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A retrospective analysis of the "Neverending Trip" after administration of a potent full agonist of 5-HT2A receptor - 25I-NBOMe.

Biomed Pharmacother 2022 Feb 1;146:112295. Epub 2022 Jan 1.

Department of Pharmacology, Medical University of Gdańsk, Poland.

Background: 5-HT2A receptor (e.g. 25I-NBOMe) agonists not only pose risks of acute intoxication but also long-term effects and significant adverse reactions, e. Read More

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February 2022

Markers of kidney tubular and interstitial injury and function among sugarcane workers with cross-harvest serum creatinine elevation.

Occup Environ Med 2021 Dec 31. Epub 2021 Dec 31.

La Isla Network, Washington, DC, USA.

Objectives: Serum creatinine (SCr) is a routine marker of kidney injury but also increases with dehydration and muscular work. This study was to elucidate whether increase in SCr is associated with more specific markers of kidney tubular and interstitial injury and function, during prolonged heat stress among workers at high risk of chronic kidney disease of non-traditional origin (CKDnt).

Methods: Urine monocyte chemoattractant protein-1 (MCP-1), kidney injury molecule-1 (KIM-1), calbindin, glutathione S-transferase-π (GST-π), clusterin, interleukin 18 and albumin, fractional excretion of potassium (FEK), blood haemoglobin, serum potassium, ferritin and erythropoietin were measured before and after harvest in a sample of 30 workers with a ≥0. Read More

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December 2021

Replacing meat with alternative plant-based products (RE-MAP): a randomized controlled trial of a multicomponent behavioral intervention to reduce meat consumption.

Am J Clin Nutr 2021 Dec 27. Epub 2021 Dec 27.

University of Oxford, Nuffield Department of Primary Care Health Sciences, Radcliffe Primary Care Building, Woodstock Rd, Oxford OX2 6GG.

Background: Reducing meat consumption could protect the environment and human health.

Objectives: We tested the impact of a behavioral intervention to reduce meat consumption.

Design: Adult volunteers who regularly consumed meat, were recruited from the general public and randomized 1:1 to an intervention or control condition. Read More

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December 2021

Differences in the Association between Physical Activity and People's Resilience and Emotions during Two Consecutive Covid-19 Lockdowns in Israel.

Int J Environ Res Public Health 2021 12 15;18(24). Epub 2021 Dec 15.

The Wingate Institute, The Academic College at Wingate, Netanya 4290200, Israel.

Governments worldwide have imposed harsh restrictions for decreasing the Covid-19 pandemic and maintaining public health. Yet such limitations have impacted people's physical activity. This study examined relationships between changes in physical activity and resilience, emotions, and depression during two lockdowns in Israel. Read More

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December 2021

CRISPR Gene Editing in Lipid Disorders and Atherosclerosis: Mechanisms and Opportunities.

Metabolites 2021 Dec 9;11(12). Epub 2021 Dec 9.

School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK.

Elevated circulating concentrations of low-density lipoprotein cholesterol (LDL-C) have been conclusively demonstrated in epidemiological and intervention studies to be causally associated with the development of atherosclerotic cardiovascular disease. Enormous advances in LDL-C reduction have been achieved through the use of statins, and in recent years, through drugs targeting proprotein convertase subtilisin/kexin type 9 (PCSK9), a key regulator of the hepatic LDL-receptor. Existing approaches to PCSK9 targeting have used monoclonal antibodies or RNA interference. Read More

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December 2021

A case of Crohn's disease combined with inflammatory myofibroblastoma of abdominal wall.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Nov;46(11):1310-1314

Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013.

Inflammatory myofibroblastoma (IMT) is a rare solid tumor, and its etiology and pathogenesis are unclear. Crohn's disease is a non-specific intestinal inflammatory disease. The clinical manifestations, laboratory examinations, and imaging examinations of IMT are not specific, making diagnosis difficult. Read More

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November 2021

Critical Care Echocardiography: A Primer for the Nephrologist.

