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Predictive factors for postpartum glucose intolerance in women with gestational diabetes mellitus.

J Obstet Gynaecol Res 2022 Jan 20. Epub 2022 Jan 20.

Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.

Aim: The aim of this prospective cohort study was to evaluate the risk factors for postpartum glucose intolerance (GI) in women with gestational diabetes mellitus (GDM).

Method: A total of 140 women with GDM were enrolled. Of these, 115 underwent a 75-g oral glucose tolerance test (OGTT) at 12 weeks after delivery. Read More

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January 2022

Association between nonpharmacological strategies and delirium in intensive care unit.

Nurs Crit Care 2022 Jan 20. Epub 2022 Jan 20.

Escola Paulista de Enfermagem, Universidade Federal de São Paulo, São Paulo, Brazil.

Background: Several nonpharmacological strategies for the prevention and treatment of delirium have been increasingly used because the aetiology of delirium is multifactorial.

Aims: To verify the association between nonpharmacological strategies (presence of companion, mobilization, absence of physical restraint and natural light) and the occurrence of delirium, and to identify risk factors for delirium in intensive care unit (ICU) patients.

Study Design: The study was conducted in a Brazilian medical and surgical ICU. Read More

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January 2022

Reduced intensity hematopoietic stem cell transplantation for myelofibrosis in accelerated-phase.

Blood Adv 2022 Jan 20. Epub 2022 Jan 20.

University Medical Center Hamburg_Eppendorf, Hamburg, Germany.

Accelerated-phase (AP) myelofibrosis, currently defined by circulating blasts 10-19%, usually confers very high risk for progression and poor outcome. The outcome of hematopoietic stem cell transplantation for AP myelofibrosis has not been evaluated yet. We analyzed the outcome of 349 clinically and genetically annotated patients with primary or secondary myelofibrosis undergoing reduced intensity transplantation, of whom 35 had AP myelofibrosis. Read More

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January 2022

Rapid Review of Dermal Penetration and Absorption of Inorganic Lead Compounds for Occupational Risk Assessment.

Ann Work Expo Health 2021 Nov 23. Epub 2021 Nov 23.

College of Medicine, Department of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USA.

Lead (Pb) exposure continues to be a significant public health issue in both occupational and non-occupational settings. The vast majority of exposure and toxicological studies have focused on effects related to inhalation and gastrointestinal exposure routes. Exposure to inorganic Pb compounds through dermal absorption has been less well studied, perhaps due to the assumption that the dermal pathway is a minor contributor to aggregate exposures to Pb compounds. Read More

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November 2021

Intestinal failure-associated liver disease in the neonatal ICU: what we know and where we're going.

Curr Opin Pediatr 2022 Jan 19. Epub 2022 Jan 19.

Department of Pediatrics, University of South Florida Morsani College of Medicine, Tampa, Florida, USA.

Purpose Of Review: Parenteral nutrition is an integral part of the care of infants in the neonatal ICU. However, prolonged use of parenteral nutrition can be associated with adverse outcomes, most notably parenteral nutrition-associated liver disease, now known as intestinal failure-associated liver disease (IFALD). This review highlights pertinent developments in the epidemiology of IFALD as it pertains to neonates and showcases recent advances in the pathophysiology, treatment, and outcomes of neonates with IFALD. Read More

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January 2022

Reducing Opioid-Induced Constipation Post-Cardiac Surgery: An Improvement Project in a Pediatric Cardiac Intensive Care Unit.

J Nurs Care Qual 2022 Jan 19. Epub 2022 Jan 19.

Heart Center (Dr Rodrigues) and Cardiac Intensive Care Unit (Drs Tume and Lemming), Texas Children's Hospital, Houston; and Talent Management, Mobile Infirmary Medical Center, Mobile, Alabama (Dr Lofton).

Background: Pain management with opioids and underutilization of prophylaxis for constipation can prolong a patient's hospital length of stay and impede pain management efforts.

Problem: In pediatric postoperative cardiac patients, opioid therapy is a common approach to pain management but often places them at greater risk for constipation due to anatomy and age.

Methods: A retrospective review of 50 patients' medical records for baseline data was conducted, and a survey evaluated providers' current knowledge and practice. Read More

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January 2022

Effect of Varying Repositioning Frequency on Pressure Injury Prevention in Nursing Home Residents: The TEAM-UP Randomized Clinical Trial Results.

Adv Skin Wound Care 2022 Jan 19. Epub 2022 Jan 19.

