25,018 results match your criteria release capacity

Effect of osteopathic manipulative therapy on pulmonary function testing in children with asthma.

J Osteopath Med 2021 May 7. Epub 2021 May 7.

Department of Pediatrics, Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA.

Context: Asthma is a leading cause of pediatric chronic illness, and poor disease control can lead to decreased quality of life and impaired academic performance. Although osteopathic manipulative treatment (OMT) has been shown to have positive effects on pulmonary function in adult patient populations, less is known about its impact in children.

Objectives: To evaluate changes in pulmonary function testing (PFT) in pediatric patients on the same day they received OMT compared with PFT in those who received usual care. Read More

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Synthesis of a PVA drug delivery system for controlled release of a Tramadol-Dexketoprofen combination.

J Mater Sci Mater Med 2021 May 7;32(5):56. Epub 2021 May 7.

Facultad de Odontología, Región Orizaba-Córdoba, Universidad Veracruzana, Abasolo Sur, SN, Tenango de Río Blanco, 94732, Veracruz, México.

The local administration of analgesic combinations by means of degradable polymeric drug delivery systems is an alternative for the management of postoperative pain. We formulated a Tramadol-Dexketoprofen combination (TDC) loaded in poly(vinyl alcohol) (PVA) film. Films were prepared by the solvent casting method using three different molecular weights of PVA and crosslinking those films with citric acid, with the objective of controlling the drug release rate, which was evaluated by UV-vis spectrometry. Read More

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In vitro studies of Annona muricata L. extract-loaded electrospun scaffolds for localized treatment of breast cancer.

J Biomed Mater Res B Appl Biomater 2021 May 7. Epub 2021 May 7.

Department of Mechanical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts, USA.

This paper presents in vitro studies of the sustained release of Annona muricata leaf extracts (AME) from hybrid electrospun fibers for breast cancer treatment. Electrospun hybrid scaffolds were fabricated from crude AME extracts, poly(lactic-co-glycolic acid)/gelatin (PLGA/Ge) and pluronic F127. The physicochemical properties of the AME extract and scaffolds were studied. Read More

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A novel encapsulation of Streptomyces fulvissimus Uts22 by spray drying and its biocontrol efficiency against Gaeumannomyces graminis, the causal agent of take-all disease in wheat.

Pest Manag Sci 2021 May 7. Epub 2021 May 7.

Department of Plant Protection, Faculty of Agriculture, Vali-e-Asr University of Rafsanjan, Iran.

Background: Wheat is a valuable food source that is exposed to many diseases that reduce its quantity and quality. One of the most important diseases affecting wheat is take-all, caused by Gaeumannomyces graminis var. tritici. Read More

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An individual alginate lyase is effective in the disruption of Laminaria digitata recalcitrant cell wall.

Sci Rep 2021 May 6;11(1):9706. Epub 2021 May 6.

CIISA - Centro de Investigação Interdisciplinar Em Sanidade Animal, Faculdade de Medicina Veterinária, Universidade de Lisboa, 1300-477, Lisboa, Portugal.

In the present study, 199 pre-selected Carbohydrate-Active enZymes (CAZymes) and sulfatases were assessed, either alone or in combination, to evaluate their capacity to disrupt Laminaria digitata cell wall, with the consequent release of interesting nutritional compounds. A previously characterized individual alginate lyase, belonging to the family 7 of polysaccharide lyases (PL7) and produced by Saccharophagus degradans, was shown to be the most efficient in the in vitro degradation of L. digitata cell wall. Read More

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DPD simulations and experimental study on reduction-sensitive polymeric micelles self-assembled from PCL-SS-PPEGMA for doxorubicin controlled release.

Colloids Surf B Biointerfaces 2021 Apr 28;204:111797. Epub 2021 Apr 28.

School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, 510006, PR China. Electronic address:

Delivery of anticancer drugs by amphiphilic polymeric micelles with disulfide bonds as the reduction-responsive groups has potential application in the field of drug-controlled release. In this study, three disulfide-linked polycaprolactone-b-polyethylene glycol methyl ether methacrylate (PCL-SS-PPEGMA) were synthesized and confirmed by H NMR and GPC, and then used for doxorubicin (DOX) delivery. The CMC values of the three PCL-SS-PPEGMA micelles were low (0. Read More

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Diet Recommendations for Hospitalized Patients With Inflammatory Bowel Disease: Better Options Than Nil Per Os.

