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A molecularly imprinted polymerized high internal phase emulsion adsorbent for sensitive chemiluminescence determination of clopidogrel.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Sep 10;265:120371. Epub 2021 Sep 10.

Department of Chemistry, Majlesi Branch, Islamic Azad University, Majlesi, Iran.

A molecularly imprinted polymerized high internal phase emulsion (MIP-polyHIPE) adsorbent was used for selective separating and preconcentrating the anti-plaque drug, clopidogrel. For the first time in this study, chemiluminescence (CL) methods were evaluated for the determination of clopidogrel. The synthesis of adsorbents by the emulsion templating method showed that the sensitivity of the method can be increased up to 42 times. Read More

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September 2021

Hydrothermal aging affects the three-dimensional fit and fatigue lifetime of zirconia abutments.

J Mech Behav Biomed Mater 2021 Sep 8;124:104832. Epub 2021 Sep 8.

Department of Prosthodontics and Periodontology, Bauru School of Dentistry - University of Sao Paulo, 9-75 Octavio Pinheiro Brizolla, 17012-901, Bauru, SP, Brazil.

Objective: Evaluate the effect of aging using two different methods on the three-dimensional fit of zirconia abutments at the implant-abutment connection and estimate the probability of survival of anterior crowns supported by straight and 17-degree angled abutments.

Materials And Methods: Two different zirconia abutment designs, straight and 17-degree angled abutments (n = 63/group), were evaluated in the current study. The abutments were randomly allocated into three experimental groups according to laboratory aging condition (134°C, 2. Read More

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September 2021

Innovative Therapies for Neuroblastoma: The Surprisingly Potent Role of Iron Chelation in Up-Regulating Metastasis and Tumor Suppressors and Down-Regulating the Key Oncogene, N-myc.

Pharmacol Res 2021 Sep 15:105889. Epub 2021 Sep 15.

Centre for Cancer Cell Biology and Drug Discovery, Griffith Institute for Drug Discovery, Griffith University, Nathan, Brisbane, Queensland, 4111, Australia; Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan. Electronic address:

Iron is an indispensable requirement for essential biological processes in cancer cells. Due to the greater proliferation of neoplastic cells, their demand for iron is considerably higher relative to normal cells, making them highly susceptible to iron depletion. Understanding this sensitive relationship led to research exploring the effect of iron chelation therapy for cancer treatment. Read More

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September 2021

LncRNA MEG3 reverses CCl-induced liver fibrosis by targeting NLRC5.

Eur J Pharmacol 2021 Sep 15:174462. Epub 2021 Sep 15.

Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China. Electronic address:

Liver fibrosis is a persistent pathological repair of chronic liver injury, which is characterized by excessive deposition of collagen-dominated extracellular matrix (ECM). It is well known that hepatic fibrosis can be reversed in the absence of etiology. Studies have shown that long non-coding RNA (Lnc RNA) maternally expressed gene3 (MEG3) has strong effects on the activation of hepatic stellata cells (HSCs). Read More

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September 2021

Constitutive expression and discovery of antimicrobial peptides in Zygogramma bicolorata (Coleoptera: Chrysomelidae).

Proteins 2021 Sep 18. Epub 2021 Sep 18.

Department of Biochemistry and Biochemical Engineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, India.

The expression, identification, and discovery of less toxic antimicrobial peptides (AMPs) are significant in managing infectious pathogens. AMPs triggered in response to the immune system have evolved to defend against pathogens and wounding. The protein composition of Zygogramma bicolorata hemolymph is of diagnostic importance as the open circulatory systems of the insects involve signaling through hemolymph. Read More

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September 2021

Nickelate Superconductivity without Rare-Earth Magnetism: (La,Sr)NiO.

Adv Mater 2021 Sep 18:e2104083. Epub 2021 Sep 18.

Stanford Institute for Materials and Energy Sciences, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA.