Tracey L. Yap, PhD, RN, CNE, WCC, FGSA, FAAN, Duke University School of Nursing, Durham, North Carolina, United States. Susan D. Horn, PhD, University of Utah School of Medicine, Salt Lake City, Utah. Phoebe D. Sharkey, PhD, Loyola University Maryland, Baltimore. Tianyu Zheng, MS, University of Utah Department of Population Health Sciences, Salt Lake City. Nancy Bergstrom, PhD, RN, FAAN, University of Texas Health Science Center at Houston School of Nursing. Cathleen Colon-Emeric, MD, Duke University School of Medicine. Valerie K. Sabol, PhD, MBA, ACNP, GNP, FAANP, FAAN, Duke University School of Nursing. Jenny Alderden, PhD, APRN, University of Utah College of Nursing. Winston Yap, MD, Carroll County Memorial Hospital, Carrollton, Kentucky. Susan M. Kennerly, PhD, RN, CNE, WCC, FAAN, East Carolina University College of Nursing, Greenville, North Carolina. Acknowledgments: The authors thank Judith Hayes, PhD, RN, and Elizabeth Flint, PhD, for editorial assistance. This project was funded by the National Institutes of Health, National Institute of Nursing Research (R01NR016001) Yap, PI. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors have disclosed no other financial relationships related to this article. Submitted December 5, 2021; accepted December 23, 2021.

Objective: To investigate the clinical effectiveness of three repositioning intervals (2-, 3-, or 4-hour intervals) without compromising pressure injury (PI) incidence.

Methods: An embedded pragmatic cluster randomized controlled trial was conducted in nine nursing homes (NH) that were randomly assigned to one of three repositioning intervals. Baseline and 4-week intervention data were provided. Read More

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January 2022

Increased Health Risk in Office Workers in the COVID-19 era: Comparison of One-Year Incidence of Health Problems Before and During the COVID-19 Pandemic.

J Occup Environ Med 2022 Jan 19. Epub 2022 Jan 19.

Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan (Suka); Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Tokyo, Japan (Shimazaki); Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Tokyo, Japan (Yamauchi); The Jikei University School of Medicine, Tokyo, Japan (Yanagisawa).

Objective: To examine whether the incidence of health problems increases during the COVID-19 pandemic.

Methods: Using the health examination data (April 2018 - March 2021) of Japanese workers aged 15-64 years, the one-year incidence of 5 health problems (overweight, hypertension, hypercholesterolemia, hyperglycemia, and liver damage) and 4 unhealthy habits (snacking, heavy drinking, physical inactivity, and sleep deprivation) were compared before and during the COVID-19 pandemic.

Results: The one-year incidence of overweight, hypertension, hyperglycemia, and liver damage increased by 15-65% during the COVID-19 pandemic. Read More

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January 2022

Physical Activity, Sedentary Time and Cardiometabolic Health in Heavy Goods Vehicle Drivers: A Cross-Sectional Analysis.

J Occup Environ Med 2022 Jan 19. Epub 2022 Jan 19.

School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom (Ruettger, Varela-Mato, Chen, Guest, Paine, Sherry, Sayyah, King, Clemes), NIHR Leicester Biomedical Research Centre, United Kingdom (Varela-Mato, Edwardson, Paine, Sherry, Yates, King, Clemes), Diabetes Research Centre, University of Leicester, United Kingdom (Edwardson, Yates), School of Human Movement and Nutrition Sciences, University of Queensland (Gilson), Department of Health Sciences, University of Leicester, Leicester UK (Gray).

Objective: Physical inactivity, prolonged sitting, and unhealthy dietary habits are common in Heavy Goods Vehicle (HGV) drivers. These factors increase risk of long-term health conditions.

Methods: 329 HGV drivers across 25 UK depots completed a health assessment, including questionnaire completion, and objectively measured anthropometrics, blood biomarkers, physical activity (PA) and sedentary behaviour. Read More

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January 2022

Volunteering Improves Employee Health and Organizational Outcomes through Bonding with Coworkers and Enhanced Identification with Employers.

J Occup Environ Med 2022 Jan 19. Epub 2022 Jan 19.

Graduate School of Business, Stanford University, Stanford, CA, USA (Pfeffer); School of Medicine and Graduate School of Business, Stanford University, Stanford, CA, USA (Singer); Institute of Economic Studies, Charles University, Prague, Czech Republic and Vitality, London, UK (Stepanek).

Objective: To understand the determinants and consequences of employee volunteering and possible psychological mechanisms that produce these effects.

Methods: Using data from more than 50,000 responses to Britain's Healthiest Workplace survey, we employed structural equation modeling to investigate the determinants and effects of people volunteering.

