44,635 results match your criteria relative hydrogen


Enhanced trichloroethylene biodegradation: Roles of biochar-microbial collaboration beyond adsorption.

Sci Total Environ 2021 Jun 16;792:148451. Epub 2021 Jun 16.

School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; China-UK Low Carbon College, Shanghai Jiao Tong University, Shanghai 201306, China.

Trichloroethylene (TCE) is a pollutant widely found in groundwater, especially in the heavily contaminated industrial sites. Biological dechlorination method is environmentally friendly and low-cost. However, microorganisms grow slowly and their activity is susceptible to environmental fluctuations. Read More

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The protective effect of small peptides from Periplaneta americana on hydrogen peroxide-induced apoptosis of granular cells.

In Vitro Cell Dev Biol Anim 2021 Jun 21. Epub 2021 Jun 21.

School of Public Health, Dali University, Dali, Yunnan Province, 671000, People's Republic of China.

This study investigates the protective effect of small peptides from Periplaneta americana (SPPA) on hydrogen peroxide (HO)-induced apoptosis of ovarian granular cells. HO was applied to human ovarian granular cells (KGN cell strains). Cell viability was tested by cell counting Kit-8 (CCK-8). Read More

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Identification and functional characterization of Gh_D01G0514 (GhNAC072) transcription factor in response to drought stress tolerance in cotton.

Plant Physiol Biochem 2021 Jun 9;166:361-375. Epub 2021 Jun 9.

State Key Laboratory of Cotton Biology/Institute of Cotton Research, Chinese Academy of Agricultural Science (ICR, CAAS), Anyang, Henan, 455000, China; School of Agricultural Sciences, Zhengzhou University, Zhengzhou, Henan, 450001, PR China. Electronic address:

Cotton encounters long-term drought stress problems resulting in major yield losses. Transcription factors (TFs) plays an important role in response to biotic and abiotic stresses. The coexpression patterns of gene networks associated with drought stress tolerance were investigated using transcriptome profiles. Read More

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Additions of optimum water, spent mushroom compost and wood biochar to improve the growth performance of Althaea rosea in drought-prone coal-mined spoils.

J Environ Manage 2021 Jun 19;295:113076. Epub 2021 Jun 19.

Institute of Soil and Water Conservation, Northwest A&F University, Yangling, Shaanxi, 712100, People's Republic of China. Electronic address:

Ecosystem degradation as a result of coal mining is a common phenomenon in various regions of the world, especially in arid and semi-arid zones. The implementation of appropriate revegetation techniques can be considered crucial to restore these degraded areas. In this regard, the additions of spent mushroom compost (SMC) and wood biochar (WB) to infertile and degraded soils have been reported to enhance soil fertility and plant growth under water (W) deficit conditions. Read More

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Transition Metal Aluminum Boride as a New Candidate for Ambient-Condition Electrochemical Ammonia Synthesis.

Nanomicro Lett 2020 Feb 28;12(1):65. Epub 2020 Feb 28.

Discipline of Chemistry, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW, 2308, Australia.

Achieving more meaningful N conversion by reducing the energy input and carbon footprint is now being investigated through a method of N fixation instead of the Haber-Bosch process. Unfortunately, the electrochemical N reduction reaction (NRR) method as a rising approach currently still shows low selectivity (Faradaic efficiency < 10%) and high-energy consumption [applied potential at least - 0.2 V versus the reversible hydrogen electrode (RHE)]. Read More

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February 2020

Solvation Free Energy of Self-Assembled Complexes: Using Molecular Dynamics to Understand the Separation of ssDNA-Wrapped Single-Walled Carbon Nanotubes.

J Phys Chem C Nanomater Interfaces 2020 ;124

Materials Science and Engineering Division, National Institute of Standards and Technology, Gaithersburg, Maryland.