The occurrence of unconventional superconductivity in cuprates has long motivated the search for manifestations in other layered transition metal oxides. Recently, superconductivity is found in infinite-layer nickelate (Nd,Sr)NiO and (Pr,Sr)NiO thin films, formed by topotactic reduction from the perovskite precursor phase. A topic of much current interest is whether rare-earth moments are essential for superconductivity in this system. Read More

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September 2021

Fast liquid chromatography method for separation of peptides using a sub-2 μm ground silica monolith packed column.

J Sep Sci 2021 Sep 17. Epub 2021 Sep 17.

Department of pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China.

A stationary phase based on sub-2 μm ground silica monolith particles was fabricated by in situ polymerization and applied in micro-column for separation of peptides. The sub-2 μm silica particles were obtained from monolith using sol-gel process followed by grinding and sedimentation to remove the fines. Initially, the silica monolith particles were pretreated with 3-trimethoxysilyl propyl methacrylate to attach double-bonded ligands onto the surface, then a network structure was formed onto the surface of the particle using styrene, N-isopropylacrylamide and ethylene glycoldimethacrylate. Read More

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September 2021

Exploring women's experiences of participation in shared decision-making during childbirth: a qualitative study at a reference hospital in Spain.

BMC Pregnancy Childbirth 2021 Sep 17;21(1):631. Epub 2021 Sep 17.

Preventive Medicine and Epidemiology Department, Hospital Clínic, Barcelona, Spain.

Background: Women's engagement in healthcare decision-making during childbirth has been increasingly emphasised as a priority in maternity care, since it increases satisfaction with the childbirth experience and provides health benefits for women and newborns. The birth plan was developed as a tool to facilitate communication between health professionals and women in Spain, but their value in routine practice has been questioned. Besides, little is known about women's experiences of participation in decision-making in the Spanish context. Read More

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September 2021

Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer.

N Engl J Med 2021 Sep 18. Epub 2021 Sep 18.

From the University of Milan-Bicocca and European Institute of Oncology IRCCS, Milan (N.C.), and Fondazione Policlinico Universitario A. Gemelli IRCCS and Catholic University of the Sacred Heart, Rome (D.L.) - both in Italy; Institut Curie Saint-Cloud, Group d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens, Saint-Cloud, France (C.D.); Instituto de Oncología Ángel H. Roffo, Buenos Aires (M.V.C.); Saitama Medical University International Medical Center, Hidaka, Japan (K.H.); Ella Lemelbaum Institute for Immuno-Oncology, Sheba Medical Center, Ramat Gan, Israel (R.S.-F.); the University of California, Irvine, Orange (K.S.T.); Oncovida Cancer Center, Providencia (P.S.), and Universidad de la Frontera, Temuco (E.Y.) - both in Chile; IMAT (Instituto Médico de Alta Tecnología) Oncomedica, Monteria, Colombia (E.H.U.); Istanbul Medeniyet University Hospital, Istanbul, Turkey (M.G.); Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru (M.O.H.M.); Centre Hospitalier de l'Université de Montréal, Centre de Recherche de l'Université de Montréal, Université de Montréal, Montreal (V.S.), and Centre Hospitalier Universitaire de Québec, Université Laval, Quebec (V.C.) - both in Quebec, Canada; the Medical Rehabilitation Center of the Ministry of Health of the Russian Federation, Moscow (A.A.); Merck, Kenilworth, NJ (S.T., K.L., S.M.K.); and Arizona Oncology (U.S. Oncology Network), University of Arizona College of Medicine, Creighton University School of Medicine, Phoenix (B.J.M.).

Background: Pembrolizumab has efficacy in programmed death ligand 1 (PD-L1)-positive metastatic or unresectable cervical cancer that has progressed during chemotherapy. We assessed the relative benefit of adding pembrolizumab to chemotherapy with or without bevacizumab.

Methods: In a double-blind, phase 3 trial, we randomly assigned patients with persistent, recurrent, or metastatic cervical cancer in a 1:1 ratio to receive pembrolizumab (200 mg) or placebo every 3 weeks for up to 35 cycles plus platinum-based chemotherapy and, per investigator discretion, bevacizumab. Read More

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September 2021

Three-year durable efficacy of dolutegravir plus lamivudine in antiretroviral therapy-naive adults with HIV-1 infection.

