81,499 results match your criteria regression revealed


Vitamin D Receptor Gene Polymorphisms and Risk of Alzheimer Disease and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.

Adv Nutr 2021 Jun 24. Epub 2021 Jun 24.

Department of Geratology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

The results from epidemiologic studies suggest that vitamin D receptor (VDR) gene polymorphisms are potentially associated with Alzheimer disease (AD) and mild cognitive impairment (MCI), but this association has yet to be confirmed. Here, we conducted a meta-analysis based on a larger sample size to clarify the contribution of VDR gene polymorphisms to MCI and AD susceptibility. The PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure databases were searched to obtain studies published before 30 October, 2020. Read More

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Comorbidities worsen the prognosis of generalized myasthenia gravis post-thymectomy.

J Neurol Sci 2021 Jun 19;427:117549. Epub 2021 Jun 19.

Department of Neurosciences, University of Helsinki, Helsinki, Finland; Department of Neurology, Neurocenter, Helsinki University Hospital, Helsinki, Finland.

Background: The effect of comorbidities on the prognosis of myasthenia gravis (MG) remains unclear. In particular, the role of other autoimmune diseases (AD) is controversial.

Methods: In this retrospective single-center cohort study, we investigated 154 consecutive generalized thymectomized MG patients, with a mean follow-up time of 8. Read More

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Association of baseline diaphragm, rectus femoris and vastus intermedius muscle thickness with weaning from mechanical ventilation.

Respir Med 2021 Jun 12;185:106503. Epub 2021 Jun 12.

Division of Intensive Care Medicine, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey. Electronic address:

Background: To determine whether baseline diaphragm (T), rectus femoris (RF) and vastus intermedius (VI) muscle thickness (T and T) are associated with weaning success.

Material And Methods: Right T, T and T were measured by ultrasonography within 36 h of intubation and diaphragmatic excursion (DE) was evaluated at the first spontaneous breathing trial in adult critically-ill patients. Reintubation or death within 7 days after extubation was defined as weaning failure. Read More

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The role of the observers' perception of a model's self-confidence in observationally induced placebo analgesia.

J Pain 2021 Jun 21. Epub 2021 Jun 21.

Jagiellonian University, Institute of Psychology, Pain Research Group, ul. Ingardena 6, 30-060, Kraków, Poland. Electronic address:

The aim of this study was to investigate the effect on observationally acquired placebo analgesia of a model's self-confidence as well as the observer's self-esteem and self-efficacy. In addition, we aimed to verify the stability of the placebo effect induced by observational learning. Participants (N = 60) were randomly assigned to one of three groups: a self-confident model, an unself-confident model, and a control group. Read More

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Survival prediction based on the gene expression associated with cancer morphology and microenvironment in primary central nervous system lymphoma.

PLoS One 2021 24;16(6):e0251272. Epub 2021 Jun 24.

Osaka Iseikai Clinic for Cancer Therapy, Iseikai Holonics Group, Osaka, Japan.

Dysregulation of cell morphology and cell-cell interaction results in cancer cell growth, migration, invasion, and metastasis. Besides, a balance between the extracellular matrix (ECM) and matrix metalloprotease (MMP) is required for cancer cell morphology and angiogenesis. Here, we determined gene signatures associated with the morphology and microenvironment of primary central nervous system lymphoma (PCNSL) to enable prognosis prediction. Read More

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Remote and adjacent psychological predictors of early-adulthood resilience: Role of early-life trauma, extraversion, life-events, depression, and social-support.

PLoS One 2021 24;16(6):e0251859. Epub 2021 Jun 24.

Department of Nursing Psychology, Army Medical University, Chongqing, China.

Resilience is important for people to maintain mental health after negative life-events. However, its longitudinal psychological and social predictors are poorly revealed. Based on the ecological system theory model, the current study aimed to determine the longitudinal temporal mechanism underlying the development of early-adulthood resilience using long-term (early-life trauma and personality), medium-term and short-term (life-events, social support, and depression) psychosocial predictors. Read More

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[Redo surgery of carotid arteries in patients with contraindications to carotid angioplasty and stenting].

Angiol Sosud Khir 2021 ;27(2):92-98

Kemerovo State Medical University of the RF Ministry of Public Health, Kemerovo, Russia.