Adv Chronic Kidney Dis 2021 May;28(3):244-251

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia. Electronic address:

Critical care echocardiography (CCE) refers to the goal-directed use of transthoracic or transesophageal echocardiography and represents one of the most common applications of critical care ultrasound. CCE can be performed at the point of care, is easily repeated following changes in clinical status, and does not expose the patient to ionizing radiation. Nephrologists who participate in the care of patients in the intensive care unit will regularly encounter CCE as part of the decision-making and bedside management of ICU patients. Read More

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Staying alive-training with anaesthetists.

Best Pract Res Clin Obstet Gynaecol 2021 Nov 14. Epub 2021 Nov 14.

Department of Anaesthesia, St Michael's Hospital, Southwell Street, Bristol, BS2 8EJ, UK. Electronic address:

An effective working relationship between obstetricians and anaesthetists is crucial for patient safety in maternity care. Anaesthetists' skills and scope of clinical practice complement those of obstetricians, particularly during obstetric emergencies. Anaesthetists also bring expertise in resuscitation, critical care, and a training programme that is underpinned by non-technical as well as technical skills. Read More

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November 2021

Short-Term Effects of Supplemental L-Arginine, Diosmin, Troxerutin, and Hesperidin in Diabetic Patients: A Pilot Study.

Biomed Res Int 2021 2;2021:3508281. Epub 2021 Dec 2.

SCDU Clinical Chemistry Laboratory, Maggiore della Carità University Hospital, Novara, Italy.

Background And Aims: Inflammatory, oxidative stress, and endothelial dysfunction play a key role in the pathogenesis of long-term cardiovascular complications in patients with diabetes. The present observational prospective study is aimed at evaluating the effects of micronutrients and phytochemicals contained in the dietary supplement Flebotrofine® (AMNOL Chimica Biologica) on biochemical markers of inflammation, endothelial dysfunction, and glycemic control in patients with diabetes.

Methods: 105 type 1 or type 2 diabetes patients regularly took a daily dose of the dietary supplement Flebotrofine® for three consecutive months, and haematological and biochemical parameters were checked at baseline, after three months of treatment, and one month after its suspension. Read More

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January 2022

An exploration of the use of 3D printed foot models and simulated foot lesions to supplement scalpel skill training in undergraduate podiatry students: A multiple method study.

PLoS One 2021 13;16(12):e0261389. Epub 2021 Dec 13.

Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia.

Background: Podiatrists regularly use scalpels in the management of foot pathologies, yet the teaching and learning of these skills can be challenging. The use of 3D printed foot models presents an opportunity for podiatry students to practice their scalpel skills in a relatively safe, controlled risk setting, potentially increasing confidence and reducing associated anxiety. This study evaluated the use of 3D printed foot models on podiatry students' anxiety and confidence levels and explored the fidelity of using 3D foot models as a teaching methodology. Read More

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January 2022

An Item Response Theory analysis of the Unified Multiple System Atrophy Rating Scale.

Parkinsonism Relat Disord 2021 Nov 30;94:40-44. Epub 2021 Nov 30.

French Reference Centre for MSA, University Hospital Bordeaux, Bordeaux, France; Institut des Maladies Neurodégénératives, CNRS, UMR 5293, Bordeaux University, Bordeaux, France; Dept. Medicine, University of Otago, Christchurch, and New Zealand Brain Research Institute, Christchurch, New Zealand.

Introduction: The Unified Multiple System Atrophy Rating Scale (UMSARS) has four subscales that have been specifically designed for the clinical assessment of MSA patients. UMSARS I (activities of daily living) and II (motor examination) subscales are regularly used as primary endpoints in treatment trials. The main objective of this study was to identify UMSARS I and II subscale items that best describe progression over time. Read More

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November 2021

Genetic ablation of PRDM1 in antitumor T cells enhances therapeutic efficacy of adoptive immunotherapy.

Blood 2021 Dec 3. Epub 2021 Dec 3.

Nagoya University, Japan.

Adoptive cancer immunotherapy can induce objective clinical efficacy in patients with advanced cancer; however, a sustained response is achieved in a minority of cases. The persistence of infused T cells is an essential determinant of a durable therapeutic response. Antitumor T cells undergo a genome-wide remodeling of the epigenetic architecture upon repeated antigen encounters, which inevitably induces progressive T-cell differentiation and the loss of longevity. Read More

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December 2021

Squamous cell carcinoma of the renal pelvis in a patient with long-term spinal cord injury-a case report.

