247,976 results match your criteria relationship observed

Decreased serum testosterone levels associated with 17β-hydroxysteroid dehydrogenase activity in 7-year-old children from a dioxin-exposed area of Vietnam.

Sci Total Environ 2021 Mar 30;783:146701. Epub 2021 Mar 30.

Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.

Since 2008, we have conducted epidemiological cohort studies on the relationship between dioxin exposure and disruption with children in the area sprayed with defoliants during the Vietnam War. In a long-term survey of children through the age of five, we observed androgen disruption due to decreased dehydroepiandrosterone (DHEA) and testosterone levels. In this study of 7-year-old, we separately elucidated androgen disruption for boys and girls, and discussed with respect to hormone disruption with sex differences on the steroid hormone biosynthesis process. Read More

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A pilot study of near-field airborne particle concentrations in young children undergoing high flow nasal cannula therapy.

J Hosp Infect 2021 Apr 14. Epub 2021 Apr 14.

Department of Pediatrics, School of Medicine, Oregon Health & Science University; OHSU-PSU School of Public Health. Electronic address:

Background: High flow nasal cannula therapy (HFNC) may increase aerosol generation, putting healthcare workers at risk, including from SARS-CoV-2.

Aim: This study examined whether use of HFNC increases near-field aerosols and if there is a relationship with flow rate.

Methods: Subjects aged four weeks to 24 months were recruited. Read More

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Inhibition of soluble epoxide hydrolase alleviates insulin resistance and hypertension via downregulation of SGLT2 in the mouse kidney.

J Biol Chem 2021 Apr 14:100667. Epub 2021 Apr 14.

Division of Cardiology and Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan 430030, China. Electronic address:

The epoxyeicosatrienoic acid (EET) exerts beneficial effects on insulin resistance and/or hypertension. EETs could be readily converted to less biological active diols by soluble epoxide hydrolase (sEH). However, whether sEH inhibition can ameliorate the comorbidities of insulin resistance and hypertension, and the underlying mechanisms of this relationship, are unclear. Read More

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Late adverse events in patients with pulmonary atresia intact ventricular septum after valvuloplasty.

Ann Thorac Surg 2021 Apr 14. Epub 2021 Apr 14.

Cardiovascular Surgery, Kyushu Hospital, Japan Community Healthcare Organization.

Background: We aimed to explore the relationship between temporal right heart growth and long-term outcomes in patients with pulmonary atresia with intact ventricular septum (PA/IVS) who underwent balloon pulmonary valvulopalsty (BPV).

Methods: Echocardiography was performed to measure the pulmonary valve diameter (PVD), the right atrial end-systolic area (RAA), and the right ventricular end-diastolic area (RVA) before BPV, 1 and 5 years after BPV. The primary and secondary endpoints were to explore temporal changes in the right heart structures and to determine echocardiographic parameters related to late adverse events (LAEs). Read More

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Dynamic insulin-stimulated mTOR/GSK3 signaling in peripheral immune cells: Preliminary evidence for an association with lithium response in bipolar disorder.

Bipolar Disord 2021 Apr 17. Epub 2021 Apr 17.

Mayo Clinic Depression Center, Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, 55905, United States.

Introduction: A key mechanism of lithium is the inhibition of glycogen synthase kinase-3β (GSK3β) and activation of mammalian target of rapamycin (mTOR), two contributors to insulin signaling. We explored the relationship between these markers and clinical response to lithium in bipolar disorder (BD).

Methods: Thirty-four subjects with BD who had been taking lithium for ≥ 2 years and had a maintenance lithium Alda score defined as either high (≥7; n=20) or low (≤2; n=14) were included in the study. Read More

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The Effect of Islamic Belief and Spiritual Well-being on Organ Donation in Turkey: A Descriptive-Relational Study.

J Relig Health 2021 Apr 17. Epub 2021 Apr 17.

Department of Public Health Nursing, Faculty of Health Science, University of Bandırma Onyedi Eylul, Bandırma, Balıkesir, Turkey.