Crohns Colitis 360 2020 Oct 17;2(4). Epub 2020 Jul 17.

Division of Gastroenterology and Hepatology, Perelman School of Medicine at the University of Pennsylvania.

Hospitalizations are a time when providers often have uncertainty about what to feed patients with inflammatory bowel disease (IBD). While there are many trials evaluating the role of diet in the management of IBD, the role of diet for the hospitalized patient is less clear. The hospitalization may serve as an opportunity to educate patients about the role of diet, try different diets, and develop dietary recommendations for after discharge. Read More

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October 2020

pH-Controlled Release of Antigens Using Mesoporous Silica Nanoparticles Delivery System for Developing a Fish Oral Vaccine.

Front Immunol 2021 19;12:644396. Epub 2021 Apr 19.

Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Science, Fujian Normal University, Fuzhou, China.

The development of effective vaccines and delivery systems in aquaculture is a long-term challenge for controlling emerging and reemerging infections. Cost-efficient and advanced nanoparticle vaccines are of tremendous applicability in prevention of infectious diseases of fish. In this study, dihydrolipoamide dehydrogenase (DLDH) antigens of were loaded into mesoporous silica nanoparticles (MSN) to compose the vaccine delivery system. Read More

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FoldAffinity: binding affinities from nDSF experiments.

Sci Rep 2021 May 5;11(1):9572. Epub 2021 May 5.

European Molecular Biology Laboratory - Hamburg Outstation, Notkestr. 85, Hamburg, 22607, Germany.

Differential scanning fluorimetry (DSF) using the inherent fluorescence of proteins (nDSF) is a popular technique to evaluate thermal protein stability in different conditions (e.g. buffer, pH). Read More

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Peptide-coated polyurethane material reduces wound infection and inflammation.

Acta Biomater 2021 May 2. Epub 2021 May 2.

Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, SE, 22184 Lund, Sweden. Electronic address:

There is an urgent need for treatments that not only reduce bacterial infection that occurs during wounding but that also target the accompanying excessive inflammatory response. TCP-25, a thrombin-derived antibacterial peptide, scavenges toll-like receptor agonists such as endotoxins and lipoteichoic acid and prevents toll-like receptor-4 dimerization to reduce infection-related inflammation in vivo. Using a combination of biophysical, cellular, and microbiological assays followed by experimental studies in mouse and pig models, we show that TCP-25, when delivered from a polyurethane (PU) material, exerts anti-infective and anti-inflammatory effects in vitro and in vivo. Read More

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Drug Release from Thermo-Responsive Polymer Brush Coatings to Control Bacterial Colonization and Biofilm Growth on Titanium Implants.

Adv Healthc Mater 2021 May 5:e2100069. Epub 2021 May 5.

Physical Chemistry I and Research Center of Micro and Nanochemistry and Engineering (Cµ), Department of Chemistry and Biology, School of Science and Technology, University of Siegen, Adolf-Reichwein-Str. 2, Siegen, 57076, Germany.

Despite decades of biomedical advances, the colonization of implant devices with bacterial biofilms is still a leading cause of implant failure. Clearly, new strategies and materials that suppress both initial and later stage bacterial colonization are required in this context. Ideal would be the implementation of a bactericidal functionality in the implants that is temporally and spatially triggered in an autonomous fashion at the infection site. Read More

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A carrier-free nanoparticle with dual NIR/acid responsiveness by co-assembly of enediyne and IR820 for combined PTT/chemotherapy.

J Mater Chem B 2021 May 5. Epub 2021 May 5.

Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.

Combined photothermal therapy/chemotherapy by co-delivery of a photosensitizer (PS) and a chemotherapeutic drug has demonstrated great potential for cancer treatment. The intrinsic drawbacks of traditional drug delivery systems (DDSs), such as tedious synthetic procedures, side effects originated from the carrier materials, low loading efficiency, and uncontrolled drug release, however, have impaired their further advancement. On the other hand, enediyne antibiotics are highly cytotoxic toward cancer cells through the generation of lethal carbon radicals via thermal-induced cyclization, endowing them with great potential to achieve enhanced synergistic anticancer performance by incorporation with the photothermal effect of PS. Read More

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Ionic framework constructed with protic ionic liquid units for improving ammonia uptake.

Chem Commun (Camb) 2021 May;57(36):4384-4387

College of Materials Science and Engineering, Huaqiao University, Xiamen 361021, P. R. China.