Results: Company sponsorship and workplace flexibility policies increased the likelihood of individuals volunteering. Read More

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January 2022

Psychological Distress of Healthcare Workers in Québec (Canada) During the Second and the Third Pandemic Waves.

J Occup Environ Med 2022 Jan 19. Epub 2022 Jan 19.

Department of CHU de Québec-Laval University Research Center, Québec, Québec, Canada (Carazo, Talbot, Serres); Biological and occupational risks unit. Quebec national institute of public health, Québec, Québec, Canada (Carazo, Pelletier, Jauvin, Serres, Vézina); Social and preventive medicine department, Faculty of Medicine, Laval University, Québec, Québec, Canada (Talbot, Serres, Vézina).

Objective: We aimed to measure the prevalence of psychological distress among Quebec healthcare workers (HCWs) during the second and third pandemic waves and to assess the effect of psychosocial risk factors (PSRs) on work-related psychological distress among SARS-CoV-2 infected (cases) and non-infected (controls) HCWs.

Methods: A self-administered survey was used to measure validated indicators of psychological distress (K6 scale) and PSR (questions based on Karasek and Siegrist models, value conflicts and work-life balance). Adjusted robust Poisson models were used to estimate prevalence ratios. Read More

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January 2022

Advances in Interventional Therapies for Painful Diabetic Neuropathy: A Systematic Review.

Anesth Analg 2022 Jan 20. Epub 2022 Jan 20.

Department of Pain Management, Anesthesiology Institute.

Background: Painful diabetic neuropathy (PDN) is one of the major complications of diabetes mellitus. It is often debilitating and refractory to pharmaceutical therapies. Our goal was to systematically review and evaluate the strength of evidence of interventional management options for PDN and make evidence-based recommendations for clinical practice. Read More

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January 2022

Risk Factors for Rebound After Correction of Genu Valgum in Skeletal Dysplasia Patients Treated by Tension Band Plates.

J Pediatr Orthop 2022 Jan 20. Epub 2022 Jan 20.

Department of Orthopaedics, Nemours Childrens Hospital, Delaware, Wilmington, DE.

Background: Growth modulation using tension band plates (TBPs) is increasingly important for lower limb deformity correction in patients with skeletal dysplasia (SKD). Development of rebound deformity is a concern after TBP removal. Data regarding this complication are rare; therefore, we evaluated the prevalence and risk factors for rebound deformity in children with SKD undergoing correction of genu valgum using TBP. Read More

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January 2022

Epidural Analgesia Versus Lumbar Plexus Blockade After Hip Reconstruction Surgery in Children With Cerebral Palsy and Intrathecal Baclofen Pumps: A Comparison of Safety and Efficacy.

J Pediatr Orthop 2022 Jan 20. Epub 2022 Jan 20.

Departments of Orthopaedic Surgery Anesthesiology, Critical Care, and Pain Medicine Neurosurgery, Boston Children's Hospital, Boston, MA.

Background: Epidural analgesia is commonly used for pain control after reconstructive hip surgery, but its use is controversial in the presence of an intrathecal baclofen pump (ITB). The purpose of this retrospective study was to investigate the rate of serious anesthetic and postoperative complications as well as the efficacy of epidural analgesia compared with lumbar plexus blocks (LPBs) for pain management after neuromuscular hip reconstruction in children with cerebral palsy (CP) and ITB.

Methods: Pediatric patients with CP and ITB undergoing hip reconstructive surgery from 2010 to 2019 were retrospectively identified. Read More

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January 2022

Validation of Continuous Noninvasive Blood Pressure Monitoring Using Error Grid Analysis.

Anesth Analg 2022 Jan 20. Epub 2022 Jan 20.

From the Department of Anesthesiology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background: Error grid analysis was recently proposed to compare blood pressure obtained by 2 measurement methods. This study aimed to compare continuous noninvasive blood pressure (CNBP) with invasive blood pressure (IBP) using the error grid analysis and investigate the confounding risk factors attributable to the differences between CNBP and IBP.

Methods: Sixty adult patients undergoing general anesthesia were prospectively enrolled. Read More

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January 2022

Severe Intraoperative Hyperglycemia and Infectious Complications After Elective Brain Neurosurgical Procedures: Prospective Observational Study.

Anesth Analg 2022 Jan 20. Epub 2022 Jan 20.

Department of Anesthesiology, Critical Care and Pain Medicine, Sapienza University, Rome, Italy.

