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Association between Vitamin D and Risk of Stroke: A PRISMA-Compliant Systematic Review and Meta-Analysis.

Eur Neurol 2021 Jul 29:1-10. Epub 2021 Jul 29.

Department of Neurology, Fourth People's Hospital of Zhenjiang, Zhenjiang, China.

Background: Previous studies have shown inconsistent results for associations between vitamin D and risk of stroke. We gathered the existing published articles and conducted this meta-analysis with the aim to explore the association between vitamin D and risk of stroke.

Methods: We searched for articles exploring the association between vitamin D and risk of stroke and published before April 2021 in the following databases: PubMed, Web of Science, MEDLINE, EMBASE, and Google Scholar. Read More

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Determination of six parabens in biological samples by magnetic solid-phase extraction with magnetic mesoporous carbon adsorbent and UHPLC-MS/MS.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Jul 3;1179:122817. Epub 2021 Jul 3.

School of Biology and Chemistry, Key Laboratory of Chemical Synthesis and Environmental Pollution Control-Remediation Technology of Guizhou Province, Xingyi Normal University for Nationalities, Xingyi 562400, PR China. Electronic address:

Although parabens are useful due to their antiseptic properties, their widespread use has caused concerns regarding their potential toxicological effects. In this study, a novel magnetic solid-phase extraction combined with ultra-high-performance liquid chromatography-tandem mass spectrometry (MSPE-UHPLC-MS/MS) was developed, based on ordered magnetic mesoporous carbon (MMC), for paraben analysis. The MMC was prepared by soft-template synthesis, with a unique pore structure and a highly specific surface response, indicating potential as an excellent adsorbent. Read More

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Adaptive authority allocation-based driver-automation shared control for autonomous vehicles.

Accid Anal Prev 2021 Jul 26;160:106301. Epub 2021 Jul 26.

School of Automotive Engineering, Dalian University of Technology, Dalian 116024, China.

To avoid crashes caused by driver error in avoiding obstacles, a driver-centered steering assist controller with an adaptive authority allocation system is proposed for cooperative control purposes. To begin with, a concept of space collision risk (SCR) is introduced creatively for assessing the vehicle's safety status in which the relative distance and the relative angle between the vehicle and the obstacle are taken into consideration. Meanwhile, the SCR-based authority allocation system is addressed to allocate steering authorities between the human driver and the assist controller adaptively to reduce SCR to zero as soon as possible. Read More

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Children's inhibitory control abilities in the presence of rewards are related to weight status and eating in the absence of hunger.

Appetite 2021 Jul 26:105610. Epub 2021 Jul 26.

Department of Nutritional Sciences, The Pennsylvania State University, PA, USA.

The Reflective-Impulsive Dual Processes Model suggests that overeating occurs when the temptation to consume food overrides inhibitory control processes. However, how rewards interact with inhibitory control and their relation to children's weight status and food intake is not understood. Here, 7-to-11-year-old children (n = 66; 32 overweight/obese) completed two versions (baseline [i. Read More

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Cavitation modulated inflammatory response following focused ultrasound blood-brain barrier opening.

J Control Release 2021 Jul 26. Epub 2021 Jul 26.

Department of Biomedical Engineering, Columbia University, New York, NY, USA; Department of Radiology, Columbia University, New York, NY, USA. Electronic address:

Focused ultrasound (FUS) in combination with systemically injected microbubbles can be used to non-invasively open the blood-brain barrier (BBB) in targeted regions for a variety of therapeutic applications. Over the past two decades, preclinical research into the safety and efficacy of FUS-induced BBB opening has proven this technique to be transient and efficacious, propelling FUS-induced BBB opening into several clinical trials in recent years. However, as clinical trials further progress, the neuroinflammatory response to FUS-induced BBB opening needs to be better understood. Read More

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IGF-1 TMJ Injections Enhance Mandibular Growth and Bone Quality in Juvenile Rats.

