490,407 results match your criteria regulatory

Comparative analysis of alfalfa (Medicago sativa L.) seedling transcriptomes reveals genotype-specific drought tolerance mechanisms.

Plant Physiol Biochem 2021 May 29;166:203-214. Epub 2021 May 29.

Agricultural College, Ningxia University, Yinchuan, 750021, China. Electronic address:

Drought is one of the main abiotic factors that affect alfalfa yield. The identification of genes that control this complex trait can provide important insights for alfalfa breeding. However, little is known about how alfalfa responds and adapts to drought stress, particularly in cultivars of differing drought tolerance. Read More

View Article and Full-Text PDF

Co-occurring risk and protective factors and regulatory behavior of infants living in low-income homes.

Infant Behav Dev 2021 Jun 9;64:101598. Epub 2021 Jun 9.

Crane Center for Early Childhood Research and Policy, The Ohio State University, United States.

Early self-regulation is a foundation for lifelong wellness and can be shaped by the interplay among several vital exposures. In this study, we examined the emergence of reliable profiles based upon exposure to risk and protective factors in infancy, determined if sociodemographic resources predict profile membership, and determined if these profiles predict early regulatory behaviors in a sample of infants reared in low-income homes. Data were collected from a sample of primarily Black or White mother-infant dyads living in low-income homes in the Midwest (n = 222) during the infants' first year of life (mean maternal age at enrollment: 26. Read More

View Article and Full-Text PDF

Pesticides are the dominant stressors for vulnerable insects in lowland streams.

Water Res 2021 May 17;201:117262. Epub 2021 May 17.

Department of River Ecology, Helmholtz Centre for Environmental Research, UFZ, 04318 Leipzig, Germany.

Despite elaborate regulation of agricultural pesticides, their occurrence in non-target areas has been linked to adverse ecological effects on insects in several field investigations. Their quantitative role in contributing to the biodiversity crisis is, however, still not known. In a large-scale study across 101 sites of small lowland streams in Central Europe, Germany we revealed that 83% of agricultural streams did not meet the pesticide-related ecological targets. Read More

View Article and Full-Text PDF

Differential lncRNA expression profiling of cognitive function in middle and old aged monozygotic twins using generalized association analysis.

J Psychiatr Res 2021 Jun 2;140:197-204. Epub 2021 Jun 2.

Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Denmark; Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, Denmark. Electronic address:

Cognitive impairment is the most prominent symptom in neurodegenerative disorders affecting quality of life and mortality. However, despite years of research, the molecular mechanism underlying the regulation of cognitive function and its impairment is poorly understood. This study aims to elucidate the role of long non-coding RNAs (lncRNAs) expression and lncRNA-mRNA interaction networks, by analyzing lncRNA expression in whole blood samples of 400 middle and old aged monozygotic twins in association with cognitive function using both linear models and a generalized correlation coefficient (GCC) to capture the diverse patterns of correlation. Read More

View Article and Full-Text PDF

Microwave-enhanced reductive immobilization of high concentrations of chromium in a field soil using iron polysulfide.

J Hazard Mater 2021 Jun 3;418:126293. Epub 2021 Jun 3.

School of Environment and Energy, Guangdong Provincial Key Laboratory of Solid Wastes Pollution Control and Resource Recycling, South China University of Technology, Guangzhou 510006, China; School of Metallurgy and Environment, Central South University, Changsha 410083, China.

High concentrations of Cr(VI) are often detected in contaminated soil. Yet, cost-effective remediation technologies have been lacking. In this study, we prepared a type of FeS based on commercial FeSO. Read More

View Article and Full-Text PDF

Acute experimental barrier injury triggers ulcerative colitis specific innate hyper-responsiveness and ulcerative colitis-type microbiome changes in humans.

Cell Mol Gastroenterol Hepatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Gastroenterology, Herlev Hospital, University of Copenhagen, Denmark.

Background And Aims: The trigger hypothesis opens the possibility of anti-flare-initiation therapies by stating that ulcerative colitis (UC) flares originates from inadequate responses to acute mucosal injuries. However, experimental evidence is restricted by a limited use of suitable human models. We thus aimed to investigate the acute mucosal barrier injury responses in humans with and without UC using an experimental injury model. Read More

View Article and Full-Text PDF

Multiscale modeling of bone tissue Mechanobiology.

Bone 2021 Jun 9:116032. Epub 2021 Jun 9.