Molecular dynamics simulations were used to characterize the self-assembly of single-stranded DNA (ssDNA) on a (6,5) single-walled carbon nanotube (SWCNT) in aqueous solution for the purpose of gaining an improved theoretical understanding of separation strategies for SWCNTs using ssDNA as a dispersant. Four separate ssDNA sequences, ((TAT), TTA(TAT)ATT, C, (GTC)GT), at various levels of loading, were chosen for study based on published experimental work showing selective extraction of particular SWCNT species based on the ssDNA dispersant sequence. We develop a unique workflow based on free energy perturbation (FEP) and use this to determine the relative solubility of these complexes due to the adsorption of the ssDNA on the SWCNT surface, and hence, rank the favorability of separations observed during experiments. Read More

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January 2020

The vibronic absorption spectrum and electronic properties of Azure B in aqueous solution: TD-DFT/DFT study.

J Mol Graph Model 2021 Jun 11;107:107964. Epub 2021 Jun 11.

Physics Department, Sevastopol State University, Universitetskaya st., 33, Sevastopol, Crimea, 299053, Ukraine. Electronic address:

The vibronic absorption spectrum of Azure B (AB) in an aqueous solution is calculated using the time-dependent density functional theory (TD-DFT). The results of calculations are analyzed using all hybrid functionals supported by Gaussian16, the 6-31++G(d,p) basis set, and the IEFPCM and SMD solvent models. The solvent model IEFPCM gave significantly underestimated values of λ in comparison with the experiment. Read More

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Combined application of ascorbic acid and endophytic N-fixing Azotobacter chroococcum Avi2 modulates photosynthetic efficacy, antioxidants and growth-promotion in rice under moisture deficit stress.

Microbiol Res 2021 Jun 10;250:126808. Epub 2021 Jun 10.

ICAR- National Rice Research Institute, Cuttack, Odisha, 753006, India.

This group has previously reported the role of ascorbic acid (AA) as an antioxidant for survivability and ability to enhancing diazotrophic efficacy in Azotobacter chroococcum Avi2 under hydrogen peroxide (HO) stress. However, the present study showed the combined application of AA and Avi2 in drought-susceptible (IR64 and Naveen) and drought-tolerant (Ankit and Satyabhama) rice cultivars to determine their photosynthetic efficacy (chlorophyll fluorescence-imaging), antioxidants, and plant growth-promotion (PGP) under moisture deficit stress (MS, -60 kPa). The results indicated that combined application of AA and Avi2 significantly (p < 0. Read More

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Genome-wide identification of heat shock transcription factors and potential role in regulation of antioxidant response under hot water and glycine betaine treatments in cold stored peaches.

J Sci Food Agric 2021 Jun 19. Epub 2021 Jun 19.

College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, PR China.

Background: Heat shock transcription factors (Hsfs) play pivotal roles in plant response to stress. Although glycine betaine (GB) and hot water (HW) treatments are effective in reducing chilling injury (CI), little is known about characterization of Hsfs gene family and their potential roles in alleviating CI by regulating antioxidant system in peach fruit.

Results: In this study, 17 PpHsfs were identified in peach genome and investigated by using bioinformatics, including chromosomal locations, phylogenetic relationships, gene structure, motifs and promoter analyses. Read More

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Constructing Co-N-C Catalyst via a Double Crosslinking Hydrogel Strategy for Enhanced Oxygen Reduction Catalysis in Fuel Cells.

Small 2021 Jun 17:e2100735. Epub 2021 Jun 17.

State Key Laboratory of Material Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China.

Exploiting platinum-group-metal (PGM)-free electrocatalysts with remarkable activity and stability toward oxygen reduction reaction (ORR) is of significant importance to the large-scale commercialization of proton exchange membrane fuel cells (PEMFCs). Here, a high-performance and anti-Fenton reaction cobalt-nitrogen-carbon (Co-N-C) catalyst is reported via employing double crosslinking (DC) hydrogel strategy, which consists of the chemical crosslinking between acrylic acid (AA) and acrylamide (AM) copolymerization and metal coordinated crosslinking between Co and P(AA-AM) copolymer. The resultant DC hydrogel can benefit the Co dispersion via chelated Co-N/O bonds and relieve metal agglomeration during the subsequent pyrolysis, resulting in the atomically dispersed Co-Nx/C active sites. Read More

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Inductively coupled nonthermal plasma synthesis of aluminum nanoparticles.