In this work, an ionic framework [Ph3ImH][Tf2N]2 constructed from protic imidazolium ionic liquid units through ionic and hydrogen bonding interactions was synthesized for selective ammonia uptake. Investigation of the NH3 uptake mechanism indicates that the acid sites in [Ph3ImH][Tf2N]2 would be frustrated when contacted with NH3, and the frustration of [Ph3ImH][Tf2N]2 precipitates NH3 capture by hydrogen bonding and physical interactions, and the NH3 could be released under mild conditions. There was no obvious decrease in capacity over 10 consecutive cycles of ammonia uptake and release. Read More

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Drug -driven self-assembly of pH-sensitive nano-vesicles with high loading capacity and anti-tumor efficacy.

Biomater Sci 2021 May;9(9):3348-3361

Ministry of Education (MOE), Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.

The in vivo delivery of nanomedicine is severely hampered by the limited enhanced permeability and retention effect (EPR) in tumors. Aiming at overcoming this limitation and achieving high anti-tumor effect of chemotherapeutics, we specially addressed an available strategy from a viewpoint of increasing the drug loading of nano-carriers. Here, we constructed a novel pH-responsive polymersome based on the drug-driven self-assembly of amphiphilic polyphosphazenes PAP containing the ortho ester group ABD and mPEG2000. Read More

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Role of rehabilitation in a COVID-19 survivor with intensive care unit-acquired weakness: A case report.

Turk J Phys Med Rehabil 2021 Mar 4;67(1):115-119. Epub 2021 Mar 4.

Department of Physical Medicine and Rehabilitation, Pamukkale University Faculty of Medicine, Denizli, Turkey.

Intensive care unit-acquired weakness (ICU-AW) is a catastrophic and debilitating clinical condition that causes generalized weakness and predisposes to adverse short- and long-term outcomes. Novel coronavirus disease-2019 (COVID-19) has been a global pandemic since November 2019. Each additional ICU admission for COVID-19 stresses intensive care unit (ICU) and hospital capacity. Read More

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Relaxation capacity of cartilage is a critical factor in rate- and integrity-dependent fracture.

Sci Rep 2021 May 4;11(1):9527. Epub 2021 May 4.

Department of Mechanical Engineering, University of Wisconsin-Madison, 1513 University Ave., Madison, WI, 53706, USA.

Articular cartilage heals poorly but experiences mechanically induced damage across a broad range of loading rates and matrix integrity. Because loading rates and matrix integrity affect cartilage mechanical responses due to poroviscoelastic relaxation mechanisms, their effects on cartilage failure are important for assessing and preventing failure. This paper investigated rate- and integrity-dependent crack nucleation in cartilage from pre- to post-relaxation timescales. Read More

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Stimuli-responsive mesoporous silica nanoparticles: A custom-tailored next generation approach in cargo delivery.

Mater Sci Eng C Mater Biol Appl 2021 May 31;124:112084. Epub 2021 Mar 31.

PDX Pharmaceuticals, Inc., Portland, OR 97239, USA; Biomedical Engineering, OHSU School of Medicine, Portland, OR 97239, USA. Electronic address:

The pre-mature release of therapeutic cargos in the bloodstream or off-target sites is a major hurdle in drug delivery. However, stimuli-specific drug release responses are capable of providing greater control over the cargo release. Herein, various types of nanocarriers have been employed for such applications. Read More

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Radio-sensitivity enhancement in HT29 cells through magnetic hyperthermia in combination with targeted nano-carrier of 5-Flourouracil.

Mater Sci Eng C Mater Biol Appl 2021 May 24;124:112043. Epub 2021 Mar 24.

Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran; Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran.

Normal tissue complication and development of radioresistance in cancer cells are known as the main challenges of ionizing radiation treatment. In the current study, we intended to induce selective radiosensitization in HT29 cancer cells by developing folic acid modified magnetic triblock copolymer nanoparticles as carrier of 5-Flourouracil (5-FU) which was further used in combination with hyperthermia. The aforementioned nanoparticles were synthesized and characterized by differential scanning calorimetric analysis (DSC), UV-visible spectroscopy, dynamic light scattering (DLS), zeta sizer, and transmission electron microscopy (TEM). Read More

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Magnetic κ-carrageenan/chitosan/montmorillonite nanocomposite hydrogels with controlled sunitinib release.

Mater Sci Eng C Mater Biol Appl 2021 May 23;124:112042. Epub 2021 Mar 23.