The aim of the study is to determine how Islamic belief and spiritual well-being affect the attitudes of individuals towards organ donation. The study was designed as a descriptive-relational study and included the participation of 402 adults in the eastern Mediterranean region of Turkey. For data collection, a personal information form, the Organ Donation Attitude Scale, and the Spiritual Well-being Scale were used. Read More

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From acute to long-term alterations in pain processing and modulation after spinal cord injury: mechanisms related to chronification of central neuropathic pain.

Pain 2021 Apr 13. Epub 2021 Apr 13.

Department of Physical Therapy at Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University Department of Neurological Rehabilitation, Chaim Sheba Medical Center, Tel Hashomer Department of Rehabilitation Sackler Faculty of Medicine, Tel Aviv University Barzilai Medical Center, Ashkelon.

Abstract: A severe and debilitating consequence of a spinal cord injury (SCI) is central neuropathic pain (CNP). Our aim was to investigate the processes leading to CNP emergence and chronification by analyzing causal relationship over time between spinothalamic function, pain excitability, and pain inhibition after SCI.This longitudinal follow-up study included 53 patients with acute SCI and 20 healthy controls. Read More

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Amount of blood during the subacute phase and clot clearance rate as prognostic factors for delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.

J Clin Neurosci 2021 May 11;87:74-79. Epub 2021 Mar 11.

Service de réanimation neurologique, Hôpital neurologique Pierre Wertheimer, Hospices Civils de Lyon, 69 bld Pinel, 69650 BRON Cedex, France.

Delayed cerebral ischemia (DCI) is a poorly predictable complication occurring after aneurysmal subarachnoid hemorrhage (SAH) that can have dramatic functional consequences. Identifying the patients with the highest risk of DCI may help to institute more suitable monitoring and therapy. Early brain injuries and aneurysm-securing procedure complications could be regarded as confounding factors leading to severity misjudgment. Read More

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Optimal combination of temperature and photoperiod for sex steroid hormone secretion and egg development of Oreochromis niloticus as determined by response surface methodology.

J Therm Biol 2021 Apr 21;97:102889. Epub 2021 Feb 21.

Fisheries of College of Guangdong Ocean University, Zhanjiang, 524025, Guangdong, China.

For successful reproduction of farmed fish, it is important to understand the relationship between gonadal development and environmental factors such as temperature and photoperiod. In this study, we determined the effects of temperature (T) and photoperiod (Pp) on serum estradiol-17β (E) and progesterone (P) contents, gonadosomatic index (GSI), and oocyte development in female tilapia. We used a central composite experimental design and response surface methodology. Read More

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Impact of heat stress on broilers with varying body weights: Elucidating their interactive role through physiological signatures.

J Therm Biol 2021 Apr 20;97:102840. Epub 2021 Jan 20.

Division of Avian Genetics and Breeding, ICAR-Central Avian Research Institute, Izatnagar, 243122, Uttar Pradesh, India.

Physiological determinants of different body weight (BW) broiler chickens under heat stressed conditions were investigated to compare the performance at market age considering medium body weight group as standard. At 5 weeks, broilers were categorized randomly into 3 treatments (N = 24 per group) as high (HBW) (>1050 g), medium (MBW) (900-1050 g) and low (LBW) (<900 g) followed by simultaneous exposure to normal and heat stress (HS) conditions at 40 ± 1 °C and 45 ± 5% RH for 4 h/day for a period of 7 days (D) and sample collection was employed at D0, D3 and D7. Physiological and stress responses, haematological and biochemical profile, intestinal gross and histological aspects were estimated using standard protocols. Read More

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Association between active pulmonary tuberculosis and circulating microRNAs: A preliminary study from Turkey.

Turk J Med Sci 2021 Apr 17. Epub 2021 Apr 17.

Background/aim: Tuberculosis is a public health problem that still remains significant. For prevention, diagnosis and treatment on tuberculosis more effective novel biomarkers are needed. MicroRNAs can regulate innate and adaptive immune responses, alter host-pathogen interactions and affect progression of diseases. Read More

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A time series analysis of the short-term association between climatic variables and acute respiratory infections in Singapore.

Int J Hyg Environ Health 2021 Apr 13;234:113748. Epub 2021 Apr 13.

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, 12 Science Drive 2, 117549, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, 10 Medical Drive, 117597, Singapore.