AIDS 2021 Sep 15. Epub 2021 Sep 15.

Fundación Huésped, Buenos Aires, Argentina Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico Hospital Universitario La Paz, Madrid, Spain Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani IRCCS, Rome, Italy Bliss Healthcare Services, Orlando, FL, USA Royal Sussex County Hospital, Brighton, UK, and Brighton & Sussex Medical School, Brighton, UK National Taiwan University Hospital, Taipei, Taiwan Department of Medicine, Universitätsklinikum Bonn, Bonn, Germany Hôpital Saint Antoine, Paris, France ViiV Healthcare, Brentford, UK ViiV Healthcare, Research Triangle Park, NC, USA GlaxoSmithKline, Stockley Park, UK.

Objective: To assess efficacy and safety of dolutegravir (DTG) + lamivudine (3TC) vs DTG + tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) in treatment-naive adults with HIV-1 in the prespecified 144-week secondary analyses of GEMINI-1 and GEMINI-2.

Design: Identical, multicenter, phase III, randomized, non-inferiority studies (double-blind through 96 weeks).

Methods: Participants with HIV-1 RNA ≤500,000 copies/mL and no major viral resistance mutations to nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, or protease inhibitors were randomized 1:1 to once-daily DTG + 3TC or DTG + TDF/FTC. Read More

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September 2021

Role of Pairwise Reactions on the Synthesis of LiLaTiO and the Resulting Structure-Property Correlations.

Inorg Chem 2021 Sep 17. Epub 2021 Sep 17.

Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.

The performance of single-ion conductors is highly sensitive to the material's defect chemistry. Tuning these defects is limited for solid-state reactions as they occur at particle-particle interfaces, which provide a complex evolving energy landscape for atomic rearrangement and product formation. In this report, we investigate the (1) order of addition and (2) lithium precursor decomposition temperature and their effect on the synthesis and grain boundary conductivity of the perovskite lithium lanthanum titanium oxide (LLTO). Read More

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September 2021

Quantum Sampling Algorithms for Near-Term Devices.

Phys Rev Lett 2021 Sep;127(10):100504

Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA.

Efficient sampling from a classical Gibbs distribution is an important computational problem with applications ranging from statistical physics over Monte Carlo and optimization algorithms to machine learning. We introduce a family of quantum algorithms that provide unbiased samples by preparing a state encoding the entire Gibbs distribution. We show that this approach leads to a speedup over a classical Markov chain algorithm for several examples, including the Ising model and sampling from weighted independent sets of two different graphs. Read More

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September 2021

Excited-State Energy Surfaces in Molecules Revealed by Impulsive Stimulated Raman Excitation Profiles.

J Phys Chem Lett 2021 Sep 17:9239-9247. Epub 2021 Sep 17.

Dipartimento di Fisica, Universitá di Roma "La Sapienza", Roma I-00185, Italy.

Photophysical and photochemical processes are ruled by the interplay between transient vibrational and electronic degrees of freedom, which are ultimately determined by the multidimensional potential energy surfaces (PESs). Differences between ground and excited PESs are encoded in the relative intensities of resonant Raman bands, but they are experimentally challenging to access, requiring measurements at multiple wavelengths under identical conditions. Herein, we perform a two-color impulsive vibrational scattering experiment to launch nuclear wavepacket motions by an impulsive pump and record their coupling with a targeted excited-state potential by resonant Raman processes with a delayed probe, generating in a single measurement background-free vibrational spectra across the entire sample absorption. Read More

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September 2021

Newly Diagnosed Atrial Fibrillation in Acute Myocardial Infarction.

J Am Heart Assoc 2021 Sep 17:e021417. Epub 2021 Sep 17.

Department of Cardiovascular Medicine Kyoto University Graduate School of Medicine Kyoto Japan.