Department of Chemical Engineering, Faculty of Engineering, University of Maragheh, 55181-83111 Maragheh, Iran.

This work aimed to design montmorillonite-incorporated pH-responsive and magnetic κ-carrageenan/chitosan hydrogels via a completely green route for controlled release of sunitinib anticancer drug. This was accomplished by ionic cross-linking of two biopolymers, κ-carrageenan and chitosan, in the presence of magnetic montmorillonite (mMMt) nanoplatelets. Interestingly, it was observed that the amount of mMMt affected not only the microstructure of hydrogels, but also the drug loading efficiency of nanocomposite hydrogels was noticeably increased by introducing mMMt (from 69 to 96%). Read More

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Phenotypic and Functional Consequences of PLT Binding to Monocytes and Its Association with Clinical Features in SLE.

Int J Mol Sci 2021 Apr 29;22(9). Epub 2021 Apr 29.

Laboratory of Inflammatory Diseases, Hospital de la Santa Creu I Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), 08041 Barcelona, Spain.

Platelets (PLTs) can modulate the immune system through the release of soluble mediators or through interaction with immune cells. Monocytes are the main immune cells that bind with PLTs, and this interaction is increased in several inflammatory and autoimmune conditions, including systemic lupus erythematosus (SLE). Our aim was to characterize the phenotypic and functional consequences of PLT binding to monocytes in healthy donors (HD) and in SLE and to relate it to the pathogenesis of SLE. Read More

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Cold Gas-Dynamic Spray for Catalyzation of Plastically Deformed Mg-Strips with Ni Powder.

Nanomaterials (Basel) 2021 Apr 29;11(5). Epub 2021 Apr 29.

Nanotechnology and Applications Program, Energy and Building Research Center, Kuwait Institute for Scientific Research, Safat 13109, Kuwait.

Magnesium hydride (MgH) has received significant attention due to its potential applications as solid-state hydrogen storage media for useful fuel cell applications. Even though MgH possesses several attractive hydrogen storage properties, it cannot be utilized in fuel cell applications due to its high thermal stability and poor hydrogen uptake/release kinetics. High-energy ball milling, and mechanically-induced cold-rolling processes are the most common techniques to introduce severe plastic deformation and lattice imperfection in the Mg/MgH. Read More

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Phytostabilization of Phosphate Mine Wastes Used as a Store-and-Release Cover to Control Acid Mine Drainage in a Semiarid Climate.

Plants (Basel) 2021 Apr 29;10(5). Epub 2021 Apr 29.

Laboratory of Plant Physiology and Biotechnology, Research Center on Plant and Microbial Biotechnology, Biodiversity and Environment, Faculty of Sciences, Mohammed V University in Rabat, Laboratoire Mixte International-LMI AMIR, Rabat 10001, Morocco.

The abandoned Kettara pyrrhotite mine, located near Marrakech, Morocco, is an acid mine drainage (AMD) producer site. A store-and-release cover system made of phosphate wastes was built to prevent water infiltration and the formation of AMD. This cover system should be vegetated with appropriate plants to ensure its long-term sustainability and allow its reintegration in the surrounding ecosystem. Read More

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Potential Use of Amla ( L.) Fruit Extract to Protect Skin Keratinocytes from Inflammation and Apoptosis after UVB Irradiation.

Antioxidants (Basel) 2021 Apr 29;10(5). Epub 2021 Apr 29.

Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand.

Ultraviolet B (UVB) exposure is the primary risk factor for the deadliest type of skin cancer-melanoma. Incorporating natural antioxidants in skin protection products is currently a favored research theme. For this study, we selected L. Read More

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Preservation of the Antioxidant Capacity of Resveratrol via Encapsulation in Niosomes.

Foods 2021 Apr 30;10(5). Epub 2021 Apr 30.

Facultad de Ciencias Químicas, Departamento de Química Orgánica, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba X5000HUA, Argentina.

Resveratrol (RSV) is a natural polyphenol which produces several benefits to human health, being the isomer the most bioactive. However, its systemic absorption is limited due to its low water solubility, that reduces the oral bioavailability, and its chemical instability (owing to the - RSV isomer conversion upon light irradiation). Thus, encapsulation of this bioactive compound is required to protect it from destructive environmental conditions. Read More

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Curdlan-Based Hydrogels for Potential Application as Dressings for Promotion of Skin Wound Healing-Preliminary In Vitro Studies.

Materials (Basel) 2021 Apr 30;14(9). Epub 2021 Apr 30.

