12,310 results match your criteria regulation longitudinal

Acceptability and Effectiveness of Artificial Intelligence Therapy for Anxiety and Depression (Youper): Longitudinal Observational Study.

J Med Internet Res 2021 Jun 22;23(6):e26771. Epub 2021 Jun 22.

Department of Psychology, Stanford University, Stanford, CA, United States.

Background: Youper is a widely used, commercially available mobile app that uses artificial intelligence therapy for the treatment of anxiety and depression.

Objective: Our study examined the acceptability and effectiveness of Youper. Further, we tested the cumulative regulation hypothesis, which posits that cumulative emotion regulation successes with repeated intervention engagement will predict longer-term anxiety and depression symptom reduction. Read More

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Developmental Stage-Specific Effects of Parenting on Adolescents' Emotion Regulation: A Longitudinal Study From Infancy to Late Adolescence.

Front Psychol 2021 4;12:582770. Epub 2021 Jun 4.

Faculty of Social Sciences/Psychology, Tampere University, Tampere, Finland.

The quality of parenting shapes the development of children's emotion regulation. However, the relative importance of parenting in different developmental stages, indicative of sensitive periods, has rarely been studied. Therefore, we formulated four hypothetical developmental timing models to test the stage-specific effects of mothering and fathering in terms of parental autonomy and intimacy in infancy, middle childhood, and late adolescence on adolescents' emotion regulation. Read More

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Longitudinal Associations between Parental Warmth, Harsh Discipline, Child Emotion Regulation, and ODD Dimensions.

Child Psychiatry Hum Dev 2021 Jun 19. Epub 2021 Jun 19.

Department of Psychology, Simon Fraser University, Burnaby, BC, Canada.

Research has yet to investigate the mediating role of emotion regulation in the relation between parental warmth and harsh discipline with oppositional defiant disorder (ODD). Further, few studies have investigated ODD as both a unitary construct and as three distinct dimensions (anger, defiance, spitefulness). Thus, the present study aimed to investigate child emotion regulation (grade 2) as a mediator of the relation between parental warmth and harsh discipline (kindergarten, grade 1, grade 2) and ODD and its dimensions (grade 3). Read More

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Decreased COVID-related adaptive behavior and increased negative affect: A multivariate latent growth curve model.

J Health Psychol 2021 Jun 18:13591053211021651. Epub 2021 Jun 18.

Southwest University, China.

Data from a longitudinal questionnaire investigation of three time waves were used to investigate affective and behavioral changes and their covariant relationship among Chinese general population during the COVID-19 pandemic from March to May 2020. 145 participants aging from 15 to 63 completed three waves of survey. Latent growth curve analyses found that negative affect gradually increased as the pandemic continued. Read More

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The single-point insulin sensitivity estimator (SPISE) index is a strong predictor of abnormal glucose metabolism in overweight/obese children: a long-term follow-up study.

J Endocrinol Invest 2021 Jun 17. Epub 2021 Jun 17.

Department of Clinical Medicine, Public Health, Life and Environmental Sciences (MeSVA), University of L'Aquila, L'Aquila, Italy.

Purpose: To investigate the relationship between the single-point insulin sensitivity estimator (SPISE) index, an insulin sensitivity indicator validated in adolescents and adults, and metabolic profile in overweight/obese children, and to evaluate whether basal SPISE is predictive of impaired glucose regulation (IGR) development later in life.

Methods: The SPISE index (= 600 × HDL/Triglycerides × BMI) was calculated in 909 overweight/obese children undergoing metabolic evaluations at University of Cagliari, Italy, and in 99 normal-weight, age-, sex-comparable children, selected as a reference group, together with other insulin-derived indicators of insulin sensitivity/resistance. 200 overweight/obese children were followed-up for 6. Read More

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DNA methylation at birth potentially mediates the association between prenatal lead (Pb) exposure and infant neurodevelopmental outcomes.

Environ Epigenet 2021 16;7(1):dvab005. Epub 2021 Jun 16.

Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA.

Early-life lead (Pb) exposure has been linked to adverse neurodevelopmental outcomes. Recent evidence has indicated a critical role of DNA methylation (DNAm) in cognition, and Pb exposure has also been shown to alter DNAm. However, it is unknown whether DNAm is part of the mechanism of Pb neurotoxicity. Read More

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Effects of Social Distancing During the COVID-19 Pandemic on Anxiety and Eating Behavior-A Longitudinal Study.

