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Expression of long non-coding RNA LUCAT1 in patients with chronic obstructive pulmonary disease and its potential functions in regulating cigarette smoke extract-induced 16HBE cell proliferation and apoptosis.

J Clin Lab Anal 2021 Jun 14:e23823. Epub 2021 Jun 14.

Department of Blood Transfusion, The First Affiliated Hospital of Soochow University, Suzhou, China.

Background: Chronic obstructive pulmonary disease (COPD), characterized by persistent airflow limitation, was a disease mediated by a combination of inflammatory factors, immune cells, and immune mediators. COPD was an inflammatory and autoimmune disease involving T-lymphocytes triggered by cigarette smoke and other factors that progressively affected the bronchi, lung parenchyma, and pulmonary blood vessels. LncRNAs were reported to be implicated in COPD pathogenesis and development. Read More

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The Relationship of Aging and Smoking with Rotator Cuff Disease: A Systematic Review and Meta-Analysis.

Am J Phys Med Rehabil 2021 Jun 12. Epub 2021 Jun 12.

Vanderbilt University School of Medicine, Nashville, TN Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN Division of Quantitative Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN University of Rochester School of Medicine, Rochester, NY Department of Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN Departments of Physical Medicine and Rehabilitation, Orthopaedics, and Population & Data Sciences, University of Texas Southwestern.

Objective: Despite rotator cuff disease being one of the most common causes of shoulder pain, its pathogenesis and biology are poorly understood. In this study, we synthesized evidence from studies reporting associations for aging and smoking status in relation to rotator cuff disease.

Design: A systematic review was performed using multiple databases (PubMed, Embase, Cochrane, CINAHL, and Science Direct). Read More

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Life-time tobacco consumption and oral cancer among citizens of a high incidence metropolis.

J Pak Med Assoc 2021 Jun;71(6):1588-1591

Department of Pathology, Ziauddin University, Clifton Campus, Karachi, Pakistan.

Objective: To analyse dose-response relationship between the common risk factor of tobacco consumption and oral lesions like squamous cell carcinoma and pre-cancerous lesions.

Methods: The cross-sectional case-control study was conducted at Ziauddin University, Karachi from 2011 to 2016, and comprised histologically-confirmed cases of oral squamous cell carcinoma in group A, clinically-diagnosed oral pre-cancerous lesions in group B, and habit-matched controls in group C. The subjects were enrolled from 2011 to 2016. Read More

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Increased myofibroblasts in the small airways, and relationship to remodelling and functional changes in smokers and COPD patients: potential role of epithelial-mesenchymal transition.

ERJ Open Res 2021 Apr 7;7(2). Epub 2021 Jun 7.

Respiratory Translational Research Group, Dept of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Australia.

Introduction: Previous reports have shown epithelial-mesenchymal transition (EMT) as an active process that contributes to small airway fibrotic pathology. Myofibroblasts are highly active pro-fibrotic cells that secrete excessive and altered extracellular matrix (ECM). Here we relate small airway myofibroblast presence with airway remodelling, physiology and EMT activity in smokers and COPD patients. Read More

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[Preliminary study on the relationship between different blood glucose levels and periodontitis in patients with diabetes mellitus type 2].

Zhonghua Kou Qiang Yi Xue Za Zhi 2021 Jun;56(6):517-524

Department of Periodontology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine & College of Stomatology, Shanghai Jiao Tong University & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Shanghai Key Laboratory of Stomatology, Shanghai 200011, China.

To determine the correlation between the diabetes mellitus control and periodontitis. This study was a cross-sectional survey using stratified system sampling model design. The target population was the patients with diabetes investigated from May to July 2018 in Huangpu District of Shanghai. Read More

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Bronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking status.

World Allergy Organ J 2021 May 18;14(5):100544. Epub 2021 May 18.

Department of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden.

Background: Fractional exhaled nitric oxide (FeNO) is a marker of type-2 inflammation used both to support diagnosis of asthma and follow up asthma patients. The associations of FeNO with lung function decline and bronchodilator (BD) response have been studied only scarcely in large populations.

Objectives: To study the association between FeNO and a) retrospective lung function decline over 20 years, and b) lung function response to BD among asthmatic subjects compared with non-asthmatic subjects and with regards to current smoking and sex. Read More

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The Relationship Between Chemokine and Chemokine Receptor Genes Polymorphisms and Chronic Obstructive Pulmonary Disease Susceptibility in Tatar Population from Russia: A Case Control Study.

Biochem Genet 2021 Jun 6. Epub 2021 Jun 6.

Department of Biology, Bashkir State Medical University, Lenina Str, 3, Ufa, 450008, Russian Federation.