Aim: The study was aimed at analysing the in-hospital results of carotid re-endarterectomy and plasty of the zone of reconstruction with a biological patch in patients with haemodynamically significant restenosis and contraindications to carotid angioplasty with stenting.

Patients And Methods: During the period from 2008 to 2019, we operated on a total of 22 patients presenting with carotid restenosis and found to have contraindications to carotid angioplasty with stenting (an extended lesion, unstable neointima, calcification, pronounced tortuosity). Carotid re-endarterectomy was performed according to the classical technique. Read More

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January 2021

Pathophysiologic Signature of Impending ICU Hypoglycemia in Bedside Monitoring and Electronic Health Record Data: Model Development and External Validation.

Crit Care Med 2021 Jun 24. Epub 2021 Jun 24.

Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA. Center for Advanced Medical Analytics, University of Virginia, Charlottesville, VA. Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA. Advanced Medical Predictive Devices, Diagnostics, and Displays, Charlottesville, VA. Division of Cardiology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA.

Objectives: We tested the hypothesis that routine monitoring data could describe a detailed and distinct pathophysiologic phenotype of impending hypoglycemia in adult ICU patients.

Design: Retrospective analysis leading to model development and validation.

Setting: All ICU admissions wherein patients received insulin therapy during a 4-year period at the University of Virginia Medical Center. Read More

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Increased Risk of Adverse Cardiovascular Events by Strict Glycemic Control after Percutaneous Coronary Intervention (HbA1c < 6.5% at 2 Years) in Type 2 Diabetes Mellitus Combined with Acute Coronary Syndrome: a 5-years follow-up study.

Curr Med Res Opin 2021 Jun 24. Epub 2021 Jun 24.

Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110000.

This study assessed the association between HbA1c level measured 2 years after percutaneous coronary intervention (PCI) and long-term clinical outcomes in type 2 diabetes mellitus combined with acute coronary syndrome (ACS) who underwent PCI. This prospective observational study analyzed 2877 ACS patients with type 2 diabetes mellitus whose baseline HbA1c ≥ 7.0% and underwent PCI. Read More

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Mental Stress, Anxiety and Depressive Symptoms and Interleuken-6 Level among Healthcare Workers during the COVID-19 Pandemic.

J Prim Care Community Health 2021 Jan-Dec;12:21501327211027432

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Objectives: This study aimed to evaluate the interleukin-6 (IL-6) levels and its relationship to stress, anxiety, and depressive symptoms among healthcare workers (HCWs) compared to controls during the COVID-19 pandemic.

Methods: A total of 80 HCWs in Suez Canal University Hospital in Ismailia, Egypt, and 80 controls were analyzed during the COVID-19 pandemic. The Depression, Anxiety and Stress Scale (DASS 21) questionnaire was used, and serum IL-6 level was determined in both groups. Read More

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Silent Neurological Lesions Detected by Magnetic Resonance Imaging: Relationship to Hyperparathyroidism among End Stage Renal Disease Young Patients on Hemodialysis.

Int J Clin Pract 2021 Jun 24:e14569. Epub 2021 Jun 24.

Department of Neurology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Background: End-stage renal disease (ESRD) patients on hemodialysis (HD) suffer from several peripheral and central neurological complications. They are at high risk for developing silent neurological lesions (SNL) that may detected accidentally by magnetic resonance imaging (MRI). Many factors are implicated in the development of neurological deficits in ESRD patients on HD. Read More

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Development and Validation of a Preference-Based Glaucoma Utility Instrument Using Discrete Choice Experiment.

JAMA Ophthalmol 2021 Jun 24. Epub 2021 Jun 24.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

Importance: A glaucoma-specific instrument for estimating utilities across the spectrum of glaucoma severity is currently lacking, hindering the assessment of the cost-effectiveness of glaucoma treatments.

Objective: To develop and validate the preference-based Glaucoma Utility Instrument (Glau-U) and to ascertain the association between Glau-U utilities and severity of glaucoma and vision impairment.

Design, Setting, And Participants: This cross-sectional study was conducted in 2 stages at the Singapore National Eye Centre glaucoma clinics. Read More

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QSCR Analysis of Cytotoxicity of 6-Fluoro-3-(4H-1,2,4-triazol-3-yl)quinolin-4(1H)-ones on Chinese Hamster Ovary Cell Line: Design of REPUBLIC1986.

Curr Med Chem 2021 Jun 23. Epub 2021 Jun 23.

