4,300 results match your criteria rejection defined


Cytosporone B (Csn-B), an NR4A1 agonist, attenuates acute cardiac allograft rejection by inducing differential apoptosis of CD4+T cells.

Int Immunopharmacol 2022 Jan 10;104:108521. Epub 2022 Jan 10.

Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

CD4+T cell-mediated acute rejection remains a major factor that affects the early survival of transplanted organs post-transplantation. Here, we reveal that nuclear receptor subfamily 4 Group A member 1 (Nr4A1) was upregulated during cardiac allograft rejection and that the increased Nr4A1 was primarily localized in intragraft-infiltrating CD4+T cells. Nr4A1 acts as a transcription factor with an important role in CD4+T cell apoptosis, differentiation and T cell dysfunction, which indicates that Nr4A1 may play a critical role in transplant rejection. Read More

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January 2022

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of Kidney Transplant Recipients.

Ann Transplant 2022 Jan 12;27:e934738. Epub 2022 Jan 12.

Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, Uppsala, Sweden.

BACKGROUND BK virus (BKV) infection after kidney transplantation leads to BKV-associated nephropathy (BKVAN) in up to 10% of recipients, and is associated with an increased risk of allograft dysfunction or loss. The objective of this study was to estimate the incidence of BKVAN and to analyze whether enhanced induction is associated with an increased risk of BKVAN, possibly justifying more intensive surveillance. MATERIAL AND METHODS This was a single-center retrospective cohort study. Read More

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January 2022

Plasma cell rich acute rejection: Risk factors, treatment and outcomes.

Saudi J Kidney Dis Transpl 2021 Mar-Apr;32(2):387-397

Department of Pathology, Army Hospital (Research and Referral), New Delhi, India.

Plasma cell-rich rejection is a rare and poorly defined entity. Its treatment is not clearly defined and has universally poor prognosis. More data should be published from various transplant centers around the world to identify the treatment that has the best outcomes and to formulate treatment guidelines for these cases. Read More

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January 2022

Engineering Commercial TiO Powder into Tailored Beads for Efficient Water Purification.

Materials (Basel) 2022 Jan 3;15(1). Epub 2022 Jan 3.

Institute of Nanoscience and Nanotechnology, N.C.S.R. "Demokritos", Ag. Paraskevi, 15310 Athens, Greece.

In this study, efficient commercial photocatalyst (Degussa P25) nanoparticles were effectively dispersed and stabilized in alginate, a metal binding biopolymer. Taking advantage of alginate's superior metal chelating properties, copper nanoparticle-decorated photocatalysts were developed after a pyrolytic or calcination-sintering procedure, yielding ceramic beads with enhanced photocatalytic and mechanical properties, excellent resistance to attrition, and optimized handling compared to powdered photocatalysts. The morphological and structural characteristics were studied using LN porosimetry, SEM, and XRD. Read More

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January 2022

Low dose rabbit antithymocyte globulin is non-inferior to higher dose in low-risk pediatric kidney transplant recipients.

Pediatr Nephrol 2022 Jan 10. Epub 2022 Jan 10.

Division of Nephrology, Department of Pediatrics, Stanford University, Palo Alto, CA, USA.

Background: Currently, there is no consensus among pediatric kidney transplant centers regarding the use and regimen for immunosuppressive induction therapy.

Methods: In this single center, retrospective cohort study, pediatric kidney transplant recipients transplanted between 1 May 2013 and 1 May 2018 with rabbit antithymocyte globulin (rATG) induction were included. We stratified patients based on immunological risk, with high risk defined as those with repeat transplant, preformed donor specific antibody, current panel-reactive antibodies > 20%, 0 antigen match and/or African-American heritage. Read More

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January 2022

Textbook surgical outcome in lung transplantation: Analysis of a US national registry.

Clin Transplant 2022 Jan 9:e14588. Epub 2022 Jan 9.

Department of Surgery, Duke University Medical Center, Durham, NC, USA.

Textbook surgical outcome (TO) is a novel composite quality measure in lung transplantation (LTx). Compared to one-year survival metrics, TO may better differentiate center performance, and motivate improvements in care. To understand the feasibility of implementing this metric, we defined TO in LTx using US national data, and evaluated its ability to predict post-transplant outcomes and differentiate center performance. Read More

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January 2022

Rabbit antithymocyte globulin dose and early subclinical and clinical rejections in kidney transplantation.