Orthod Craniofac Res 2021 Jul 29. Epub 2021 Jul 29.

Division of Orthodontics, University of California San Francisco, California, USA.

Objectives: Dentofacial orthopedic treatment of mandibular hypoplasia has unpredictable skeletal outcomes. Although several biomodulators including insulin-like growth factor 1 (IGF-1) are known to contribute to chondrocyte proliferation, their efficacy in modulating mandibular growth has not been validated. The aim of this study was to determine the effect of locally delivered IGF-1 on mandibular growth and condylar bone quality/quantity in juvenile rats. Read More

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Heparan sulfate proteoglycan molecules, syndecan and perlecan, have distinct roles in the maintenance of Drosophila germline stem cells.

Dev Growth Differ 2021 Jul 29. Epub 2021 Jul 29.

Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8577, Japan.

The Drosophila female germline stem cell (GSC) niche provides an excellent model for understanding the stem cell niche in vivo. The GSC niche is composed of stromal cells that provide growth factors for the maintenance of GSCs and the associated extracellular matrix (ECM). Although the function of stromal cells/growth factors has been well-studied, the function of the ECM in the GSC niche is largely unknown. Read More

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Breast Cancer Screening Among Childhood Cancer Survivors Treated Without Chest Radiation: Clinical Benefits and Cost-Effectiveness.

J Natl Cancer Inst 2021 Jul 29. Epub 2021 Jul 29.

Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA.

Background: Early initiation of breast cancer screening is recommended for high-risk women, including survivors of childhood cancer treated with chest radiation. Recent studies suggest that female survivors of childhood leukemia or sarcoma treated without chest radiation are also at elevated early onset breast cancer risk. However, the potential clinical benefits and cost-effectiveness of early breast cancer screening among these women are uncertain. Read More

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Pre-release dietary supplements of methoprene and raspberry ketone increase field abundance of sterile Queensland fruit flies (Diptera: Tephritidae).

J Econ Entomol 2021 Jul 29. Epub 2021 Jul 29.

Applied BioSciences, Macquarie University, Sydney, Australia.

The sterile insect technique (SIT) is a sustainable pest management tool based on the release of millions of sterile insects that suppress reproduction in targeted populations. Success of SIT depends on survival, maturation, dispersal, and mating of released sterile insects. Laboratory and field cage studies have demonstrated that dietary supplements of methoprene and raspberry ketone (RK) promote sexual maturation of adult Queensland fruit fly, Bactrocera tryoni (Froggatt), and may hence shorten the delay between release and maturity in the field. Read More

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Host tropism determination by convergent evolution of immunological evasion in the Lyme disease system.

PLoS Pathog 2021 Jul 29;17(7):e1009801. Epub 2021 Jul 29.

Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, United States of America.

Pathogens possess the ability to adapt and survive in some host species but not in others-an ecological trait known as host tropism. Transmitted through ticks and carried mainly by mammals and birds, the Lyme disease (LD) bacterium is a well-suited model to study such tropism. Three main causative agents of LD, Borrelia burgdorferi, B. Read More

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Experiences of people with opioid use disorder during the COVID-19 pandemic: A qualitative study.

PLoS One 2021 29;16(7):e0255396. Epub 2021 Jul 29.

Department of Emergency Medicine, St Paul's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.

Aim: To capture pandemic experiences of people with opioid use disorder (OUD) to better inform the programs that serve them.

Design: We designed, conducted, and analyzed semi-structured qualitative interviews using grounded theory. We conducted interviews until theme saturation was reached and we iteratively developed a codebook of emerging themes. Read More

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Impact of a family history of cardiovascular disease on prevalence, awareness, treatment, control of dyslipidemia, and healthy behaviors: Findings from the Korea National Health and Nutrition Examination Survey.

PLoS One 2021 29;16(7):e0254907. Epub 2021 Jul 29.

