12,990 results match your criteria rejection model


Outcomes after heart transplantation in patients with cardiac sarcoidosis.

ESC Heart Fail 2022 Jan 15. Epub 2022 Jan 15.

Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.

Background: The number of patients with sarcoidosis requiring heart transplantation (HT) is increasing. The aim of this study was to evaluate outcomes of isolated HT in patients with sarcoid cardiomyopathy and compare them to recipients with non-ischaemic restrictive or dilated cardiomyopathy.

Methods And Results: Adult HT recipients were identified in the UNOS Registry between 1990 and 2020. Read More

View Article and Full-Text PDF
January 2022

Cytosporone B (Csn-B), an NR4A1 agonist, attenuates acute cardiac allograft rejection by inducing differential apoptosis of CD4+T cells.

Int Immunopharmacol 2022 Jan 10;104:108521. Epub 2022 Jan 10.

Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

CD4+T cell-mediated acute rejection remains a major factor that affects the early survival of transplanted organs post-transplantation. Here, we reveal that nuclear receptor subfamily 4 Group A member 1 (Nr4A1) was upregulated during cardiac allograft rejection and that the increased Nr4A1 was primarily localized in intragraft-infiltrating CD4+T cells. Nr4A1 acts as a transcription factor with an important role in CD4+T cell apoptosis, differentiation and T cell dysfunction, which indicates that Nr4A1 may play a critical role in transplant rejection. Read More

View Article and Full-Text PDF
January 2022

Isolation of TCR genes with tumor-killing activity from tumor-infiltrating and circulating lymphocytes in a tumor rejection cynomolgus macaque model.

Mol Ther Oncolytics 2022 Mar 6;24:77-86. Epub 2021 Dec 6.

Department of Biochemistry and Molecular Biology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.

To develop effective adoptive cell transfer therapy using T cell receptor (TCR)-engineered T cells, it is critical to isolate tumor-reactive TCRs that have potent anti-tumor activity. In humans, tumor-infiltrating lymphocytes (TILs) have been reported to contain CD8PD-1 T cells that express tumor-reactive TCRs. Characterization of tumor reactivity of TILs from non-human primate tumors could improve anti-tumor activity of TCR-engineered T cells in preclinical research. Read More

View Article and Full-Text PDF

RtNet: a deep hybrid neural networks for the identification of acute rejection and chronic allograft nephropathy after renal transplantation using multiparametric MRI.

Nephrol Dial Transplant 2022 Jan 10. Epub 2022 Jan 10.

Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

Background: Reliable diagnosis of the cause of renal allograft dysfunction is of clinical importance. The aim of this study is to develop a hybrid deep learning approach for determining acute rejection (AR), chronic allograft nephropathy (CAN) and renal function in kidney-allografted patients by multimodality integration.

Methods: Clinical and MRI data of 252 kidney-allografted patients who underwent post-transplantation MRI between Dec 2014 and Nov 2019 were retrospectively collected. Read More

View Article and Full-Text PDF
January 2022

miR-31, miR-155, and miR-221 expression profiles and their association with graft skin tolerance in a syngeneic vs. allogeneic murine skin transplantation model.

J Burn Care Res 2022 Jan 9. Epub 2022 Jan 9.

Laboratory of Connective Tissue, Centro Nacional de Investigación y Atención a Quemados, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Mexico City, Mexico.

Grafting is the gold standard for the treatment of severe skin burns. Frequently, allogeneic tissue is the only transient option for wound coverage, but their use risks damage to surrounding tissues. MicroRNAs have been associated with acute rejection of different tissues/organs. Read More

View Article and Full-Text PDF
January 2022

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of Kidney Transplant Recipients.

Ann Transplant 2022 Jan 12;27:e934738. Epub 2022 Jan 12.

Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, Uppsala, Sweden.

BACKGROUND BK virus (BKV) infection after kidney transplantation leads to BKV-associated nephropathy (BKVAN) in up to 10% of recipients, and is associated with an increased risk of allograft dysfunction or loss. The objective of this study was to estimate the incidence of BKVAN and to analyze whether enhanced induction is associated with an increased risk of BKVAN, possibly justifying more intensive surveillance. MATERIAL AND METHODS This was a single-center retrospective cohort study. Read More

View Article and Full-Text PDF
January 2022

Immunologic constant of rejection signature is prognostic in soft-tissue sarcoma and refines the CINSARC signature.