Spinal Cord Ser Cases 2021 Nov 29;7(1):102. Epub 2021 Nov 29.

Occupational Medicine, Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund (IfADo), Dortmund, Germany.

Introduction: For individuals with spinal cord injury/disease (SCI/D) the risk of developing a stone in the upper urinary tract is up to six times higher than in the able-bodied population. Upper urinary tract carcinomas, in general, are rare and account for only 5-10% of all urinary tract carcinomas. It is believed that chronic upper urinary tract irritation caused by e. Read More

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November 2021

The Impact of Routine Molecular Screening for SARS-CoV-2 in Patients Receiving Anti-Cancer Therapy: An Interim Analysis of the Observational COICA Study.

Oncology 2021 Nov 26. Epub 2021 Nov 26.

Introduction: Cancer aggravates COVID-19 prognosis. Nosocomial transmission of SARS-CoV-2 is particularly frequent in cancer patients, who need to attend hospitals regularly. Since March, 2020, all cancer patients having access to the Oncology Unit at the "Andrea Tortora" Hospital (Pagani, Salerno - referred to as "the Hospital") as inpatients or outpatients receiving intravenous therapy have been screened for SARS-CoV-2 using RT-PCR nasal swab. Read More

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November 2021

The Role of Gender in Association between Emotional Intelligence and Self-Control among University Student-Athletes.

Int J Environ Res Public Health 2021 11 11;18(22). Epub 2021 Nov 11.

Department of Health Promotion and Rehabilitation, Lithuanian Sports University, 44221 Kaunas, Lithuania.

The purpose of this study was to reveal the peculiarities of undergraduate studies university student-athletes' emotional intelligence and self-control indicators, and the role of gender as a predictor in the association between emotional intelligence and self-control. The study included students regularly involved in training at least three times a week. The sample consisted of 1395 student athletes from Lithuanian universities, among them 59. Read More

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November 2021

Creating Ferroic Micropatterns through Geometrical Transformation.

Nano Lett 2021 Dec 22;21(23):9889-9895. Epub 2021 Nov 22.

Institute for Integrative Nanosciences, Leibniz IFW Dresden, 01069Dresden, Germany.

The functionality of a ferroic device is intimately coupled to the configuration of domains, domain boundaries, and the possibility for tailoring them. Exemplified with a ferromagnetic system, we present a novel approach which allows the creation of new, metastable multidomain patterns with tailored wall configurations through a self-assembled geometrical transformation. By preparing a magnetic layer system on a polymeric platform including swelling layer, a repeated self-assembled rolling into a multiwinding tubular structure and unrolling of the functional membrane is obtained. Read More

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December 2021

Overview of DaxibotulinumtoxinA for Injection: A Novel Formulation of Botulinum Toxin Type A.

Drugs 2021 Dec 17;81(18):2091-2101. Epub 2021 Nov 17.

Revance Therapeutics, Inc., 7555 Gateway Boulevard, Newark, CA, 94560, USA.

Botulinum toxin type A (BoNTA) products are widely used for therapeutic and aesthetic indications, but there is a need for longer-lasting treatments that maintain symptom relief between injections and reduce the frequency of re-treatment. DaxibotulinumtoxinA for Injection (DAXI) is a novel BoNTA product containing highly purified 150-kDa core neurotoxin and is the first to be formulated with a proprietary stabilizing excipient peptide (RTP004) instead of human serum albumin. The positively charged RTP004 has been shown to enhance binding of the neurotoxin to neuronal surfaces, which may enhance the likelihood of neurotoxin internalization. Read More

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December 2021

The Effects of Repeated Thermal Stress on the Physiological Parameters of Young Physically Active Men Who Regularly Use the Sauna: A Multifactorial Assessment.

Int J Environ Res Public Health 2021 11 1;18(21). Epub 2021 Nov 1.

Department of Tourism, Faculty of Geoengineering, Recreation and Ecology, University of Warmia and Mazury in Olsztyn, ul. Oczapowskiego 5, 10-719 Olsztyn, Poland.

The aim of this study was to determine the effects of thermal stress (TS) on changes in blood biochemical parameters and fluid electrolyte levels in young adult men with moderate and high levels of physical activity. Thirty men (22.67 ± 2. Read More

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November 2021

Empirical underidentification in estimating random utility models: The role of choice sets and standardizations.