Multiscale in Mechanical and Biological Engineering, Instituto de Investigación en Ingeniería de Aragón (I3A), Instituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, Zaragoza, Spain.

Mechanical environment has a crucial role in our organism at the different levels, ranging from cells to tissues and our own organs. This regulatory role is especially relevant for bones, given their importance as load-transmitting elements that allow the movement of our body as well as the protection of vital organs from load impacts. Therefore bone, as living tissue, is continuously adapting its properties, shape and repairing itself, being the mechanical loads one of the main regulatory stimuli that modulate this adaptive behavior. Read More

View Article and Full-Text PDF

Heart rate variability biofeedback in chronic disease management: a systematic review.

Complement Ther Med 2021 Jun 9:102750. Epub 2021 Jun 9.

Laboratoire IRISSE EA4075, UFR des Sciences de l'Homme et de l'Environnement, Université de la Réunion, Le Tampon, La Réunion, France. Electronic address:

Background: Heart rate variability biofeedback (HRVB) is a non-pharmacological intervention used in the management of chronic diseases.

Method: A systematic search was performed according to eligibility criteria including adult chronic patients, HRVB as main treatment with or without control conditions, and psychophysiological outcomes as dependent variables.

Results: In total, 29 articles were included. Read More

View Article and Full-Text PDF

Revealing transcriptional and post-transcriptional regulatory mechanisms of γ-glutamyl transferase and keratin isoforms as novel cooperative biomarkers in low-grade glioma and glioblastoma multiforme.

Genomics 2021 Jun 9. Epub 2021 Jun 9.

Laboratory of Systems Biology and Bioinformatics (LBB), Department of Bioinformatics, University of Tehran, Kish International Campus, Kish, Iran; Laboratory of Systems Biology and Bioinformatics (LBB), Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran. Electronic address:

Gamma-glutamyltransferase (GGT) and keratins (KRT) are key factors in regulating tumor progression rely on emerging evidence. However, the prognostic values of GGT and KRT isoforms and their regulation patterns at transcriptional and post-transcriptional levels have been rarely studied. In this study, we aimed to identify cooperative prognostic biomarker signature conducted by GGT and KRT genes for overall survival prediction and discrimination in patients with low-grade glioma (LGG) and glioblastoma multiforme (GBM). Read More

View Article and Full-Text PDF

CCHamide2-receptor regulates feeding behavior in the pea aphid, Acyrthosiphon pisum.

Peptides 2021 Jun 9:170596. Epub 2021 Jun 9.

Key Laboratory of Integrated Crop Pest Management of Shandong Province, College of Plant Health and Medicine, Qingdao Agricultural University, 700 Changcheng Road, Qingdao, Shandong, 266109, China. Electronic address:

Neuropeptide CCHamide-2 is a recently discovered peptide presents in many arthropods and it is the ligand of the CCHamide-2 receptor (CCHa2-R), which is playing a regulatory role in diverse physiological processes, such as feeding, insulin production, lipid metabolism, growth and reproduction, however, the function of this gene in aphids is still unknown. Here, we characterized and determined the presumed role of CCHa2-R signaling in the wingless pea aphid, Acyrthosiphon pisum. Quantitative real-time reverse transcription-PCR (qRT-PCR) revealed the expression levels of CCHa2-R transcripts in different development stages and different tissues, which indicates that the CCHa2-R expression was high in the first instar as compared to the upcoming nymphal instars and adult and was predominantly high in the brain. Read More

View Article and Full-Text PDF

Arsenic disrupts neuronal insulin signaling through increasing free PI3K-p85 and decreasing PI3K activity.

Toxicol Lett 2021 Jun 9. Epub 2021 Jun 9.

Laboratory of Pharmacology, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Rd, Bangkok, 10210, Thailand; Environmental Toxicology Program, Chulabhorn Graduate Institute, 54 Kamphaeng Phet 6 Rd, Bangkok, 10210, Thailand; Center of Excellence on Environmental Health and Toxicology (EHT), Ministry of Higher Education, Science, Research and Innovation, Thailand.

Previously, we reported that prolonged arsenic exposure impaired neuronal insulin signaling. Here we have further identified novel molecular mechanisms underlying neuronal insulin signaling impairment by arsenic. Arsenic treatment altered insulin dose-response curve and reduced maximum insulin response in differentiated human neuroblastoma SH-SY5Y cells, suggesting that arsenic hindered neuronal insulin signaling in a non-competitive like manner. Read More

View Article and Full-Text PDF

Expression profiling, immune functions, and molecular characteristics of the tetraspanin molecule CD63 from Amphiprion clarkii.