Background: Postoperative infections after brain surgery are a serious complication potentially worsening the outcome of surgical treatment. Severe intraoperative hyperglycemia (SIH) contributes to both infectious and noninfectious postoperative complications. However, there are a lack of data on the incidence of SIH in patients undergoing elective neurosurgical brain procedures and its association with the risk of postoperative infections. Read More

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January 2022

Histological Prognostic Factors of Endometrial Cancer in Patients with Adenomyosis: A Systematic Review and Meta-Analysis.

Pathobiology 2022 Jan 20:1-8. Epub 2022 Jan 20.

Gynecology and Obstetrics Unit, Department of Medicine, Surgery and Dentistry "Schola Medica Salernitana", University of Salerno, Baronissi, Italy.

Background: A better endometrial cancer (EC) prognosis in patients with coexistent adenomyosis has been hypothesized based on a different prevalence of favorable EC histological prognostic factors. However, pooled risk of EC unfavorable histological prognostic factors in patients with adenomyosis has never been calculated.

Objectives: We aimed to assess the risk of EC unfavorable histological prognostic factors in patients with adenomyosis. Read More

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January 2022

The Simple Nephrectomy Is Not Always Simple: Predictors of Surgical Difficulties.

Urol Int 2022 Jan 20:1-7. Epub 2022 Jan 20.

Department of Urology, Faculty of Medicine, Sakarya University, Sakarya, Turkey.

Background: Inflammation is one of the major risk factors for SN complications because the dense and fibrotic tissue leads to significant challenges to dissection.

Objectives: We aimed to evaluate the predictive factors preoperatively, especially inflammation markers and radiologic findings, which can pose challenges to surgery in simple nephrectomy.

Methods: We retrospectively evaluated the data of 156 patients who underwent simple open nephrectomy. Read More

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January 2022

MicroRNAs in Obesity-Associated Disorders: The Role of Exercise Training.

Obes Facts 2022 Jan 20:1-13. Epub 2022 Jan 20.

Laboratory of Biochemistry and Molecular Biology of Exercise, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil.

Obesity is a worldwide epidemic affecting over 13% of the adult population and is defined by an excess of body fat that predisposes comorbidities. It is considered a multifactorial disease in which environmental and genetic factors interact, and it is a risk marker for cardiovascular disease. Lifestyle modifications remain the mainstay of treatment for obesity based on adequate diet and physical exercise. Read More

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January 2022

Effectiveness of an Internet-Based Self-Help Intervention versus Public Mental Health Advice to Reduce Worry during the COVID-19 Pandemic: A Pragmatic, Parallel-Group, Randomized Controlled Trial.

Psychother Psychosom 2022 Jan 20:1-13. Epub 2022 Jan 20.

Department of Health Psychology and Applied Biological Psychology, Institute of Psychology, Leuphana University of Lüneburg, Lüneburg, Germany.

Introduction: The mental health burden for the general population due to the COVID-19 pandemic has been highlighted. Evidence on effective, easily accessible public health interventions to reduce worry, a major transdiagnostic risk-factor for, e.g. Read More

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January 2022

Seasonal variation and risk of febrile seizures; a Danish nationwide cohort study.

Neuroepidemiology 2022 Jan 20. Epub 2022 Jan 20.

Introduction Onset of febrile seizures varies with calendar season. However, it has not previously been assessed, how season of birth interacts with age and peak risk of febrile seizures, and whether season of birth correlates with the cumulative risk of febrile seizures at 5 years of age (i.e. Read More

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January 2022

Threshold of Serum Ferritin to Discriminate against Those at Greater Risk of Platelet Increase during Treatment with Hypoxia-Inducible Factor Prolyl Hydroxylase Domain Inhibitor.

Acta Haematol 2022 Jan 20. Epub 2022 Jan 20.

Introduction: Hypoxia-inducible factor prolyl hydroxylase domain inhibitors (HIF-PHI) are a new treatment for renal anemia. HIF-PHI is believed to increase iron usage to improve availability of iron for erythropoiesis. Therefore, there is concern that HIF-PHI might be prone to iron deficiency and that thrombosis might be induced by increased platelet and transferrin levels due to this iron deficiency. Read More

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January 2022

Frequency and Predictors of Pulmonary Arterial Stump Thrombosis following Pneumonectomy or Lobectomy.

Med Princ Pract 2022 Jan 20. Epub 2022 Jan 20.

Objectives: Pulmonary artery stump thrombosis (PAST) following pneumonectomies/lobectomies is rare and the clinical importance is unknown. The objectives of this study were to analyse the prevalence and risk factors of PAST and the clinical significance (follow-up, treatment, resolution, etc.) in patients with pneumonectomy/lobectomy. Read More

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January 2022

Alginate in corneal tissue engineering.