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease affecting primarily distal respiratory pathways and lung parenchyma. This study aimed to determine possible genetic association of chemokine and chemokine receptor genes polymorphisms with COPD in a Tatar population from Russia. SNPs of CCL20, CCR6, CXCL8, CXCR1, CXCR2, CCL8, CCL23, CCR2, and CX3CL1 genes and their gene-gene interactions were analyzed for association with COPD in cohort of 601 patients and 617 controls. Read More

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Exposure to waterpipe smoke and blood heavy metal concentrations.

Environ Res 2021 Jun 4;200:111460. Epub 2021 Jun 4.

Non-Communicable Diseases Research Center, Department of Environmental Health, School of Public Health, Sabzevar University of Medical Sciences, Sabzevar, Iran. Electronic address:

Waterpipe (WP) smoking is a global phenomenon, with the most consumers in Middle East countries and China. Heavy metals exposure related to WP smoking has been associated with many adverse health effects. However, the association of lifestyle factors and smoking habits with blood heavy metals concentration in WP smokers is unclear yet. Read More

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The risk of colorectal neoplasm in ex- and never-smokers according to urinary cotinine level.

Medicine (Baltimore) 2021 Jun;100(22):e25842

Center for Colorectal Cancer.

Abstract: To investigate the relationship between urinary cotinine and colorectal neoplasm (CRN).The participants in the health screening cohort of the National Cancer Center who underwent screening colonoscopy between June 2007 and December 2009 were included. A total of 8121 subjects who underwent urinary cotinine measurement within 14 days from the index colonoscopy were included. Read More

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Cigarette smoking frequency, quantity, dependence, and quit intentions during adolescence: Comparison of menthol and non-menthol smokers (National Youth Tobacco Survey 2017-2020).

Addict Behav 2021 Oct 15;121:106986. Epub 2021 May 15.

Department of Psychiatry and Behavioral Neuroscience, Addiction Sciences Division, University of Cincinnati College of Medicine, United States.

Background: Use of menthol cigarettes is linked to sustained cigarette smoking adults. However, the relationship between menthol and smoking profile has not been thoroughly explored in adolescent cigarette smokers. This study examines the relationship between use of menthol cigarette and smoking frequency (i. Read More

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October 2021

Relationship between health literacy in substance use and alcohol consumption and tobacco use among adolescents, Northeast Thailand.

J Educ Health Promot 2021 31;10:120. Epub 2021 Mar 31.

Department of Public Health, Faculty of Public Health, Mahasarakham University, Mahasarakham, Thailand.

Background: Health literacy (HL) is an important role-play in health risk behaviors such as alcohol drinking and smoking. Inadequate HL in substance use (HLSU) is a barrier to reduce the risk of alcohol and tobacco use. This study aims to investigate the association of HLSU with alcohol consumption and tobacco use among Thai adolescents. Read More

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Smoking cessation, weight gain and risk of cardiovascular disease.

Heart 2021 Jun 2. Epub 2021 Jun 2.

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.

Objective: To examine whether the relationship between smoking cessation and risk of cardiovascular disease (CVD) was modified by weight gain.

Methods: A total of 69 910 participants (29 650 men and 46 260 women) aged 45-74 years were grouped into six groups by smoking status in the first and 5-year surveys: sustained smokers, recent quitters according to postcessation weight gain (no weight gain, 0.1-5. Read More

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Relationship between cigarette smoking and hearing loss in China: A cross-sectional study in Zhejiang province.

Tob Induc Dis 2021 26;19:40. Epub 2021 May 26.

Department of Medicine, Hangzhou Normal University, Hangzhou City, China.

Introduction: Hearing loss and cigarette smoking are major challenges that affect public health in China. Revealing the effect of smoking on hearing loss in the Chinese general population is critical for hearing health protection. We investigated the relationship between smoking status and hearing loss in China, especially in stratified sex and age groups. Read More

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Smoking and COVID-19 Infection and Related Mortality: A Prospective Cohort Analysis of UK Biobank Data.

Clin Epidemiol 2021 25;13:357-365. Epub 2021 May 25.

Department of Primary Care and Population Health, UCL, London, NW3 2PF, UK.

Background: Several papers have shown contradictory evidence about the relationship between smoking and COVID-19-related deaths. There is little evidence about smoking and risk of infection. We aim to examine association between smoking and COVID-19 infection and subsequent mortality. Read More

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Factors Associated with Gender-Based Violence Perpetration by Male High School Students in Eastern Ethiopia.

J Interpers Violence 2021 Jun 2:8862605211021978. Epub 2021 Jun 2.

Centre For Women's Health Research, Faculty of Health and Medicine, University of Newcastle, Australia.

Gender-based violence (GBV) perpetration is a severe problem among youths in schools and the community at large. As most studies focused on adults, this study aimed to investigate factors associated with GBV by male high school students in eastern Ethiopia. An institutional based cross-sectional survey was conducted with 1,109 male students aged 15-24 years in eastern Ethiopia in December 2018 using self-administered WHO Multi-Country Study on Women's Health and Life Events and UN Multi-Country study on perpetration. Read More

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Relation between smoking and visual processing in bipolar disorder.