Dev Comp Immunol 2021 Jun 9:104168. Epub 2021 Jun 9.

Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju 63333, Republic of Korea. Electronic address:

CD63, a member of the tetraspanin family, is involved in the activation of immune cells, antiviral immunity, and signal transduction. The economically important anemonefishes Amphiprion sp. often face disease outbreaks, and the present study aimed to characterize CD63 in Amphiprion clarkii (denoted AcCD63) to enable better disease management. Read More

View Article and Full-Text PDF

Dynamical Robustness and Its Structural Dependence in Biological Networks.

J Theor Biol 2021 Jun 9:110808. Epub 2021 Jun 9.

Faculty of Life and Environmental Sciences, University of Tsukuba, Tennodai, Tsukuba 305-8672, Japan.

We discuss the dynamical robustness of biological networks represented by directed graphs, such as neural networks and gene regulatory networks. The theoretical results indicate that networks with low indegree variance and high outdegree variance are dynamically robust. We propose a machine learning method that gives equilibrium states to inpus with a recurrent hidden layer. Read More

View Article and Full-Text PDF

Novel archetype in psoriasis management bridging molecular dynamics in exploring novel therapies.

Eur J Pharmacol 2021 Jun 9:174254. Epub 2021 Jun 9.

University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, 492010, India. Electronic address:

Psoriasis is an autoimmune chronic inflammatory condition of skin affecting 125 million populaces around the globe. It is implicated as a result of multifaceted phenomena involving various cell and subcell activities with the aid of numerous cellular and molecular components including signaling aisle and regulatory proteins owing to the development of such hyperproliferative dermatological conditions. This involves a deeply complex and conflicting pathology owing to genetic and immunological deviations resulting from the unusual presentation of different signaling pathways and regulatory proteins. Read More

View Article and Full-Text PDF

In Situ Tumor Vaccination with Nanoparticle Co-Delivering CpG and STAT3 siRNA to Effectively Induce Whole-Body Antitumor Immune Response.

Adv Mater 2021 Jun 12:e2100628. Epub 2021 Jun 12.

PDX Pharmaceuticals, Inc., Portland, OR, 97239, USA.

The success of immunotherapy with immune checkpoint inhibitors (ICIs) in a subset of individuals has been very exciting. However, in many cancers, responses to current ICIs are modest and are seen only in a small subsets of patients. Herein, a widely applicable approach that increases the benefit of ICIs is reported. Read More

View Article and Full-Text PDF

Gender-Specific Regulation of Interferon-γ Cytotoxicity in Mouse Liver by Autophagy.

Hepatology 2021 Jun 12. Epub 2021 Jun 12.

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.

Background & Aims: Interferon-γ (IFNγ) is a central activator of immune responses in the liver and other organs. IFNγ triggers tissue injury and inflammation in immune diseases which occur predominantly in females for unknown reasons. Recent findings that autophagy regulates hepatotoxicity from proinflammatory cytokines led to an examination of whether defective hepatocyte autophagy underlies gender-specific liver injury and inflammation induced by IFNγ. Read More

View Article and Full-Text PDF

Backbone resonance assignment of the cAMP-binding domains of the protein kinase A regulatory subunit Iα.

Biomol NMR Assign 2021 Jun 12. Epub 2021 Jun 12.

Department of Chemistry and Chemical Biology and Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4M1, Canada.

Protein kinase A (PKA) is the main receptor for the universal cAMP second messenger. PKA is a tetramer with two catalytic (C) and two regulatory (R) subunits, each including two tandem cAMP-binding domains, i.e. Read More

View Article and Full-Text PDF

Safety of Dapagliflozin in Patients with Type 2 Diabetes Mellitus in Saudi Arabia: A Post Authorization Safety Study.

Diabetes Ther 2021 Jun 12. Epub 2021 Jun 12.

Department of Internal Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Introduction: Sodium-glucose co-transporter-2 (SGLT2) inhibitors moderately reduce glucose levels in type-2 diabetes mellitus (T2DM). Some cases of diabetic ketoacidosis (DKA) were reported with SGLT2 inhibitors. However, data on the long-term safety of dapagliflozin in Saudi Arabia are lacking. Read More

View Article and Full-Text PDF

Treg cells in atherosclerosis.

Mol Biol Rep 2021 Jun 12. Epub 2021 Jun 12.