Nanotechnology 2021 Jun 18. Epub 2021 Jun 18.

Department of Mechanical Engineering Institute of Technology, University of Minnesota Twin Cities, 111 Church Street SE, Minneapolis, Minnesota, 55455, UNITED STATES.

Metallic nanoparticles of aluminum (Al), a nontoxic and earth-abundant element, are relevant to plasmonic and energetic applications. However, monodisperse Al nanoparticles are difficult to synthesize using all gas-phase approaches, especially in the 10 to 20 nm size range; yet, many applications require particles of this size due to their enhanced properties. Here, an inductive nonthermal plasma reactor fed with aluminum chloride (AlCl3) and Ar is used to synthesize single-crystal aluminum nanoparticles. Read More

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An in vitro senescence model of gingival epithelial cell induced by hydrogen peroxide treatment.

Odontology 2021 Jun 18. Epub 2021 Jun 18.

Division of Periodontology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, 061-0293, Japan.

Gingival tissue shows progressive changes with aging and an in vitro model of gingival tissue could be useful in understanding age-associated oral diseases. The present study aims to establish a hydrogen peroxide (HO) treatment model to induce aging in human gingival epithelial cells. In addition, fisetin, a flavonoid component studied for the anti-aging property is used to examine if it could reverse the induced senescence. Read More

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Structure-Based Design of A-1293102, a Potent and Selective BCL-X Inhibitor.

ACS Med Chem Lett 2021 Jun 12;12(6):1011-1016. Epub 2021 May 12.

AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States.

BCL-X, an antiapoptotic member of the BCL-2 family of proteins, drives tumor survival and maintenance and thus represents a key target for cancer treatment. Herein we report the rational design of a novel series of selective BCL-X inhibitors exemplified by A-1293102. This molecule contains structural elements of selective BCL-X inhibitor A-1155463 and the dual BCL-X/BCL-2 inhibitors ABT-737 and navitoclax, while representing a distinct pharmacophore as assessed by an objective cheminformatic evaluation. Read More

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Snapshots of Ce Toroid Assembly from Solids and Solution.

J Am Chem Soc 2021 Jun 17. Epub 2021 Jun 17.

Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, United States.

Crystallization at the solid-liquid interface is difficult to spectroscopically observe and therefore challenging to understand and ultimately control at the molecular level. The Ce-torroid formulated [Ce(OH)(O)(SO)(HO)], part of a larger emerging family of M-materials (M = Zr, U, Ce), presents such an opportunity. We elucidated assembly mechanisms by the X-ray scattering (small-angle scattering and total scattering) of solutions and solids as well as crystallizing and identifying fragments of Ce by single-crystal X-ray diffraction. Read More

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Benchmark of the Extension of Frozen-Density Embedding Theory to Nonvariational Correlated Methods: The Embedded-MP2 Case.

J Chem Theory Comput 2021 Jun 17. Epub 2021 Jun 17.

Department of Physical Chemistry, University of Geneva, 30, Quai Ernest-Ansermet, CH-1211 Genève 4, Switzerland.

The extension of the frozen-density embedding theory for nonvariational methods [ 6880] was utilized to evaluate intermolecular interaction energies for complexes in the Zhao-Truhlar basis set. In the applied method (FDET-MP2-FAT-LDA), the same auxiliary system is used to evaluate the correlation energy by means of the second-order Møller-Plesset perturbation theory (MP2), as in our previous work [ 121101]. Local density approximation is used for [ρ,ρ] in both cases. Read More

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Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay.

Bioorg Med Chem 2021 Jun 6;42:116246. Epub 2021 Jun 6.

Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, United States. Electronic address:

We report the discovery of a fluorescent small molecule probe. This probe exhibits an emission increase in the presence of the oncoprotein MYC that can be attenuated by a competing inhibitor. Hydrogen-deuterium exchange mass spectrometry analysis, rationalized by induced-fit docking, suggests it binds to the "coiled-coil" region of the leucine zipper domain. Read More

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Transmembrane anion transport mediated by halogen bonding and hydrogen bonding triazole anionophores.