Front Psychol 2021 1;12:645754. Epub 2021 Jun 1.

Post-Graduate Program in Psychobiology, Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, Brazil.

As social animals, humans need to live in groups. This contact with conspecifics is essential for their evolution and survival. Among the recommendations to reduce transmission of the new coronavirus (SARS-CoV-2) responsible for COVID-19 are social distancing and home confinement. Read More

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Association of medically assisted reproduction with offspring cord blood DNA methylation across cohorts.

Hum Reprod 2021 Jun 17. Epub 2021 Jun 17.

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

Study Question: Is cord blood DNA methylation associated with having been conceived by medically assisted reproduction?

Summary Answer: This study does not provide strong evidence of an association of conception by medically assisted reproduction with variation in infant blood cell DNA methylation.

What Is Known Already: Medically assisted reproduction consists of procedures used to help infertile/subfertile couples conceive, including ART. Due to its importance in gene regulation during early development programming, DNA methylation and its perturbations associated with medically assisted reproduction could reveal new insights into the biological effects of assisted reproductive technologies and potential adverse offspring outcomes. Read More

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Exploring Perinatal Indicators of Infant Social-Emotional Development: A Review of the Replicated Evidence.

Clin Child Fam Psychol Rev 2021 Jun 14. Epub 2021 Jun 14.

Deakin University, Centre for Social and Early Emotional Development, Geelong, Australia.

The importance of infant social-emotional development for outcomes across the lifecourse has been amply demonstrated. Despite this, most screening measures of social-emotional development are designed for children 18 months of age and over, with a clear gap in earlier infancy. No systematic review has yet harvested the evidence for candidate indicators in the perinatal window. Read More

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Long-term effects of father involvement in childhood on their son's physiological stress regulation system in adulthood.

Dev Psychobiol 2021 Jun 14. Epub 2021 Jun 14.

Department of Anthropology, University of Oregon, Eugene, Oregon, USA.

Using a long-term prospective longitudinal study of U.S. men and their fathers, the present study examined the extent to which the quantity (i. Read More

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Genetic Influences on Hippocampal Subfields: An Emerging Area of Neuroscience Research.

Neurol Genet 2021 Jun 21;7(3):e591. Epub 2021 May 21.

Barcelonaβeta Brain Research Center (BBRC) (N.V.-T., J.M.G.-d-E., J.L.M., J.D.G., G.O.), Pasqual Maragall Foundation; Centre for Genomic Regulation (CRG) (N.V.-T., R.G.), the Barcelona Institute for Science and Technology, Spain; Department of Clinical Genetics (N.V.-T., T.E.E., H.H.A.), Erasmus Medical Center, Rotterdam, the Netherlands; Universitat Pompeu Fabra (N.V.-T., J.M.G.--E., J.L.M., R.G., J.D.G.), Barcelona, Spain; Department of Radiology and Nuclear Medicine (H.H.A.), Erasmus Medical Center, Rotterdam, the Netherlands; IMIM (Hospital del Mar Medical Research Institute) (J.L.M., J.D.G., G.O.), Barcelona, Spain; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES) (J.L.M., G.O.); and Centro de Investigación Biomédica en Red Bioingeniería (J.D.G.), Biomateriales y Nanomedicina, Madrid, Spain.

There is clear evidence that hippocampal subfield volumes have partly distinct genetic determinants associated with specific biological processes. The identification of genetic correlates of hippocampal subfield volumes may help to elucidate the mechanisms of neurologic diseases, as well as aging and neurodegenerative processes. However, despite the emerging interest in this area of research, the current knowledge of the genetic architecture of hippocampal subfields has not yet been consolidated. Read More

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Identity Functioning and Eating Disorder Symptomatology: The Role of Cognitive Emotion Regulation Strategies.

Front Psychol 2021 28;12:667235. Epub 2021 May 28.

Department of Psychology, KU Leuven, Leuven, Belgium.