Background: Acute respiratory infections (ARIs) are among the most common human illnesses globally. Previous studies that examined the associations between climate variability and ARIs or ARI pathogens have reported inconsistent findings. Few studies have been conducted in Southeast Asia to date, and the impact of climatic factors are not well-understood. Read More

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Efficiency of aminolevulinic acid (ALA)-photodynamic therapy based on ALA uptake transporters in a cell density-dependent malignancy model.

J Photochem Photobiol B 2021 Apr 13;218:112191. Epub 2021 Apr 13.

School of Life Science and Technology, Tokyo Institute of Technology, 4259 B47, Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan. Electronic address:

The effectiveness of the conventional chemotherapy for cancer are compromised as the cancer cells advances in their malignancy level as they acquired drug resistance. In this study, we aimed to evaluate the efficiency of aminolevulinic acid-photodynamic therapy (ALA-PDT) against cancer of various malignancy levels, indicated by the expression level of receptor associated nuclear factor-κB ligand (RANKL), through the expression levels of ALA uptake transporters. We established a malignancy model by gradually increasing the cell density of cancer cells. Read More

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Principal postural acceleration and myoelectric activity: Interrelationship and relevance for characterizing neuromuscular function in postural control.

Hum Mov Sci 2021 Apr 13;77:102792. Epub 2021 Apr 13.

Department of Sport Science, University of Innsbruck, Fürstenweg 185, A-6020 Innsbruck, Austria. Electronic address:

One approach to investigating sensorimotor control is to assess the accelerations that produce changes in the kinematic state of the system. When assessing complex whole-body movements, structuring the multi-segmental accelerations is important. A useful structuring can be achieved through a principal component analysis (PCA) performed on segment positions followed by double-differentiation to obtain "principal accelerations" (PAs). Read More

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Estimation of stressed blood volume in patients with cardiogenic shock from acute myocardial infarction and decompensated heart failure.

J Card Fail 2021 Apr 13. Epub 2021 Apr 13.

Cardiovascular Research Foundation, New York, NY. Electronic address:

Background: Sympathetically mediated re-distribution of blood from the unstressed venous reservoir to the hemodynamically active stressed compartment is thought to contribute to congestion in cardiogenic shock. We employed a novel computational method to estimate stressed blood volume in cardiogenic shock and assess its relationship with clinical outcomes.

Methods: Hemodynamic parameters including estimated stressed blood volume (eSBV) were compared among patients from the Cardiogenic Shock Working Group (CSWG) registry with a complete set of hemodynamic data. Read More

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Early postnatal allergic airway inflammation induces dystrophic microglia leading to excitatory postsynaptic surplus and autism-like behavior.

Brain Behav Immun 2021 Apr 13. Epub 2021 Apr 13.

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Translational Neuroscience Center, Graduate School of Medicine, and School of Pharmacy at Fukuoka, International University of Health and Welfare, 137-1 Enokizu, Ookawa, Fukuoka 831-8501, Japan; Department of Neurology, Brain and Nerve Center, Fukuoka Central Hospital, International University of Health and Welfare, 2-6-11 Yakuin, Chuo-ku, Fukuoka 810-0022, Japan. Electronic address:

Microglia play key roles in synaptic pruning, which primarily occurs from the postnatal period to adolescence. Synaptic pruning is essential for normal brain development and its impairment is implicated in neuropsychiatric developmental diseases such as autism spectrum disorders (ASD). Recent epidemiological surveys reported a strong link between ASD and atopic/allergic diseases. Read More

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A mitophagy inhibitor targeting p62 attenuates the leukemia-initiation potential of acute myeloid leukemia cells.

Cancer Lett 2021 Apr 13. Epub 2021 Apr 13.

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, PUMC Department of Stem Cell and Regenerative Medicine, CAMS Key Laboratory of Gene Therapy for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China. Electronic address:

There has been an increasing focus on the tumorigenic potential of leukemia initiating cells (LICs) in acute myeloid leukemia (AML). Despite the important role of selective autophagy in the life-long maintenance of hematopoietic stem cells (HSCs), cancer progression, and chemoresistance, the relationship between LICs and selective autophagy remains to be fully elucidated. Sequestosome 1 (SQSTM1), also known as p62, is a selective autophagy receptor for the degradation of ubiquitinated substrates, and its loss impairs leukemia progression in AML mouse models. Read More

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[Left Ventricular Mass Index and Cardiovascular Compromise in children on dialysis].