Chem Sci 2020 Apr 15;11(18):4722-4729. Epub 2020 Apr 15.

Chemistry Research Laboratory, University of Oxford Mansfield Road Oxford OX1 3TA UK

Transmembrane ion transport by synthetic anionophores is typically achieved using polar hydrogen bonding anion receptors. Here we show that readily accessible halogen and hydrogen bonding 1,2,3-triazole derivatives can efficiently mediate anion transport across lipid bilayer membranes with unusual anti-Hofmeister selectivity. Importantly, the results demonstrate that the iodo-triazole systems exhibit the highest reported activity to date for halogen bonding anionophores, and enhanced transport efficiency relative to the hydrogen bonding analogues. Read More

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Sterics and Hydrogen Bonding Control Stereochemistry and Self-Sorting in BINOL-Based Assemblies.

J Am Chem Soc 2021 Jun 14;143(24):9009-9015. Epub 2021 Jun 14.

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.

Here we demonstrate how the hydrogen-bonding ability of a BINOL-based dialdehyde subcomponent dictated the stereochemical outcome of its subsequent self-assembly into one diastereomeric helicate form when bearing free hydroxy groups, and another in the case of its methylated congener. The presence of methyl groups also altered the self-sorting behavior when mixed with another, short linear dialdehyde subcomponent, switching the outcome of the system from narcissistic to integrative self-sorting. In all cases, the axial chirality of the BINOL building block also dictated helicate metal center handedness during stereospecific self-assembly. Read More

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Biosynthesis of the catalytic H-cluster of [FeFe] hydrogenase: the roles of the Fe-S maturase proteins HydE, HydF, and HydG.

Chem Sci 2020 Sep 22;11(38):10313-10323. Epub 2020 Sep 22.

Department of Chemistry, University of California, Davis Davis CA 95616 USA

[FeFe] hydrogenases carry out the redox interconversion of protons and molecular hydrogen (2H + 2e ⇌ H) at a complex Fe-S active site known as the H-cluster. The H-cluster consists of a [4Fe-4S] subcluster, denoted here as [4Fe], linked a cysteine sulfur to an interesting organometallic [2Fe] subcluster thought to be the subsite where the catalysis occurs. This [2Fe] subcluster consists of two Fe atoms, linked with a bridging CO and a bridging SCHNHCHS azadithiolate (adt), with additional terminal CO and CN ligands bound to each Fe. Read More

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September 2020

Crystallographic characterization of the metal-organic framework Fe(bdp) upon reductive cation insertion.

Chem Sci 2020 Aug 10;11(34):9173-9180. Epub 2020 Aug 10.

Department of Chemistry, University of California Berkeley California 94720 USA

Precisely locating extra-framework cations in anionic metal-organic framework compounds remains a long-standing, yet crucial, challenge for elucidating structure-performance relationships in functional materials. Single-crystal X-ray diffraction is one of the most powerful approaches for this task, but single crystals of frameworks often degrade when subjected to post-synthetic metalation or reduction. Here, we demonstrate the growth of sizable single crystals of the robust metal-organic framework Fe(bdp) (bdp = benzene-1,4-dipyrazolate) and employ single-crystal-to-single-crystal chemical reductions to access the solvated framework materials AFe(bdp)·THF (A = Li, Na, K). Read More

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Photo-triggered hydrogen atom transfer from an iridium hydride complex to unactivated olefins.

Chem Sci 2020 Aug 6;11(32):8582-8594. Epub 2020 Aug 6.

Department of Chemistry, University of Basel St. Johanns-Ring 19 4056 Basel Switzerland

Many photoactive metal complexes can act as electron donors or acceptors upon photoexcitation, but hydrogen atom transfer (HAT) reactivity is rare. We discovered that a typical representative of a widely used class of iridium hydride complexes acts as an H-atom donor to unactivated olefins upon irradiation at 470 nm in the presence of tertiary alkyl amines as sacrificial electron and proton sources. The catalytic hydrogenation of simple olefins served as a test ground to establish this new photo-reactivity of iridium hydrides. Read More

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Contrasting hydrogen peroxide- and persulfate-driven oxidation systems: Impact of radical scavenging on treatment efficiency and cost.