Clin Transplant 2022 Jan 9:e14582. Epub 2022 Jan 9.

University of Pittsburgh Medical Center, Division of Transplant Nephrology.

Antithymocyte globulin (ATG) is a commonly used induction agent in kidney transplant recipients. However, the optimal dosing has not been well defined. Our protocol aims for a 5-6 mg/kg cumulative dose. Read More

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January 2022

Fungal infections in lung transplantation.

J Thorac Dis 2021 Nov;13(11):6695-6707

University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Lung transplant is a potential life-saving procedure for chronic lung diseases. Lung transplant recipients (LTRs) are at the greatest risk for invasive fungal infections (IFIs) among solid organ transplant (SOT) recipients because the allograft is directly exposed to fungi in the environment, airway and lung host defenses are impaired, and immunosuppressive regimens are particularly intense. IFIs occur within a year of transplant in 3-19% of LTRs, and they are associated with high mortality, prolonged hospital stays, and excess healthcare costs. Read More

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November 2021

Characterization of Cytomegalovirus Viremia in Renal Transplant Recipients.

Can J Hosp Pharm 2022 ;75(1):6-14

, BSc(Pharm), MSc(Pharm), ACPR, is with St Paul's Hospital, Vancouver, British Columbia.

Background: Kidney transplantation, while improving outcomes for patients with end-stage renal disease, comes with a risk of potentially life-threatening infections such as infection with cytomegalovirus (CMV), a virus associated with allograft rejection, organ dysfunction, and increased mortality.

Objectives: To characterize whether the choice and dose of immunosuppressant therapy and the duration of antiviral prophylaxis after transplant are associated with the incidence of CMV viremia.

Methods: This study was a retrospective review of all kidney-only transplant recipients at the authors' centre from 2012 to 2016, with a minimum 1 year of follow-up. Read More

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January 2022

Outcomes among CMV-mismatched and highly sensitized kidney transplants recipients who develop neutropenia.

Clin Transplant 2022 Jan 4:e14583. Epub 2022 Jan 4.

Division of Nephrology, University of California, San Francisco School of Medicine, San Francisco, California, USA.

Limited data exist on the incidence and clinical outcomes of neutropenia among kidney transplant recipients. Our study included 572 adults who received a kidney transplant at the University of California, San Francisco Medical Center between 2012 and 2018, and were CMV-mismatched or had a PRA ≥ 80%. Recipients with HIV, Hepatitis B and C, and primary non-function were excluded. Read More

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January 2022

Efficient Ways to Combat Doping in a Sports Education Context!? A Systematic Review on Doping Prevention Measures Focusing on Young Age Groups.

Front Sports Act Living 2021 16;3:673452. Epub 2021 Dec 16.

Institute of Sport Science, Research Group "Sport and Education", Carl von Ossietzky University of Oldenburg, Oldenburg, Germany.

Youth is characterized by testing and crossing natural boundaries, sometimes with the help of performance-enhancing substances. In this context, doping prevention measures play a crucial role to protect individuals both within and outside the context of elite sport. Based on the PRISMA guidelines, a systematic literature search was conducted in the databases ProQuest (ERIC), Scopus, PSYNDEX/PsychInfo, PubMed, and Web of Science Core Collection to provide an overview of the impact of doping prevention measures, with particular attention to the underlying understanding of learning. Read More

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December 2021

B Cell-Derived Extracellular Vesicles Reveal Residual B Cell Activity in Kidney Graft Recipients Undergoing Pre-Transplant Desensitization.

Front Med (Lausanne) 2021 16;8:781239. Epub 2021 Dec 16.

Department of Nephrology and Kidney Transplantation, Hospital Clínic, Barcelona, Spain.