Rev Chil Pediatr 2020 Dec 12;91(6):917-923. Epub 2020 Dec 12.

Departamento Pediatría y cirugía Infantil Oriente, Facultad de Medicina, universidad de chile, Santiago, Chile.

Introduction: There is a close relationship between chronic kidney disease (CKD) and cardiovascular disease. One of its clinical manifestations is left ventricular hypertrophy (LVH), expressed as Left Ventricular Mass Index (LVMI gr/m27). In CKD patients with growth retardation, the LVMI calculation should be adjusted by correcting age for length/height. Read More

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December 2020

The Effect of Inhibition through DZNep on Epithelial-Mesenchymal Transition Mechanism.

Cell Reprogram 2021 Apr;23(2):139-148

Department of Biochemistry, Erciyes University School of Medicine, Kayseri, Turkey.

Although the molecular pathogenesis of hepatocellular carcinoma (HCC) is uncertain, it is known that the epithelial-mesenchymal transition (EMT) mechanism and epigenetic changes have an important role. This study was focused on evaluating the relationship of 3-Deazaneplanocin A (DZNep) with the EMT mechanism, which is a histone methyltransferase inhibitor on HCC and is also known as an enhancer of zeste homolog 2 (EZH2) inhibitor. Cell viability of HepG2 cells (HCC cell line) assessed for DZNep over 72 hours with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Read More

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Usability of a Mobile App for Real-Time Assessment of Fatigue and Related Symptoms in Patients With Multiple Sclerosis: Observational Study.

JMIR Mhealth Uhealth 2021 Apr 16;9(4):e19564. Epub 2021 Apr 16.

Center for Neurological Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Background: Although fatigue is one of the most debilitating symptoms in patients with multiple sclerosis (MS), its pathogenesis is not well understood. Neurogenic, inflammatory, endocrine, and metabolic mechanisms have been proposed. Taking into account the temporal dynamics and comorbid mood symptoms of fatigue may help differentiate fatigue phenotypes. Read More

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Cannabidiol modulation of hippocampal glutamate in early psychosis.

J Psychopharmacol 2021 Apr 16:2698811211001107. Epub 2021 Apr 16.

Department of Psychosis Studies, King's College London, London, UK.

Background: Emerging evidence supports the antipsychotic effect of cannabidiol, a non-intoxicating component of cannabis, in people with psychosis. Preclinical findings suggest that this antipsychotic effect may be related to cannabidiol modulating glutamatergic signalling in the brain.

Aim: The purpose of this study was to investigate the effects of cannabidiol on the neurochemical mechanisms underlying psychosis. Read More

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Circulating pro-gastrin releasing peptide (ProGRP) in patients with medullary thyroid carcinoma.

Clin Chem Lab Med 2021 Apr 16. Epub 2021 Apr 16.

Clinic for Nuclear Medicine and Competence Centre for Thyroid Diseases, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.

Objectives: Serum calcitonin (CT) is pivotal in medullary thyroid cancer (MTC) management. Recently, progastrin releasing peptide (ProGRP) has been proposed as a candidate complementary tumor marker of MTC. As current data are sparse our study was undertaken to evaluate the distribution of ProGRP in patients with MTC and its relationship with the tumor burden. Read More

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Olaparib dose re-escalation in ovarian cancer patients who experienced severe and/or uncommon adverse events: A case series.

Asia Pac J Clin Oncol 2021 Apr;17 Suppl 3:3-11

Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, Hong Kong.

Aim: Few real-world studies have reported detailed management and dose adjustment strategies of adverse events (AEs) of ovarian cancer (OC) patients treated with the poly(adenosine diphosphate-ribose) polymerase inhibitor olaparib. This case series aimed to describe olaparib AEs in Chinese OC patients in real-life settings and to explore dose modification strategies.