Chem Eng J 2021 Jan;404

U.S. Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory, Robert S. Kerr Environmental Research Center, 919 Kerr Lab Dr., Ada, OK 74820 USA.

For the first time, the fate of radicals generated in heterogeneous chemical oxidation treatment systems has been accounted for and used to assess treatment performance in three reaction compartments; reaction with the target compound, rhodamine B (RhB), the aqueous phase scavengers, and the solid phase scavengers. Radicals formed during the ultra-violet (UV) activation of hydrogen peroxide (HO) (UV-AHP) and persulfate (SO) (UV-APS) include hydroxyl (•OH) and sulfate radicals (SO), respectively. •OH and SO, used in oxidation treatment systems to degrade a broad spectrum of environmental contaminants, may also react with non-target chemical species (scavengers) that limit treatment efficiency. Read More

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January 2021

Chemical dynamics study on the gas-phase reaction of the D1-silylidyne radical (SiD; XΠ) with deuterium sulfide (DS) and hydrogen sulfide (HS).

Phys Chem Chem Phys 2021 Jun;23(24):13647-13661

School of Maths and Physics, Queen's University Belfast, University Road, Belfast BT7 1NN, Northern Ireland, UK.

The reactions of the D1-silylidyne radical (SiD; X2Π) with deuterium sulfide (D2S; X1A1) and hydrogen sulfide (H2S; X1A1) were conducted utilizing a crossed molecular beams machine under single collision conditions. The experimental work was carried out in conjunction with electronic structure calculations. The elementary reaction commences with a barrierless addition of the D1-silylidyne radical to one of the non-bonding electron pairs of the sulfur atom of hydrogen (deuterium) sulfide followed by possible bond rotation isomerization and multiple atomic hydrogen (deuterium) migrations. Read More

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Miniaturized TOC analyzer using dielectric barrier discharge for catalytic oxidation vapor generation and point discharge optical emission spectrometry.

Anal Chim Acta 2021 Aug 24;1172:338683. Epub 2021 May 24.

Analytical & Testing Center, Sichuan University, Chengdu, Sichuan, 610064, China. Electronic address:

Total organic carbon (TOC) is an important parameter describing organic pollution degree of waters. Due to the increasing need of field analysis and drawbacks of conventional TOC analytical instruments, miniaturized TOC analyzers are still demanding. In this work, a dielectric barrier discharge (DBD) microplasma was utilized for catalytic oxidation vapor generation (COVG) of organic compounds into CO, and a point discharge (PD) microplasma was employed to excite the carbon atomic emission spectra for quantification. Read More

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A comparison of Prx- and OxyR-based HO probes expressed in S. cerevisiae.

J Biol Chem 2021 Jun 9:100866. Epub 2021 Jun 9.

German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120 Heidelberg, Germany. Electronic address:

Genetically encoded fluorescent HO probes continue to advance the field of redox biology. Here we compare the previously established peroxiredoxin-based HO probe roGFP2-Tsa2ΔC with the newly described OxyR-based HO probe HyPer7, using yeast as the model system. While not as sensitive as roGFP2-Tsa2ΔC, HyPer7 is much improved relative to earlier HyPer versions, most notably by ratiometric pH stability. Read More

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Peroxidasin promotes diabetic vascular endothelial dysfunction induced by advanced glycation end products via NOX2/HOCl/Akt/eNOS pathway.

Redox Biol 2021 Jun 6;45:102031. Epub 2021 Jun 6.

Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, 41008, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. Electronic address:

Reactive oxygen species (ROS) derived from NADPH oxidases (NOX) plays an essential role in advanced glycation end products (AGEs)-induced diabetic vascular endothelial dysfunction. Peroxidasin (PXDN, VPO1) is one member of peroxidases family that catalyzes hydrogen peroxide (HO) to hypochlorous acid (HOCl). This present study aimed to elucidate the role of PXDN in promoting vascular endothelial dysfunction induced by AGEs in diabetes mellitus. Read More

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Structural Changes beyond the EF-Hand Contribute to Apparent Calcium Binding Affinities: Insights from Parvalbumins.