J Addict Dis 2021 Jun 2:1-7. Epub 2021 Jun 2.

Department of Psychology, Federal University of Paraiba, Joao Pessoa, Brazil.

Background: Although some studies have shown impairments in patients with bipolar disorder (BPD) and in smokers, it is unclear how these two factors work together. Our premise was that chronic smoking affects color discrimination and this is more pronounced in BPD. Our main purpose was to investigate the influence of smoking and BPD on color discrimination. Read More

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Examination of Correlates of OUD Outcomes in Young Adults: Secondary Analysis From the XBOT Trial.

Am J Addict 2021 Jun 1. Epub 2021 Jun 1.

Department of Psychiatry, Columbia University Irving Medical Center, Columbia University Medical Center, New York State Psychiatric Institute, New York, New York.

Background And Objectives: Opioid use disorder (OUD) treatment outcomes are poorer for young adults than older adults. Developmental differences are broadly implicated, but particular vulnerability factor interactions are poorly understood. This study sought to identify moderators of OUD relapse between age groups. Read More

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When primary care providers and smokers meet: a systematic review and metasynthesis.

NPJ Prim Care Respir Med 2021 Jun 1;31(1):31. Epub 2021 Jun 1.

Université de Paris, ECEVE UMR 1123, Inserm, Paris, France.

Primary Care Providers (PCPs) often deal with patients on daily clinical practice without knowing anything about their smoking status and willingness to quit. The aim of this metasynthesis is to explore the PCPs and patients who are smokers perspectives regarding the issue of smoking cessation within primary care settings. It relies on the model of meta-ethnography and follows thematic synthesis procedures. Read More

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Tobacco smoking and HIV-related immunologic and virologic response among individuals of the Canadian HIV Observational Cohort (CANOC).

AIDS Care 2021 Jun 1:1-10. Epub 2021 Jun 1.

British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.

We assessed the relationship between tobacco smoking and immunologic and virologic response among people living with HIV (PLWH) initiating combination antiretroviral therapy (cART) in the Canadian HIV Observational Cohort (CANOC). Positive immunologic and virologic response, respectively, were defined as ≥50 cells/mm CD4 count increase (CD4+) and viral suppression ≤50 copies/mL (VL+) within 6 months of cART initiation. Using multinomial regression, we examined the relationship between smoking, immunologic, and virologic response category. Read More

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Importance of Genetic Polymorphisms in and Genes in Metals Homeostasis and Their Relationship with the Risk of Acute Pancreatitis Occurrence in Smokers-Preliminary Findings.

Int J Mol Sci 2021 May 27;22(11). Epub 2021 May 27.

Department of Biomedical and Environmental Analyses, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland.

This study was aimed at evaluating the changes in metallothionein (MT) concentration in the blood of patients with acute pancreatitis (AP) and healthy subjects, taking into account the extracellular (plasma) and intracellular (erythrocyte lysate) compartments. The impact of single-nucleotide polymorphisms (SNPs) in the (rs11640851), (rs964372) and (rs10636) genes on MT concentration and their association with the concentration of metals (Cu, Zn, Cd) and ceruloplasmin as Cu-related proteins were analyzed. The concentration of a high-sensitivity C-reactive protein (hs-CRP) and IL-6 as markers of inflammation, and malonyldialdehyde (MDA), superoxide dismutase (SODs) activity and the value of total antioxidant capacity (TAC) as parameters describing the pro/antioxidative balance were also assessed. Read More

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Population Pharmacokinetics and Exposure-Response Analyses of Varenicline in Adolescent Smokers.

CPT Pharmacometrics Syst Pharmacol 2021 Jun 1. Epub 2021 Jun 1.

Pfizer Inc, Groton, Connecticut, USA.

Varenicline is an approved smoking cessation aid in adults. Population pharmacokinetics (popPK) and exposure-response (ER) (continuous abstinence rates [CAR] weeks 9-12 and nausea/vomiting incidence) for varenicline in adolescent smokers were characterized using data from two phase 1 and one phase 4 studies. A one-compartment popPK model with first-order absorption and elimination adequately fitted the observed data. Read More

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Statin adherence and health outcomes after st-elevation myocardial infarction: 1-year follow-up study.

A Padilla López

Rev Clin Esp (Barc) 2021 Jun-Jul;221(6):331-340. Epub 2021 Apr 25.

Servicio de Farmacia de Área, Departamento de Salud de Valencia Clínico-Malvarrosa, Valencia, Spain. Electronic address:

Background And Objectives: There is deficient control of dyslipidaemia after ST-elevation myocardial infarction (STEMI) despite high rates of statin prescription. The aim of this study was to estimate the rate of statin treatment adherence after a first type 1 STEMI episode, the factors that determine the adherence and its impact on cardiovascular outcomes during the first year of progression.