Department of Family Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: Family history (FH) is one of important risk factors for cardiovascular disease (CVD). However, little is known about its impact on dyslipidemia prevalence and management status. Thus, we aimed to investigate the impact of FH of CVD on dyslipidemia prevalence, awareness, treatment, control, and healthy behaviors in Korean adults. Read More

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Pregnancy denial: A complex symptom with life context as a trigger?: A prospective case-control study.

BJOG 2021 Jul 29. Epub 2021 Jul 29.

Service de Psychothérapie de l'enfant et de l'adolescent, Pôle Femme-Parents-Enfant, Centre Hospitalier Universitaire, Université Reims Champagne Ardenne (URCA, Av du Gl Koenig, 51092, Reims Cedex, France.

Objective: To identify risk factors for a woman to experience pregnancy denial.

Design, Setting And Population: A French multicentric prospective case-control study with 71 mother-infant dyads having experienced a pregnancy denial versus a control group of 71 dyads.

Methods: Data were collected within the week after delivery through an observational leaflet and two psychiatric scales (MINI and QSSP). Read More

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Provider Perspectives on Navigating Relationship Challenges in Assisting HIV-Affected Couples to Meet Their Reproductive Goals: Lessons Learned from a Safer Conception Counseling Intervention in Uganda.

AIDS Behav 2021 Jul 29. Epub 2021 Jul 29.

Schools of Medicine and Pharmacy, Childrens Mercy Research Institute, University of Missouri, Kansas, MO, USA.

In Uganda, 60% of HIV-affected couples are serodiscordant, many of whom want children. There is a need to assess their reproductive intentions and provide appropriate services that limit transmission risks while meeting reproductive goals. Our Choice intervention engaged male and female HIV-infected clients and their partners in safer conception counseling (SCC) or family planning based on their childbearing decision. Read More

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Cancer Clinical Trial Participation at the 1-Year Anniversary of the Outbreak of the COVID-19 Pandemic.

JAMA Netw Open 2021 Jul 1;4(7):e2118433. Epub 2021 Jul 1.

SWOG Cancer Research Network Group Chair's Office, Portland, Oregon.

Importance: During the initial outbreak of the COVID-19 pandemic, cancer clinical trial participation decreased precipitously. Given the continued pandemic-especially the severe wave of new cases and deaths in winter 2020 to 2021-a vital question is whether trial enrollments have remained low or even worsened.

Objective: To examine the experience of cancer clinical trial enrollment 1 year after the COVID-19 outbreak. Read More

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Metformin in Combination With Chemoradiotherapy in Locally Advanced Non-Small Cell Lung Cancer: The OCOG-ALMERA Randomized Clinical Trial.

JAMA Oncol 2021 Jul 29. Epub 2021 Jul 29.

Juravinski Cancer Center, Hamilton Health Science, Hamilton, Ontario, Canada.

Importance: Unresected locally advanced non-small cell lung cancer (LA-NSCLC) shows poor survival outcomes even after aggressive concurrent chemoradiotherapy. Whether metformin, a diabetes agent that inhibits the mitochondria oxidative phosphorylation chain, could improve radiotherapy and chemotherapy response in LA-NSCLC remains to be studied.

Objective: To examine whether metformin, given concurrently with chemoradiotherapy and as consolidation treatment, could improve outcomes in patients with LA-NSCLC. Read More

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Bioturbation frequency alters methane emissions from reservoir sediments.

Sci Total Environ 2021 May 26;789:148033. Epub 2021 May 26.

United States Environmental Protection Agency, Office of Research and Development, Cincinnati, OH 45268, United States of America. Electronic address:

Inland aquatic systems are major global contributors to the atmospheric carbon budget through greenhouse gas (GHG) emissions, although the amount and form of carbon released varies widely across and within systems. Bioturbation of aquatic sediments can impact biogeochemical conditions and physically release sediment-bound bubbles containing GHGs, but variation in the frequency of such disturbance may modify the rate and composition of resulting GHG emissions. We hypothesized that an intermediate bioturbation frequency would result in the greatest methane (CH) releases due to mechanical release of trapped bubbles, while frequent disturbance would result in greater diffusive carbon dioxide (CO) releases relative to CH, due to increased aeration of the sediment. Read More

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Associations between home renovation and asthma, allergic rhinitis, and eczema among preschool children in Wuhan, China.