Department of Biochemistry and Biotechnology, Medical University of Lublin, Chodzki 1 Street, 20-093 Lublin, Poland.

The aim of this work was to establish whether novel curdlan-based hydrogels enriched with Ca ions may be considered as potential candidates for dressings, for the acceleration of skin wound healing. Firstly, biomaterials were allocated for evaluation of structural and mechanical properties. Subsequently, the ability of hydrogels to absorb simulated wound fluid and water vapor permeability, as well their capacity to release calcium ions, was evaluated. Read More

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Novel antiadipogenic effect of menadione in 3T3-L1 cells.

Chem Biol Interact 2021 May 1:109491. Epub 2021 May 1.

Instituto de Investigaciones Bioquímicas de Bahía Blanca, Universidad Nacional Del Sur (UNS)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Bahía Blanca, Argentina. Departamento de Biología, Bioquímica y Farmacia, UNS, Bahía Blanca, Argentina. Electronic address:

Inhibition of adipocyte differentiation can be used as a strategy for preventing adipose tissue expansion and, consequently, for obesity management. Since reactive oxygen species (ROS) have emerged as key modulators of adipogenesis, the effect of menadione (a synthetic form of vitamin K known to induce the increase of intracellular ROS) on 3T3-L1 preadipocyte differentiation was studied. Menadione (15 μM) increased ROS and lipid peroxidation, generating mild oxidative stress without affecting cell viability. Read More

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Diagnostic and therapeutic nanoenzymes for enhanced chemotherapy and photodynamic therapy.

J Mater Chem B 2021 May 4. Epub 2021 May 4.

State Key Laboratory of Metastable Materials Science and Technology, Applying Chemistry Key Lab of Hebei Province, Heavy metal deep remediation in water and resource reuse Key Lab of Hebei, Yanshan University, Qinhuangdao, 066004, P. R. China.

Nanozymes, as a kind of artificial mimic enzymes, have superior catalytic capacity and stability. As lack of O2 in tumor cells can cause resistance to drugs, we designed drug delivery liposomes (MnO2-PTX/Ce6@lips) loaded with catalase-like nanozymes of manganese dioxide nanoparticles (MnO2 NPs), paclitaxel (PTX) and chlorin e6 (Ce6) to consume tumor's native H2O2 and produce O2. Based on the catalysis of MnO2 NPs, a large amount of oxygen was produced by MnO2-PTX/Ce6@lips to burst the liposomes and achieve a responsive release of the loaded drug (paclitaxel), and the released O2 relieved the chemoresistance of tumor cells and provided raw materials for photodynamic therapy. Read More

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Lignite, thermally-modified and Ca/Mg-modified lignite for phosphate remediation.

Sci Total Environ 2021 Jun 5;773:145631. Epub 2021 Feb 5.

Department of Chemistry, Mississippi State University, Mississippi State, MS, USA. Electronic address:

Aqueous phosphate uptake is needed to reduce global eutrophication. Negatively charged adsorbent surfaces usually give poor phosphate sorption. Chemically- and thermally-modified lignite (CTL) was prepared by impregnating low-cost lignite (RL) with Ca and Mg cations, basified with KOH (pH ̴ 13. Read More

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Exploring the potential of polysaccharides or plant proteins as structuring agents to design cheeses with sensory properties focused toward consumers in East and Southeast Asia: a review.

Crit Rev Food Sci Nutr 2021 May 3:1-14. Epub 2021 May 3.

Teagasc Food Research Centre Moorepark, Fermoy, Ireland.

The focus of the global cheese industry on accessing new markets for cheese is currently driving a greater need for innovation in cheese products. Research to date suggests that, for example, East Asian consumers prefer cheeses that have a soft texture, with mild and milky flavors. Strategies for achieving such cheese characteristics are reviewed in this article. Read More

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Zn-MOF Encapsulated Antibacterial and Degradable Microneedles Array for Promoting Wound Healing.

Adv Healthc Mater 2021 May 3:e2100056. Epub 2021 May 3.

State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, 100850, China.

An infected skin wound caused by external injury remains a serious challenge in clinical practice. Wound dressings with the properties of antibacterial activity and potent regeneration capacity are highly desirable for wound healing. In this paper, a degradable, ductile, and wound-friendly Zn-MOF encapsulated methacrylated hyaluronic acid (MeHA) microneedles (MNs) array is fabricated through the molding method for promoting wound healing. Read More

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