Br J Math Stat Psychol 2021 Nov 8. Epub 2021 Nov 8.

Center for Economic Psychology, University of Basel, Switzerland.

A standard approach to distinguishing people's risk preferences is to estimate a random utility model using a power utility function to characterize the preferences and a logit function to capture choice consistency. We demonstrate that with often-used choice situations, this model suffers from empirical underidentification, meaning that parameters cannot be estimated precisely. With simulations of estimation accuracy and Kullback-Leibler divergence measures we examined factors that potentially mitigate this problem. Read More

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November 2021

[SARS-CoV-2 incidence, transmission, and containment measures in daycare centers during the COVID-19 pandemic-findings from the Corona Daycare Study].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2021 Dec 3;64(12):1581-1591. Epub 2021 Nov 3.

Institutsleitung, Deutsches Jugendinstitut, München, Deutschland.

Background: Daycare centers are of substantial sociopolitical and pedagogical relevance; at the same time, the close contact of children in daycare groups among each other and with employees favors the transmission of infections. In the COVID-19 pandemic, questions arose about how infection events occur in daycare centers, what role daycare children play in the pandemic, and what protective and hygienic measures are implemented in daycare centers. From 06/2020 to 12/2021, we conducted the "Corona Day Care Study," in which we address pedagogical and infection epidemiological topics in a joint approach. Read More

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December 2021

What Should Be Considered in the Evidence-Based Practice Competency-Based Curriculum for Undergraduate Nursing Students? From the Student's Point of View.

Int J Environ Res Public Health 2021 10 19;18(20). Epub 2021 Oct 19.

Department of Nursing, Nambu University, Gwangju 62271, Korea.

Background: The nursing curriculum should be systematically developed to improve the evidence-based practice (EBP) competencies of undergraduate nursing students. We attempted to identify the factors important for developing or improving the EBP-integrated nursing curriculum.

Methods: This study adopted the qualitative research design using qualitative content analysis. Read More

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October 2021

Current practice trends for lacrimal gland neurotoxin in the management of epiphora-a BOPSS survey.

Graefes Arch Clin Exp Ophthalmol 2021 Oct 18. Epub 2021 Oct 18.

Department of Oculoplastic, Orbit and Lacrimal Surgery, Manchester Royal Eye Hospital, Manchester University NHS Foundation Trust, Manchester, UK.

Purpose: Injection of botulinum neurotoxin A (BoNTA) to the lacrimal gland (LG) offers a simple and effective treatment in the management of epiphora. However, there is little data on current practice trends or uptake as an alternative to surgery. This study assesses current practice trends of such treatment amongst BOPSS (British Oculoplastic Surgery Society) members. Read More

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October 2021

Challenges with buprenorphine inductions in the context of the fentanyl overdose crisis: A case series.

Drug Alcohol Rev 2021 Oct 13. Epub 2021 Oct 13.

Interdepartmental Division of Addiction Medicine, St. Paul's Hospital, Vancouver, Canada.

Introduction And Aims: North America is currently experiencing an epidemic of opioid overdose deaths, driven by the proliferation of fentanyl in the street drug market. Although buprenorphine/naloxone (BUP/NX) is an evidence-based, first-line opioid agonist for the management of opioid use disorder, a key challenge in its prescribing lies in the fact that it can precipitate opioid withdrawal during its initial induction process. At this time, there is minimal literature on the BUP/NX induction process in individuals who use illicit fentanyl regularly. Read More

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October 2021

Prevalence and factors associated with urinary incontinence in females with cystic fibrosis: An Italian single-center cross-sectional analysis.

Pediatr Pulmonol 2022 01 18;57(1):132-141. Epub 2021 Oct 18.

Cystic Fibrosis Centre, Fondazione IRCCS Ca', Granda Ospedale Maggiore Policlinico, Milano, Italy.

Background: Individuals with cystic fibrosis (CF) are deemed to have a higher risk of developing urinary incontinence (UI), likely due to repeated increasing pressure on the pelvic floor. We aimed to determine the prevalence of female UI in a large CF referral center, and to assess the association between UI and severity of CF disease.