Int J Environ Health Res 2021 Jul 29:1-11. Epub 2021 Jul 29.

Department of Occupational and Environmental Health, School of Public Health, Wuhan University of Science and Technology, Wuhan, Hubei, China.

To investigate the potential associations between household renovation and allergic diseases among preschool children in Wuhan, we conducted a large cross-sectional questionnaire survey among 9455 preschool children aged 3-6 years in Wuhan during November to December 2019. Data on demographics, health status, and home decoration conditions were analysed based on a questionnaire. Compared with tiles/stone/cement floor covering, the use of composite floor significantly increased the risk of diagnosed rhinitis and eczema among children (rhinitis: AOR, 95% CI: 1. Read More

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Complete Genome Sequence of Pseudomonas Phage Zikora.

Microbiol Resour Announc 2021 Jul 29;10(30):e0048921. Epub 2021 Jul 29.

Centre for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital, Lausanne, Switzerland.

Pseudomonas aeruginosa is a major pathogen in humans and other animals, frequently harboring mechanisms of resistance to commonly used antimicrobials. Here, we describe the isolation of Pseudomonas bacteriophage Zikora. The full 65,837-bp genome was annotated and demonstrates similarity to phages, making Zikora a new member of this genus of the family. Read More

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Tongue muscle contractile, fatigue and fiber type properties in rats.

J Appl Physiol (1985) 2021 Jul 29. Epub 2021 Jul 29.

Department of Physiology and Biomedical Engineering, grid.66875.3aMayo Clinic, Rochester, MN, United States.

The intrinsic and extrinsic tongue muscles manipulate the position and shape of the tongue and are activated during many oral and respiratory behaviors. In the present study in 6-month-old Fischer 344 rats, we examined mechanical and fatigue properties, of tongue muscles in relation to their fiber type composition. In an ex vivo preparation, isometric force and fatigue was assessed by direct muscle stimulation. Read More

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Tailored motivational interviewing (TMI): Translating basic science in skills acquisition into a behavioral intervention to improve community health worker motivational interviewing competence for youth living with HIV.

Health Psychol 2021 Jul 29. Epub 2021 Jul 29.

Department of Pediatrics, Section of Adolescent Medicine, Indiana University School of Medicine.

Interventions to promote evidence-based practices are particularly needed for paraprofessional staff working with minority youth with HIV who have higher rates of HIV infection but lower rates of linkage and retention in care compared to older adults. Utilizing the ORBIT model for behavioral intervention development, we defined and refined a behavioral intervention for providers, Tailored Motivational Interviewing (TMI), to improve provider competence in previous studies (Phase 1a and 1b). The current study focuses on ORBIT Phase 2a-proof of concept. Read More

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Motor control and learning in individuals with early-treated phenylketonuria.

Neuropsychology 2021 Jul 29. Epub 2021 Jul 29.

Department of Psychological Sciences.

Objective: Although past studies have documented motor control impairments in individuals with early-treated phenylketonuria (ETPKU), much less is known regarding motor learning in ETPKU. The goal of the present study was to advance our understanding on this front.

Method: We isolated and examined motor kinematics associated with the learning of a rapid aimed limb movement in a sample of 40 individuals (13-34 years of age) with ETPKU and a matched comparison group of 40 individuals without phenylketonuria (PKU). Read More

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The effects of mood and cognition on daily functioning and quality of life in older people living with HIV and people with Parkinson's disease.

Neuropsychology 2021 Jul 29. Epub 2021 Jul 29.

Neuroscience Program.

