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Association of global cardiac calcification with atrial fibrillation and recurrent stroke in patients with embolic stroke of undetermined source.

J Am Soc Echocardiogr 2021 Apr 16. Epub 2021 Apr 16.

Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore; Department of Cardiology, National University Heart Centre Singapore, Singapore.

Background: Calcium deposits in the heart have been associated with cardiovascular events, mortality, stroke as well as atrial fibrillation (AF). However, there is no accepted standard method for scoring cardiac calcifications. Existing methods have also not been validated for assessment of patients with embolic strokes of undetermined source (ESUS). Read More

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Veno-occlusive disease risk in pediatric patients with acute myeloid leukemia treated with gemtuzumab ozogamicin before allogeneic hematopoietic cell transplantation.

Pediatr Blood Cancer 2021 Apr 19:e29067. Epub 2021 Apr 19.

CIBMTR® (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Background: Gemtuzumab ozogamicin (GO) administered before allogeneic hematopoietic cell transplantation (alloHCT) has been linked to an increased risk of hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS).

Procedure: This retrospective analysis examined VOD/SOS risk and clinical outcomes in pediatric patients with acute myeloid leukemia who received myeloablative alloHCT in 2008-2011 with (n = 148) and without (n = 348; controls) prior GO exposure and were reported to the Center for International Blood and Marrow Transplant Research.

Results: Cumulative incidences (95% confidence interval [CI]) of VOD/SOS and severe VOD/SOS, respectively, at 100 days were 16% (11-23%) and 8% (4-13%) for GO-exposed patients and 10% (7-13%) and 3% (2-5%) for controls. Read More

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Gastric and Small Intestine Gist: Results of 156 Cases in 20 Years.

J Gastrointest Cancer 2021 Apr 19. Epub 2021 Apr 19.

Esofagogastric Unit, Bellvitge University Hospital, de La Feixa Llarga, s/n L´Hospitalet de Llobregat, Barcelona, Spain.

Purpose: Gastric and small intestine are the most common gastrointestinal stromal tumors (GISTs). There are few studies of patients who underwent surgical treatment with disparate findings. We aimed to evaluate the differences between groups and the risk factors for recurrence and mortality. Read More

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Evaluation of the validity of pancreatectomy for very elderly patients with pancreatic ductal adenocarcinoma.

Langenbecks Arch Surg 2021 Apr 19. Epub 2021 Apr 19.

Department of Surgery, Institute of Gastroenterology, Tokyo Woman's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Purpose: The role of pancreatectomy for very elderly patients with pancreatic adenocarcinoma is controversial. This study aimed to clarify the validity of pancreatic resection in octogenarian patients with pancreatic ductal adenocarcinoma.

Methods: We compared 31 patients aged ≥ 80 years and 548 patients aged < 80 years who underwent pancreatectomy for pancreatic ductal adenocarcinoma and evaluated the relationship between age, clinicopathological factors, recurrence, and outcomes. Read More

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Clinical considerations after endovascular therapy of peripheral artery disease.

Expert Rev Cardiovasc Ther 2021 Apr 19:1-10. Epub 2021 Apr 19.

Division of Cardiology, Rocky Mountain Regional VA Medical Center, University of Colorado, Denver, CO, USA.

: Patients with peripheral artery disease (PAD) are at higher risk for all-cause mortality, driven by increased cardiovascular mortality rates. In this manuscript we review the literature on guideline-recommended therapies and discuss the major clinical considerations after endovascular therapy of PAD.: Current guidelines recommend smoking cessation, aspirin, statin, and renin-angiotensin system inhibitors in order to reduce the risk of cardiovascular and limb-related adverse events. Read More

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Impacts of the American Joint Committee on Cancer (AJCC) 8 edition tumor, node, metastasis (TNM) staging system on outcomes of differentiated thyroid cancer in Thai patients.

Heliyon 2021 Mar 30;7(3):e06624. Epub 2021 Mar 30.

Diabetes and Thyroid Center, Theptarin Hospital, Bangkok, Thailand.

