5,763 results match your criteria regulation covid-19


A detailed review of the outbreak of COVID-19.

Front Biosci (Landmark Ed) 2021 May;26(6):149-170

Department of Applied Sciences, Indian Institute of Information Technology Allahabad, 211012 Allahabad, India.

The disease COVID-19 caused by SARS-CoV-2 is the third highly infectious human Coronavirus epidemic in the 21 century due to its high transmission rate and quick evolution of its pathogenicity. Genomic studies indicate that it is zoonotic from bats. The COVID-19 has led to significant loss of lives and a tremendous economic decline in the world. Read More

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ACE2 Expression Is Upregulated in Inflammatory Corneal Epithelial Cells and Attenuated by Resveratrol.

Invest Ophthalmol Vis Sci 2021 Jun;62(7):25

Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin, China.

Purpose: The ocular surface is considered an important route for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. The expression level of the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) is vital for viral infection. However, the regulation of ACE2 expression on the ocular surface is still unknown. Read More

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Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen.

bioRxiv 2021 Jun 15. Epub 2021 Jun 15.

Effective therapies are needed to combat emerging viruses. Seventeen candidates that rescue cells from SARS-CoV-2-induced lethality and target diverse functions emerged in a screen of 4,413 compounds. Among the hits was lapatinib, an approved inhibitor of the ErbB family of receptor tyrosine kinases. Read More

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Who should be tested in a pandemic? Ethical considerations.

BMC Med Ethics 2021 Jun 22;22(1):76. Epub 2021 Jun 22.

Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, 171 77, Stockholm, Sweden.

Background: In the initial phase of the Covid-19 pandemic, difficult decisions had to be made on the allocation of testing resources. Similar situations can arise in future pandemics. Therefore, careful consideration of who should be tested is an important part of pandemic preparedness. Read More

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SARS-CoV-2 and the role of fomite transmission: a systematic review.

F1000Res 2021 24;10:233. Epub 2021 Mar 24.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK.

SARS-CoV-2 RNA has been detected in fomites which suggests the virus could be transmitted via inanimate objects. However, there is uncertainty about the mechanistic pathway for such transmissions. Our objective was to identify, appraise and summarise the evidence from primary studies and systematic reviews assessing the role of fomites in transmission. Read More

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Cutaneous and systemic hyperinflammation drives maculopapular drug exanthema in severely ill COVID-19 patients.

Allergy 2021 Jun 22. Epub 2021 Jun 22.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Background: Coronavirus disease 2019 (COVID-19) has been associated with cutaneous findings, some being the result of drug hypersensitivity reactions such as maculopapular drug rashes (MDR). The aim of this study was to investigate whether COVID-19 is associated with the development of the MDR.

Methods: Blood and skin samples from COVID-19 patients (based on a positive nasopharyngeal PCR) suffering from MDR (COVID-MDR), healthy controls, non-COVID-19-related patients with drug rash with eosinophilia and systemic symptoms (DRESS), and MDR were analyzed. Read More

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Integrated docking and enhanced sampling-based selection of repurposing drugs for SARS-CoV-2 by targeting host dependent factors.

J Biomol Struct Dyn 2021 Jun 22:1-12. Epub 2021 Jun 22.

Prescience Insilico Private Limited, Bangalore, India.

Since the onset of global pandemic, the most focused research currently in progress is the development of potential drug candidates and clinical trials of existing FDA approved drugs for other relevant diseases, in order to repurpose them for the COVID-19. At the same time, several high throughput screenings of drugs have been reported to inhibit the viral components during the early course of infection but with little proven efficacies. Here, we investigate the drug repurposing strategies to counteract the coronavirus infection which involves several potential targetable host proteins involved in viral replication and disease progression. Read More

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Stress Decreases Host Viral Resistance and Increases Covid Susceptibility in Embryonic Stem Cells.

Stem Cell Rev Rep 2021 Jun 21. Epub 2021 Jun 21.

Department of Ob/Gyn, Reproductive Endocrinology and Infertility, CS Mott Center for Human Growth and Development, WayneState UniversitySchoolofMedicine, Detroit, Michigan, 48201, USA.

Stress-induced changes in viral receptor and susceptibility gene expression were measured in embryonic stem cells (ESC) and differentiated progeny. Rex1 promoter-Red Fluorescence Protein reporter ESC were tested by RNAseq after 72hr exposures to control stress hyperosmotic sorbitol under stemness culture (NS) to quantify stress-forced differentiation (SFD) transcriptomic programs. Control ESC cultured with stemness factor removal produced normal differentiation (ND). Read More

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Partners' Consensus About Joint Effort and COVID-19 Prevention Among Sexual Minority Men.