Adolescence is the most critical life period for the development of eating disorder (ED) symptomatology. Although problems in identity functioning and emotion dysregulation have been proven important risk and maintaining factors of ED symptomatology, they have never been integrated in a longitudinal study. The present study is part of the Longitudinal Identity research in Adolescence (LIA)-study and aimed to uncover the temporal interplay between identity functioning, cognitive emotion regulation, and ED symptomatology in adolescence. Read More

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Deficits in Emotion Regulation Partly Mediate the Relation Between Sleep Problems and Depressive Symptoms in Adolescent Inpatients With Depression.

Front Psychiatry 2021 17;12:622833. Epub 2021 May 17.

LWL-University Hospital for Child and Adolescent Psychiatry and Psychotherapy Hamm, Ruhr-University Bochum, Bochum, Germany.

Sleep problems are a risk factor for the development of depressive disorders and influence the severity and treatment of depressive symptoms negatively. To enhance treatment for depression in young people, it is important to advance the understanding of the relationship between sleep problems and depressive symptoms. Since deficits in emotion regulation are discussed as possible underlying mechanisms, the present study investigated the mediating effect of maladaptive and adaptive strategies for emotion regulation on the association between sleep problems and depressive symptoms. Read More

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Survival analysis of dairy cows in the Netherlands under altering agricultural policy.

Prev Vet Med 2021 Jun 4;193:105398. Epub 2021 Jun 4.

Farm Animal Health, Faculty of Veterinary Medicine, Department Population Health Sciences, Utrecht University, Utrecht, the Netherlands.

Culling of underperforming dairy cows by replacement heifers is a fundamental part of Dutch dairy farm management. Changes in national agricultural policies can influence farmers' culling decisions. The objective of this study was to analyse the relevancy of cow-level risk factors for survival of Dutch dairy cows under perturbations due to national policy changes related to the -milk quota abolishment of 2015 and the phosphate regulations since 2017. Read More

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High-Performance Joule Heating and Electromagnetic Shielding Properties of Anisotropic Carbon Scaffolds.

ACS Appl Mater Interfaces 2021 Jun 11;13(24):29101-29112. Epub 2021 Jun 11.

Laboratory of Advanced Materials, Shanghai Key Lab of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200438, P. R. China.

Highly efficient electrical heaters along with excellent electromagnetic interference (EMI) shielding properties are urgently required for the progress of miniaturization electronics, artificial intelligence, and smart heating management setups. Herein, lignin removal, which comprises two efficient and versatile steps, followed by carbonization produces multifunctional carbon monoliths derived from natural wood. The obtained carbonized wood exhibits a high specific surface area (655. Read More

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Superior Frontal Gyrus Locus DNA Methylation in Alzheimer's Disease.

J Alzheimers Dis Rep 2021 Apr 6;5(1):275-282. Epub 2021 Apr 6.

Department of Life Sciences, Manchester Metropolitan University, Manchester, UK.

Background: The ɛ4 allele is the strongest known genetic risk factor for sporadic Alzheimer's disease (AD). The neighboring gene has also been implicated in AD due to its close proximity to .

Objective: Here we tested whether methylation of the locus may influence ApoE protein levels and AD pathology. Read More

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Quality of life, emotion regulation, and dissociation: Evaluating unique relations in an undergraduate sample and probable PTSD subsample.

Psychol Trauma 2021 Jun 10. Epub 2021 Jun 10.

Department of Psychology, Binghamton University (SUNY).

Objective: Previous research has documented a strong association between emotion regulation (ER) and quality of life (QoL). Nevertheless, extant studies have not tested this association in participants meeting diagnostic criteria for posttraumatic stress disorder nor accounted for other explanatory variables statistically. Our primary objective was to evaluate the unique relations among ER dimensions and QoL while controlling for dissociation, neuroticism, and PTSD symptoms statistically. Read More

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An investigation of psychological responses to COVID-19 in Irish healthcare workers: longitudinal quantitative and nested qualitative study.

HRB Open Res 2021 3;4:15. Epub 2021 Feb 3.

Medicine and HRB CRF, University College Cork, Cork, Ireland.

