanning optoacoustic mesoscopy.

Photoacoustics 2021 Jun 20;22:100268. Epub 2021 Apr 20.

Laboratory of Bio Optical Imaging, Singapore Bioimaging Consortium, Agency of Science, Technology and Research (ASTAR), Singapore.

The ability to monitor oxygen delivery in microvasculature plays a vital role in measuring the viability of skin tissue and the probability of recovery. Using currently available clinical imaging tools, it is difficult to observe non-invasive hemodynamic regulation in the peripheral vessels. Here we propose the use of a novel multispectral raster-scanning optoacoustic mesoscopy (RSOM) system for noninvasive clinical monitoring of hemodynamic changes in the skin microvasculature's oxy- (HbO) and deoxy-hemoglobin (Hb), total hemoglobin (HbT) and oxygen saturation (rsO). Read More

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Poor nutritional status, risk of sarcopenia and nutrition related complaints are prevalent in COVID-19 patients during and after hospital admission.

Clin Nutr ESPEN 2021 06 20;43:369-376. Epub 2021 Apr 20.

Department of Nutrition & Dietetics, Amsterdam University Medical Centers, AMS Research Institute, VU University, Amsterdam, the Netherlands. Electronic address:

Background And Aims: Patients with COVID-19 infection presents with a broad clinical spectrum of symptoms and complications. As a consequence nutritional requirements are not met, resulting in weight- and muscle loss, and malnutrition. The aim of the present study is to delineate nutritional complaints, the (course of the) nutritional status and risk of sarcopenia of COVID-19 patients, during hospitalisation and after discharge. Read More

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Outcomes of nutritionally at-risk Coronavirus Disease 2019 (COVID 19) patients admitted in a tertiary government hospital: A follow-up study of the MalnutriCoV study.

Clin Nutr ESPEN 2021 06 27;43:239-244. Epub 2021 Apr 27.

Division of Adult Medicine, Department of Medicine, Philippine General Hospital, University of the Philippines Manila, Philippines; UP College of Medicine, University of the Philippines Manila, Philippines. Electronic address:

Background And Aims: The prevalence of malnutrition among adult Filipino patients with COVID 19 is 71.83%. Malnutrition has long been associated with poor outcomes among patients with pneumonia. Read More

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Interferon-gamma release assay levels and risk of progression to active tuberculosis: a systematic review and dose-response meta-regression analysis.

BMC Infect Dis 2021 May 22;21(1):467. Epub 2021 May 22.

Institute for Health Metrics and Evaluation, University of Washington, 3980 15th Ave. NE, Seattle, WA, 98195, USA.

Background: Identifying and treating individuals with high risk of progression from latent tuberculosis infection to active tuberculosis (TB) disease is critical for eliminating the disease. We aimed to conduct a systematic review and meta-regression analysis to quantify the dose-response relationship between interferon-gamma release assay (IGRA) levels and the risk of progression to active TB.

Methods: We searched PubMed and Embase from 1 January 2001 to 10 May 2020 for longitudinal studies that reported the risk of progression from latent to active TB as a function of baseline IGRA values. Read More

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Inhibitory synaptic transmission is impaired at higher extracellular Ca concentrations in Scn1a mouse model of Dravet syndrome.

Sci Rep 2021 May 20;11(1):10634. Epub 2021 May 20.

Research Institute for the Molecular Pathogeneses of Epilepsy, Fukuoka University, Fukuoka, Japan.

Dravet syndrome (DS) is an intractable form of childhood epilepsy that occurs in infancy. More than 80% of all patients have a heterozygous abnormality in the SCN1A gene, which encodes a subunit of Na channels in the brain. However, the detailed pathogenesis of DS remains unclear. Read More

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COVID-19 vaccine hesitancy among medical students in India.

Epidemiol Infect 2021 05 20;149:e132. Epub 2021 May 20.

Department of Community Medicine and Family Medicine, All India Institute of Medical Sciences (AIIMS), Basni, Jodhpur, Rajasthan342005, India.

The coronavirus disease 2019 (COVID-19) vaccine was launched in India on 16 January 2021, prioritising health care workers which included medical students. We aimed to assess vaccine hesitancy and factors related to it among medical students in India. An online questionnaire was filled by 1068 medical students across 22 states and union territories of India from 2 February to 7 March 2021. Read More

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