Background: In 2018, the American Joint Committee on Cancer (AJCC) 8 edition (AJCC8) was introduced to replace the previous version (AJCC7) due to superiority of AJCC8 over AJCC7 for better prediction of survival from thyroid cancer.

Aim: To compare AJCC staging systems with the American Thyroid Association (ATA) risk classification for the prediction of 5-year disease-free survival (DFS), and 5-year disease-specific survival (DSS) in Thai patients.

Methods: We retrospectively reviewed all patients with histopathologic diagnosis of DTC who were treated at Theptarin Hospital, Bangkok, Thailand from 1987 to 2019. Read More

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Nuclear export protein CSE1L interacts with P65 and promotes NSCLC growth via NF-κB/MAPK pathway.

Mol Ther Oncolytics 2021 Jun 10;21:23-36. Epub 2021 Mar 10.

State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.

Non-small cell lung cancer (NSCLC) is characterized with high morbidity and mortality, mainly due to frequent recurrence and metastasis. However, the underlying molecular mechanisms of NSCLC tumorigenesis are largely unclear. Through data mining in the ONCOMINE and Gene Expression Omnibus (GEO) databases, the expression of CSE1L (chromosome segregation like 1 protein/CAS), an exportin, was identified to be significantly upregulated in NSCLC and positively associated with poor prognosis of patients. Read More

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Strangulated small-bowel internal hernia through a defect in the broad ligament of the uterus presenting as acute intestinal obstruction: A case report.

Case Rep Womens Health 2021 Apr 26;30:e00310. Epub 2021 Mar 26.

Department of Surgery, College of Medicine, University of Duhok, Kurdistan Region, Iraq.

Background: Internal hernias rarely lead to bowel obstruction; they are caused by a natural or unnatural opening within the peritoneal cavity. Defects in the broad ligament are extremely rare. Patients present with features of intestinal obstruction and most cases are diagnosed during surgery. Read More

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Prophylactic or Early Use of Eculizumab and Graft Survival in Kidney Transplant Recipients With Atypical Hemolytic Uremic Syndrome in the United States: Research Letter.

Can J Kidney Health Dis 2021 31;8:20543581211003763. Epub 2021 Mar 31.

Nephrology Service, Walter Reed National Military Medical Center, Bethesda, MD, USA.

Introduction: Among kidney transplant recipients (KTRs) with end-stage kidney disease (ESKD) due to atypical hemolytic uremic syndrome (aHUS), recurrence is associated with poor allograft outcomes. We compared graft and patient survival of aHUS KTRs with and without prophylactic/early use of eculizumab, a monoclonal antibody that binds complement protein C5, at the time of transplantation.

Methods: We conducted a retrospective cohort study using the United States Renal Data System. Read More

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The management of hidradenitis suppurativa degenerating into squamous cell carcinoma: About three case reports.

Ann Med Surg (Lond) 2021 Apr 24;64:102239. Epub 2021 Mar 24.

Department of Surgery A, Rabta Hosptial, Tunis, Tunisia.

Introduction And Importance: Hidradenitis suppurativa (HS) is a chronic inflammatory and suppurative disease of the apocrine sweat glands. Its transformation into squamous cell carcinoma (SCC) is very rare.

Case Presentation: We describe 3 cases of males aged 57, 58 and 55-years-old. Read More

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Factors associated with prognosis after small-vessel occlusion among young and middle-aged patients: a hospital-based follow-up study.

Postgrad Med 2021 Apr 19. Epub 2021 Apr 19.

Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300350, China.

Objective: Small-vessel occlusions are the most common causes of mild strokes and, in China, account for approximately 27.3% of ischemic stroke cases. However, the factors associated with short- and long-term outcomes appear contradictory. Read More

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Long-term outcome after allogeneic stem cell transplantation in multiple myeloma.

Ann Hematol 2021 Apr 17. Epub 2021 Apr 17.

Comprehensive Cancer Center, Department of Hematology, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4, P.O. Box 372, 00290, Helsinki, Finland.