Living-donor kidney transplant (LDKT) recipients undergoing desensitization for Human Leukocyte Antigen (HLA)-incompatibility have a high risk of developing antibody-mediated rejection (ABMR). The purpose of the study is to evaluate if residual B cell activity after desensitization could be estimated by the presence of circulating B cell-derived extracellular vesicles (BEVs). BEVs were isolated by Sepharose-based size exclusion chromatography and defined as CD19+ and HLA-II+ extracellular vesicles. Read More

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December 2021

Monitoring B cell alloresponses in rats.

J Immunol Methods 2021 Dec 29;501:113212. Epub 2021 Dec 29.

Department of Nephrology, University Hospital Regensburg, Germany.

Antibody-mediated rejection is a major cause of graft failure in organ transplantation. For this reason, B cell responses are of particular interest to transplantation research. Rats are important model organisms for transplant studies, but B cell alloimmune assays and B cell subset markers are poorly established in rats. Read More

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December 2021

"Nothing more will be changed here": A qualitative study on the needs of people with dementia.

Alzheimers Dement 2021 Dec;17 Suppl 8:e052906

German Center for Neurodegenerative Diseases (DZNE) - Rostock/Greifswald, Rostock, Germany.

Background: To prepare nursing students optimally for their future daily working life as formal caregivers of people with age-related diseases such as dementia, the needs of this target group must be identified. We explored the needs of people with dementia based on Maslow's need hierarchy theory to systematically identify requirements of nursing professionals as part of the project Digital Training of Nursing and Health Management (DigiCare).

Method: We conducted semi-structured interviews with people with dementia (n = 10) and caregivers of people with dementia (n = 32). Read More

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December 2021

Funnel tracking control for nonlinear servo drive systems with unknown disturbances.

ISA Trans 2021 Dec 13. Epub 2021 Dec 13.

School of Automation, Qingdao University, and Shanodng Key Laboratory of Industrial Control Technology, Qingdao, 266071, China. Electronic address:

In this paper, a novel robust tracking control strategy based on funnel control is proposed for servo drive systems with unknown disturbances. A modified funnel variable is defined and incorporated into the control design to guarantee the tracking error within a prescribed boundary. To reject the bounded disturbances, a robust integral of the sign of the error (RISE) controller based on the funnel variable is proposed for servo drive systems. Read More

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December 2021

Two-Stage Single-Arm Trials Are Rarely Analyzed Effectively or Reported Adequately.

JCO Precis Oncol 2021 16;5. Epub 2021 Dec 16.

Centre for Trials Research, Cardiff University, Cardiff, United Kingdom.

Purpose: Two-stage single-arm designs have historically been the most common design used in phase II oncology. They remain a mainstay today, particularly for trials in rare subgroups. Consequently, it is imperative such studies be designed, analyzed, and reported effectively. Read More

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December 2021

Clinical Relevance of Isoagglutinin Rebound in Adult ABO-Incompatible Living Donor Liver Transplantation.

J Pers Med 2021 Dec 5;11(12). Epub 2021 Dec 5.

Division of Liver and Transplantation Surgery, Department of General Surgery, Chang-Gung Memorial Hospital, Linkou 33357, Taiwan.

ABO-incompatible (ABO-I) living donor liver transplantation (LDLT) can be performed successfully. However, anti-ABO isoagglutinin rebound may cause antibody-mediated rejection (AMR) and graft loss. The risk threshold of isoagglutinin rebound is still not defined. Read More

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December 2021

The Summarized Assessment of Endothelin A Receptor Expression in Renal Transplant Compartments Associated with Antibody-Mediated Rejection.

Diagnostics (Basel) 2021 Dec 15;11(12). Epub 2021 Dec 15.

Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland.

The occurrence of anti-endothelin A receptor antibodies may be useful in diagnosis of transplant damage. We noticed that the presence of the endothelin A receptor (ETA receptor) in biopsy compartments is yet to be defined. We decided therefore to analysed the presence and relevance of the ETA receptor in biopsy to define the cause. Read More

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December 2021

Development of a Nomogram to Predict Graft Survival After Descemet Stripping Endothelial Keratoplasty.

Cornea 2021 Dec 23. Epub 2021 Dec 23.

Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA; Dicle University, Diyarbakır, Turkey; Biostatistics Consulting Core, Vickie and Jack Farber Vision Research Center, Wills Eye Hospital, Philadelphia, PA; and Cornea Service, Wills Eye Hospital, Philadelphia, PA.