COVID-19 is an unprecedent occurrence in modern times and individuals who work within healthcare settings, face a broad array of challenges in responding to this worldwide event. Key information on the psychosocial responses of such healthcare workers (HCWs) in the context of COVID-19 is limited and in particular there is a need for studies that utilise longitudinal methods, an overarching theoretical model, and use of a cohort of participants within a defined geographical area across acute and community settings. The work packages making up the current research project use quantitative and qualitative methods to examine the psychological sequelae for HCWs in the context of COVID-19 in geographically adjacent healthcare areas (South and Mid-West of Ireland) across four time points (induction, 3 months, 6 months, and 1 year follow-up). Read More

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February 2021

Impacts of Parental Burnout on Chinese Youth's Mental Health: The Role of Parents' Autonomy Support and Emotion Regulation.

J Youth Adolesc 2021 Jun 9. Epub 2021 Jun 9.

East China Normal University, Shanghai, China.

Parental burnout is a state that parents experience overwhelming exhaustion in their parental role. Given the detrimental impacts of parents' stress on adolescent development, youth may suffer from undesirable emotional adjustment due to parental burnout. Therefore, it is key to understand the underlying mechanisms through which parental burnout may play a role in youth's mental health and identify protective factors that may reduce the potential negative impacts. Read More

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Longitudinal associations between emotion malleability beliefs and avoidance in college students.

Cogn Emot 2021 Jun 9:1-10. Epub 2021 Jun 9.

Department of Psychology, University of Nevada, Reno, Reno, NV, USA.

, or beliefs that emotions are changeable versus fixed, may be an important and modifiable determinant of emotion regulation strategy employment and psychological distress. The present study evaluated the prospective relationship between college students' emotion malleability beliefs, depression and anxiety symptom severity, cognitive and behavioural avoidance, social engagement, and cognitive reappraisal. Participants were college students ( = 177) who completed a battery of questionnaires at the beginning of the academic year and again at a 6-month follow-up. Read More

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SARS-CoV-2 infection activates a subset of intrinsic pathways to inhibit type I interferons and .

Int J Med Sci 2021 28;18(12):2561-2569. Epub 2021 Apr 28.

Guangzhou Jinan Biomedicine Research and Development Center, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou 510632, PR China.

SARS-CoV-2 infection poses a global challenge to human health. Upon viral infection, host cells initiate the innate antiviral response, which primarily involves type I interferons (I-IFNs), to enable rapid elimination of the invading virus. Previous studies revealed that SARS-CoV-2 infection limits the expression of I-IFNs and , but the underlying mechanism remains incompletely elucidated. Read More

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The course of disease in major depressive disorder is associated with altered activity of the limbic system during negative emotion processing.

Biol Psychiatry Cogn Neurosci Neuroimaging 2021 Jun 5. Epub 2021 Jun 5.

Institute for Translational Psychiatry, University of Münster, Münster, Germany. Electronic address:

Background: Brain functional alterations during emotion processing in patients with major depressive disorder (MDD) compared to healthy controls (HC) are frequently reported. However, evidence for functional correlates of emotion processing with regard to MDD trajectories is scarce. The present study investigated the role of lifetime disease course for limbic brain activation during negative emotional face processing in patients with MDD. Read More

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Primary ciliary dyskinesia due to CCNO mutations-A genotype-phenotype correlation contribution.

Pediatr Pulmonol 2021 Jun 8. Epub 2021 Jun 8.

Paediatric Respiratory Unit, Department of Paediatrics, Hospital de Santa Maria-Centro Hospitalar Universitário de Lisboa Norte, Lisbon, Portugal.

Primary ciliary dyskinesia (PCD) is genetically and clinically heterogeneous. CCNO mutations are associated with chronic destructive lung disease and were first described in 2014. Early reports suggest that CCNO is mutated more frequently than expected, however, these are considered rare. Read More

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Dynamics of amygdala connectivity in bipolar disorders: a longitudinal study across mood states.

Neuropsychopharmacology 2021 Jun 7. Epub 2021 Jun 7.

Laboratory for Behavioral Neurology and Imaging of Cognition, Department of Fundamental Neurosciences, University of Geneva, Geneva, Switzerland.