Objective: In light of the increased longevity of people living with HIV infection (PLWH) undergoing antiretroviral therapy (ART), the present study aimed to determine the effects of mood disturbances alongside cognitive and motor symptoms on activities of daily living (ADLs) and quality of life (QOL) in older PLWH in comparison to an aging control sample without notable medical history (CTL) and individuals with Parkinson's disease (PD).

Method: Forty-one PLWH, 41 individuals with PD, and 37 CTL, aged 45-79 years, underwent neuropsychological, psychological, and neurological assessment including depressive and anxiety symptoms, physical (ADL-p) and instrumental (ADL-i) daily activities, Unified Parkinson's Disease Rating Scale motor ADLs (ADL-UPDRS-II), QOL, and cognitive and motor functions. Hierarchical regression analyses assessed the relative contribution of predictors including demographics, disease-related factors, comorbid conditions, and mood-related factors for ADL and QOL scales. Read More

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Adolescents' daily executive function: Methodological considerations, daily variation, and associations with daily experiences.

Psychol Assess 2021 Jul 29. Epub 2021 Jul 29.

Department of Psychology.

Research has rarely considered within-person variability in executive function. Using a web-based program, this study investigated end-of-day executive function for 2 weeks among 178 racially/ethnically diverse adolescents ( = 14.53). Read More

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Accumulation of PFAS by livestock - determination of transfer factors from water to serum for cattle and sheep in Australia.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2021 Jul 29:1-17. Epub 2021 Jul 29.

Agriculture Victoria, Department of Economic Development, Jobs, Transport and Resources (Now Known as the Department of Jobs, Precincts and Regions), Hamilton, Australia.

In this study accumulation has been determined of several per- and polyfluoroalkyl substances (PFAS) from ingested water to steady state serum concentration for adult beef cattle and sheep raised on a hobby farm impacted by PFAS contamination. PFAS concentrations in stock water were stable for more than a year, they were non-measurable in grass but present at very low levels in soil which equated to just 1% of the intake from water. Prior to quantifying PFAS in cattle serum there had been no breeding for 18 months. Read More

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Association of bilateral oophorectomy and menopause hormone therapy with mild cognitive impairment: the REDLINC X study.

Climacteric 2021 Jul 29:1-8. Epub 2021 Jul 29.

Instituto de Investigación e Innovación en Salud Integral, Facultad de Ciencias Médicas, Universidad Católica de Santiago de Guayaquil, Guayaquil, Ecuador.

Background: Dementia is a major public health problem. Estrogen is a regulator of the central nervous system and its deficit could be involved in cognitive decline in older women.

Objective: This study aimed to evaluate the association of bilateral oophorectomy, menopause hormone therapy (MHT) and other factors on mild cognitive impairment (MCI). Read More

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[Animal Experimental Study of the Role of Menthol and Cineole, Two Tobacco Additives, on Nicotine Dependence].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Jul;52(4):649-654

Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.

Objective: To establish a nicotine intravenous self-administration rat model, and to examine, with this model, the effects of two flavoring additives, menthol and cineole, on nicotine dependence.

Methods: Thirty male Sprague-Dawley (SD) rats were included in the study. After jugular venous catheterization was performed, fixed concentration of nicotine was administered in order to train the rats and establish the rat model of intravenous self-administration groups, receiving intraperitoneal injection of menthol, cineole, and dimethyl sulfoxide (DMSO), the vehicle that was used for the control group. Read More

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Is Mean Platelet Volume Related to Disease Activity in Systemic Lupus Erythematosus?

Int J Clin Pract 2021 Jul 29:e14676. Epub 2021 Jul 29.

Department of Hematology, Lokman Hekim hospital, Ankara, Turkey.

Systemic lupus erythematosus (SLE) is a connective tissue disease that is chronic, recurrent, and multisystem with unknown etiology. There is still no single biomarker that is pathognomonic for the disease. We know that platelets are the main part of hemostasis and thrombosis. Read More

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