West China School of Nursing / Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.

Background: 6-Fluoro-3-(4H-1,2,4-triazol-3-yl)quinolin-4(1H)-ones are promising antitumor agents with enormous data on their profound cytotoxic effects on the human cancer cell lines.

Objectives: We sought to perform a Quantitative structure cytotoxicity relationship (QSCR) analysis of a series of previously reported fluoroquinolone analogues using computer-assisted multiple regression analysis and investigate the cytotoxicity-inducing structural parameters among these congeners.

Methods: The dataset was segregated into training and test sets of 6-Fluoro-3-(4H-1,2,4-triazol-3-yl)quinolin-4(1H)-ones by using a random selection method embedded in Vlife MDS 4. Read More

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Interleukin-6 and triceps skinfold are associated with severity/cancer stage in newly-diagnosed colorectal cancer patients.

Nutr Hosp 2021 Jun 24. Epub 2021 Jun 24.

Faculdade de Nutrição (FANUT). Universidade Federal de Alagoas (UFAL).

Introduction: colorectal cancer (CRC) has an important impact on morbidity and mortality globally, and nitroxidative stress, inflammation, and nutritional status are linked with its progression.

Aim: to analyze the association of inflammatory, anthropometric, functional, and oxidative markers with tumor stage in newly-diagnosed CRC patients at a public reference center in Maceió, Alagoas, Brazil.

Methods: patient-generated subjective global assessment was applied, and weight, height, arm circumference, triceps skinfold (TSF), arm muscle circumference, and handgrip strength were obtained. Read More

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Neutrophil to lymphocyte ratio predicts early growth of traumatic intracerebral haemorrhage.

Ann Clin Transl Neurol 2021 Jun 24. Epub 2021 Jun 24.

Department of Neurosurgery, First Affiliated Hospital, Shantou University Medical College, 57 Changping Road, Shantou, Guangdong, 515000, China.

Objective: The neutrophil to lymphocyte ratio (NLR) has been proposed to capture the inflammatory status of patients with various conditions involving the brain. This retrospective study aimed to explore the association between the NLR and the early growth of traumatic intracerebral haemorrhage (tICH) in patients with traumatic brain injury (TBI).

Methods: A multicentre, observational cohort study was conducted. Read More

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Risk Factors Associated with Ninety Day Readmission in Chronic Obstructive Pulmonary Disease Exacerbation at a Tertiary Care Hospital: A retrospective cohort study.

Authors:
P Pant A Joshi

Kathmandu Univ Med J (KUMJ) 2020 Oct.-Dec.;18(72):372-375

Department of General Practice and Emergency Medicine, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal.

Background Chronic obstructive pulmonary disease (COPD) exacerbation is a leading cause of frequent hospital admission. Globally, several studies have reported potential risk factors associated with COPD exacerbations which are largely unknown in Nepalese health care setting. Objective To identify the risk factors associated with hospital readmission within ninety days of discharge in acute COPD exacerbation. Read More

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Polymorphisms in the GCK gene increase the risk of clopidogrel resistance in stable coronary artery disease (SCAD) patients.

Hematology 2021 Dec;26(1):447-452

Department of Cardiology, Ningbo No. 1 Hospital, Ningbo, People's Republic of China.

Background: Diabetes mellitus is a major factor in clopidogrel resistance (CR), and the glucokinase (GCK) gene plays a pivotal role in glucose homeostasis. This study investigated the contribution of GCK polymorphisms to CR risk.

Methods: Two hundred SCAD patients were recruited, and their platelet functions were detected by the Verify-Now P2Y12 assay. Read More

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December 2021

Identifying a novel biological mechanism for alcohol addiction associated with circRNA networks acting as potential miRNA sponges.

Addict Biol 2021 Jun 23:e13071. Epub 2021 Jun 23.

Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.

Our lab and others have shown that chronic alcohol use leads to gene and miRNA expression changes across the mesocorticolimbic (MCL) system. Circular RNAs (circRNAs) are noncoding RNAs that form closed-loop structures and are reported to alter gene expression through miRNA sequestration, thus providing a potentially novel neurobiological mechanism for the development of alcohol dependence (AD). Genome-wide expression of circRNA was assessed in the nucleus accumbens (NAc) from 32 AD-matched cases/controls. Read More

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Role of corpus callosum in sleep spindle synchronization and coupling with slow waves.