Alterations in activity and connectivity of brain circuits implicated in emotion processing and emotion regulation have been observed during resting-state for different clinical phases of bipolar disorders (BD), but longitudinal investigations across different mood states in the same patients are still rare. Furthermore, measuring dynamics of functional connectivity patterns offers a powerful method to explore changes in the brain's intrinsic functional organization across mood states. We used a novel co-activation pattern (CAP) analysis to explore the dynamics of amygdala connectivity at rest in a cohort of 20 BD patients prospectively followed-up and scanned across distinct mood states: euthymia (20 patients; 39 sessions), depression (12 patients; 18 sessions), or mania/hypomania (14 patients; 18 sessions). Read More

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Association of exposure to residential greenness with semen quality: A retrospective longitudinal study of sperm donation volunteers in Guangdong province, China.

Ecotoxicol Environ Saf 2021 Sep 4;220:112396. Epub 2021 Jun 4.

Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510080, China. Electronic address:

Background: Exposure to residential greenness has been associated with benefits on certain reproductive health outcomes. However, its potential benefits on semen quality remain unknown.

Objectives: To quantitatively explore the association between exposure to residential greenness and semen quality. Read More

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September 2021

Cannabis use and misuse in the year following recreational cannabis legalization in Canada: A longitudinal observational cohort study of community adults in Ontario.

Drug Alcohol Depend 2021 May 21;225:108781. Epub 2021 May 21.

Michael G. DeGroote Centre for Medicinal Cannabis Research, McMaster University & St. Joseph's Healthcare Hamilton, 100 West 5th St, Hamilton, ON, Canada; Peter Boris Centre for Addictions Research, McMaster University & St. Joseph's Healthcare Hamilton, 100 West 5th St, Hamilton, ON, Canada; Homewood Research Institute, 150 Delhi St, Guelph, ON, Canada. Electronic address:

Background: Canada legalized cannabis for non-medical purposes federally in October 2018. This study examined changes in cannabis use over the following year in a sample of general community adults. A secondary aim was to examine forecasted cannabis use following legalization in relation to actual post-legalization cannabis use. Read More

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Endocrine and metabolic aspects of narcolepsy type 1 in children.

Eur J Paediatr Neurol 2021 May 18;33:68-74. Epub 2021 May 18.

Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; The Queen Silvia Children's Hospital, University of Gothenburg, Gothenburg, Sweden.

Study Objectives: To study whether the onset of narcolepsy type 1 (NT1) in children and adolescents affects BMI, specific metabolic risk factors, the onset of puberty, longitudinal growth or other endocrine functions.

Methods: A population-based study, comprising 34 patients, was performed with a clinical evaluation, an assessment of puberty and growth, actigraphy and blood samples at fasting, from patients and controls, to evaluate pituitary function, growth factors, thyroid gland, gonads, insulin sensitivity, appetite regulation and blood lipids.

Results: In the post-H1N1 vaccination (PHV) narcolepsy group, the median BMI SDS was higher 6-12 months after the onset of narcolepsy (p < 0. Read More

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A mutation in CsHY2 encoding a phytochromobilin (PΦB) synthase leads to an elongated hypocotyl 1(elh1) phenotype in cucumber (Cucumis sativus L.).

Theor Appl Genet 2021 Jun 6. Epub 2021 Jun 6.

College of Horticulture, Northwest A&F University, Yangling, 712100, Shaanxi, China.

Key Message: The elongated hypocotyl1 (elh1) mutant in cucumber is due to a mutation in CsHY2, which is a homolog of the Arabidopsis HY2 encoding the phytochromobilin (PΦB) synthase for phytochrome biosynthesis Hypocotyl length is a critical determinant in establishing high quality seedlings for successful cucumber production, but knowledge on the molecular regulation of hypocotyl growth in cucumber is very limited. Here, we reported identification and characterization of a cucumber elongated hypocotyl 1 (elh1) mutant. We found that the longer hypocotyl in elh1 was due to longitudinal growth of hypocotyl cells. Read More

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Psychosocial predictors of substance use in adolescents and young adults: Longitudinal risk and protective factors.

Addict Behav 2021 10 16;121:106985. Epub 2021 May 16.

University of California, San Diego, United States.

Many psychosocial factors have been implicated in the onset and escalation of substance use in adolescence and young adulthood. Typically, each factor explains a small amount of the variance in substance use outcomes, and effects are typically applied across a broad range of ages or computed from cross-sectional data. The current study evaluated the association of factors including social influence (e. Read More

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October 2021