Background/purpose: The purpose of this study was to analyze Descemet stripping endothelial keratoplasty (DSEK) outcomes and develop a nomogram to compute the probability of 3- and 5-year DSEK graft survival based on risk factors.

Study Design/methods: The medical records of 794 DSEK procedures between January 1, 2008, and August 1, 2019, were retrospectively reviewed to identify 37 variables. We also evaluated for the presence of corneal graft failure, defined as irreversible and visually significant graft edema, haze, or scarring. Read More

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December 2021

Trends in Public Stigma of Mental Illness in the US, 1996-2018.

JAMA Netw Open 2021 12 1;4(12):e2140202. Epub 2021 Dec 1.

Department of Sociology, Indiana University, Bloomington.

Importance: Stigma, the prejudice and discrimination attached to mental illness, has been persistent, interfering with help-seeking, recovery, treatment resources, workforce development, and societal productivity in individuals with mental illness. However, studies assessing changes in public perceptions of mental illness have been limited.

Objective: To evaluate the nature, direction, and magnitude of population-based changes in US mental illness stigma over 22 years. Read More

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December 2021

Improve in-depth immunological risk assessment to optimize genetic-compatibility and clinical outcomes in child and adolescent recipients of parental donor kidney transplants: protocol for the INCEPTION study.

BMC Nephrol 2021 Dec 19;22(1):416. Epub 2021 Dec 19.

Sydney School of Public Health, The University of Sydney, Sydney, Australia.

Background: Parental donor kidney transplantation is the most common treatment option for children and adolescents with kidney failure. Emerging data from observational studies have reported improved short- and medium-term allograft outcomes in recipients of paternal compared to maternal donors. The INCEPTION study aims to identify potential differences in immunological compatibility between maternal and paternal donor kidneys and ascertain how this affects kidney allograft outcomes in children and adolescents with kidney failure. Read More

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December 2021

Post-transplantation outcomes of sensitized patients receiving durable mechanical circulatory support.

J Heart Lung Transplant 2021 Nov 18. Epub 2021 Nov 18.

Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address:

Background: Sensitization, defined as the presence of circulating antibodies, presents challenges, particularly in patients undergoing heart transplantation (HTx) bridged with durable mechanical circulatory support (MCS). We aimed to investigate the post-transplantation outcomes of sensitized MCS patients.

Methods: Among 889 consecutively enrolled heart transplant (HTx) recipients between 2010 and 2018, 86 (9. Read More

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November 2021

Pathways from exposure to racial/ethnic discrimination to depression: Testing a social-cognitive model.

Soc Sci Med 2022 Jan 17;292:114558. Epub 2021 Nov 17.

St. John's University, 8000 Utopia Parkway, Jamaica, NY, 11439, United States. Electronic address:

Rationale And Objective: Interpersonal racial/ethnic discrimination is a risk factor for depression across the lifespan in minoritized racial/ethnic groups. This study tests a model proposing that social cognitive processes, including relational schemas, mediate the link between discrimination and depression. Relational schemas enable individuals to form mental representations of others, reflecting prior social learning and generating expectations about future social relations. Read More

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January 2022

Outcomes of Deceased Donor Kidney Transplantation in the Eurotransplant Senior Program with A Focus on Recipients ≥75 Years.

J Clin Med 2021 Nov 29;10(23). Epub 2021 Nov 29.

Department of Urology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 10117 Berlin, Germany.

To evaluate the outcomes of kidney transplantations (KTs) in the Eurotransplant Senior Program (ESP) with a focus on the very old, defined as recipients ≥75 years. This retrospective clinical study included 85 patients, who under the ESP protocol underwent deceased donor kidney transplantation from January 2010 to July 2018 at the Charité-Universitätsmedizin Berlin in Germany. Recipients were divided in three age groups, i. Read More

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November 2021

C-Reactive protein level and left ventricular mass are associated with acute cellular rejection after heart transplant.

Clinics (Sao Paulo) 2021 6;76:e3020. Epub 2021 Dec 6.

Programa de Transplante Cardiaco, Hospital Israelita Albert Einstein (HIAE), Sao Paulo, SP, BR.