J Phys Chem B 2021 Jun 11. Epub 2021 Jun 11.

Stritch School of Medicine, Maywood, Illinois 60153, United States.

Members of the parvalbumin (PV) family of calcium (Ca) binding proteins (CBPs) share a relatively high level of sequence similarity. However, their Ca affinities and selectivities against competing ions like Mg can widely vary. We conducted molecular dynamics simulations of several α-parvalbumin (αPV) constructs with micromolar to nanomolar Ca affinities to identify structural and dynamic features that contribute to their binding of ions. Read More

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Deep Desulfurization with Record SO Adsorption on the Metal-Organic Frameworks.

J Am Chem Soc 2021 Jun 11;143(24):9040-9047. Epub 2021 Jun 11.

Key Laboratory of Biomass Chemical Engineering of ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, 38 Zheda Road, Hangzhou 310027, P. R. China.

Selective elimination of sulfur dioxide is significant in flue gas desulfurization and natural gas purification, yet developing adsorbents with high capture capacity especially at low partial pressure as well as excellent cycling stability remains a challenge. Herein, a family of isostructural gallate-based MOFs with abundant hydrogen bond donors decorating the pore channel was reported for selective recognition and dense packing of sulfur dioxide via multiple hydrogen bonding interactions. Multiple O···H-O hydrogen bonds and O···H-C hydrogen bonds guarantee SO molecules are firmly grasped within the framework, and appropriate pore apertures afford dense packing of SO with high uptake and density up to 1. Read More

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Signal-on photoelectrochemical immunoassay mediated by the etching reaction of oxygen/phosphorus co-doped g-CN/AgBr/MnO nanohybrids.

Anal Chim Acta 2021 Aug 24;1171:338680. Epub 2021 May 24.

Key Laboratory for Analytical Science of Food Safety and Biology (MOE & Fujian Province), State Key Laboratory of Photocatalysis on Energy and Environment, Department of Chemistry, Fuzhou University, Fuzhou, 350108, People's Republic of China. Electronic address:

We designed a signal-on photoelectrochemical (PEC) immunoassay for the sensitive monitoring of prostate-specific antigen (PSA) based on the etching reaction of hydrogen peroxide (HO) toward oxygen/phosphorus co-doped graphitic CN/AgBr/MnO nanosheets (OP-g-CN/AgBr/MnO). Initially, glucose oxidase (GO)-labeled detection antibodies were introduced into the capture antibody-coated microplate with a sandwich-type immunoreaction in the presence of PSA. Then, the as-generated HO from the decomposition of glucose by GO etched the manganese dioxide (MnO) nanosheets into manganese ions (Mn), thereby causing the exposure of the underlying OP-g-CN/AgBr. Read More

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New Insights into the Critical Importance of Intratubular Na/H Exchanger 3 and Its Potential Therapeutic Implications in Hypertension.

Curr Hypertens Rep 2021 Jun 10;23(6):34. Epub 2021 Jun 10.

Tulane Hypertension and Renal Center of Excellence and Department of Physiology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, USA.

Purpose Of Review: The sodium (Na) and hydrogen (H) exchanger 3 (NHE3), known as solute carrier family 9 member 3 (SLC9A3), mediates active transcellular Na and bicarbonate reabsorption in the small intestine of the gut and proximal tubules of the kidney. The purpose of this article is to review and discuss recent findings on the critical roles of intestinal and proximal tubule NHE3 in maintaining basal blood pressure (BP) homeostasis and their potential therapeutic implications in the development of angiotensin II (Ang II)-dependent hypertension.

Recent Findings: Recently, our and other laboratories have generated or used novel genetically modified mouse models with whole-body, kidney-specific, or proximal tubule-specific deletion of NHE3 to determine the critical roles and underlying mechanisms of NHE3 in maintaining basal BP homeostasis and the development of Ang II-induced hypertension at the whole-body, kidney, or proximal tubule levels. Read More

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