The role of allogeneic hematopoietic stem cell transplantation (allo-SCT) in multiple myeloma is controversial. We analyzed the results of 205 patients transplanted in one center during 2000-2017. Transplantation was performed on 75 patients without a previous autologous SCT (upfront-allo), on 74 as tandem transplant (auto-allo), and on 56 patients after relapse. Read More

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The Effect of Donor Graft Cryopreservation on Allogeneic Hematopoietic Cell Transplantation Outcomes: A Center for International Blood and Marrow Transplant Research Analysis. Implications during the COVID-19 Pandemic.

Transplant Cell Ther 2021 Mar 22. Epub 2021 Mar 22.

Division of Hematology & Oncology, Department of Medicine, University of Florida, Gainesville, Florida.

The COVID-19 pandemic has resulted in the increased use of cryopreserved grafts for allogeneic hematopoietic cell transplantation (HCT). However, information about the effect of cryopreservation on outcomes for patients receiving allogeneic donor grafts is limited. We evaluated outcomes of HCT recipients who received either fresh or cryopreserved allogeneic bone marrow (BM) or peripheral blood stem cell (PBSC) grafts reported to the Center for International Blood and Marrow Transplant Research. Read More

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Delayed Postoperative Hemorrhage Complicating Major Supramesocolic Surgery Management and Outcomes.

World J Surg 2021 Apr 17. Epub 2021 Apr 17.

Centre Hospitalier Universitaire Grenoble Alpes, Department of Digestive Surgery, Grenoble, France.

Background: The place of surgery and interventional radiology in the management of delayed (> 24 h) hemorrhage (DHR) complicating supramesocolic surgery is still to define. The aim of the study was to evaluate outcomes of DHR using a combined multimodal strategy.

Methods: Between 2005 and 2019, 57 patients (median age 64 years) experienced 86 DHR episodes after pancreatic resection (n = 26), liver transplantation (n = 24) and other (n = 7). Read More

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Megaprosthesis Versus Allograft Prosthesis Composite for the Management of Massive Skeletal Defects: A Meta-Analysis of Comparative Studies.

Curr Rev Musculoskelet Med 2021 Apr 17. Epub 2021 Apr 17.

Department of Orthopedics, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India.

Purpose Of Review: Megaprosthesis and Allograft Prosthesis Composite (APC) are the established treatment modalities for massive skeletal defects. There are a handful of studies comparing the use of megaprosthesis and APC in the management of substantial bone loss and it has always been a topic of debate regarding the superiority of one modality over the other. Therefore, we aim to compare the functional outcome and implant survivorship of each modality including complications, revision rates, amputation rate and mortality. Read More

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CMV viral load kinetics predict CMV end-organ disease and mortality after hematopoietic cell transplant (HCT).

J Infect Dis 2021 Apr 17. Epub 2021 Apr 17.

Memorial Sloan Kettering Cancer Center, Infectious Disease Service, New York, NY, United States.

Background: We investigated the association between time-averaged area under the curve (AAUC) of CMV viral load (VL) by D100 and overall survival (OS) at one-year post-hematopoietic cell transplantation (HCT).

Methods: A retrospective cohort study, including patients receiving HCT between 2010.6 and 2017. Read More

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Autologous stem cell transplantation for post-transplant lymphoproliferative disorders after solid organ transplantation: a retrospective analysis from the Lymphoma Working Party of the EBMT.

Bone Marrow Transplant 2021 Apr 16. Epub 2021 Apr 16.

Lymphoma Working Party EBMT, Paris, France.

Published data describing the efficacy and safety of autologous stem-cell transplantation (autoSCT) in post-transplant lymphoproliferative disorders (PTLD) is limited to case reports. This is a retrospective analysis of 21 patients reported to the EBMT registry who received an autoSCT for PTLD post solid organ transplant (SOT). Median age at autoSCT was 47 (range: 22-71) years. Read More

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Impact of depth of clinical response on outcomes of acute myeloid leukemia patients in first complete remission who undergo allogeneic hematopoietic cell transplantation.

Bone Marrow Transplant 2021 Apr 16. Epub 2021 Apr 16.