Arch Sex Behav 2021 Jun 21. Epub 2021 Jun 21.

Department of Psychology, Hunter College of the City University of New York (CUNY), New York, NY, 10065, USA.

The current study examined the relevance of relationship functioning to partners' agreement or consensus about joint effort surrounding COVID-19 prevention. Interdependence theory has been widely used to understand how relationship partners influence health behavior, including how sexual minority male (SMM) couples regulate HIV risk. Couples with better relationship functioning tend to be more successful at negotiating joint (shared) goals and subsequently accomplishing them. Read More

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Association of CXCR6 with COVID-19 severity: delineating the host genetic factors in transcriptomic regulation.

Hum Genet 2021 Jun 21. Epub 2021 Jun 21.

Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, 7000 Fannin St. Suite 600, Houston, TX, 77030, USA.

The coronavirus disease 2019 (COVID-19) is an infectious disease that mainly affects the host respiratory system with ~ 80% asymptomatic or mild cases and ~ 5% severe cases. Recent genome-wide association studies (GWAS) have identified several genetic loci associated with the severe COVID-19 symptoms. Delineating the genetic variants and genes is important for better understanding its biological mechanisms. Read More

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SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.

Nat Commun 2021 06 21;12(1):3818. Epub 2021 Jun 21.

Center for Digital Health, Berlin Institute of Health (BIH) and Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces autophagy. Read More

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Protocol for a cohort study of the impact of the COVID-19 pandemic on the rate and incidence of bystander cardiopulmonary resuscitation (CPR) after out-of-hospital cardiac arrest.

Scand J Trauma Resusc Emerg Med 2021 Jun 21;29(1):82. Epub 2021 Jun 21.

Institute for Emergency Medicine, University Hospital Schleswig-Holstein, Kiel, Germany.

Background: Survival after out-of-hospital cardiac arrest (OHCA) is dependent on early recognition, early cardiopulmonary resuscitation (CPR) and early defibrillation. The purpose of CPR is to maintain some blood flow until the arrival of the emergency medical services (EMS). Our concern is that the COVID-19 pandemic has had a negative effect on the number of patients who get CPR before EMS arrival. Read More

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Role of toll-like receptor 7/8 pathways in regulation of interferon response and inflammatory mediators during SARS-CoV2 infection and potential therapeutic options.

Biomed Pharmacother 2021 Jun 10;141:111794. Epub 2021 Jun 10.

Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160014, India; National Interdisciplinary Centre of Vaccine, Immunotherapeutics and Antimicrobials, Panjab University, Chandigarh, 160014, India. Electronic address:

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) is the causative agent of Corona Virus Disease 2019 (COVID-19). Lower production of type I and III interferons and higher levels of inflammatory mediators upon SARS-CoV2 infection contribute to COVID-19 pathogenesis. Optimal interferon production and controlled inflammation are essential to limit COVID-19 pathogenesis. Read More

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Intravenous methylprednisolone with or without tocilizumab in patients with severe COVID-19 pneumonia requiring oxygen support: A prospective comparison.

J Infect Public Health 2021 Jun 10;14(8):985-989. Epub 2021 Jun 10.

Health Regulation Sector, Dubai Health Authority, United Arab Emirates. Electronic address:

Background: Cytokine storm is a marker of severity and severe mortality in patients with coronavirus disease 2019 (COVID-19) pneumonia. Immunomodulatory treatments may reduce morbidity and mortality.

Objectives: To determine whether a 7-day course of methylprednisolone (MP) administered with and without tocilizumab improves outcomes in patients with severe COVID-19 (SARS-CoV-2) pneumonia requiring oxygen therapy, relative to historical controls. Read More

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Comparative study of predicted miRNA between Indonesia and China (Wuhan) SARS-CoV-2: a bioinformatics analysis.

Genes Genomics 2021 Jun 21. Epub 2021 Jun 21.

Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, 11480, Indonesia.

Background: Several reports on the discovery of SARS-CoV-2 mutations and variations in Indonesia COVID-19 cases led to genomic dysregulation with the first pandemic cases in Wuhan, China. MicroRNA (miRNA) plays an important role in this genetic regulation and contributes to the enhancement of viral RNA binding through the host mRNA.