Department of Translational Research, Western University of Health Sciences, 309 E. Second Street, Pomona, CA, 91766-1854, USA.

Atherosclerosis involves both innate and adaptive immunity. Here, we provide an overview of the role of regulatory T (Treg) cells in atherosclerotic diseases. Treg cells and their inhibitory cytokines, IL-10 and TGF-β, have been identified in atherosclerotic lesions and to inhibit progression through lipoprotein metabolism modulation. Read More

View Article and Full-Text PDF

Nodal status in luminal A invasive breast cancer: relationships with cytotoxic CD8 + and regulatory FOXP3 + cells tumor-associated infiltrate and other prognostic factors.

Virchows Arch 2021 Jun 12. Epub 2021 Jun 12.

Department of Pathomorphology, Jagiellonian University Medical College, Cracow, Poland.

Luminal A breast cancers are generally associated with low metastatic potential and good prognosis. However, there is a proportion of patients, who present with metastases in lymph nodes. The aim of our study was to determine the association between the number of positive lymph nodes and infiltrates of tumor-associated cytotoxic CD8 + (CTLs), regulatory FOXP3 + T cells (Tregs), as well as other prognostic factors. Read More

View Article and Full-Text PDF

Research advances on epigenetics and cancer metabolism.

Zhejiang Da Xue Xue Bao Yi Xue Ban 2021 Feb;50(1):1-16

School of Medicine,Tsinghua University,Beijing 100084,China.

Epigenetics concerns gene regulatory mechanisms beyond DNA sequence,such as DNA methylation,histone modification,chromatin remodeling,and non-coding RNA. Epigenetic mechanisms play a key role in development,cell fate decision and tumorigenesis. Chromatin modifications and its high order structure across our genome are major forms of epigenetic information,and its establishment and maintenance are closely related to cell metabolism. Read More

View Article and Full-Text PDF
February 2021

Risk of Bleeding Associated with Antidepressant Drugs: The Competitive Impact of Antithrombotics in Quantitative Signal Detection.

Drugs Real World Outcomes 2021 Jun 11. Epub 2021 Jun 11.

Department of Psychiatry and Psychotherapy III, University of Ulm, Leimgrubenweg 12-14, 89075, Ulm, Germany.

Background: To date, disproportionality analysis has been unable to demonstrate the increased bleeding risk associated with antidepressant drugs, especially selective serotonin reuptake inhibitors.

Objective: We hypothesised that a potential signal for an increased bleeding risk may be mitigated by the effects of agents other than antidepressant drugs that are strongly associated with haemorrhages, especially antithrombotics. In addition, we investigated if the use of more specific search terms of the Medical Dictionary for Regulatory Activities facilitates the detection of signals. Read More

View Article and Full-Text PDF

Regulation of gametangia and gametangiophore initiation in the liverwort Marchantia polymorpha.

Plant Reprod 2021 Jun 11. Epub 2021 Jun 11.

Graduate School of Biostudies, Kyoto University, Kyoto, 606-8501, Japan.

Key Message: The liverwort Marchantia polymorpha regulates gametangia and gametangiophore development by using evolutionarily conserved regulatory modules that are shared with angiosperm mechanisms regulating flowering and germ cell differentiation. Bryophytes, the earliest diverged lineage of land plants comprised of liverworts, mosses, and hornworts, produce gametes in gametangia, reproductive organs evolutionarily conserved but lost in extant angiosperms. Initiation of gametangium development is dependent on environmental factors such as light, although the underlying mechanisms remain elusive. Read More

View Article and Full-Text PDF

Minimal contribution of the hepatic uptake transporter OATP1B1 to the inter-individual variability in SN-38 pharmacokinetics in cancer patients without severe renal failure.

Cancer Chemother Pharmacol 2021 Jun 11. Epub 2021 Jun 11.

Division of Cancer Genome and Pharmacotherapy, Department of Clinical Pharmacy, Showa University School of Pharmacy, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.

Purpose: SN-38, a pharmacologically active metabolite of irinotecan, is taken up into hepatocytes by organic anion transporting polypeptide (OATP) 1B1. The effects of functional OATP1B1 521T>C on the pharmacokinetics of SN-38 remain controversial. Here, we prospectively examined the effects of OATP1B1 function on the area under the plasma total or unbound concentration-time curve (tAUC or uAUC) of SN-38 by assessing OATP1B1 521T>C and the plasma levels of endogenous OATP1B1 substrates, coproporphyrin (CP)-I and III, in cancer patients treated with irinotecan. Read More

View Article and Full-Text PDF

AGO2 localizes to cytokinetic protrusions in a p38-dependent manner and is needed for accurate cell division.