Division of Medical Oncology, University of Washington and Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Acute myeloid leukemia (AML) patients often undergo allogeneic hematopoietic cell transplantation (alloHCT) in first complete remission (CR). We examined the effect of depth of clinical response, including incomplete count recovery (CRi) and/or measurable residual disease (MRD), in patients from the Center for International Blood and Marrow Transplantation Research (CIBMTR) registry. We identified 2492 adult patients (1799 CR and 693 CRi) who underwent alloHCT between January 1, 2007 and December 31, 2015. Read More

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Mobile Health Intervention Promoting Physical Activity in Adults Post Cardiac Rehabilitation: Pilot Randomized Controlled Trial.

JMIR Form Res 2021 Apr 16;5(4):e20468. Epub 2021 Apr 16.

Departments of Medicine and Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, United States.

Background: Cardiac rehabilitation (CR) is an exercise-based program prescribed after cardiac events associated with improved physical, mental, and social functioning; however, many patients return to a sedentary lifestyle leading to deteriorating functional capacity after discharge from CR. Physical activity (PA) is critical to avoid recurrence of cardiac events and mortality and maintain functional capacity. Leveraging mobile health (mHealth) strategies to increase adherence to PA is a promising approach. Read More

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Long-Term Outcome Assessment Between Anti-Septic and Normal Saline for Negative Pressure Wound Therapy with Instillation.

Adv Wound Care (New Rochelle) 2021 Apr 16. Epub 2021 Apr 16.

MedStar Georgetown University Hospital, 71541, Center for Wound Healing, Washington, District of Columbia, United States;

Objective: To analyze long-term outcomes following inpatient treatment of infected wounds with antimicrobial or normal saline instillation during negative-pressure wound therapy.

Approach: This was a single-center retrospective study analyzing the course of patients receiving 0.9% normal saline or 0. Read More

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Small Steatotic HCC: A Radiological Variant Associated With Improved Outcome After Ablation.

Hepatol Commun 2021 Apr 31;5(4):689-700. Epub 2020 Dec 31.

Department of Radiology St-Eloi University Hospital Montpellier France.

Percutaneous thermal ablation is a validated treatment option for small hepatocellular carcinoma (HCC). Steatotic HCC can be reliably detected by magnetic resonance imaging. To determine the clinical relevance of this radiological variant, we included 235 patients (cirrhosis in 92. Read More

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Short and Mid Term Outcomes of Cryopreserved Abdominal Aortic Allografts Used as a Substitute for Infected Prosthetic Grafts in 200 Patients.

Eur J Vasc Endovasc Surg 2021 Apr 12. Epub 2021 Apr 12.

Sorbonne Université, Department of Vascular Surgery, Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris, France.

Objective: To investigate the use of cryopreserved arterial allografts (CAA) as a substitute for infected infrarenal aortic prostheses, and its outcomes.

Methods: A single centre retrospective study of consecutive patients receiving an abdominal aortic CAA after removal of an infected graft was conducted between January 1997 and December 2013. The primary outcome was the rate of allograft related revision surgery. Read More

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Clinical outcome of patients with differentiated thyroid cancer and raised antithyroglobulin antibody levels: a retrospective study.

Thyroid Res 2021 Apr 15;14(1). Epub 2021 Apr 15.

Department of Nuclear Medicine, SGPGIMS, Lucknow, India.

Background: Thyroglobulin (Tg) is a specific tumor marker for differentiated thyroid cancer (DTC). However, in the presence of an antithyroglobulin antibody (TgAb), it becomes unreliable. The purpose of the study was to assess the long-term outcome of DTC patients with raised TgAb. Read More

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A comparison of postoperative outcomes after open and laparoscopic reduction of Petersen's Hernia: a multicenter observational cohort study.

BMC Surg 2021 Apr 15;21(1):195. Epub 2021 Apr 15.

Department of Surgery, Gyeongsang National University School of Medicine, Jinju, South Korea.

Background: The aim of this multicenter cohort study was to compare the clinical courses between open and laparoscopic Petersen's hernia (PH) reduction.

Method: We retrospectively collected the clinical data of patients who underwent PH repair surgery after gastrectomy for gastric cancer from 2015-2018. Forty patients underwent PH reduction operations that were performed by six surgeons at four hospitals. Read More

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Hematopoietic Stem Cell Transplantation in T-cell and NK-cell lymphomas-Update on Recent Advances.