Brain Commun 2021 25;3(2):fcab108. Epub 2021 May 25.

School of Bioscience and Veterinary Medicine, University of Camerino, Camerino 62032, Italy.

Sleep spindles of non-REM sleep are transient, waxing-and-waning 10-16 Hz EEG oscillations, whose cortical synchronization depends on the engagement of thalamo-cortical loops. However, previous studies in animal models lacking the corpus callosum due to agenesis or total callosotomy and in humans with agenesis of the corpus callosum suggested that cortico-cortical connections may also have a relevant role in cortical (inter-hemispheric) spindle synchronization. Yet, most of these works did not provide direct quantitative analyses to support their observations. Read More

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Expression and prognostic analysis of Rho GTPase-activating protein 11A in lung adenocarcinoma.

Ann Transl Med 2021 May;9(10):872

Department of Radiation Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.

Background: Rho GTPase-activating protein 11A (ARHGAP11A) is a member of the Rho GTPase-activating protein (RhoGAP) subfamily. However, its expression, prognostic significance and clinicopathologic factors correlation in lung adenocarcinoma is still unclear.

Methods: The original gene expression profile, survival data, and clinical information of patients with lung adenocarcinoma (LUAD) were downloaded from The Cancer Genome Atlas (TCGA) database. Read More

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Carbon nanoparticle-guided intraoperative lymph node biopsy predicts the status of lymph nodes posterior to right recurrent laryngeal nerve in cN0 papillary thyroid carcinoma.

Gland Surg 2021 May;10(5):1554-1563

Center for Thyroid and Breast Surgery, Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

Background: The lymph nodes in the right central compartment can be divided into 2 parts by the right recurrent laryngeal nerve (RLN), and there is a lack of an accurate and convenient method for assessing metastases in the lymph node posterior to the right recurrent laryngeal nerve (LN-prRLN) in cN0 thyroid papillary carcinoma patients.

Methods: Patients diagnosed with cN0 thyroid papillary carcinoma and underwent intraoperative carbon nanoparticle-guided lymph node biopsy from January 2017 to November 2020 at the Center for Thyroid and Breast Surgery of Xuanwu Hospital were retrospectively analyzed. The intraoperative frozen section examination and postoperative LN-prRLN status should have been comprehensively recorded. Read More

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Characteristics of hypoxic tumor microenvironment in non-small cell lung cancer, involving molecular patterns and prognostic signature.

Transl Lung Cancer Res 2021 May;10(5):2132-2147

Nantong Key Laboratory of Translational Medicine in Cardiothoracic Diseases, and Research Institution of Translational Medicine in Cardiothoracic Diseases, Affiliated Hospital of Nantong University, Nantong, China.

Background: The mechanisms of hypoxia or immune microenvironment in cancer have been studied respectively, but the role of hypoxia immune microenvironment in non-small cell lung cancer (NSCLC) still needs further exploration.

Methods: By applying the K-means algorithm, 1,121 patients with NSCLC were divided into three categories. We evaluated the constructed signature in order to link it with the prognosis, which was constructed by univariate and least absolute shrinkage operator (LASSO) Cox regression analysis. Read More

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Assessment of relationships among clinicopathological characteristics, morphological computer tomography features, and tumor cell proliferation in stage I lung adenocarcinoma.

J Thorac Dis 2021 May;13(5):2844-2857

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Surgically resected stage I lung adenocarcinoma (ADC) has wide variation in prognosis. It is significant to identify high-risk patients and optimize therapeutic strategy. This study aimed to investigate the relationships among histological grade, serum tumor marker index (TMI), morphological computer tomography (CT) features, and a well-established prognosticator cell proliferation (Ki-67) in stage I ADC. Read More

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Role of surgery in a case-control study of patients with clinical stage IIIA small cell lung cancer.

J Thorac Dis 2021 May;13(5):2738-2745

Department of Thoracic Surgery, Tongji University Affiliated Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Background: The role of surgery in the multidisciplinary treatment of clinical stage IIIA small cell lung cancer is yet to be verified. This study was performed to determine the benefit of surgery in patients with stage IIIA small cell lung cancer.