Background It remains controversial whether long-term clinical impact of newly diagnosed atrial fibrillation (AF) in the acute phase of acute myocardial infarction (AMI) is different from that of prior AF diagnosed before the onset of AMI. Methods and Results The current study population from the CREDO-Kyoto AMI (Coronary Revascularization Demonstrating Outcome Study in Kyoto Acute Myocardial Infarction) Registry Wave-2 consisted of 6228 patients with AMI who underwent percutaneous coronary intervention. The baseline characteristics and long-term clinical outcomes were compared according to AF status (newly diagnosed AF: N=489 [7. Read More

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September 2021

Gephyromycinifex aptenodytis gen. nov., sp. nov., isolated from gut of Antarctic emperor penguin Aptenodytes forsteri.

Antonie Van Leeuwenhoek 2021 Sep 16. Epub 2021 Sep 16.

Key Laboratory of Fermentation Engineering, Ministry of Education, Natural "111" Center for Cellular Regulation and Molecular Pharmaceutics, College of Bioengineering, Hubei University of Technology, Wuhan, 430068, China.

A novel actinobacterium NJES-13 was isolated from the gut of Antarctic emperor penguin Aptenodytes forsteri. The new isolate produces bioactive gephyromycin metabolites and exopolysaccharides (EPS). Cells were Gram-negative, motile with the peritrichous flagella, and with a faint layer of extracellular slime. Read More

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September 2021

MoS stacking matters: 3R polytype significantly outperforms 2H MoS for the hydrogen evolution reaction.

Nanoscale 2021 Sep 17. Epub 2021 Sep 17.

Department of Inorganic Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic.

Transition metal dichalcogenides (TMDs) are an intriguing family of materials with large application potential in a variety of scientific fields ranging from electronics to electrocatalysis. Within this group of materials, MoS has been attracting a lot of scientific attention due to its chemical and physical properties. In this report, we studied the exfoliation of the largely unexplored 3R MoS polytype prepared by high-temperature, high-pressure synthesis. Read More

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September 2021

The Progress of the Gait Impairment and Brain Activation in a Patient with Post-stroke Hemidystonia.

Phys Ther Res 2021 24;24(2):176-186. Epub 2021 Feb 24.

Center for Medical Sciences, Ibaraki Prefectural University of Health Sciences, Japan.

Objective: We explore the effects of body weight-supported (BWS) treadmill training, including the change of cortical activation, on a patient with post-stroke hemidystonia.

Patient: The patient was a 71-year-old man with left thalamus hemorrhage. His motor symptoms indicated slight impairment. Read More

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February 2021

Using an exploratory sequential mixed methods design to adapt an Illness Perception Questionnaire for African Americans with diabetes: the mixed data integration process.

Health Psychol Behav Med 2021 13;9(1):796-817. Epub 2021 Sep 13.

School of Nursing, University of Wisconsin-Madison, Madison, WI, USA.

Background: Although qualitative methods have been used to develop quantitative behavioral health measurements, studies rarely report on the exact development process of these questionnaires. In this methodological paper, we highlight the procedure of a mixed data integration process in using qualitative data to create quantitative questionnaire items.

Methods: We used an exploratory sequential mixed methods study design to culturally adapt the Illness Perception Questionnaire-Revised (IPQ-R) and address the sociocultural contexts of African Americans with type 2 diabetes. Read More

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September 2021

Muscone suppresses gastric cancer via regulation of miRNA-145.

Food Sci Nutr 2021 Sep 26;9(9):4711-4721. Epub 2021 Jul 26.

Department of Clinical Laboratory Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing China.

This study aims to determine the effects and mechanism of action of muscone on the biological activity of the gastric cancer cell lines SGC-7901 and MGC-803 (proliferation, apoptosis, invasion, and migration) in vitro. An optimal muscone concentration was determined using MTT and cell apoptosis tests. The SGC-7901 and MGC-803 cells were divided into five groups: normal control, muscone, miRNA, muscone + miRNA, and muscone + miRNA inhibitor. Read More

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September 2021

Exposure to oxybenzone from sunscreens: daily transdermal uptake estimation.