J Immunother Cancer 2022 Jan;10(1)

Laboratory of Predictive Oncology, Centre de Recherche en Cancérologie de Marseille (CRCM), Institut Paoli-Calmettes, Aix-Marseille Université, INSERM UMR1068, CNRS UMR725, Marseille, France.

Background: Soft-tissue sarcomas (STSs) are heterogeneous and aggressive tumors, with high metastatic risk. The immunologic constant of rejection (ICR) 20-gene signature is a signature of cytotoxic immune response. We hypothesized that ICR might improve the prognostic assessment of early-stage STS. Read More

View Article and Full-Text PDF
January 2022

Factors associated with follow-up outside a transplant center among pediatric kidney transplant recipients.

Pediatr Nephrol 2022 Jan 11. Epub 2022 Jan 11.

Department of Pediatrics, Brody School of Medicine at East Carolina University, 600 Moye Blvd, Greenville, NC, 27858, USA.

Background: Transfer of follow-up care after pediatric kidney transplantation (KTx) may jeopardize quality of care and patient outcomes. We sought to determine if minority status and socioeconomic factors were associated with increased likelihood of follow-up outside a transplant center, and whether this transition of care was associated with worse long-term graft and patient survival.

Methods: We performed an analysis of the United Network for Organ Sharing database, including children age < 18 years who received a kidney transplant between 2003 and 2018. Read More

View Article and Full-Text PDF
January 2022

Sex differences in the likelihood of pre-emptive living donor kidney transplantation, and outcomes after kidney transplantation in children and adolescents.

Pediatr Transplant 2022 Jan 10:e14224. Epub 2022 Jan 10.

Centre for Kidney Disease Research, University of Queensland, Brisbane, Queensland, Australia.

Background: Data on sex-based disparities in children with kidney failure and outcomes after kidney transplantation are relatively sparse. This study examined the association between sex differences and the odds of receiving a pre-emptive living donor kidney transplantation, and post-transplant outcomes in children and adolescents.

Methods: We studied all patients (aged <20 years) who commenced kidney replacement therapy (KRT) between 2002 and 2017 using data from the ANZDATA Registry. Read More

View Article and Full-Text PDF
January 2022

The effect of latent and error non-normality on corrections to the test statistic in structural equation modeling.

Behav Res Methods 2022 Jan 10. Epub 2022 Jan 10.

Department of Psychological Research Methods, Institute of Psychology and Education, Ulm University, Albert-Einstein-Allee 47, 89081, Ulm, Germany.

In structural equation modeling, several corrections to the likelihood-ratio model test statistic have been developed to counter the effects of non-normal data. Previous robustness studies investigating the performance of these corrections typically induced non-normality in the indicator variables. However, non-normality in the indicators can originate from non-normal errors or non-normal latent factors. Read More

View Article and Full-Text PDF
January 2022

Rejection-identification and increased use of geosocial networking apps to meet male sexual partners among Black men who have sex with men.

Cultur Divers Ethnic Minor Psychol 2022 Jan 10. Epub 2022 Jan 10.

Psychological Sciences Department.

The use of geosocial networking (GSN) apps to meet male sexual partners may contribute to HIV infection risk for Black men who have sex with men (MSM), but the psychosocial underpinnings of this behavior are not understood. In social psychology, the Rejection-Identification Model posits that identification with a socially stigmatized group emerges as a means of coping in response to perceived stigmatization-which can shape behavior. This study tested the Rejection-Identification process as a facilitator of increased use of GSN apps to meet male sexual partners among Black MSM who use these apps. Read More

View Article and Full-Text PDF
January 2022

Hybrid Hydrogel Composed of Hyaluronic Acid, Gelatin, and Extracellular Cartilage Matrix for Perforated TM Repair.

Front Bioeng Biotechnol 2021 24;9:811652. Epub 2021 Dec 24.

ENT Department, Joint Centre of Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

A novel series of composite hydrogels, built from the three components 1), hyaluronic acid methacryloyl (HAMA); 2), gelatin methacryloyl (GelMA), and 3), extracellular cartilage matrix (ECM), was prepared and studied regarding the possible utility in the surgical repair of damaged (perforated) tympanic membrane (TM). Noteworthy is component 3), which was harvested from the ribs of α-1,3-galactosidyltransferase-knockout (α-1,3 GalT-KO) pigs. The absence of α-1,3-galactosyl glycoprotein is hypothesized to prevent rejection due to foreign-body immunogenicity. Read More

View Article and Full-Text PDF
December 2021

Positively charged nanofiltration membrane synthesis, transport models, and lanthanides separation.