Objective: This research is aimed to detect miRNA targets of SARS-CoV-2 and examines their role in Indonesia cases against Wuhan cases. Read More

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MedTech Forum 2021 (April 20-22, 2021 - Virtual Meeting).

Authors:
M Colina

Drugs Today (Barc) 2021 Jun;57(6):401-405

Clarivate, Barcelona, Spain.

The MedTech Forum 2021 was an online event at which participants from the field of medical devices, diagnostics and digital health openly shared their views on the latest trends, challenges and opportunities currently being faced. The event enticed representatives from around 30 companies from the healthcare sector, as well as those from competent authorities, notified bodies, healthcare providers, academia and patients. Parallel sessions distributed across 3 days enabled the audience to interact with the speakers through a live-chat platform. Read More

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The renin-angiotensin system and specifically angiotensin-converting enzyme 2 as a potential therapeutic target in SARS-CoV-2 infections.

Naunyn Schmiedebergs Arch Pharmacol 2021 Jun 21. Epub 2021 Jun 21.

Pharmaceutical Department, Usl Umbria 1, A. Migliorati Street, 06132, Perugia, Italy.

In March 2019, the global COVID-19 pandemic caused by the novel SARS-CoV-2 coronavirus began. The first cases of SARS-CoV-2 infection occurred in November 19 in Wuhan, China. Preventive measures taken have not prevented the rapid spread of the virus to countries around the world. Read More

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Identification of Novel MicroRNAs Targeting SARS-CoV-2 through the Regulation of TMPRSS2/PI3K/AKT/PTEN Alignment in Lung Cancer: An Analysis.

ACS Pharmacol Transl Sci 2021 Jun 16;4(3):1075-1078. Epub 2021 Apr 16.

Chemical Engineering Department, American University of Sharjah, Sharjah, United Arab Emirates.

In this study, we investigated the interactions between SARS-CoV-2 and miRNAs associated with lung cancer using bioinformatic approaches. A special focus was placed on TMPRSS2 and lung cancer progression pathways involving AKT/PI3K/PTEN genes. Read More

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Expression of SARS-CoV-2 entry genes ACE2 and TMPRSS2 at single cell resolution in the peripartum decidua.

Am J Transl Res 2021 15;13(5):4389-4400. Epub 2021 May 15.

Department of Obstetrics, Xiangya Hospital Central South University Changsha, China.

Angiotensin-converting enzyme 2 (ACE2) is the key receptor for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). However, the susceptibility of the decidua to infection during the peripartum period has not been explored, even though this may affect vertical transmission. The objective of this study was to investigate the expression of ACE2 and related genes in the decidua during delivery. Read More

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Psychometric Properties of the Spanish Version of the Cognitive Emotional Regulation Difficulties Questionnaire (CERQ) in Higher Education Students in Times of Covid-19.

Front Psychol 2021 4;12:695147. Epub 2021 Jun 4.

Department of Pedagogy, Faculty of Education Sciences, University of Granada, Granada, Spain.

The Cognitive Emotion Regulation Questionnaire (CERQ) is an instrument developed to assess the cognitive strategies of emotional regulation used by people after experiencing a negative event. The present study aimed to validate the Spanish version of the CERQ in students of the University of Granada (Spain) during the Covid-19 homebound. An online scale was developed and applied based on the Spanish version of the CERQ-S36, consisting of 36 items structured around nine cognitive strategies. Read More

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The NHS needs a comprehensive plan for recovery.

Authors:
Richard Murray

BMJ 2021 06 18;373:n1555. Epub 2021 Jun 18.

King's Fund, London, UK

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Nurses' Emotional Stress Levels When Caring for COVID-19 Patients in an Intensive Care Unit.

Altern Ther Health Med 2021 Jun 18. Epub 2021 Jun 18.

Context: The COVID-19 pandemic has had an effect on many communities' physical and mental well-being, especially that of healthcare workers. During the pandemic, health workers have shown signs of depression and anxiety and have experienced sleep disturbances. Few studies have examined health workers' resilience during the pandemic. Read More

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The politics of COVID-19 vaccination in middle-income countries: Lessons from Brazil.

Soc Sci Med 2021 Jun 2;281:114093. Epub 2021 Jun 2.