J Expo Sci Environ Epidemiol 2021 Sep 16. Epub 2021 Sep 16.

Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background: Fugacity, the driving force for transdermal uptake of chemicals, can be difficult to predict based only on the composition of complex, non-ideal mixtures such as personal care products.

Objective: Compare the predicted transdermal uptake of benzophenone-3 (BP-3) from sunscreen lotions, based on direct measurements of BP-3 fugacity in those products, to results of human subject experiments.

Methods: We measured fugacity relative to pure BP-3, for commercial sunscreens and laboratory mixtures, using a previously developed/solid-phase microextraction (SPME) method. Read More

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September 2021

Pembrolizumab with low-dose carboplatin for recurrent platinum-resistant ovarian, fallopian tube, and primary peritoneal cancer: survival and immune correlates.

J Immunother Cancer 2021 Sep;9(9)

University of Washington School of Medicine, Seattle, Washington, USA.

Background: Anti-programmed death 1 (PD1)/programmed cell death ligand 1 (PD-L1) therapies have shown modest activity as monotherapy in recurrent ovarian cancer. Platinum chemotherapies induce T-cell proliferation and enhance tumor recognition. We assessed activity and safety of pembrolizumab with carboplatin in recurrent platinum-resistant ovarian cancer. Read More

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September 2021

Pyrotinib combined with thalidomide in advanced non-small-cell lung cancer patients harboring HER2 exon 20 insertions (PRIDE): protocol of an open-label, single-arm phase II trial.

BMC Cancer 2021 Sep 16;21(1):1033. Epub 2021 Sep 16.

Department of Oncology, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, No.241 West Huaihai Road, Shanghai, 200030, China.

Background: Standard therapy for human epidermal growth factor receptor 2 (HER2)-mutant non-small-cell lung cancer (NSCLC) is lacking. The clinical benefits with pan-HER inhibitors (afatinib, neratinib, and dacomitinib), anti-HER2 antibody drug conjugate (ADC) trastuzumab emtansine, and an emerging irreversible tyrosine kinase inhibitor (TKI) poziotinib were modest. Another new ADC trastuzumab deruxtecan showed encouraging outcomes, but only phase I study was completed. Read More

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September 2021

A simple optical pH sensor based on pectin and L-derived anthocyanin for fish freshness monitoring.

F1000Res 2021 27;10:422. Epub 2021 May 27.

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia.

A simple optical pH sensor using the active compound anthocyanin (ACN), derived L. flower immobilized in a pectin membrane matrix, was been fabricated and employed to monitor the freshness of tilapia fish at room temperature and 4 C storage. The quantitative pH values were measured based on the UV-Vis spectroscopy absorbance. Read More

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[Impact and Temporal Evolution of the Corona Pandemic on Pediatric Emergency Care].

Klin Padiatr 2021 Sep 16. Epub 2021 Sep 16.

Department of Pediatric Surgery, AKK Altona Children's Hospital, Hamburg, Deutschland.

Hintergrund: Die COVID-19 Pandemie hat zu massiven gesellschaftlichen und wirtschaftlichen Einschränkungen geführt. Im Kindesalter wurden elektive Vorsorgeuntersuchung oftmals nicht wahrgenommen und es zeigte sich eine Reduktion der Zahl der Notfallvorstellungen.

Material Und Methoden: In einer retrospektiven Studie erfolgte eine quantitative Auswertung aller Notfallpatienten der 5 Kindernotaufnahmen Hamburgs und der Kinder- und Jugendarztpraxen der Jahre 2019 und 2020. Read More

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September 2021

Centromedial amygdala is more relevant for phobic confrontation relative to the bed nucleus of stria terminalis in patients with spider phobia.

J Psychiatr Res 2021 Sep 3;143:268-275. Epub 2021 Sep 3.