Methods: Patients diagnosed with stage IIIA small cell lung cancer at Shanghai Pulmonary Hospital from 2005 to 2015 were included and divided into two groups: the surgery with neoadjuvant and adjuvant chemotherapy group and the concurrent chemo-radiotherapy group. Read More

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Gray Matter Abnormalities in Type 1 and Type 2 Diabetes: A Dual Disorder ALE Quantification.

Front Neurosci 2021 7;15:638861. Epub 2021 Jun 7.

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong.

Diabetes mellitus (DM) is associated with comorbid brain disorders. Neuroimaging studies in DM revealed neuronal degeneration in several cortical and subcortical brain regions. Previous studies indicate more pronounced brain alterations in type 2 diabetes mellitus (T2DM) than in type 1 diabetes mellitus (T1DM). Read More

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Sleep Quality and Related Factors in Patients with Breast Cancer: A Cross-Sectional Study in Taiwan.

Cancer Manag Res 2021 14;13:4725-4733. Epub 2021 Jun 14.

Division of Thoracic Oncology, Department of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi branch, Puzi City, Chiayi County, 61363, Taiwan, R.O.C.

Background: Sleep disturbances are common and symptomatic burden in patients with breast cancer, but they are poorly documented and managed in routine clinical practice. This descriptive and cross-sectional study evaluated factors associated with post-treatment sleep disturbances in patients with breast cancer.

Patients And Methods: Patients with breast cancer who underwent standard treatment were enrolled and surveyed for their basic demographic data and precancerous and cancer treatment-related factors; they were also administered self-report questionnaires including the Family Adaptation, Partnership, Growth, Affection, Resolve questionnaire; Impact of Event Scale; Center for Epidemiologic Studies Depression Scale; and Maudsley Personality Inventory. Read More

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KDELC1 and TRMT1 Serve as Prognosis-Related SARS-CoV-2 Proteins Binding Human mRNAs and Promising Biomarkers in Clear Cell Renal Cell Carcinoma.

Int J Gen Med 2021 14;14:2475-2490. Epub 2021 Jun 14.

Department of Breast Surgery and General Surgery, Guangzhou Women and Children's Medical Center, Guangzhou, Guangdong, People's Republic of China.

Background: SARS-CoV-2 proteins binding human mRNAs (SPBRs) have been proven to regulate a variety of tumor-related functions in different types of cancer. However, their biological roles and potential mechanisms in clear cell renal cell carcinoma (ccRCC) are still elusive. Herein, we investigate the expression and prognostic value of SPBRs in ccRCC through bioinformatics methods. Read More

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Zc3h12d, a Novel of Hypomethylated and Immune-Related for Prognostic Marker of Lung Adenocarcinoma.

J Inflamm Res 2021 15;14:2389-2401. Epub 2021 Jun 15.

Department of Thoracic Surgery, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, 300192, People's Republic of China.

Background: Zc3h12d is a negative regulator which plays a crucial role in immune modulation. However, the role of zc3h12d in lung adenocarcinoma (LUAD) remains unclear. We aim to explore the prognostic of zc3h12d and investigate the relationship between zc3h12d expression and immune infiltration in LUAD. Read More

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The impact of diabetes mellitus on spinal fracture with diffuse idiopathic skeletal hyperostosis: A multicenter retrospective study.

J Orthop Sci 2021 Jun 20. Epub 2021 Jun 20.

Dept. of Orthopaedic Surgery, Keio University, Tokyo, Japan; Japanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo, Japan. Electronic address:

Background: Patients with diffuse idiopathic skeletal hyperostosis (DISH) are susceptible to spinal column injuries with neurological deterioration. Previous studies indicated that the prevalence of diabetes mellitus (DM) in patients with DISH was higher than that in patients without DISH. This study investigates the impact of DM on surgical outcomes for spinal fractures in patients with DISH. Read More

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Cardiovascular magnetic resonance for the detection of descending thoracic aorta calcification in patients with end-stage renal disease.

J Cardiovasc Magn Reson 2021 Jun 24;23(1):85. Epub 2021 Jun 24.

Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, G12 8TA, UK.

Background: Vascular calcification is an independent predictor of cardiovascular disease in patients with chronic kidney disease. Computed tomography (CT) is the gold-standard for detecting vascular calcification. Radial volumetric-interpolated breath-hold examination (radial-VIBE), a free-breathing gradient-echo cardiovascular magnetic resonance (CMR) sequence, has advantages over CT as it is ionising radiation-free. Read More

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