Biomed Mater 2022 Jan 20. Epub 2022 Jan 20.

Newcastle University, Biomedicine West, International Centre for Life, Times Square, Newcastle Upon Tyne, NE1 3BZ, UK, Newcastle upon Tyne, NE1 3BZ, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Corneal blindness is the major cause of vision impairment and the fourth-largest leading cause of blindness worldwide. An allograft corneal transplant is the most routine treatment for visual loss. Further complications can occur, such as transplant rejection, astigmatism, glaucoma, uveitis, retinal detachment, corneal ulceration due to reopening of the surgical wounds, and infection. Read More

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January 2022

Immunological significance of survival-related alternative splicing in uveal melanoma.

Aging (Albany NY) 2022 Jan 19;14(undefined). Epub 2022 Jan 19.

Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.

Uveal melanoma (UM) is a highly malignant intraocular tumor. The imbalance of alternative splicing (AS) is a landmark of tumor initiation and progression. However, there are few studies of AS in UM. Read More

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January 2022

Leisure-Time and Transport-Related Physical Activity and the Risk of Mortality: The CRONICAS Cohort Study.

J Phys Act Health 2022 Jan 20:1-7. Epub 2022 Jan 20.

Background: The long-term health association of the leisure-time and transport-related physical activity domains of the International Physical Activity Questionnaire have not been established in Latin American settings. The authors aimed to quantify the 7-year all-cause mortality risk associated with levels of leisure-time and transport-related physical activity.

Methods: Ongoing prospective cohort study conducted in 4 sites in Peru. Read More

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January 2022

No difference in radiologic outcomes for natalizumab patients treated with extended interval dosing compared with standard interval dosing: Real-world evidence from MS PATHS.

Mult Scler Relat Disord 2022 Jan 2;58:103480. Epub 2022 Jan 2.

Biogen, 225 Binney St., Cambridge, MA 02142, USA.

Background: Extended interval dosing (EID; average dosing interval approximately every 6 weeks) of natalizumab is associated with significantly lower risk of progressive multifocal leukoencephalopathy than standard interval dosing (SID; every 4 weeks) in patients with relapsing-remitting multiple sclerosis (MS). Real-world studies, though limited, suggest that natalizumab effectiveness is generally maintained in patients who switch to EID after initiation of stable treatment with SID. MS PATHS (Multiple Sclerosis Partners Advancing Technology and Health Solutions) is a collaborative, multicenter learning health system that generates real-world clinical and MRI data using highly standardized acquisition protocols. Read More

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January 2022

A preliminary study on health impacts of Mexican mercury mining workers in a context of precarious employment.

J Trace Elem Med Biol 2022 Jan 6;71:126925. Epub 2022 Jan 6.

Coordination for the Innovation and Application of Science and Technology (CIACYT), Autonomous University of San Luis Potosi, San Luis Potosi, Mexico. Electronic address:

Mercury mining is one of the main sources of mercury (Hg) release into the environment, causing serious impacts on human health and the environment. Workers in these mines are employed informally and precariously and therefore lack labor rights such as social security. The objective of the study is to make visible the exposure to environmental contaminants and the health of workers in mercury mines. Read More

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January 2022

Therapeutic implications of germline vulnerabilities in DNA repair for precision oncology.

Cancer Treat Rev 2022 Jan 5;104:102337. Epub 2022 Jan 5.

Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA, United States; Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, United States. Electronic address:

DNA repair vulnerabilities are present in a significant proportion of cancers. Specifically, germline alterations in DNA repair not only increase cancer risk but are associated with treatment response and clinical outcomes. The therapeutic landscape of cancer has rapidly evolved with the FDA approval of therapies that specifically target DNA repair vulnerabilities. Read More

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January 2022

Association between daily number of eating occasions with fasting glucose and insulin sensitivity in adults from families at high risk for type 2 diabetes in Europe: the Feel4Diabetes Study.

Nutrition 2021 Dec 11;95:111566. Epub 2021 Dec 11.

National and Kapodistrian, University of Athens Medical School, 11527 Athens, Greece.

Objective: The aim of this study was to examine the association between the number of times one eats daily (termed eating occasions [EO]) with indices of glycemic control and insulin resistance (IR) in a large sample of adults from families at high risk for type 2 diabetes mellitus (T2DM) from six European countries. The study also considered sex and socioeconomic status (SES).

Methods: Standardized questionnaires and procedures were used to assess sociodemographic characteristics, dietary intake, sedentary behavior, and anthropometric and biochemical indices. Read More

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December 2021