Methods: We conducted a detailed examination of the clinical records of OC patients who were treated with olaparib at the Gynecologic Oncology Unit in Hong Kong from September 2015 to December 2019, including baseline characteristics, treatment outcomes, AEs, and management strategies, particularly dose modifications. Read More

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Single-handed Double Helix and Spiral Platelet Formed by Racemate of Dissymmetric Cages.

Angew Chem Int Ed Engl 2021 Apr 16. Epub 2021 Apr 16.

Shanghai Jiao Tong University, School of Chemistry and Chemical Engineering, CHINA.

Since Pasteur's seminal work, spontaneous deracemization or symmetry breaking has been applied to separate homochiral domains from the erstwhile racemic system. However, the resulting homochirality can only be referred to when the scales of these domains and systems are specified. To clarify this notion, we report on the self-assembly of racemates of dissymmetric cages DC-1 with a cone-shape propeller geometry, forming a centrosymmetric columnar crystalline phase, namely racemic at crystallographic level . Read More

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Ambiguity Tolerance and Prospective Specialty Choice Among Third-Year Medical Students.

PRiMER 2021 8;5. Epub 2021 Jan 8.

Department of Family Medicine, University of Alberta, Edmonton, Alberta, Canada.

Introduction: Poor tolerance of ambiguity is consequential in clinical practice, and has been linked to avoidance of family medicine, in which there is inherently more ambiguity. This study aimed to investigate the relationship between tolerance of ambiguity and prospective specialty choice of medical students in their third year of medical school. This stage of medical training is of particular importance as students develop clinical reasoning skills and encounter clinical ambiguity. Read More

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January 2021

Characteristics of the gut microbiome profile in obese patients with colorectal cancer.

JGH Open 2021 Apr 19;5(4):498-507. Epub 2021 Mar 19.

Department of Gastroenterology, Faculty of Medicine Yamagata University Yamagata Japan.

Background And Aim: Obesity affects the gut microbiome, which in turn increases the risk for colorectal cancer. Several studies have shown the mechanisms by which some bacteria may influence the development of colorectal cancer; however, gut microbiome characteristics in obese patients with colorectal cancer remain unclear. Therefore, this study evaluated their gut microbiome profile and its relationship with metabolic markers. Read More

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Relationship between Myopia Progression and School Entrance Age: A 2.5-Year Longitudinal Study.

J Ophthalmol 2021 30;2021:7430576. Epub 2021 Mar 30.

The Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Objective: To investigate the association between myopia progression and school entrance age among Chinese schoolchildren and to suggest a more appropriate school age.

Methods: 1,463 children aged six to nine years from Wenzhou, China, were examined and followed up for two and a half consecutive years. Their noncycloplegic refraction was measured twice each year by using an automatic refractometer; axial length (AL) and corneal radius of curvature (CRC) were tested annually by using the IOLMaster for 2. Read More

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Early vascular aging in adult patients with congenital heart disease.

Hypertens Res 2021 Apr 15. Epub 2021 Apr 15.

Department of Cardiology, St. Luke's International Hospital, Tokyo, Japan.

Many studies have reported that adults with congenital heart disease suffer from hypertension and cardiovascular disease even at younger ages. Therefore, we analyzed early vascular aging, which is defined as pulse wave velocity values higher than the 95th percentile for age and sex, and clarified the relationship between early vascular aging and many parameters related to cardiovascular disorders in adults with congenital heart disease. We enrolled 72 adult patients with congenital heart disease and measured their brachial-ankle pulse wave velocity. Read More

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Activation of 4-1BB signaling in bone marrow stromal cells triggers bone loss via the p-38 MAPK-DKK1 axis in aged mice.

Exp Mol Med 2021 Apr 15. Epub 2021 Apr 15.

Department of Orthopedics, Tongji Hospital affiliated with Tongji University School of Medicine, Shanghai, China.

Senile osteoporosis can cause bone fragility and increased fracture risks and has been one of the most prevalent and severe diseases affecting the elderly population. Bone formation depends on the proper osteogenic differentiation of bone marrow stromal cells (BMSCs) in the bone marrow microenvironment, which is generated by the functional relationship among different cell types in the bone marrow. With aging, bone marrow provides signals that repress osteogenesis. Read More

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