Design: We conducted an observational retrospective study with a cohort of patients hospitalised between 2008 and 2013, with an active statin prescription during the first year of follow-up. Read More

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Intraosseous Regional Administration of Antibiotic Prophylaxis in Total Knee Arthroplasty.

JBJS Essent Surg Tech 2020 Oct-Dec;10(4). Epub 2020 Dec 24.

Department of Orthopaedic Surgery, University of Auckland, Auckland, New Zealand.

Background: Periprosthetic joint infection (PJI) is a devastating complication following total knee arthroplasty (TKA), and perioperative antibiotics are commonly administered to try to mitigate the chance of infection. Intraosseous regional administration (IORA) of prophylactic antibiotics during TKA is a method of antibiotic delivery that has been shown to achieve markedly higher tissue concentrations at much lower doses. Other advantages include ease of administration, ability to time the antibiotic delivery with the surgical start time for maximal effectiveness, and less systemic side effects. Read More

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December 2020

Association of smoking status and recurrence of non-muscle invasive bladder cancer among patients managed with blue light cystoscopy.

Urol Oncol 2021 May 27. Epub 2021 May 27.

Department of Urology, New York University Grossman School of Medicine, New York, NY.

Purpose: Smoking has a strong causal association with bladder cancer but the relationship with recurrence is not well established. We sought to assess the association of smoking status on recurrence of non-muscle invasive bladder cancer (NMIBC) in a contemporary cohort of patients with predominantly high-risk, recurrent NMIBC managed with photodynamic enhanced cystoscopy.

Materials And Methods: We performed a retrospective study of patients with NMIBC included in a multi-institutional registry. Read More

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[A dose-response meta-analysis on the relationship between daily tea intake and cardiovascular mortality based on the GRADE system].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 May;49(5):496-502

Department of Pharmacy, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To explore the relationship between daily tea intake and cardiovascular disease (CVD) mortality. PubMed, EMbase, The Cochrane, Chinese Biomedical Literature Database, CNKI, and Wanfang Database were searched to collect research on tea intake and CVD mortality. The search period was from the establishment of the database to June 2020. Read More

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Importance of active and passive smoking as one of the risk factors for female sexual dysfunction in Chinese women.

Gynecol Endocrinol 2021 Jun 24;37(6):541-545. Epub 2021 May 24.

Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.

Objective: To assess possible risk factors for female sexual dysfunction (FSD), aiming especially at smoking in China.

Methods: Female Sexual Function Index (FSFI) for assessing FSD; 621 women (24-75 years) divided into 'group FSD' (FSFI≤ 26.55) and 'group No FSD' (FSFI > 26. Read More

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Mechanisms Underlying the Association of Chronic Obstructive Pulmonary Disease With Heart Failure.

JACC Cardiovasc Imaging 2021 May 12. Epub 2021 May 12.

Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, United Kingdom; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom; Division of Cell-Matrix Biology and Regenerative Medicine, Wellcome Centre for Cell-Matrix Research, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom. Electronic address:

Objectives: The purposes of this study were to determine why chronic obstructive pulmonary disease (COPD) is associated with heart failure (HF). Specific objectives included whether COPD is associated with myocardial fibrosis, whether myocardial fibrosis is associated with hospitalization for HF and death in COPD, and whether COPD and smoking are associated with myocardial inflammation.

Background: COPD is associated with HF independent of shared risk factors. Read More

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Relationship between urinary cotinine and serum vitamin A levels in Korean adults: the Korea National Health and Nutrition Examination Survey (KNHANES), 2016-2018.

Soo Hyun Cho

J Int Med Res 2021 May;49(5):3000605211016742

Department of Family Medicine, College of Medicine, Chung-Ang University Hospital, Seoul, Republic of Korea.

Objective: To examine the relationship between urinary cotinine and serum vitamin A levels in Korean adults.

Methods: A total of 4445 adults (age ≥19 years) participating in the Korea National Health and Nutrition Examination Survey (KNHANES) from 2016 to 2018 were classified by sex and as smokers/electronic cigarette users (SE) or non-smokers (NS). Data were analyzed using complex sample general linear models. Read More

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Maternal tobacco exposure and health-related quality of life during pregnancy: a national-based study of pregnant women in China.

Health Qual Life Outcomes 2021 May 20;19(1):152. Epub 2021 May 20.

Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.

Background: With the increase of the number of smokers, tobacco exposure among pregnant women is becoming more and more common. Pregnant women exposed to first-hand smoke and second-hand smoke are susceptible to physiological and psychological health issues has been proved in previous studies. Nevertheless, there are no enough studies focus on the impact of third-hand smoke during pregnancy. Read More

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