Objectives: Acute cellular rejection (ACR) remains a major complication of heart transplant (HT). The gold standard for its diagnosis is endomyocardial biopsy (EMB), whereas the role of non-invasive biomarkers for detecting ACR is unclear. This study aimed to identify non-invasive biomarkers for the diagnosis of ACR in patients undergoing HT and presenting with normal left ventricular function. Read More

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December 2021

Transcripts associated with chronic lung allograft dysfunction in transbronchial biopsies of lung transplants.

Am J Transplant 2021 Nov 30. Epub 2021 Nov 30.

University of Alberta, Edmonton, Alberta, Canada.

Transplanted lungs suffer worse outcomes than other organ transplants with many developing chronic lung allograft dysfunction (CLAD), diagnosed by physiologic changes. Histology of transbronchial biopsies (TBB) yields little insight, and the molecular basis of CLAD is not defined. We hypothesized that gene expression in TBBs would reveal the nature of CLAD and distinguish CLAD from changes due simply to time posttransplant. Read More

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November 2021

Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-Specific HLA Antibodies and C4d⁺ Antibody-Mediated Rejection in Kidney Transplant Recipients.

Ann Transplant 2021 Dec 1;26:e934175. Epub 2021 Dec 1.

Immunogenetics and Transplantation Laboratory, Department of Surgery, University of California San Francisco (UCSF), San Francisco, CA, USA.

BACKGROUND Solid-phase assays to investigate the complement-activating capacity of HLA antibodies have been utilized to optimize organ allocation and improve transplant outcomes. The clinical utility of C1q/C3d-binding characteristics of de novo donor-specific anti-HLA antibodies (dnDSA) associated with C4d-positive antibody-mediated rejection (C4d⁺ AMR) in kidney transplants (KTx) has not been defined. MATERIAL AND METHODS Sera from 120 KTx recipients that had dnDSA concurrent with protocol/cause biopsy (median 3. Read More

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December 2021

Policies and practices in the field of laboratory hematology in Croatia - a current overview and call for improvement.

Clin Chem Lab Med 2022 Jan 1;60(2):271-282. Epub 2021 Dec 1.

Working Group for Laboratory Hematology of the Croatian Society of Medical Biochemistry and Laboratory Medicine, Zagreb, Croatia.

Objectives: In 2019 The Croatian Working Group for Laboratory Hematology, on behalf of the Croatian Society of Medical Biochemistry and Laboratory Medicine, wanted to explore the background in field of laboratory hematology routine practice among Croatian laboratories in order to develop future strategies for producing national recommendations, if needed.

Methods: During April and May 2019, a comprehensive survey covering all main parts of the total testing process within the field of laboratory hematology among Croatian medical laboratories was conducted. The survey comprised 49 inquiries. Read More

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January 2022

Impact of lockdown during the COVID-19 outbreak on ophthalmological emergencies in a referral center in France.

J Fr Ophtalmol 2022 Jan 22;45(1):1-8. Epub 2021 Nov 22.

Neuro-ophthalmology and Emergency department, Hôpital Fondation Rothschild, Paris, France.

Purpose: In March 2020, the sudden rise in the number of SARS-CoV-2 infections in France led the government to impose a strict lockdown during which all non-urgent medical consultations were postponed. From March 17 to May 10, 2020, private medical practices were closed, and telemedicine was encouraged. The consequences on ophthalmic care were dramatic, with over 90% of scheduled consultations canceled. Read More

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January 2022

Comparison of FOXP3 and Interleukin 35 Expression Profiles in Kidney Transplant Recipients With Excellent Long-Term Graft Function and Acute Rejection.

Exp Clin Transplant 2021 Nov;19(11):1142-1148

From the Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Objectives: Transplant tolerance is defined as graft acceptance without long-term use of immunosuppressive agents. Regulatory T cells are involved in the maintenance of peripheral self-tolerance by actively suppressing the activation and expansion of autoreactive T cells. In the present study, we compared the expression profiles of forkhead box protein P3 (FOXP3) and interleukin 35 in kidney transplant recipients who had excellent long-term graft function under immunosuppression versus recipients who had acute rejection. Read More

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November 2021