Center of Mental Health, Dept. of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital of Wuerzburg, Wuerzburg, Germany. Electronic address:

Recent studies indicate differential involvement of the centromedial amygdala (CM) and the bed nucleus of the stria terminalis (BNST) during processing (anticipation and confrontation) of threat stimuli. Here, temporal predictability was shown to be a relevant factor. In this study, we want to investigate the relevance of these effects, which were found in healthy subjects, for anxiety disorders. Read More

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September 2021

Microbial community competition rather than high-temperature predominates ARGs elimination in swine manure composting.

J Hazard Mater 2021 Sep 9;423(Pt B):127149. Epub 2021 Sep 9.

School of Civil Engineering and Architecture, Northeast Electric Power University, Jilin 132000, PR China. Electronic address:

Aerobic composting is commonly used in pig manure treatment, however, antibiotic resistance genes (ARGs) and their unclear transformation during composting process make the treated manure land using risky. The effects of enhanced thermophilic phase strategy (external heating (HTC) and thermophiles inoculation (MC)) on ARGs removal and the underlying mechanisms were investigated during swine manure composting. HTC increased the total relative abundance (RA) of ARGs by 32. Read More

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September 2021

SPIB acts as a tumor suppressor by activating the NFkB and JNK signaling pathways through MAP4K1 in colorectal cancer cells.

Cell Signal 2021 Sep 13:110148. Epub 2021 Sep 13.

Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, People's Republic of China. Electronic address:

Spi-B transcription factor (SPIB) is a member of the E-twenty-six (ETS) transcription factor family. Previous studies have shown that the expression of SPIB is downregulated in human colorectal cancer tissues. The purpose of our study was to explore the biological function and related mechanism of SPIB in colorectal cancer cells. Read More

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September 2021

How I Treat Chronic Phase Chronic Myelogenous Leukemia.

Authors:
Ellin Berman

Blood 2021 Sep 16. Epub 2021 Sep 16.

Memorial Sloan-Kettering Cancer Center, New York, New York, United States.

When imatinib, the first tyrosine kinase inhibitor (TKI) developed for use in chronic myelogenous leukemia (CML) was approved in 2001, the treatment of this disease was forever changed. Significant reductions in the molecular burden of disease were seen with the first generation TKI imatinib and with the addition of dasatinib (2006), nilotinib (2007), bosutinib (2012) and ponatinib (2013), deeper and more rapid reductions were noted. Physicians could begin to tailor TKI therapy to individual patients, and patients who did not respond to or could not tolerate first line therapy now had options. Read More

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September 2021

The Project Appropriate Birth and Reduction of Cesarean Section Rates: an analysis using the Robson classification system.

BJOG 2021 Sep 16. Epub 2021 Sep 16.

Postgraduate Program in Health Sciences, University of Southern Santa Catarina at Tubarão, Santa Catarina, Brazil.

Objective: The objective of this study was to assess C-section rates, before and after the implementation of the Project Appropriate Birth based on the Robson 10-group classification system.

Design: A before and after study.

Setting: Maternity hospital in South Brazil. Read More

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September 2021

Diagnostic Accuracy of 68Ga-PSMA-11 PET for Pelvic Nodal Metastasis Detection Prior to Radical Prostatectomy and Pelvic Lymph Node Dissection: A Multicenter Prospective Phase 3 Imaging Trial.

JAMA Oncol 2021 Sep 16. Epub 2021 Sep 16.

Ahmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles.

Importance: The presence of pelvic nodal metastases at radical prostatectomy is associated with biochemical recurrence after prostatectomy.

Objective: To assess the accuracy of prostate-specific membrane antigen (PSMA) 68Ga-PSMA-11 positron emission tomographic (PET) imaging for the detection of pelvic nodal metastases compared with histopathology at time of radical prostatectomy and pelvic lymph node dissection.

Design, Setting, And Participants: This investigator-initiated prospective multicenter single-arm open-label phase 3 imaging trial of diagnostic efficacy enrolled 764 patients with intermediate- to high-risk prostate cancer considered for prostatectomy at University of California, San Francisco and University of California, Los Angeles from December 2015 to December 2019. Read More

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September 2021