Transplant Cell Ther 2021 Apr 12. Epub 2021 Apr 12.

Department of Hematology-Oncology, National University Cancer Institute, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

Mature T- and natural killer (NK)-cell non-Hodgkin lymphoma (T-cell NHL) have a poor prognosis. Data from existing retrospective and prospective studies has suggested that high-dose chemotherapy (HDT) followed by autologous hematopoietic cell transplantation (auto-HCT) may improve the survival in patients with chemosensitive disease, either in the upfront or salvage setting. Auto-HCT is currently recommended to be used as frontline consolidation in peripheral T-cell lymphoma not otherwise specified (PTCL-nos), angioimmunoblastic T-cell lymphoma (AITL), anaplastic large cell lymphoma-anaplastic lymphoma kinase (ALCL-ALK) negative, NK/T-cell (disseminated), and enteropathy-associated T-cell lymphoma (EATL). Read More

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Allogeneic Stem Cell Transplantation in Mature T Cell and Natural Killer/T Neoplasias: A Registry Study from Spanish GETH/GELTAMO Centers.

Transplant Cell Ther 2021 Mar 15. Epub 2021 Mar 15.

Hematology Department, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain.

Despite advances in understanding the biology of mature T and natural killer (NK)/T cell neoplasia, current therapies, even the most innovative ones, are still far from ensuring its cure. The only treatment to date that has been shown to control aggressive T cell neoplasms in the long term is allogeneic stem cell transplantation (alloSCT). We aim to report the results of alloSCT for advanced mature T and NK/T neoplasias performed in centers from our national GELTAMO/GETH (Grupo Español de Linfoma y Trasplante de Médula Ósea/Grupo Español de Trasplante Hematopoyético y Terapia Celular) over the past 25 years. Read More

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Thrombolytic therapy for pulmonary embolism.

Cochrane Database Syst Rev 2021 Apr 15;4:CD004437. Epub 2021 Apr 15.

The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China.

Background: Thrombolytic therapy is usually reserved for people with clinically serious or massive pulmonary embolism (PE). Evidence suggests that thrombolytic agents may dissolve blood clots more rapidly than heparin and may reduce the death rate associated with PE. However, there are still concerns about the possible risk of adverse effects of thrombolytic therapy, such as major or minor haemorrhage. Read More

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Microbiota restoration for recurrent Clostridioides difficile: Getting one step closer every day!

Authors:
S Khanna

J Intern Med 2021 Apr 15. Epub 2021 Apr 15.

From the Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

Clostridioides difficile infection (CDI) is an urgent health threat being the most common healthcare-associated infection, and its management is a clinical conundrum. Over 450 000 infections are seen in the United States with similar incidence seen in the rest of the developed world. The majority of infections seen are mild-moderate with fulminant disease and mortality being rare complications seen in the elderly and in those with comorbidities. Read More

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Different chemokine profile between systemic and testicular diffuse large B-cell lymphoma.

Leuk Lymphoma 2021 Apr 15:1-10. Epub 2021 Apr 15.

Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland.

Although treatment for diffuse large B-cell lymphoma (DLBCL) has taken some notable steps in the 2000s, there are still subgroups of patients suffering from high mortality and relapse rates. To further improve treatment outcomes, it is essential to discover new mechanisms of chemotherapy resistance and create new treatment approaches to overcome them. In the present study, we analyzed the expression of chemokines and their ligands in systemic and testicular DLBCL. Read More

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Excellent overall and chronic graft-versus-host-disease-free event-free survival in Fanconi anaemia patients undergoing matched related- and unrelated-donor bone marrow transplantation using alemtuzumab-Flu-Cy: the UK experience.

Br J Haematol 2021 Apr 14. Epub 2021 Apr 14.

Department of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK.

Haematopoietic stem cell transplantation (HSCT) remains the only curative option in Fanconi anaemia (FA). We analysed the outcome of children transplanted for FA between 1999 and 2018 in the UK. A total of 94 transplants were performed in 82 patients. Read More

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