J Memb Sci 2021 Feb 14;620. Epub 2020 Dec 14.

Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA.

The design and understanding of rejection mechanisms for both positively and negatively charged nanofiltration (NF) membranes are needed for the development of highly selective separation of multivalent ions. In this study, positively charged nanofiltration membranes were created via an addition of commercially available polyallylamine hydrochloride (PAH) by conventional interfacial polymerization technique. Demonstration of real increase in surface zeta potential, along with other characterization methods, confirmed the addition of weak basic functional groups from PAH. Read More

View Article and Full-Text PDF
February 2021

Recent progress in the pig-to-nonhuman primate kidney transplantation model: Report of a symposium.

Authors:
David K C Cooper

Xenotransplantation 2022 Jan 10:e12728. Epub 2022 Jan 10.

Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, Massachusetts, USA.

Three excellent presentations at an industry-sponsored symposium at the (virtual) congress of the combined IXA/CTRMS (September 23-25, 2021) were directed to the value and limitations of the pig-to-nonhuman primate (NHP) kidney transplantation model. Daniel Firl and James Markmann provided a meta-analysis comparing the results of kidney allotransplantation and xenotransplantation in NHPs during the past 25 years. Remarkably, the authors had identified 73 published reports that included 910 individual experiments. Read More

View Article and Full-Text PDF
January 2022

Cognitive cascades: How to model (and potentially counter) the spread of fake news.

PLoS One 2022 7;17(1):e0261811. Epub 2022 Jan 7.

Department of Computer Science, Tufts University, Medford, Massachusetts, United States of America.

Understanding the spread of false or dangerous beliefs-often called misinformation or disinformation-through a population has never seemed so urgent. Network science researchers have often taken a page from epidemiologists, and modeled the spread of false beliefs as similar to how a disease spreads through a social network. However, absent from those disease-inspired models is an internal model of an individual's set of current beliefs, where cognitive science has increasingly documented how the interaction between mental models and incoming messages seems to be crucially important for their adoption or rejection. Read More

View Article and Full-Text PDF
January 2022

Reliability Analysis For Finger Movement Recognition With Raw Electromyographic Signal by Evidential Convolutional Networks.

IEEE Trans Neural Syst Rehabil Eng 2022 Jan 7;PP. Epub 2022 Jan 7.

Hand gesture recognition with surface electromyography (sEMG) is indispensable for Muscle-Gesture-Computer Interface. The usual focus of it is upon performance evaluation involving the accuracy and robustness of hand gesture recognition. However, addressing the reliability of such classifiers has been absent, to our best knowledge. Read More

View Article and Full-Text PDF
January 2022

Modeling and control of an invasive mechanical ventilation system using the active disturbances rejection control structure.

ISA Trans 2021 Dec 22. Epub 2021 Dec 22.

Facultad de Medicina, Universidad Autónoma de Baja California, Mexicali, B.C., Mexico.

We propose a mandatory invasive mechanical ventilator prototype for severe COVID-19 patients with volume and pressure control operation modes. This system comprises basic pneumatic elements and sensors. Its performance is similar to commercial equipment, and it presents robustness to external disturbances and parametric uncertainties. Read More

View Article and Full-Text PDF
December 2021

Versatility of Protocols for Resistance Training and Assessment using Static and Dynamic Ladders in Animal Models.

J Vis Exp 2021 Dec 17(178). Epub 2021 Dec 17.

Instituto de Investigación Sanitaria del Principado de Asturias (ISPA); Department of Morphology and Cellular Biology, University of Oviedo;

Resistance training is a physical exercise model with profound benefits for health throughout life. The use of resistance exercise animal models is a way to gain insight into the underlying molecular mechanisms that orchestrate these adaptations. The aim of this article is to describe exercise models and training protocols designed for strength training and evaluation of resistance in animal models and provide examples. Read More

View Article and Full-Text PDF
December 2021

A Liquid Hydrogel to Restore Long Term Corneal Integrity After Perforating and Non-Perforating Trauma in Feline Eyes.