Commun Biol 2021 Jun 11;4(1):726. Epub 2021 Jun 11.

Biomedical Research Foundation of the Academy of Athens, Athens, Greece.

Argonaute 2 (AGO2) is an indispensable component of the RNA-induced silencing complex, operating at the translational or posttranscriptional level. It is compartmentalized into structures such as GW- and P-bodies, stress granules and adherens junctions as well as the midbody. Here we show using immunofluorescence, image and bioinformatic analysis and cytogenetics that AGO2 also resides in membrane protrusions such as open- and close-ended tubes. Read More

View Article and Full-Text PDF

Transcriptional response to prolonged perchlorate exposure in the methanogen Methanosarcina barkeri and implications for Martian habitability.

Sci Rep 2021 Jun 11;11(1):12336. Epub 2021 Jun 11.

Department of Geosciences, Princeton University, Princeton, NJ, USA.

Observations of trace methane (CH) in the Martian atmosphere are significant to the astrobiology community given the overwhelming contribution of biological methanogenesis to atmospheric CH on Earth. Previous studies have shown that methanogenic Archaea can generate CH when incubated with perchlorates, highly oxidizing chaotropic salts which have been found across the Martian surface. However, the regulatory mechanisms behind this remain completely unexplored. Read More

View Article and Full-Text PDF

Melatonin influences the early growth stage in Zoysia japonica Steud. by regulating plant oxidation and genes of hormones.

Sci Rep 2021 Jun 11;11(1):12381. Epub 2021 Jun 11.

College of Grassland Science, Beijing Forestry University, Beijing, 100083, China.

Zoysia japonica is a commonly used turfgrass species around the world. Seed germination is a crucial stage in the plant life cycle and is particularly important for turf establishment and management. Experiments have confirmed that melatonin can be a potential regulator signal in seeds. Read More

View Article and Full-Text PDF

Evaluation of the prognostic value of CBXs in gastric cancer patients.

Sci Rep 2021 Jun 11;11(1):12375. Epub 2021 Jun 11.

Department of Epidemiology, College of Public Health, Hainan Medical University, Longhua District, No.3 Xueyuan Road, Haikou, 570216, China.

Chromobox (CBX) proteins were suggested to exert epigenetic regulatory and transcriptionally repressing effects on target genes and might play key roles in the carcinogenesis of a variety of carcinomas. Nevertheless, the functions and prognostic significance of CBXs in gastric cancer (GC) remain unclear. The current study investigated the roles of CBXs in the prognosis of GC using the Oncomine, The Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN, The Cancer Genome Atlas (TCGA), and cBioPortal databases. Read More

View Article and Full-Text PDF

Knockdown of lncRNA Abhd11os attenuates myocardial ischemia/reperfusion injury by inhibiting apoptosis in cardiomyocytes.

J Cardiovasc Pharmacol 2021 May 31. Epub 2021 May 31.

Department of Children's Heart Center, Henan Provincial People's Hospital, Department of Children's Heart Center of Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, China.

Abstract: Long non-coding RNA (lncRNA) is one potential target for the treatment of various disorders. Here, we explored the role of Abhd11os in ischemia/reperfusion-induced myocardial injury, and preliminarily explored the regulatory mechanisms. Relative Abhd11os expression level was examined by qRT-PCR. Read More

View Article and Full-Text PDF

Patents for the Plastic Surgeon: A Primer.

Ann Plast Surg 2021 Jun 10. Epub 2021 Jun 10.

From the Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX Department of Plastic and Reconstructive Surgery, Southmead Hospital, North Bristol NHS Trust, Bristol, United Kingdom Division of Plastic Surgery, Department of Surgery, McGill University, Montreal, Ontario, Canada.

Abstract: Although innovation and entrepreneurship are complementary in the process of creating new products, plastic surgeons are frequently discouraged by the challenges associated with the regulatory and administrative environments in patent filing. The following primer provides a step-by-step guide for understanding patents and outlines the steps and costs involved in patent filing. To improve opportunities for successful patent filing, we elaborate on some of the common pitfalls in the process, including the timing of public disclosure, conducting a private art search, selecting a patent attorney or agent, determining the level of inventor involvement, and navigating academic and employment contracts. Read More

View Article and Full-Text PDF