Laboratory of Health Information, Oswaldo Cruz Foundation, Av. Brasil 4365, Rio de Janeiro, RJ, 21045-900, Brazil. Electronic address:

As the world struggles to meet the challenges of vaccination against COVID-19, more attention needs to be paid to issues faced by countries at different income levels. Middle-income countries (MICs) typically lack the resources and regulatory capacities to pursue strategies that wealthier countries do, but they also face different sets of challenges and opportunities than low-income countries (LICs). We focus on three dimensions of vaccination: procurement and production; regulation of marketing registration; and distribution and uptake. Read More

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Coping With Health Threats: The Costs and Benefits of Managing Emotions.

Psychol Sci 2021 Jun 18:9567976211024260. Epub 2021 Jun 18.

Department of Psychology, University of Toronto.

How people respond to health threats can influence their own health and, when people are facing communal risks, even their community's health. We propose that people commonly respond to health threats by managing their emotions with cognitive strategies such as reappraisal, which can reduce fear and protect mental health. However, because fear can also motivate health behaviors, reducing fear may also jeopardize health behaviors. Read More

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Decreased COVID-related adaptive behavior and increased negative affect: A multivariate latent growth curve model.

J Health Psychol 2021 Jun 18:13591053211021651. Epub 2021 Jun 18.

Southwest University, China.

Data from a longitudinal questionnaire investigation of three time waves were used to investigate affective and behavioral changes and their covariant relationship among Chinese general population during the COVID-19 pandemic from March to May 2020. 145 participants aging from 15 to 63 completed three waves of survey. Latent growth curve analyses found that negative affect gradually increased as the pandemic continued. Read More

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Effects of Social Distancing During the COVID-19 Pandemic on Anxiety and Eating Behavior-A Longitudinal Study.

Front Psychol 2021 1;12:645754. Epub 2021 Jun 1.

Post-Graduate Program in Psychobiology, Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, Brazil.

As social animals, humans need to live in groups. This contact with conspecifics is essential for their evolution and survival. Among the recommendations to reduce transmission of the new coronavirus (SARS-CoV-2) responsible for COVID-19 are social distancing and home confinement. Read More

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Fear in the Chinese Population: Influential Patterns in the Early Stage of the COVID-19 Pandemic.

Front Psychol 2021 1;12:567364. Epub 2021 Jun 1.

Department of Nursing Psychology, Army Medical University, Chongqing, China.

Major global public health emergencies challenge public mental health. Negative emotions, and especially fear, may endanger social stability. To better cope with epidemics and pandemics, early emotional guidance should be provided based on an understanding of the status of public emotions in the given circumstances. Read More

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Commercial Hand Sanitizers use amid COVID-19 Pandemic: the Concerns of Antimicrobial Resistance.

Infect Drug Resist 2021 10;14:2183-2185. Epub 2021 Jun 10.

School of Pharmacy, Jimma University, Oromia, Ethiopia.

Following the outbreak of novel coronavirus disease, the rising concerns about the prevalence of alcohol-based hand sanitizers' inappropriate use and substandard products in the market create an ongoing safety concern. They can cause frequent exposure of microorganisms to below the alcohol concentrations to the range recommended for infection prevention and development of mutations. Thus, it is invaluable to sensitize the scientific community for further researches to provide additional evidence. Read More

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Nutritional management of individuals with obesity and COVID-19: ESPEN expert statements and practical guidance.

Clin Nutr 2021 May 11. Epub 2021 May 11.

Department of Clinical Nutrition, CHU Clermont-Ferrand, University of Clermont Auvergne, Human Nutrition Unit, CRNH Auvergne, F-63000, Clermont-Ferrand, France.

The COVID-19 pandemics has created unprecedented challenges and threats to patients and healthcare systems worldwide. Acute respiratory complications that require intensive care unit (ICU) management are a major cause of morbidity and mortality in COVID-19 patients. Among other important risk factors for severe COVID-19 outcomes, obesity has emerged along with undernutrition-malnutrition as a strong predictor of disease risk and severity. Read More

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Effects of the COVID19 Pandemic on Transgender and Gender Non-Conforming Adolescents' Mental Health.

Psychiatry Res 2021 Jun 4;302:114042. Epub 2021 Jun 4.

School of Psychological Sciences and the Integrated Brain and Behavior Research Center, University of Haifa, Israel. Electronic address:

We assessed the effects of the COVID19 lockdown on the mental health of transgender and gender non-conforming (TGN) youth (n = 18) vs cisgender youth (29 males; 29 females). Coronavirus Health Impact Survey (CRISIS) and Emotion Regulation Questionnaire were used in an online study. No group differences were found in demographic variables and exposure to COVID19. Read More

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