Front Bioeng Biotechnol 2021 15;9:773294. Epub 2021 Dec 15.

Department of Ophthalmology, Université de Montréal, Montreal, QC, Canada.

To evaluate long-term functionality of corneas regenerated using a cell-free, liquid hydrogel filler (LiQD Cornea) after deep corneal trauma in the feline model. Two healthy cats underwent 4 mm diameter stepwise 250/450 µm deep surgical corneal ablation with and without needle perforation. The filler comprising 10% (w/w) collagen-like peptide conjugated to polyethylene glycol (CLP-PEG) and 1% fibrinogen and crosslinked with 2% (w/w) 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM), was applied to the wound bed previously coated with thrombin (250 U/ml). Read More

View Article and Full-Text PDF
December 2021

Influence of maternal attitudes and parenting style on children`s dental caries experience.

J Pak Med Assoc 2021 Oct;71(10):2325-2329

Department of Pediatric Dentistry, Yeditepe University, Istanbul, Turkey.

Objective: To evaluate the effect parental attitudes have on the dental caries experience of children.

Methods: The cross-sectional observational study was conducted at Yeditepe University, Istanbul, Turkey, from March to September 2019, and comprised mothers of children who came to the Department of Paediatric Dentistry for treatment of children. Multi-variable poisson regression model was run to predict prevalence of dental caries. Read More

View Article and Full-Text PDF
October 2021

Active disturbance rejection control for nanopositioning: A robust U-model approach.

ISA Trans 2021 Dec 10. Epub 2021 Dec 10.

School of Computer and Information Engineering, Beijing Technology and Business University, Beijing 100048, China; National Engineering Laboratory for Agri-product Quality Traceability,Beijing Technology and Business University, Beijing 100048, China. Electronic address:

Hysteresis severely reduces positioning performance of a piezoelectric nanopositioning stage. Linear active disturbance rejection control (LADRC) is a practical solution to improve the positioning accuracy. However, the PD controller utilized in the LADRC is not effective enough to suppress the uncancelled total disturbance, and high-order pure integrators are difficult to be stabilized just by a PD controller. Read More

View Article and Full-Text PDF
December 2021

Monitoring B cell alloresponses in rats.

J Immunol Methods 2021 Dec 29;501:113212. Epub 2021 Dec 29.

Department of Nephrology, University Hospital Regensburg, Germany.

Antibody-mediated rejection is a major cause of graft failure in organ transplantation. For this reason, B cell responses are of particular interest to transplantation research. Rats are important model organisms for transplant studies, but B cell alloimmune assays and B cell subset markers are poorly established in rats. Read More

View Article and Full-Text PDF
December 2021

Establishment of a Hyperacute Rejection Model of ABO-Incompatible Renal Transplantation in Nonhuman Primates.

Front Immunol 2021 14;12:807604. Epub 2021 Dec 14.

Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The establishment of a hyperacute rejection (HAR) model of ABO-incompatible kidney transplantation (ABOi-KTx) in nonhuman primates is of great significance for the study of the relevant clinical pathophysiological processes and related interventions in ABOi-KTx. In this study, blood group B cynomolgus monkeys were presensitized with synthetic blood group A-antigen conjugated to keyhole limpet hemocyanin (A-KLH) to boost circulating anti-A antibody levels. The serum anti-A antibody levels were measured by flow cytometry using type A human reagent red blood cells (RBCs) or monkey primary renal tubular epithelial cells (RTECs) as target cells. Read More

View Article and Full-Text PDF
December 2021

Revolutionizing Membrane Design Using Machine Learning-Bayesian Optimization.

Environ Sci Technol 2021 Dec 30. Epub 2021 Dec 30.

School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.

Polymeric membrane design is a multidimensional process involving selection of membrane materials and optimization of fabrication conditions from an infinite candidate space. It is impossible to explore the entire space by trial-and-error experimentation. Here, we present a membrane design strategy utilizing machine learning-based Bayesian optimization to precisely identify the optimal combinations of unexplored monomers and their fabrication conditions from an infinite space. Read More

View Article and Full-Text PDF
December 2021

Tissue engineered endothelial keratoplasty in rabbit: tips and tricks.

Acta Ophthalmol 2021 Dec 29. Epub 2021 Dec 29.