Methods: We consecutively recruited female patients regularly attending our CF center, aged ≥6 years and with a confirmed diagnosis of CF. Read More

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January 2022

Hemodynamic Impact of Drug Interactions With Epinephrine and Antipsychotics Under General Anesthesia With Propofol.

Anesth Prog 2021 10;68(3):141-145

Department of Dental Anesthesiology, The Nippon Dental University School of Life Dentistry, Tokyo, Japan.

Objective: Antipsychotic drugs exhibit α-1 adrenergic receptor-blocking activity. When epinephrine and antipsychotic drugs are administered in combination, β-2 adrenergic effects are thought to predominate and induce hypotension. This study aimed to assess hemodynamic parameters in patients regularly taking antipsychotics who were administered epinephrine-containing lidocaine under general anesthesia in a dental setting. Read More

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October 2021

Masticatory efficiency, bite force and electrical activity of the masseter and temporalis muscles in bodybuilders.

J Clin Exp Dent 2021 Sep 1;13(9):e920-e926. Epub 2021 Sep 1.

DDS, MSC, PhD. Department of Dental Materials and Prosthodontics, Araçatuba School of Dentistry, São Paulo State University-UNESP. Road Jose Bonifacio 1193, Vila Mendonca, Aracatuba. São Paulo, Brazil.

Background: This study aimed to compare the masticatory efficiency, the maximum voluntary occlusal bite force (MVOBF) and the electrical activity (EMG) of masticatory muscles of practitioners of upper limb bodybuilding before and after physical activity.

Material And Methods: Twenty healthy individuals (10 men and 10 women, age from 18 to 30 (mean of 24.7 years old) without masticatory system disorders, that regularly practice hypertrophic physical activity were submitted to the analyses of masticatory efficiency, MVOBF, and surface EMG of the temporalis and masseter muscles. Read More

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September 2021

Reorganization of the Neurobiology of Language After Sentence Overlearning.

Cereb Cortex 2021 Sep 29. Epub 2021 Sep 29.

Experimental Psychology, University College London, London, UK.

It is assumed that there are a static set of "language regions" in the brain. Yet, language comprehension engages regions well beyond these, and patients regularly produce familiar "formulaic" expressions when language regions are severely damaged. These suggest that the neurobiology of language is not fixed but varies with experiences, like the extent of word sequence learning. Read More

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September 2021

Short-Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis.

Hepatol Commun 2021 Aug 25. Epub 2021 Aug 25.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Current guidelines recommend restricting acetaminophen (APAP) use in patients with cirrhosis, but evidence to support that recommendation is lacking. Prior studies focused on pharmacokinetics (PK) of APAP in cirrhosis but did not rigorously examine clinical outcomes, sensitive biomarkers of liver damage, or serum APAP-protein adducts, which are a specific marker of toxic bioactivation. Hence, the goal of this pilot study was to test the effects of regularly scheduled APAP dosing in a well-defined compensated cirrhosis group compared to control subjects without cirrhosis, using the abovementioned outcomes. Read More

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Promoting resilience and lower stress in nurses and improving inpatient experience through emotional intelligence training in China: A randomized controlled trial.

Nurse Educ Today 2021 Dec 6;107:105130. Epub 2021 Sep 6.

Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. Electronic address:

Background: Emotional intelligence training relieves stress and promotes resilience among nurses. Previous studies have not sufficiently explored the effect of emotional intelligence training among nurses on the experience of inpatients under their care.

Objective: To explore the effects of emotional intelligence training on emotional intelligence, resilience, and perceived stress among nurses and examine how training affects inpatient experience. Read More

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December 2021

Pediatric shunt revision analysis within the first year of shunt placement: A single center experience.

Surg Neurol Int 2021 24;12:419. Epub 2021 Aug 24.

Department of Neurosurgery, Dr. Soetomo General Academic Hospital, Surabaya, East Java, Indonesia.

Background: Hydrocephalus is a common problem in neurosurgery with shunt placement remains the mainstay of the management. However, shunt placement generally requires following surgical procedures, including shunt revision. Despite the recent developments, the incidence of shunt failure remains high, approximately 30-51% in the 1 year following the shunt placement. Read More

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