Corneal Graft Biology, Engineering and Imaging Laboratory, BiiGC, EA2521, Health & innovation campus, Faculty of Medicine, Jean Monnet University, Saint-Etienne, France.

Purpose: To report a detailed surgical procedure of tissue engineered endothelial keratoplasty (TEEK) in a rabbit model and its postoperative evaluation.

Methods: TEEKs were prepared 7 days before transplantation by seeding human or rabbit corneal endothelial cells on either femtosecond laser-cut ultrathin human stromal lamellae (fs-UTSL) or femtosecond laser-cut human anterior lens capsule (fs-HALC). Thirty transplantations were performed on aphakic eyes. Read More

View Article and Full-Text PDF
December 2021

The 2021 IXA Keith Reemtsma Lecture: Moving xenotransplantation to the clinic.

Authors:
David K C Cooper

Xenotransplantation 2021 Dec 29:e12723. Epub 2021 Dec 29.

Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.

Keith Reemtsma was a pioneer in xenotransplantation, the Honorary Founding President of the International Xenotransplantation Association (in 1998), and a wonderful personality. It is a privilege to be invited to give this lecture in his memory. If he were alive today, he would be delighted to see the progress that has been made in pig organ transplantation into nonhuman primate recipients. Read More

View Article and Full-Text PDF
December 2021

Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) agonists in islet transplantation: Endogenous in vivo regulatory T cell expansion promotes prolonged allograft survival.

Am J Transplant 2021 Dec 29. Epub 2021 Dec 29.

Department of Surgery, University of Alberta, Edmonton, Canada.

Regulatory T cells (Tregs) modulate alloimmune responses and may facilitate minimization or withdrawal of immunosuppression posttransplant. Current approaches, however, rely on complex ex vivo Treg expansion protocols. Herein, we explore endogenous in vivo Treg expansion through antibody-mediated agonistic stimulation of the tumor necrosis factor receptor superfamily member 25 (TNFRSF25) pathway and its potential to prolong graft survival in a mouse model of islet allotransplantation. Read More

View Article and Full-Text PDF
December 2021

The Present State and Future Perspectives of Cardiac Regenerative Therapy Using Human Pluripotent Stem Cells.

Front Cardiovasc Med 2021 8;8:774389. Epub 2021 Dec 8.

Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.

The number of patients with heart failure (HF) is increasing with aging in our society worldwide. Patients with HF who are resistant to medication and device therapy are candidates for heart transplantation (HT). However, the shortage of donor hearts is a serious issue. Read More

View Article and Full-Text PDF
December 2021

Intimal Arteritis and Microvascular Inflammation Are Associated With Inferior Kidney Graft Outcome, Regardless of Donor-Specific Antibodies.

Front Med (Lausanne) 2021 8;8:781206. Epub 2021 Dec 8.

Department of Nephrology, Transplant Centre, Institute for Clinical and Experimental Medicine, Prague, Czechia.

The prognostic role of intimal arteritis of kidney allografts in donor-specific antibody negative (DSA-) antibody-mediated rejection (ABMR) remains unclear. Seventy-two out of 881 patients who had undergone kidney transplantation from 2014 to 2017 exhibited intimal arteritis in biopsies performed during the first 12 months. In 26 DSA negative cases, the intimal arteritis was accompanied by tubulointerstitial inflammation as part of T cell-mediated vascular rejection (TCMRV, = 26); intimal arteritis along with microvascular inflammation occurred in 29 DSA negative (ABMRV/DSA-) and 19 DSA positive cases (ABMRV, DSA+, = 17). Read More

View Article and Full-Text PDF
December 2021

Generating novel molecule for target protein (SARS-CoV-2) using drug-target interaction based on graph neural network.

Netw Model Anal Health Inform Bioinform 2022 18;11(1). Epub 2021 Dec 18.

Department of Computer Science and Engineering, Indian Institute of Technology Patna, Patna, 801103 India.

The transmittable spread of viral coronavirus (SARS-CoV-2) has resulted in a significant rise in global mortality. Due to lack of effective treatment, our aim is to generate a highly potent active molecule that can bind with the protein structure of SARS-CoV-2. Different machine learning and deep learning approaches have been proposed for molecule generation; however, most of these approaches represent the drug molecule and protein structure in 1D sequence, ignoring the fact that molecules are by nature in 3D structure, and because of this many critical properties are lost. Read More

View Article and Full-Text PDF
December 2021